LOCUS       XM_017008416            4662 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase cGMP-dependent 2 (PRKG2),
            transcript variant X2, mRNA.
ACCESSION   XM_017008416
VERSION     XM_017008416.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017008416.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..4662
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="protein kinase cGMP-dependent 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 3 ESTs, 39 long SRA reads, 9 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5593"
                     /db_xref="HGNC:HGNC:9416"
                     /db_xref="MIM:601591"
     CDS             36..2324
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /codon_start=1
                     /product="cGMP-dependent protein kinase 2 isoform X1"
                     /protein_id="XP_016863905.2"
                     /db_xref="GeneID:5593"
                     /db_xref="HGNC:HGNC:9416"
                     /db_xref="MIM:601591"
                     /translation="MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEI
                     QEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVP
                     LEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLIT
                     DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQG
                     EKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQ
                     YRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVT
                     QSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG
                     TFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPF
                     QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEEL
                     CSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDY
                     LHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN
                     KGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDL
                     IRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY
                     FDKYPPEKGMPPDELSGWDKDF"
ORIGIN      
        1 gacagaggag ggcatgtcca gggtccctga gcaaaatggg aaatggttca gtgaaaccta
       61 aacattctaa gcacccagat ggacactctg ggaacctcac cactgatgct ctgcggaaca
      121 aggtgacaga gctggagaga gagttgagga ggaaggatgc tgagatccag gagcgggagt
      181 accatttgaa ggagctgcgg gagcagctgt cgaagcagac tgtggccatt gctgaactca
      241 cagaggagct ccagaacaag tgcatccagc tgaacaagct gcaggatgtg gtgcatatgc
      301 agggaggaag cccgcttcag gcctctccag ataaagtgcc tcttgaggtc caccggaaga
      361 cctctggatt ggtctctctc catagcagga ggggagcaaa ggctggcgtg tctgctgagc
      421 caacaacccg gacctatgac ctgaacaaac cccctgaatt ttcctttgag aaagcaagag
      481 tcagaaaaga ctccagtgag aagaagctca ttacagatgc ccttaataaa aatcagtttc
      541 tgaaaagact ggatcctcag cagatcaaag acatggtgga atgcatgtat gggagaaact
      601 atcagcaagg gagttacatt attaagcaag gagaaccagg aaaccatatc tttgtgctgg
      661 cagagggtcg actagaggtg ttccaagggg agaaattgct gtcctccatc cctatgtgga
      721 ccacatttgg ggagcttgcc attttataca attgtacaag gactgcctct gtgaaagcta
      781 ttaccaatgt taaaacatgg gcactagatc gagaggtatt ccagaatata atgaggagga
      841 cagcccaagc tagagatgaa caatacagaa acttcctcag aagtgtatcc ttgctgaaga
      901 atttacctga agataaatta accaagatca ttgactgctt ggaagtggaa tactatgaca
      961 aaggagatta catcattaga gagggcgagg aaggaagtac ctttttcatt ttggcaaaag
     1021 gaaaggtaaa agtaacacag agcacagaag gccatgatca accacagctg ataaaaacac
     1081 tgcagaaagg agaatacttt ggagaaaaag ctcttatcag tgatgatgtc aggtcagcta
     1141 acattattgc tgaagaaaat gatgttgcat gcctggttat agatcgagaa acattcaacc
     1201 aaactgtcgg tacatttgaa gagctgcaaa aataccttga aggatatgtg gcaaacctga
     1261 accgtgatga tgaaaaaaga catgcgaagc ggtccatgtc taactggaag ctgtccaaag
     1321 cactctctct ggaaatgatt cagctgaagg agaaggtggc cagattttcc tcatcatccc
     1381 cattccagaa ccttgagatt attgcaacac tgggcgttgg tgggttcgga agagttgagc
     1441 ttgttaaagt aaaaaatgag aatgttgctt ttgctatgaa gtgtataagg aagaagcaca
     1501 tagttgacac caagcagcag gagcatgtct actcagagaa gaggatccta gaggagctgt
     1561 gctctccatt cattgtgaaa ttatatcgta ctttcaagga caataagtat gtatacatgc
     1621 ttctggaggc ctgcttaggt ggggagctct ggagtatatt aagggacaga ggcagctttg
     1681 atgaacccac ctccaaattc tgcgttgctt gtgtgacaga agcatttgat tacctgcatc
     1741 gactaggtat tatctacaga gacttgaaac cagaaaactt aattctagat gctgagggtt
     1801 accttaaatt ggttgacttt ggatttgcga agaaaatagg gtctggacag aaaacatgga
     1861 cattctgtgg gactccagaa tatgtagctc ctgaagtcat tctcaacaag ggacatgact
     1921 tcagtgtgga tttctggtca ctgggaattc tagtgtatga gctcctaacg ggcaacccac
     1981 ccttttctgg ggttgaccaa atgatgacct acaatttgat tctcaaagga attgaaaaaa
     2041 tggattttcc caggaagata acacgacgac ctgaggattt gattcggagg ctttgcaggc
     2101 aaaatccaac agaaaggctg ggaaatctga agaatggaat aaatgacatt aagaaacaca
     2161 ggtggttaaa tggttttaat tgggagggac tgaaagcacg gagccttcca tcacctttgc
     2221 aaagagagct caagggaccc atagatcaca gctactttga caaatatcct cctgaaaagg
     2281 gaatgcctcc agatgagcta tcaggctggg ataaagactt ctgacagaag aaaagttgat
     2341 tactgcctgt actctacaga agaggacctc aaggatcaat aatccaacac attattttct
     2401 tttcagagta ttataatatc tttggaagac cattagggaa aagaaattcc tgcacaatgg
     2461 gaagaggaga atggtgtgga tatggttctg agttatagtg tcttatttag atgctgtgaa
     2521 ttattgatgt attacattat ttgcttttct caactgctag aggctacccc attttccttt
     2581 ccacaatcag agccattttt gttaaagtgg cagttttttc tgcaatctat tgttccattc
     2641 caatcatatc cttctcgttt gagtactact aacgtttaaa aagggtcttg cccttgaata
     2701 actaagtcat acaaatagaa ggaaaaacaa tggtgaattt tggagagctc cccagctctc
     2761 agcaacttca tataagcatg gtggtatctt aaaatggtgg tttgcagaaa ccatggtagc
     2821 caacagaacc tcctgacttt cacctgcttt taacctgaaa atatattaat acgcctctga
     2881 catgagtcca gggagaggca agattgagca atagtcagtg gcaccatttc ctaaagtaac
     2941 tgaatcaatc aatccagtca ggtaattatt ttctattggg gaacttagaa aaaaaagtaa
     3001 agcaagaaat attttctctc ctttatgatc agtgatacct tagagacttt tcgaaagtcc
     3061 ttgttaaaga tagttacaat gtgtggttaa atgatgctaa aatattttca caaccagagt
     3121 agaaaacgtg ctggaacaaa attgcgaagg cttttgcctc ccagtaaata gaaaggaaaa
     3181 tatattctag taggtaagac tgctgactct ttgaaaatct gaggtatttt gaaaaattct
     3241 gtgatagttg ctattaataa accaaaattg tatagaatca tcgttaattt ttaatataaa
     3301 tcccattgac aaatgttgat gcactgtagt cactgctgag ttaatagcgc tttttaaaga
     3361 catctgagtc atggatgtgt ttataaattt agattgttaa gacaggcaag ccaccagaaa
     3421 agtgatagga tttcagaagt aaaagggaca acagcatccc tcctatccct tccttgcact
     3481 ctcccaaata ataagtagga tagtttcaat agcatgggac ctagtaccta agaacttcac
     3541 tggtgaatgg ttgtatgtat tgaccatgat cattccctta ccctccttcc aaaatgaatg
     3601 agaagcagag acttttctgt attttttaaa tctagcagag taaaaatact gtataagttc
     3661 cgggattatt caagcttctg gttatatttt catatgttaa tgttctatgt caaaaggaac
     3721 ctctacccag tccccactca taatttcatc atccagaaaa aagccagcta tatgcttcct
     3781 taatgagtta agctagataa gtgaagccca atccagaaag gtgcatcctt aacaaattag
     3841 atttccacat ttataatcct tttgctgaac caaagagttt ttgtttcctg gagctgtatt
     3901 tttaaagatt atgtattgta catagaataa tcatttttaa taggattgac ataacctgct
     3961 taaagaattt ctaagagttt ttaaagattt ttatttgaat ttggttggtt tgtactgtat
     4021 gtttttccat gtatatattt ttaaatttcc aacctataaa gatagaaaat ttatgtattg
     4081 ggtggatatt agaactatac agttataata ggaatgatat tctcaaagca gatcaatagt
     4141 tgtaattttt aaaaccctac atatatagaa ataaccaagt tagagtacta caggtttatt
     4201 tttcctgtga ttgaccatgt caatgtgtta tcctcccatg tgatttttta ttgtttcctt
     4261 agagtacttt aaaagatgaa gaaatgagag actgaaccat tgaataatcc caactccacc
     4321 atttcctaac tgagtgactc tgggaaagtg atttagcttt tttgagtact agctttctca
     4381 ttcatagaaa aaggcagagt aaagtaatat ttacttagag gtttgtttca gggattaagt
     4441 tatgtagaga gtcttttgcc cggtatctgt gaaataacca ttgctgcata gacgggagct
     4501 actgttactg tctctattaa aattaaaggg gccttaataa ccatttagtc ctgaatctta
     4561 tgtatcattg gtatctgtat gcagaattgt acttatcaaa tccagtatct gtcttttttt
     4621 tcttttaaat catgaagtaa aaatgattga ccaaaaactt cg
//
