LOCUS       NM_006259               4922 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein kinase cGMP-dependent 2 (PRKG2), transcript
            variant 1, mRNA.
ACCESSION   NM_006259
VERSION     NM_006259.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Mollaoglu,E., Uludag Alkaya,D., Yildiz,C.A., Kasap,B. and Tuysuz,B.
  TITLE     Natural history of clinical features in two brothers with
            acromesomelic dysplasia related to PRKG2
  JOURNAL   Clin Genet 103 (5), 574-579 (2023)
   PUBMED   36504352
  REMARK    GeneRIF: Natural history of clinical features in two brothers with
            acromesomelic dysplasia related to PRKG2.
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Pagnamenta,A.T., Diaz-Gonzalez,F., Banos-Pinero,B., Ferla,M.P.,
            Toosi,M.B., Calder,A.D., Karimiani,E.G., Doosti,M., Wainwright,A.,
            Wordsworth,P., Bailey,K., Ejeskar,K., Lester,T., Maroofian,R.,
            Heath,K.E., Tajsharghi,H., Shears,D. and Taylor,J.C.
  CONSRTM   Genomics England Research Consortium
  TITLE     Variable skeletal phenotypes associated with biallelic variants in
            PRKG2
  JOURNAL   J Med Genet 59 (10), 947-950 (2022)
   PUBMED   34782440
  REMARK    GeneRIF: Variable skeletal phenotypes associated with biallelic
            variants in PRKG2.
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Diaz-Gonzalez,F., Wadhwa,S., Rodriguez-Zabala,M., Kumar,S.,
            Aza-Carmona,M., Sentchordi-Montane,L., Alonso,M., Ahmad,I.,
            Zahra,S., Kumar,D., Kushwah,N., Shamim,U., Sait,H., Kapoor,S.,
            Roldan,B., Nishimura,G., Offiah,A.C., Faruq,M. and Heath,K.E.
  TITLE     Biallelic cGMP-dependent type II protein kinase gene (PRKG2)
            variants cause a novel acromesomelic dysplasia
  JOURNAL   J Med Genet 59 (1), 28-38 (2022)
   PUBMED   33106379
  REMARK    GeneRIF: Biallelic cGMP-dependent type II protein kinase gene
            (PRKG2) variants cause a novel acromesomelic dysplasia.
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Wang,R., Kwon,I.K., Thangaraju,M., Singh,N., Liu,K., Jay,P.,
            Hofmann,F., Ganapathy,V. and Browning,D.D.
  TITLE     Type 2 cGMP-dependent protein kinase regulates proliferation and
            differentiation in the colonic mucosa
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 303 (2), G209-G219 (2012)
   PUBMED   22556146
  REMARK    GeneRIF: The work presented here demonstrates a novel
            antiproliferative and prodifferentiation role for PKG2 in the
            colon.
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Vaandrager,A.B., Hogema,B.M., Edixhoven,M., van den Burg,C.M.,
            Bot,A.G., Klatt,P., Ruth,P., Hofmann,F., Van Damme,J.,
            Vandekerckhove,J. and de Jonge,H.R.
  TITLE     Autophosphorylation of cGMP-dependent protein kinase type II
  JOURNAL   J Biol Chem 278 (31), 28651-28658 (2003)
   PUBMED   12764134
  REMARK    GeneRIF: results show that the fast phase of autophosphorylation of
            cGMP dependent protein kinase II has a small effect on its
            activity, whereas the secondary phase involving Ser126
            phosphorylation may generate an active form
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Gambaryan,S., Palmetshofer,A., Glazova,M., Smolenski,A.,
            Kristjansson,G.I., Zimmer,M. and Lohmann,S.M.
  TITLE     Inhibition of cGMP-dependent protein kinase II by its own splice
            isoform
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1438-1444 (2002)
   PUBMED   12054676
  REMARK    GeneRIF: Inhibition of cGMP-dependent protein kinase II by its own
            splice isoform
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Witczak,O., Orstavik,S., Natarajan,V., Frengen,E., Jahnsen,T. and
            Sandberg,M.
  TITLE     Characterization of the gene encoding the human type II
            cGMP-dependent protein kinase
  JOURNAL   Biochem Biophys Res Commun 245 (1), 113-119 (1998)
   PUBMED   9535793
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Orstavik,S., Solberg,R., Tasken,K., Nordahl,M., Altherr,M.R.,
            Hansson,V., Jahnsen,T. and Sandberg,M.
  TITLE     Molecular cloning, cDNA structure, and chromosomal localization of
            the human type II cGMP-dependent protein kinase
  JOURNAL   Biochem Biophys Res Commun 220 (3), 759-765 (1996)
   PUBMED   8607838
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Fujii,M., Ogata,T., Takahashi,E., Yamada,K., Nakabayashi,K.,
            Oishi,M. and Ayusawa,D.
  TITLE     Expression of the human cGMP-dependent protein kinase II gene is
            lost upon introduction of SV40 T antigen or immortalization in
            human cells
  JOURNAL   FEBS Lett 375 (3), 263-267 (1995)
   PUBMED   7498513
REFERENCE   10 (bases 1 to 4922)
  AUTHORS   Nishikawa,M., de Lanerolle,P., Lincoln,T.M. and Adelstein,R.S.
  TITLE     Phosphorylation of mammalian myosin light chain kinases by the
            catalytic subunit of cyclic AMP-dependent protein kinase and by
            cyclic GMP-dependent protein kinase
  JOURNAL   J Biol Chem 259 (13), 8429-8436 (1984)
   PUBMED   6547441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098819.3, DB455792.2,
            X94612.1, AC139722.1, DA569289.1 and BF508892.1.
            
            On Aug 14, 2020 this sequence version replaced NM_006259.2.
            
            Summary: This gene encodes a protein that belongs to the
            serine/threonine protein kinase family of proteins. The encoded
            protein binds to and inhibits the activation of several receptor
            tyrosine kinases. The membrane-bound protein is a regulator of
            intestinal secretion, bone growth and renin secretion. Alternate
            splicing results in multiple transcript variants encoding distinct
            isoforms whose regulatory N-termini differ in length but whose
            C-terminal catalytic domains are identical. [provided by RefSeq,
            May 2018].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 7 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.749412.1,
                                           SRR18074967.2456329.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264399.6/ ENSP00000264399.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC098819.3         24295-24399         c
            106-287             DB455792.2         1-182
            288-3614            X94612.1           2-3328
            3615-3731           AC139722.1         12437-12553         c
            3732-4405           DA569289.1         80-753
            4406-4523           AC139722.1         11645-11762         c
            4524-4922           BF508892.1         16-414
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..4922
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="protein kinase cGMP-dependent 2"
                     /db_xref="GeneID:5593"
                     /db_xref="HGNC:HGNC:9416"
                     /db_xref="MIM:601591"
     exon            1..287
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            288..761
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2589
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /EC_number="2.7.11.12"
                     /note="isoform a is encoded by transcript variant 1;
                     cGMP-dependent protein kinase 2; cGMP-dependent protein
                     kinase II; testicular tissue protein Li 99; protein
                     kinase, cGMP-dependent, type II"
                     /codon_start=1
                     /product="cGMP-dependent protein kinase 2 isoform a"
                     /protein_id="NP_006250.1"
                     /db_xref="CCDS:CCDS3589.1"
                     /db_xref="GeneID:5593"
                     /db_xref="HGNC:HGNC:9416"
                     /db_xref="MIM:601591"
                     /translation="MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEI
                     QEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVP
                     LEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLIT
                     DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQG
                     EKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQ
                     YRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVT
                     QSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG
                     TFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPF
                     QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEEL
                     CSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDY
                     LHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN
                     KGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDL
                     IRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY
                     FDKYPPEKGMPPDELSGWDKDF"
     exon            762..928
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1042
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1148
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1212
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1290
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1385
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1454
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1553
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1707
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1844
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1934
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2076
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2240
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2363
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2426
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2493
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..4922
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4787..4792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="hexamer: ATTAAA"
     polyA_site      4808
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="major polyA site"
     regulatory      4901..4906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="hexamer: AGTAAA"
     polyA_site      4922
                     /gene="PRKG2"
                     /gene_synonym="AMD4; cGK2; cGKII; PKG2; PRKGR2; SMDP"
                     /note="major polyA site"
ORIGIN      
        1 gcaccggccc ccgccgcgga gccaggcggc agcaccgacg ccgccgcagc tcctgcccgc
       61 atcgcgctaa cccgcgcccc cggctcacac gtagccggag cgactgagcc ggcagccccg
      121 ggcccacgct gcgcaccgtg tgcacggcgg ggctggctga gctgacctgc gctgggctcc
      181 ggcgccgcag gcggctgggg agggcggcgt gggagaggac gctgagacgc aggggcggcc
      241 gcgccgaggt gacaagctgc gcacctggaa agttacccgg ctgtctggtc cctgagcaaa
      301 atgggaaatg gttcagtgaa acctaaacat tctaagcacc cagatggaca ctctgggaac
      361 ctcaccactg atgctctgcg gaacaaggtg acagagctgg agagagagtt gaggaggaag
      421 gatgctgaga tccaggagcg ggagtaccat ttgaaggagc tgcgggagca gctgtcgaag
      481 cagactgtgg ccattgctga actcacagag gagctccaga acaagtgcat ccagctgaac
      541 aagctgcagg atgtggtgca tatgcaggga ggaagcccgc ttcaggcctc tccagataaa
      601 gtgcctcttg aggtccaccg gaagacctct ggattggtct ctctccatag caggagggga
      661 gcaaaggctg gcgtgtctgc tgagccaaca acccggacct atgacctgaa caaaccccct
      721 gaattttcct ttgagaaagc aagagtcaga aaagactcca gtgagaagaa gctcattaca
      781 gatgccctta ataaaaatca gtttctgaaa agactggatc ctcagcagat caaagacatg
      841 gtggaatgca tgtatgggag aaactatcag caagggagtt acattattaa gcaaggagaa
      901 ccaggaaacc atatctttgt gctggcagag ggtcgactag aggtgttcca aggggagaaa
      961 ttgctgtcct ccatccctat gtggaccaca tttggggagc ttgccatttt atacaattgt
     1021 acaaggactg cctctgtgaa agctattacc aatgttaaaa catgggcact agatcgagag
     1081 gtattccaga atataatgag gaggacagcc caagctagag atgaacaata cagaaacttc
     1141 ctcagaagtg tatccttgct gaagaattta cctgaagata aattaaccaa gatcattgac
     1201 tgcttggaag tggaatacta tgacaaagga gattacatca ttagagaggg cgaggaagga
     1261 agtacctttt tcattttggc aaaaggaaag gtaaaagtaa cacagagcac agaaggccat
     1321 gatcaaccac agctgataaa aacactgcag aaaggagaat actttggaga aaaagctctt
     1381 atcagtgatg atgtcaggtc agctaacatt attgctgaag aaaatgatgt tgcatgcctg
     1441 gttatagatc gagaaacatt caaccaaact gtcggtacat ttgaagagct gcaaaaatac
     1501 cttgaaggat atgtggcaaa cctgaaccgt gatgatgaaa aaagacatgc gaagcggtcc
     1561 atgtctaact ggaagctgtc caaagcactc tctctggaaa tgattcagct gaaggagaag
     1621 gtggccagat tttcctcatc atccccattc cagaaccttg agattattgc aacactgggc
     1681 gttggtgggt tcggaagagt tgagcttgtt aaagtaaaaa atgagaatgt tgcttttgct
     1741 atgaagtgta taaggaagaa gcacatagtt gacaccaagc agcaggagca tgtctactca
     1801 gagaagagga tcctagagga gctgtgctct ccattcattg tgaaattata tcgtactttc
     1861 aaggacaata agtatgtata catgcttctg gaggcctgct taggtgggga gctctggagt
     1921 atattaaggg acagaggcag ctttgatgaa cccacctcca aattctgcgt tgcttgtgtg
     1981 acagaagcat ttgattacct gcatcgacta ggtattatct acagagactt gaaaccagaa
     2041 aacttaattc tagatgctga gggttacctt aaattggttg actttggatt tgcgaagaaa
     2101 atagggtctg gacagaaaac atggacattc tgtgggactc cagaatatgt agctcctgaa
     2161 gtcattctca acaagggaca tgacttcagt gtggatttct ggtcactggg aattctagtg
     2221 tatgagctcc taacgggcaa cccacccttt tctggggttg accaaatgat gacctacaat
     2281 ttgattctca aaggaattga aaaaatggat tttcccagga agataacacg acgacctgag
     2341 gatttgattc ggaggctttg caggcaaaat ccaacagaaa ggctgggaaa tctgaagaat
     2401 ggaataaatg acattaagaa acacaggtgg ttaaatggtt ttaattggga gggactgaaa
     2461 gcacggagcc ttccatcacc tttgcaaaga gagctcaagg gacccataga tcacagctac
     2521 tttgacaaat atcctcctga aaagggaatg cctccagatg agctatcagg ctgggataaa
     2581 gacttctgac agaagaaaag ttgattactg cctgtactct acagaagagg acctcaagga
     2641 tcaataatcc aacacattat tttcttttca gagtattata atatctttgg aagaccatta
     2701 gggaaaagaa attcctgcac aatgggaaga ggagaatggt gtggatatgg ttctgagtta
     2761 tagtgtctta tttagatgct gtgaattatt gatgtattac attatttgct tttctcaact
     2821 gctagaggct accccatttt cctttccaca atcagagcca tttttgttaa agtggcagtt
     2881 ttttctgcaa tctattgttc cattccaatc atatccttct cgtttgagta ctactaacgt
     2941 ttaaaaaggg tcttgccctt gaataactaa gtcatacaaa tagaaggaaa aacaatggtg
     3001 aattttggag agctccccag ctctcagcaa cttcatataa gcatggtggt atcttaaaat
     3061 ggtggtttgc agaaaccatg gtagccaaca gaacctcctg actttcacct gcttttaacc
     3121 tgaaaatata ttaatacgcc tctgacatga gtccagggag aggcaagatt gagcaatagt
     3181 cagtggcacc atttcctaaa gtaactgaat caatcaatcc agtcaggtaa ttattttcta
     3241 ttggggaact tagaaaaaaa agtaaagcaa gaaatatttt ctctccttta tgatcagtga
     3301 taccttagag acttttcgaa agtccttgtt aaagatagtt acaatgtgtg gttaaatgat
     3361 gctaaaatat tttcacaacc agagtagaaa acgtgctgga acaaaattgc gaaggctttt
     3421 gcctcccagt aaatagaaag gaaaatatat tctagtaggt aagactgctg actctttgaa
     3481 aatctgaggt attttgaaaa attctgtgat agttgctatt aataaaccaa aattgtatag
     3541 aatcatcgtt aatttttaat ataaatccca ttgacaaatg ttgatgcact gtagtcactg
     3601 ctgagttaat agcgcttttt aaagacatct gagtcatgga tgtgtttata aatttagatt
     3661 gttaagacag gcaagccacc agaaaagtga taggatttca gaagtaaaag ggacaacagc
     3721 atccctccta tcccttcctt gcactctccc aaataataag taggatagtt tcaatagcat
     3781 gggacctagt acctaagaac ttcactggtg aatggttgta tgtattgacc atgatcattc
     3841 ccttaccctc cttccaaaat gaatgagaag cagagacttt tctgtatttt ttaaatctag
     3901 cagagtaaaa atactgtata agttccggga ttattcaagc ttctggttat attttcatat
     3961 gttaatgttc tatgtcaaaa ggaacctcta cccagtcccc actcataatt tcatcatcca
     4021 gaaaaaagcc agctatatgc ttccttaatg agttaagcta gataagtgaa gcccaatcca
     4081 gaaaggtgca tccttaacaa attagatttc cacatttata atccttttgc tgaaccaaag
     4141 agtttttgtt tcctggagct gtatttttaa agattatgta ttgtacatag aataatcatt
     4201 tttaatagga ttgacataac ctgcttaaag aatttctaag agtttttaaa gatttttatt
     4261 tgaatttggt tggtttgtac tgtatgtttt tccatgtata tatttttaaa tttccaacct
     4321 ataaagatag aaaatttatg tattgggtgg atattagaac tatacagtta taataggaat
     4381 gatattctca aagcagatca atagttgtaa tttttaaaac cctacatata tagaaataac
     4441 caagttagag tactacaggt ttatttttcc tgtgattgac catgtcaatg tgttatcctc
     4501 ccatgtgatt ttttattgtt tccttagagt actttaaaag atgaagaaat gagagactga
     4561 accattgaat aatcccaact ccaccatttc ctaactgagt gactctggga aagtgattta
     4621 gcttttttga gtactagctt tctcattcat agaaaaaggc agagtaaagt aatatttact
     4681 tagaggtttg tttcagggat taagttatgt agagagtctt ttgcccggta tctgtgaaat
     4741 aaccattgct gcatagacgg gagctactgt tactgtctct attaaaatta aaggggcctt
     4801 aataaccatt tagtcctgaa tcttatgtat cattggtatc tgtatgcaga attgtactta
     4861 tcaaatccag tatctgtctt ttttttcttt taaatcatga agtaaaaatg attgaccaaa
     4921 aa
//
