LOCUS       NM_006904              13459 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens protein kinase, DNA-activated, catalytic subunit
            (PRKDC), transcript variant 1, mRNA.
ACCESSION   NM_006904
VERSION     NM_006904.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13459)
  AUTHORS   Zhang,W., Li,W., Yin,C., Feng,C., Liu,B., Xu,H., Jin,X., Tu,C. and
            Li,Z.
  TITLE     PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to
            Stabilize GNAS and Activate AKT
  JOURNAL   Cancer Res 84 (17), 2873-2887 (2024)
   PUBMED   38900943
  REMARK    GeneRIF: PRKDC Induces Chemoresistance in Osteosarcoma by
            Recruiting GDE2 to Stabilize GNAS and Activate AKT.
REFERENCE   2  (bases 1 to 13459)
  AUTHORS   Mollinari,C., Cardinale,A., Lupacchini,L., Martire,A., Chiodi,V.,
            Martinelli,A., Rinaldi,A.M., Fini,M., Pazzaglia,S., Domenici,M.R.,
            Garaci,E. and Merlo,D.
  TITLE     The DNA repair protein DNA-PKcs modulates synaptic plasticity via
            PSD-95 phosphorylation and stability
  JOURNAL   EMBO Rep 25 (8), 3707-3737 (2024)
   PUBMED   39085642
  REMARK    GeneRIF: The DNA repair protein DNA-PKcs modulates synaptic
            plasticity via PSD-95 phosphorylation and stability.
REFERENCE   3  (bases 1 to 13459)
  AUTHORS   Xu,C., Chen,G., Yu,B., Sun,B., Zhang,Y., Zhang,M., Yang,Y.,
            Xiao,Y., Cheng,S.Y., Li,Y. and Feng,H.
  TITLE     TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression
            through snoRNA Recruitment of PHAX and DNA-PKcs
  JOURNAL   Adv Sci (Weinh) 11 (29), e2400023 (2024)
   PUBMED   38828688
  REMARK    GeneRIF: TRIM24 Cooperates with Ras Mutation to Drive Glioma
            Progression through snoRNA Recruitment of PHAX and DNA-PKcs.
REFERENCE   4  (bases 1 to 13459)
  AUTHORS   Pan,Y., Zhu,Q., Hong,T., Cheng,J. and Tang,X.
  TITLE     Targeting PRKDC activates the efficacy of antitumor immunity while
            sensitizing to chemotherapy and targeted therapy in liver
            hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 16 (10), 9047-9071 (2024)
   PUBMED   38787389
  REMARK    GeneRIF: Targeting PRKDC activates the efficacy of antitumor
            immunity while sensitizing to chemotherapy and targeted therapy in
            liver hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 13459)
  AUTHORS   Luan,W., Cheng,H., Xie,H., Liu,H., Wang,Y., Wang,S., Ye,X., Zhu,H.,
            Tang,F., Li,Y. and Chang,X.
  TITLE     PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of
            Chromosome 8-Driven Progression of Ovarian Cancer
  JOURNAL   Int J Mol Sci 25 (9), 4825 (2024)
   PUBMED   38732044
  REMARK    GeneRIF: PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy
            of Chromosome 8-Driven Progression of Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13459)
  AUTHORS   Poltoratsky,V.P., Shi,X., York,J.D., Lieber,M.R. and Carter,T.H.
  TITLE     Human DNA-activated protein kinase (DNA-PK) is homologous to
            phosphatidylinositol kinases
  JOURNAL   J Immunol 155 (10), 4529-4533 (1995)
   PUBMED   7594449
REFERENCE   7  (bases 1 to 13459)
  AUTHORS   Sipley,J.D., Menninger,J.C., Hartley,K.O., Ward,D.C., Jackson,S.P.
            and Anderson,C.W.
  TITLE     Gene for the catalytic subunit of the human DNA-activated protein
            kinase maps to the site of the XRCC7 gene on chromosome 8
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7515-7519 (1995)
   PUBMED   7638222
REFERENCE   8  (bases 1 to 13459)
  AUTHORS   Iijima,S., Teraoka,H., Date,T. and Tsukada,K.
  TITLE     DNA-activated protein kinase in Raji Burkitt's lymphoma cells.
            Phosphorylation of c-Myc oncoprotein
  JOURNAL   Eur J Biochem 206 (2), 595-603 (1992)
   PUBMED   1597196
REFERENCE   9  (bases 1 to 13459)
  AUTHORS   Carter,T., Vancurova,I., Sun,I., Lou,W. and DeLeon,S.
  TITLE     A DNA-activated protein kinase from HeLa cell nuclei
  JOURNAL   Mol Cell Biol 10 (12), 6460-6471 (1990)
   PUBMED   2247066
REFERENCE   10 (bases 1 to 13459)
  AUTHORS   Lees-Miller,S.P. and Anderson,C.W.
  TITLE     The human double-stranded DNA-activated protein kinase
            phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two
            NH2-terminal threonine residues
  JOURNAL   J Biol Chem 264 (29), 17275-17280 (1989)
   PUBMED   2507541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U47077.5.
            
            On Aug 31, 2019 this sequence version replaced NM_006904.6.
            
            Summary: This gene encodes the catalytic subunit of the
            DNA-dependent protein kinase (DNA-PK). It functions with the
            Ku70/Ku80 heterodimer protein in DNA double strand break repair and
            recombination. The protein encoded is a member of the
            PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U47077.5, SRR14038197.2457229.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314191.7/ ENSP00000313420.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13459             U47077.5           48-13506
FEATURES             Location/Qualifiers
     source          1..13459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..13459
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /note="protein kinase, DNA-activated, catalytic subunit"
                     /db_xref="GeneID:5591"
                     /db_xref="HGNC:HGNC:9413"
                     /db_xref="MIM:600899"
     exon            1..164
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..12397
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-dependent protein kinase catalytic subunit;
                     hyper-radiosensitivity of murine scid mutation,
                     complementing 1; p460; DNA-PK catalytic subunit; protein
                     kinase, DNA-activated, catalytic polypeptide; ser-473
                     kinase"
                     /codon_start=1
                     /product="DNA-dependent protein kinase catalytic subunit
                     isoform 1"
                     /protein_id="NP_008835.5"
                     /db_xref="CCDS:CCDS75735.1"
                     /db_xref="GeneID:5591"
                     /db_xref="HGNC:HGNC:9413"
                     /db_xref="MIM:600899"
                     /translation="MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVL
                     SSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAP
                     YSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGEL
                     ALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLP
                     VLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFA
                     LHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMH
                     KNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRC
                     KQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYS
                     PKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDH
                     RASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYD
                     EFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFI
                     NLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKY
                     FEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNI
                     IELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDG
                     YLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVV
                     QMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRV
                     TELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRL
                     ACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCG
                     RCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYRE
                     FREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLN
                     KAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSP
                     NLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLA
                     ALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
                     RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCE
                     PASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNL
                     YGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPG
                     DERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIH
                     FSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERAN
                     QKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSF
                     PEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQS
                     REFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRR
                     IARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFST
                     IVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVF
                     HGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNE
                     LKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAAN
                     GDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDP
                     TVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGK
                     LGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIV
                     ATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDC
                     LSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNN
                     MSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCL
                     NKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQ
                     VMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWI
                     HDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDR
                     LLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWR
                     FRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRS
                     SFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEV
                     DNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVV
                     LYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSE
                     KNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQ
                     PVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFT
                     SEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCY
                     NHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
                     LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSID
                     VLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPM
                     NIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSC
                     KFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQG
                     CSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAE
                     IEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAG
                     VIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFP
                     RLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDN
                     YPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPE
                     LLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEF
                     DKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNE
                     LEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGE
                     DLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKD
                     LLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFR
                     KRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV
                     AMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHAL
                     RAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICY
                     AKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQV
                     KCLMDQATDPNILGRTWEGWEPWM"
     exon            165..241
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            242..334
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            335..409
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            410..518
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            519..631
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            632..731
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            732..787
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            788..818
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            819..976
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1123
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1288
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1457
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1507
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1633
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1786
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1902
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2062
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2149
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2269
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2429
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2536
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2627
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2791
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2944
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3052
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3279
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3374
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3474
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3608
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3857
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4081
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4290
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4423
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4582
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4583..4786
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4972
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4973..5077
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5245
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5246..5373
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5374..5581
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5582..5760
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..5929
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5930..5995
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            5996..6068
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6217
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6218..6355
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6356..6475
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6476..6619
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6620..6771
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6772..6903
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            6904..7015
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7016..7140
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7141..7290
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7291..7464
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7465..7563
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7564..7771
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7772..7961
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            7962..8162
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8163..8275
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8276..8407
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8408..8587
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8588..8793
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8794..8932
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            8933..9121
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9122..9346
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9347..9455
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9456..9567
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9568..9757
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9758..9932
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            9933..10126
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10127..10307
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10308..10468
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10469..10680
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10681..10768
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10769..10912
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            10913..11117
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11118..11185
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11186..11406
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11407..11499
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11500..11589
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11590..11661
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11662..11863
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            11864..12052
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            12053..12192
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     exon            12193..13459
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13440..13445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /note="hexamer: AATAAA"
     polyA_site      13459
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1;
                     HYRC; HYRC1; IMD26; p350; S473K; XRCC7"
                     /note="major polyA site"
ORIGIN      
        1 actcggcggc atggcgggct ccggagccgg tgtgcgttgc tccctgctgc ggctgcagga
       61 gaccttgtcc gctgcggacc gctgcggtgc tgccctggcc ggtcatcaac tgatccgcgg
      121 cctggggcag gaatgcgtcc tgagcagcag ccccgcggtg ctggcattac agacatcttt
      181 agttttttcc agagatttcg gtttgcttgt atttgtccgg aagtcactca acagtattga
      241 atttcgtgaa tgtagagaag aaatcctaaa gtttttatgt attttcttag aaaaaatggg
      301 ccagaagatc gcaccttact ctgttgaaat taagaacact tgtaccagtg tttatacaaa
      361 agatagagct gctaaatgta aaattccagc cctggacctt cttattaagt tacttcagac
      421 ttttagaagt tctagactca tggatgaatt taaaattgga gaattattta gtaaattcta
      481 tggagaactt gcattgaaaa aaaaaatacc agatacagtt ttagaaaaag tatatgagct
      541 cctaggatta ttgggtgaag ttcatcctag tgagatgata aataatgcag aaaacctgtt
      601 ccgcgctttt ctgggtgaac ttaagaccca gatgacatca gcagtaagag agcccaaact
      661 acctgttctg gcaggatgtc tgaaggggtt gtcctcactt ctgtgcaact tcactaagtc
      721 catggaagaa gatccccaga cttcaaggga gatttttaat tttgtactaa aggcaattcg
      781 tcctcagatt gatctgaaga gatatgctgt gccctcagct ggcttgcgcc tatttgccct
      841 gcatgcatct cagtttagca cctgccttct ggacaactac gtgtctctat ttgaagtctt
      901 gttaaagtgg tgtgcccaca caaatgtaga attgaaaaaa gctgcacttt cagccctgga
      961 atcctttctg aaacaggttt ctaatatggt ggcgaaaaat gcagaaatgc ataaaaataa
     1021 actgcagtac tttatggagc agttttatgg aatcatcaga aatgtggatt cgaacaacaa
     1081 ggagttatct attgctatcc gtggatatgg actttttgca ggaccgtgca aggttataaa
     1141 cgcaaaagat gttgacttca tgtacgttga gctcattcag cgctgcaagc agatgttcct
     1201 cacccagaca gacactggtg acgaccgtgt ttatcagatg ccaagcttcc tccagtctgt
     1261 tgcaagcgtc ttgctgtacc ttgacacagt tcctgaggtg tatactccag ttctggagca
     1321 cctcgtggtg atgcagatag acagtttccc acagtacagt ccaaaaatgc agctggtgtg
     1381 ttgcagagcc atagtgaagg tgttcctagc tttggcagca aaagggccag ttctcaggaa
     1441 ttgcattagt actgtggtgc atcagggttt aatcagaata tgttctaaac cagtggtcct
     1501 tccaaagggc cctgagtctg aatctgaaga ccaccgtgct tcaggggaag tcagaactgg
     1561 caaatggaag gtgcccacat acaaagacta cgtggatctc ttcagacatc tcctgagctc
     1621 tgaccagatg atggattcta ttttagcaga tgaagcattt ttctctgtga attcctccag
     1681 tgaaagtctg aatcatttac tttatgatga atttgtaaaa tccgttttga agattgttga
     1741 gaaattggat cttacacttg aaatacagac tgttggggaa caagagaatg gagatgaggc
     1801 gcctggtgtt tggatgatcc caacttcaga tccagcggct aacttgcatc cagctaaacc
     1861 taaagatttt tcggctttca ttaacctggt ggaattttgc agagagattc tccctgagaa
     1921 acaagcagaa ttttttgaac catgggtgta ctcattttca tatgaattaa ttttgcaatc
     1981 tacaaggttg cccctcatca gtggtttcta caaattgctt tctattacag taagaaatgc
     2041 caagaaaata aaatatttcg agggagttag tccaaagagt ctgaaacact ctcctgaaga
     2101 cccagaaaag tattcttgct ttgctttatt tgtgaaattt ggcaaagagg tggcagttaa
     2161 aatgaagcag tacaaagatg aacttttggc ctcttgtttg acctttcttc tgtccttgcc
     2221 acacaacatc attgaactcg atgttagagc ctacgttcct gcactgcaga tggctttcaa
     2281 actgggcctg agctataccc ccttggcaga agtaggcctg aatgctctag aagaatggtc
     2341 aatttatatt gacagacatg taatgcagcc ttattacaaa gacattctcc cctgcctgga
     2401 tggatacctg aagacttcag ccttgtcaga tgagaccaag aataactggg aagtgtcagc
     2461 tctttctcgg gctgcccaga aaggatttaa taaagtggtg ttaaagcatc tgaagaagac
     2521 aaagaacctt tcatcaaacg aagcaatatc cttagaagaa ataagaatta gagtagtaca
     2581 aatgcttgga tctctaggag gacaaataaa caaaaatctt ctgacagtca cgtcctcaga
     2641 tgagatgatg aagagctatg tggcctggga cagagagaag cggctgagct ttgcagtgcc
     2701 ctttagagag atgaaacctg tcattttcct ggatgtgttc ctgcctcgag tcacagaatt
     2761 agcgctcaca gccagtgaca gacaaactaa agttgcagcc tgtgaacttt tacatagcat
     2821 ggttatgttt atgttgggca aagccacgca gatgccagaa gggggacagg gagccccacc
     2881 catgtaccag ctctataagc ggacgtttcc tgtgctgctt cgacttgcgt gtgatgttga
     2941 tcaggtgaca aggcaactgt atgagccact agttatgcag ctgattcact ggttcactaa
     3001 caacaagaaa tttgaaagtc aggatactgt tgccttacta gaagctatat tggatggaat
     3061 tgtggaccct gttgacagta ctttaagaga tttttgtggt cggtgtattc gagaattcct
     3121 taaatggtcc attaagcaaa taacaccaca gcagcaggag aagagtccag taaacaccaa
     3181 atcgcttttc aagcgacttt atagccttgc gcttcacccc aatgctttca agaggctggg
     3241 agcatcactt gcctttaata atatctacag ggaattcagg gaagaagagt ctctggtgga
     3301 acagtttgtg tttgaagcct tggtgatata catggagagt ctggccttag cacatgcaga
     3361 tgagaagtcc ttaggtacaa ttcaacagtg ttgtgatgcc attgatcacc tatgccgcat
     3421 cattgaaaag aagcatgttt ctttaaataa agcaaagaaa cgacgtttgc cgcgaggatt
     3481 tccaccttcc gcatcattgt gtttattgga tctggtcaag tggcttttag ctcattgtgg
     3541 gaggccccag acagaatgtc gacacaaatc cattgaactc ttttataaat tcgttccttt
     3601 attgccaggc aacagatccc ctaatttgtg gctgaaagat gttctcaagg aagaaggtgt
     3661 ctcttttctc atcaacacct ttgagggggg tggctgtggc cagccctcgg gcatcctggc
     3721 ccagcccacc ctcttgtacc ttcgggggcc attcagcctg caggccacgc tatgctggct
     3781 ggacctgctc ctggccgcgt tggagtgcta caacacgttc attggcgaga gaactgtagg
     3841 agcgctccag gtcctaggta ctgaagccca gtcttcactt ttgaaagcag tggctttctt
     3901 cttagaaagc attgccatgc atgacattat agcagcagaa aagtgctttg gcactggggc
     3961 agcaggtaac agaacaagcc cacaagaggg agaaaggtac aactacagca aatgcaccgt
     4021 tgtggtccgg attatggagt ttaccacgac tctgctaaac acctccccgg aaggatggaa
     4081 gctcctgaag aaggacttgt gtaatacaca cctgatgaga gtcctggtgc agacgctgtg
     4141 tgagcccgca agcataggtt tcaacatcgg agacgtccag gttatggctc atcttcctga
     4201 tgtttgtgtg aatctgatga aagctctaaa gatgtcccca tacaaagata tcctagagac
     4261 ccatctgaga gagaaaataa cagcacagag cattgaggag ctttgtgccg tcaacttgta
     4321 tggccctgac gcgcaagtgg acaggagcag gctggctgct gttgtgtctg cctgtaaaca
     4381 gcttcacaga gctgggcttc tgcataatat attaccgtct cagtccacag atttgcatca
     4441 ttctgttggc acagaacttc tttccctggt ttataaaggc attgcccctg gagatgagag
     4501 acagtgtctg ccttctctag acctcagttg taagcagctg gccagcggac ttctggagtt
     4561 agcctttgct tttggaggac tgtgtgagcg ccttgtgagt cttctcctga acccagcggt
     4621 gctgtccacg gcgtccttgg gcagctcaca gggcagcgtc atccacttct cccatgggga
     4681 gtatttctat agcttgttct cagaaacgat caacacggaa ttattgaaaa atctggatct
     4741 tgctgtattg gagctcatgc agtcttcagt ggataatacc aaaatggtga gtgccgtttt
     4801 gaacggcatg ttagaccaga gcttcaggga gcgagcaaac cagaaacacc aaggactgaa
     4861 acttgcgact acaattctgc aacactggaa gaagtgtgat tcatggtggg ccaaagattc
     4921 ccctctcgaa actaaaatgg cagtgctggc cttactggca aaaattttac agattgattc
     4981 atctgtatct tttaatacaa gtcatggttc attccctgaa gtctttacaa catatattag
     5041 tctacttgct gacacaaagc tggatctaca tttaaagggc caagctgtca ctcttcttcc
     5101 attcttcacc agcctcactg gaggcagtct ggaggaactt agacgtgttc tggagcagct
     5161 catcgttgct cacttcccca tgcagtccag ggaatttcct ccaggaactc cgcggttcaa
     5221 taattatgtg gactgcatga aaaagtttct agatgcattg gaattatctc aaagccctat
     5281 gttgttggaa ttgatgacag aagttctttg tcgggaacag cagcatgtca tggaagaatt
     5341 atttcaatcc agtttcagga ggattgccag aaggggttca tgtgtcacac aagtaggcct
     5401 tctggaaagc gtgtatgaaa tgttcaggaa ggatgacccc cgcctaagtt tcacacgcca
     5461 gtcctttgtg gaccgctccc tcctcactct gctgtggcac tgtagcctgg atgctttgag
     5521 agaattcttc agcacaattg tggtggatgc cattgatgtg ttgaagtcca ggtttacaaa
     5581 gctaaatgaa tctacctttg atactcaaat caccaagaag atgggctact ataagattct
     5641 agacgtgatg tattctcgcc ttcccaaaga tgatgttcat gctaaggaat caaaaattaa
     5701 tcaagttttc catggctcgt gtattacaga aggaaatgaa cttacaaaga cattgattaa
     5761 attgtgctac gatgcattta cagagaacat ggcaggagag aatcagctgc tggagaggag
     5821 aagactttac cattgtgcag catacaactg cgccatatct gtcatctgct gtgtcttcaa
     5881 tgagttaaaa ttttaccaag gttttctgtt tagtgaaaaa ccagaaaaga acttgcttat
     5941 ttttgaaaat ctgatcgacc tgaagcgccg ctataatttt cctgtagaag ttgaggttcc
     6001 tatggaaaga aagaaaaagt acattgaaat taggaaagaa gccagagaag cagcaaatgg
     6061 ggattcagat ggtccttcct atatgtcttc cctgtcatat ttggcagaca gtaccctgag
     6121 tgaggaaatg agtcaatttg atttctcaac cggagttcag agctattcat acagctccca
     6181 agaccctaga cctgccactg gtcgttttcg gagacgggag cagcgggacc ccacggtgca
     6241 tgatgatgtg ctggagctgg agatggacga gctcaatcgg catgagtgca tggcgcccct
     6301 gacggccctg gtcaagcaca tgcacagaag cctgggcccg cctcaaggag aagaggattc
     6361 agtgccaaga gatcttcctt cttggatgaa attcctccat ggcaaactgg gaaatccaat
     6421 agtaccatta aatatccgtc tcttcttagc caagcttgtt attaatacag aagaggtctt
     6481 tcgcccttac gcgaagcact ggcttagccc cttgctgcag ctggctgctt ctgaaaacaa
     6541 tggaggagaa ggaattcact acatggtggt tgagatagtg gccactattc tttcatggac
     6601 aggcttggcc actccaacag gggtccctaa agatgaagtg ttagcaaatc gattgcttaa
     6661 tttcctaatg aaacatgtct ttcatccaaa aagagctgtg tttagacaca accttgaaat
     6721 tataaagacc cttgtcgagt gctggaagga ttgtttatcc atcccttata ggttaatatt
     6781 tgaaaagttt tccggtaaag atcctaattc taaagacaac tcagtaggga ttcaattgct
     6841 aggcatcgtg atggccaatg acctgcctcc ctatgaccca cagtgtggca tccagagtag
     6901 cgaatacttc caggctttgg tgaataatat gtcctttgta agatataaag aagtgtatgc
     6961 cgctgcagca gaagttctag gacttatact tcgatatgtt atggagagaa aaaacatact
     7021 ggaggagtct ctgtgtgaac tggttgcgaa acaattgaag caacatcaga atactatgga
     7081 ggacaagttt attgtgtgct tgaacaaagt gaccaagagc ttccctcctc ttgcagacag
     7141 gttcatgaat gctgtgttct ttctgctgcc aaaatttcat ggagtgttga aaacactctg
     7201 tctggaggtg gtactttgtc gtgtggaggg aatgacagag ctgtacttcc agttaaagag
     7261 caaggacttc gttcaagtca tgagacatag agatgatgaa agacaaaaag tatgtttgga
     7321 cataatttat aagatgatgc caaagttaaa accagtagaa ctccgagaac ttctgaaccc
     7381 cgttgtggaa ttcgtttccc atccttctac aacatgtagg gaacaaatgt ataatattct
     7441 catgtggatt catgataatt acagagatcc agaaagtgag acagataatg actcccagga
     7501 aatatttaag ttggcaaaag atgtgctgat tcaaggattg atcgatgaga accctggact
     7561 tcaattaatt attcgaaatt tctggagcca tgaaactagg ttaccttcaa ataccttgga
     7621 ccggttgctg gcactaaatt ccttatattc tcctaagata gaagtgcact ttttaagttt
     7681 agcaacaaat tttctgctcg aaatgaccag catgagccca gattatccaa accccatgtt
     7741 cgagcatcct ctgtcagaat gcgaatttca ggaatatacc attgattctg attggcgttt
     7801 ccgaagtact gttctcactc cgatgtttgt ggagacccag gcctcccagg gcactctcca
     7861 gacccgtacc caggaagggt ccctctcagc tcgctggcca gtggcagggc agataagggc
     7921 cacccagcag cagcatgact tcacactgac acagactgca gatggaagaa gctcatttga
     7981 ttggctgacc gggagcagca ctgacccgct ggtcgaccac accagtccct catctgactc
     8041 cttgctgttt gcccacaaga ggagtgaaag gttacagaga gcacccttga agtcagtggg
     8101 gcctgatttt gggaaaaaaa ggctgggcct tccaggggac gaggtggata acaaagtgaa
     8161 aggtgcggcc ggccggacgg acctactacg actgcgcaga cggtttatga gggaccagga
     8221 gaagctcagt ttgatgtatg ccagaaaagg cgttgctgag caaaaacgag agaaggaaat
     8281 caagagtgag ttaaaaatga agcaggatgc ccaggtcgtt ctgtacagaa gctaccggca
     8341 cggagacctt cctgacattc agatcaagca cagcagcctc atcaccccgt tacaggccgt
     8401 ggcccagagg gacccaataa ttgcaaaaca gctctttagc agcttgtttt ctggaatttt
     8461 gaaagagatg gataaattta agacactgtc tgaaaaaaac aacatcactc aaaagttgct
     8521 tcaagacttc aatcgttttc ttaataccac cttctctttc tttccaccct ttgtctcttg
     8581 tattcaggac attagctgtc agcacgcagc cctgctgagc ctcgacccag cggctgttag
     8641 cgctggttgc ctggccagcc tacagcagcc cgtgggcatc cgcctgctag aggaggctct
     8701 gctccgcctg ctgcctgctg agctgcctgc caagcgagtc cgtgggaagg cccgcctccc
     8761 tcctgatgtc ctcagatggg tggagcttgc taagctgtat agatcaattg gagaatacga
     8821 cgtcctccgt gggattttta ccagtgagat aggaacaaag caaatcactc agagtgcatt
     8881 attagcagaa gccagaagtg attattctga agctgctaag cagtatgatg aggctctcaa
     8941 taaacaagac tgggtagatg gtgagcccac agaagccgag aaggattttt gggaacttgc
     9001 atcccttgac tgttacaacc accttgctga gtggaaatca cttgaatact gttctacagc
     9061 cagtatagac agtgagaacc ccccagacct aaataaaatc tggagtgaac cattttatca
     9121 ggaaacatat ctaccttaca tgatccgcag caagctgaag ctgctgctcc agggagaggc
     9181 tgaccagtcc ctgctgacat ttattgacaa agctatgcac ggggagctcc agaaggcgat
     9241 tctagagctt cattacagtc aagagctgag tctgctttac ctcctgcaag atgatgttga
     9301 cagagccaaa tattacattc aaaatggcat tcagagtttt atgcagaatt attctagtat
     9361 tgatgtcctc ttacaccaaa gtagactcac caaattgcag tctgtacagg ctttaacaga
     9421 aattcaggag ttcatcagct ttataagcaa acaaggcaat ttatcatctc aagttcccct
     9481 taagagactt ctgaacacct ggacaaacag atatccagat gctaaaatgg acccaatgaa
     9541 catctgggat gacatcatca caaatcgatg tttctttctc agcaaaatag aggagaagct
     9601 tacccctctt ccagaagata atagtatgaa tgtggatcaa gatggagacc ccagtgacag
     9661 gatggaagtg caagagcagg aagaagatat cagctccctg atcaggagtt gcaagttttc
     9721 catgaaaatg aagatgatag acagtgcccg gaagcagaac aatttctcac ttgctatgaa
     9781 actactgaag gagctgcata aagagtcaaa aaccagagac gattggctgg tgagctgggt
     9841 gcagagctac tgccgcctga gccactgccg gagccggtcc cagggctgct ctgagcaggt
     9901 gctcactgtg ctgaaaacag tctctttgtt ggatgagaac aacgtgtcaa gctacttaag
     9961 caaaaatatt ctggctttcc gtgaccagaa cattctcttg ggtacaactt acaggatcat
    10021 agcgaatgct ctcagcagtg agccagcctg ccttgctgaa atcgaggagg acaaggctag
    10081 aagaatctta gagctttctg gatccagttc agaggattca gagaaggtga tcgcgggtct
    10141 gtaccagaga gcattccagc acctctctga ggctgtgcag gcggctgagg aggaggccca
    10201 gcctccctcc tggagctgtg ggcctgcagc tggggtgatt gatgcttaca tgacgctggc
    10261 agatttctgt gaccaacagc tgcgcaagga ggaagagaat gcatcagtta ttgattctgc
    10321 agaactgcag gcgtatccag cacttgtggt ggagaaaatg ttgaaagctt taaaattaaa
    10381 ttccaatgaa gccagattga agtttcctag attacttcag attatagaac ggtatccaga
    10441 ggagactttg agcctcatga caaaagagat ctcttccgtt ccctgctggc agttcatcag
    10501 ctggatcagc cacatggtgg ccttactgga caaagaccaa gccgttgctg ttcagcactc
    10561 tgtggaagaa atcactgata actacccgca ggctattgtt tatcccttca tcataagcag
    10621 cgaaagctat tccttcaagg atacttctac tggtcataag aataaggagt ttgtggcaag
    10681 gattaaaagt aagttggatc aaggaggagt gattcaagat tttattaatg ccttagatca
    10741 gctctctaat cctgaactgc tctttaagga ttggagcaat gatgtaagag ctgaactagc
    10801 aaaaacccct gtaaataaaa aaaacattga aaaaatgtat gaaagaatgt atgcagcctt
    10861 gggtgaccca aaggctccag gcctgggggc ctttagaagg aagtttattc agacttttgg
    10921 aaaagaattt gataaacatt ttgggaaagg aggttctaaa ctactgagaa tgaagctcag
    10981 tgacttcaac gacattacca acatgctact tttaaaaatg aacaaagact caaagccccc
    11041 tgggaatctg aaagaatgtt caccctggat gagcgacttc aaagtggagt tcctgagaaa
    11101 tgagctggag attcccggtc agtatgacgg taggggaaag ccattgccag agtaccacgt
    11161 gcgaatcgcc gggtttgatg agcgggtgac agtcatggcg tctctgcgaa ggcccaagcg
    11221 catcatcatc cgtggccatg acgagaggga acaccctttc ctggtgaagg gtggcgagga
    11281 cctgcggcag gaccagcgcg tggagcagct cttccaggtc atgaatggga tcctggccca
    11341 agactccgcc tgcagccaga gggccctgca gctgaggacc tatagcgttg tgcccatgac
    11401 ctccaggtta ggattaattg agtggcttga aaatactgtt accttgaagg accttctttt
    11461 gaacaccatg tcccaagagg agaaggcggc ttacctgagt gatcccaggg caccgccgtg
    11521 tgaatataaa gattggctga caaaaatgtc aggaaaacat gatgttggag cttacatgct
    11581 aatgtataag ggcgctaatc gtactgaaac agtcacgtct tttagaaaac gagaaagtaa
    11641 agtgcctgct gatctcttaa agcgggcctt cgtgaggatg agtacaagcc ctgaggcttt
    11701 cctggcgctc cgctcccact tcgccagctc tcacgctctg atatgcatca gccactggat
    11761 cctcgggatt ggagacagac atctgaacaa ctttatggtg gccatggaga ctggcggcgt
    11821 gatcgggatc gactttgggc atgcgtttgg atccgctaca cagtttctgc cagtccctga
    11881 gttgatgcct tttcggctaa ctcgccagtt tatcaatctg atgttaccaa tgaaagaaac
    11941 gggccttatg tacagcatca tggtacacgc actccgggcc ttccgctcag accctggcct
    12001 gctcaccaac accatggatg tgtttgtcaa ggagccctcc tttgattgga aaaattttga
    12061 acagaaaatg ctgaaaaaag gagggtcatg gattcaagaa ataaatgttg ctgaaaaaaa
    12121 ttggtacccc cgacagaaaa tatgttacgc taagagaaag ttagcaggtg ccaatccagc
    12181 agtcattact tgtgatgagc tactcctggg tcatgagaag gcccctgcct tcagagacta
    12241 tgtggctgtg gcacgaggaa gcaaagatca caacattcgt gcccaagaac cagagagtgg
    12301 gctttcagaa gagactcaag tgaagtgcct gatggaccag gcaacagacc ccaacatcct
    12361 tggcagaacc tgggaaggat gggagccctg gatgtgaggt ctgtgggagt ctgcagatag
    12421 aaagcattac attgtttaaa gaatctacta tactttggtt ggcagcattc catgagctga
    12481 ttttcctgaa acactaaaga gaaatgtctt ttgtgctaca gtttcgtagc atgagtttaa
    12541 atcaagatta tgatgagtaa atgtgtatgg gttaaatcaa agataaggtt atagtaacat
    12601 caaagattag gtgaggttta tagaaagata gatatccagg cttaccaaag tattaagtca
    12661 agaatataat atgtgatcag ctttcaaagc atttacaagt gctgcaagtt agtgaaacag
    12721 ctgtctccgt aaatggagga aatgtgggga agccttggaa tgcccttctg gttctggcac
    12781 attggaaagc acactcagaa ggcttcatca ccaagatttt gggagagtaa agctaagtat
    12841 agttgatgta acattgtaga agcagcatag gaacaataag aacaataggt aaagctataa
    12901 ttatggctta tatttagaaa tgactgcatt tgatatttta ggatattttt ctaggttttt
    12961 tcctttcatt ttattctctt ctagttttga cattttatga tagatttgct ctctagaagg
    13021 aaacgtcttt atttaggagg gcaaaaattt tggtcatagc attcactttt gctattccaa
    13081 tctacaactg gaagatacat aaaagtgctt tgcattgaat ttgggataac ttcaaaaatc
    13141 ccatggttgt tgttagggat agtactaagc atttcagttc caggagaata aaagaaattc
    13201 ctatttgaaa tgaattcctc atttggagga aaaaaagcat gcattctagc acaacaagat
    13261 gaaattatgg aatacaaaag tggctccttc ccatgtgcag tccctgtccc cccccgccag
    13321 tcctccacac ccaaactgtt tctgattggc ttttagcttt ttgttgtttt tttttttcct
    13381 tctaacactt gtatttggag gctcttctgt gattttgaga agtatactct tgagtgttta
    13441 ataaagtttt tttccaaaa
//
