LOCUS       NM_005813               6156 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein kinase D3 (PRKD3), mRNA.
ACCESSION   NM_005813 XM_024452776
VERSION     NM_005813.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6156)
  AUTHORS   Varga,A., Nguyen,M.T., Penzes,K., Batai,B., Gyulavari,P., Gurbi,B.,
            Muranyi,J., Csermely,P., Csala,M., Vantus,T. and Soti,C.
  TITLE     Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion
            of Prostate Cancer Cell Migration
  JOURNAL   Cells 12 (2), 212 (2023)
   PUBMED   36672148
  REMARK    GeneRIF: Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and
            Promotion of Prostate Cancer Cell Migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6156)
  AUTHORS   Chen,Z., Huang,Q., Xu,W., Wang,H., Yang,J. and Zhang,L.J.
  TITLE     PRKD3 promotes malignant progression of OSCC by downregulating
            KLF16 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (24), 12709-12716 (2020)
   PUBMED   33378018
  REMARK    GeneRIF: PRKD3 promotes malignant progression of OSCC by
            downregulating KLF16 expression.
REFERENCE   3  (bases 1 to 6156)
  AUTHORS   Cui,B., Chen,J., Luo,M., Wang,L., Chen,H., Kang,Y., Wang,J.,
            Zhou,X., Feng,Y. and Zhang,P.
  TITLE     Protein kinase D3 regulates the expression of the immunosuppressive
            protein, PD-L1, through STAT1/STAT3 signaling
  JOURNAL   Int J Oncol 56 (4), 909-920 (2020)
   PUBMED   32319563
  REMARK    GeneRIF: Protein kinase D3 regulates the expression of the
            immunosuppressive protein, PDL1, through STAT1/STAT3 signaling.
REFERENCE   4  (bases 1 to 6156)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6156)
  AUTHORS   Chen,J., Deng,F., Li,J. and Wang,Q.J.
  TITLE     Selective binding of phorbol esters and diacylglycerol by
            individual C1 domains of the PKD family
  JOURNAL   Biochem J 411 (2), 333-342 (2008)
   PUBMED   18076381
REFERENCE   6  (bases 1 to 6156)
  AUTHORS   Rey,O., Papazyan,R., Waldron,R.T., Young,S.H.,
            Lippincott-Schwartz,J., Jacamo,R. and Rozengurt,E.
  TITLE     The nuclear import of protein kinase D3 requires its catalytic
            activity
  JOURNAL   J Biol Chem 281 (8), 5149-5157 (2006)
   PUBMED   16380377
  REMARK    GeneRIF: the catalytic activity of PKD3 may regulate its nuclear
            import through autophosphorylation and/or interaction with another
            protein
REFERENCE   7  (bases 1 to 6156)
  AUTHORS   Ali,A., Hoeflich,K.P. and Woodgett,J.R.
  TITLE     Glycogen synthase kinase-3: properties, functions, and regulation
  JOURNAL   Chem Rev 101 (8), 2527-2540 (2001)
   PUBMED   11749387
  REMARK    Review article
REFERENCE   8  (bases 1 to 6156)
  AUTHORS   Fang,X., Yu,S.X., Lu,Y., Bast,R.C. Jr., Woodgett,J.R. and
            Mills,G.B.
  TITLE     Phosphorylation and inactivation of glycogen synthase kinase 3 by
            protein kinase A
  JOURNAL   Proc Natl Acad Sci U S A 97 (22), 11960-11965 (2000)
   PUBMED   11035810
REFERENCE   9  (bases 1 to 6156)
  AUTHORS   Hayashi,A., Seki,N., Hattori,A., Kozuma,S. and Saito,T.
  TITLE     PKCnu, a new member of the protein kinase C family, composes a
            fourth subfamily with PKCmu
  JOURNAL   Biochim Biophys Acta 1450 (1), 99-106 (1999)
   PUBMED   10231560
REFERENCE   10 (bases 1 to 6156)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ 4 (10), 821-830 (1993)
   PUBMED   8274451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007391.3 and AC007390.4.
            
            On or before Nov 14, 2019 this sequence version replaced
            XM_024452776.1, NM_005813.5.
            
            Summary: This gene belongs to the multigene protein kinase D family
            of serine/threonine kinases, which bind diacylglycerol and phorbol
            esters. Members of this family are characterized by an N-terminal
            regulatory domain comprised of a tandem repeat of cysteine-rich
            zinc-finger motifs and a pleckstrin domain. The C-terminal region
            contains the catalytic domain and is distantly related to
            calcium-regulated kinases. Catalytic activity of this enzyme
            promotes its nuclear localization. This protein has been implicated
            in a variety of functions including negative regulation of human
            airway epithelial barrier formation, growth regulation of breast
            and prostate cancer cells, and vesicle trafficking. [provided by
            RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.15790.1,
                                           SRR11853560.15736.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234179.8/ ENSP00000234179.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC007391.3         180974-181126
            154-1096            AC007390.4         4837-5779
            1097-1235           AC007390.4         28745-28883
            1236-1367           AC007390.4         31017-31148
            1368-1525           AC007390.4         32503-32660
            1526-1718           AC007390.4         35647-35839
            1719-1796           AC007390.4         39397-39474
            1797-1980           AC007390.4         42087-42270
            1981-2104           AC007390.4         44027-44150
            2105-2182           AC007390.4         46172-46249
            2183-2459           AC007390.4         47319-47595
            2460-2512           AC007390.4         49584-49636
            2513-2585           AC007390.4         52329-52401
            2586-2692           AC007390.4         54480-54586
            2693-2854           AC007390.4         61632-61793
            2855-2953           AC007390.4         62335-62433
            2954-3221           AC007390.4         65087-65354
            3222-3307           AC007390.4         67727-67812
            3308-6156           AC007390.4         68666-71514
FEATURES             Location/Qualifiers
     source          1..6156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..6156
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="protein kinase D3"
                     /db_xref="GeneID:23683"
                     /db_xref="HGNC:HGNC:9408"
                     /db_xref="MIM:607077"
     exon            1..153
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1096
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             809..3481
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /EC_number="2.7.11.13"
                     /note="protein kinase EPK2; protein kinase C nu type"
                     /codon_start=1
                     /product="serine/threonine-protein kinase D3"
                     /protein_id="NP_005804.1"
                     /db_xref="CCDS:CCDS1789.1"
                     /db_xref="GeneID:23683"
                     /db_xref="HGNC:HGNC:9408"
                     /db_xref="MIM:607077"
                     /translation="MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGS
                     FSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGF
                     FGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVH
                     SYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLP
                     GPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAV
                     HSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSL
                     GTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISP
                     STSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQN
                     ESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNP
                     VLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQE
                     NVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEV
                     AILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQ
                     ILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTP
                     AYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPW
                     REISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHE
                     SDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP"
     exon            1097..1235
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1367
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1525
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1718
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1796
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1980
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2104
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2182
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2459
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2512
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2585
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2692
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2854
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2953
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3221
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3307
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..6156
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3695..3700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="hexamer: TATAAA"
     polyA_site      3718
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="major polyA site"
     regulatory      5925..5930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="hexamer: AATAAA"
     polyA_site      5950
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="major polyA site"
     regulatory      6121..6126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
                     /note="hexamer: AATAAA"
     polyA_site      6156
                     /gene="PRKD3"
                     /gene_synonym="EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN"
ORIGIN      
        1 gccctccggc cccaggacgg gacggggagg gagggaggaa ggggcgccgg aggcgggcgg
       61 gatcctgcga ggcgcgtgaa gcctcgctgg cgcctcgtcc ggtactcaga cgctggcggg
      121 cgcagtttct cacgacgggc cgagcctgcc actgctaact atatgtcaga aagcatcagc
      181 ttttctcgat ggacccattc atctaatgaa atatgcctgt actattttaa aaagctttgt
      241 atttcgtcat agaaaagttc atccccccag aatgaaaatg aggacatttg agaaggtgat
      301 ttaaggtgtg gacatttgag aaggtgtcct atcaaattag taaaccaaag gaaaagtact
      361 gaatagatta atccaaaaca cttactgttt tttaaacgaa gaggatttca ccttgacaga
      421 aaaacaactt ttattcaata tgtatttcct gaaattaaag agacaagtac agactgaaag
      481 gaaaatagat tcgtaaataa gctacgtcaa ctctatcctg ctgaggatag ctcagtgatg
      541 ttaaatcctt tacaaatccc tggttgtctt cctacagaca agactgcttt ttgatgggac
      601 tgatattaag agaaatagga cctttggggc attcaactcc ttgataaaac ttaaaagtat
      661 cggcatgagt ggcttaacag aggaaataaa gaagttttca actaaatcca aaagtgcggt
      721 cattttcttt actgctgtta ttttaaaaac ctcttcataa ccattgaaaa agaatcgaca
      781 actattttaa aagattaaag aaaggcagat gtctgcaaat aattcccctc catcagccca
      841 gaagtctgta ttacccacag ctattcctgc tgtgcttcca gctgcttctc cgtgttcaag
      901 tcctaagacg ggactctctg cccgactctc taatggaagc ttcagtgcac catcactcac
      961 caactccaga ggctcagtgc atacagtttc atttctactg caaattggcc tcacacggga
     1021 gagtgttacc attgaagccc aggaactgtc tttatctgct gtcaaggatc ttgtgtgctc
     1081 catagtttat caaaagtttc cagagtgtgg attctttggc atgtatgaca aaattcttct
     1141 ctttcgccat gacatgaact cagaaaacat tttgcagctg attacctcag cagatgaaat
     1201 acatgaagga gacctagtgg aagtggttct ttcagcttta gccacagtag aagacttcca
     1261 gattcgtcca catactctct atgtacattc ttacaaagct cctactttct gtgattactg
     1321 tggtgagatg ctctggggat tggtacgtca aggactgaaa tgtgaaggct gtggattaaa
     1381 ttaccataaa cgatgtgcct tcaagattcc aaataactgt agtggagtaa gaaagagacg
     1441 tctgtcaaat gtatctttac caggacccgg cctctcagtt ccaagacccc tacagcctga
     1501 atatgtagcc cttcccagtg aagagtcaca tgtccaccag gaaccaagta agagaattcc
     1561 ttcttggagt ggtcgcccaa tctggatgga aaagatggta atgtgcagag tgaaagttcc
     1621 acacacattt gctgttcact cttacacccg tcccacgata tgtcagtact gcaagcggtt
     1681 actgaaaggc ctctttcgcc aaggaatgca gtgtaaagat tgcaaattca actgccataa
     1741 acgctgtgca tcaaaagtac caagagactg ccttggagag gttactttca atggagaacc
     1801 ttccagtctg ggaacagata cagatatacc aatggatatt gacaataatg acataaatag
     1861 tgatagtagt cggggtttgg atgacacaga agagccatca cccccagaag ataagatgtt
     1921 cttcttggat ccatctgatc tcgatgtgga aagagatgaa gaagccgtta aaacaatcag
     1981 tccatcaaca agcaataata ttccgctaat gagggttgta caatccatca agcacacaaa
     2041 gaggaagagc agcacaatgg tgaaggaagg gtggatggtc cattacacca gcagggataa
     2101 cctgagaaag aggcattatt ggagacttga cagcaaatgt ctaacattat ttcagaatga
     2161 atctggatca aagtattata aggaaattcc actttcagaa attctccgca tatcttcacc
     2221 acgagatttc acaaacattt cacaaggcag caatccacac tgttttgaaa tcattactga
     2281 tactatggta tacttcgttg gtgagaacaa tggggacagc tctcataatc ctgttcttgc
     2341 tgccactgga gttggacttg atgtagcaca gagctgggaa aaagcaattc gccaagccct
     2401 catgcctgtt actcctcaag caagtgtttg cacttctcca gggcaaggga aagatcacaa
     2461 agatttgtct acaagtatct ctgtatctaa ttgtcagatt caggagaatg tggatatcag
     2521 tactgtttac cagatctttg cagatgaggt gcttggttca ggccagtttg gcatcgttta
     2581 tggaggaaaa catagaaaga ctgggaggga tgtggctatt aaagtaattg ataagatgag
     2641 attccccaca aaacaagaaa gtcaactccg taatgaagtg gctattttac agaatttgca
     2701 ccatcctggg attgtaaacc tggaatgtat gtttgaaacc ccagaacgag tctttgtagt
     2761 aatggaaaag ctgcatggag atatgttgga aatgattcta tccagtgaga aaagtcggct
     2821 tccagaacga attactaaat tcatggtcac acagatactt gttgctttga ggaatctgca
     2881 ttttaagaat attgtgcact gtgatttaaa gccagaaaat gtgctgcttg catcagcaga
     2941 gccatttcct caggtgaagc tgtgtgactt tggatttgca cgcatcattg gtgaaaagtc
     3001 attcaggaga tctgtggtag gaactccagc atacttagcc cctgaagttc tccggagcaa
     3061 aggttacaac cgttccctag atatgtggtc agtgggagtt atcatctatg tgagcctcag
     3121 tggcacattt ccttttaatg aggatgaaga tataaatgac caaatccaaa atgctgcatt
     3181 tatgtaccca ccaaatccat ggagagaaat ttctggtgaa gcaattgatc tgataaacaa
     3241 tctgcttcaa gtgaagatga gaaaacgtta cagtgttgac aaatctctta gtcatccctg
     3301 gctacaggac tatcagactt ggcttgacct tagagaattt gaaactcgca ttggagaacg
     3361 ttacattaca catgaaagtg atgatgctcg ctgggaaata catgcataca cacataacct
     3421 tgtataccca aagcacttca ttatggctcc taatccagat gatatggaag aagatcctta
     3481 atcactgagc taacctaaat aaggaaggat ttcattttat ggactgatat tttgctgtgt
     3541 aacttgttct ttgtagattg tcatctgcag tgctgcaaag atatgaagaa atatgataac
     3601 gaataagtga caccagtact gtagttcata atgagtaggt acaggcggga aactgaataa
     3661 taagaagtca taatggaatc aaggtgaagc tttttataaa cttttttagc ctaagcaata
     3721 actggttttg tattttttct taatccttca ctttaataca ataggctcac ttaatttgtc
     3781 ttcccatttc tctttatata tatatatata aatataaata tatgtttgtt tgttttttta
     3841 atgaaaaaca agtcaagcta gcatccagtt actatatagc ttggctaaat tatacaagac
     3901 ttacaagatt gattactcga caggcttgta tttaagaggt aactgtgagg ttaccattat
     3961 gtgatgttac tataaggact tttaacattg gtttaacaaa ccatagaggc attgaagggt
     4021 ttttcttaga tgcctagaaa aagcgcactg ggctgtttta cctttctttt ttaggtcaat
     4081 caagactcca aaatagtgat tcctaacctt tttggagttg ctctgctact ctgaatatgt
     4141 tctatacagc ataaggattg tcaccttctg tgtgttgcaa cagcttctaa gataattagg
     4201 gacaaatgat gttacaaaag gaagagtact gctggtctaa gtgctgagtt gtatgtcttt
     4261 gcatagctcc actctgctgc taaatatgca tgttctgact gacaccatct tgatgccagt
     4321 actggattcc agcattcagc aggtgcagat ctcggcttta cacaatttat ctttacctag
     4381 ggttcagtca gtaatttctg ctttttagca gggccagtgc agggtcagtt aatgctacag
     4441 ttactgtata gcaaacagta tccttttttc tccttcccct agcctattgg gctttgcaga
     4501 tatctggagt gttttaaagt caattatttt aagcagtttg aggggatgtg taggagtgga
     4561 gcatgaaaca gtttataagg ctggggctgt attatcagca cagcaaatta aagaatgaaa
     4621 gaagtacttc tttttacatt tcagctccag cagccagcta tttaaaaaat atttttaaat
     4681 atcttcccca aagtttaaga tgtgggacca tctacttgta agaaacagtg gcttatttct
     4741 tcatttctca gtaatcattg taaacctttt tttttttctt ctccactcta acaaaagtaa
     4801 aagaacaaaa cttttgctga ggtcttggac tccactactt gttagttatg ttggcctgga
     4861 cagatggcag gtctgtcggc agttcctcag tctgtaaaat gaagattatc attcttgcct
     4921 ctccctttgt cacagtgttg tcgtgaagat cagatatgta tgaatgcagt caaataaact
     4981 aaaaactagg aaagtgttaa ctatcgttgc ccaccgaatt tgaggtagca aaaaaaaaaa
     5041 agaatgttct ggtacatgaa cagactgaga aggcctttcg acatccctga agctagtctc
     5101 ctgtctagac taaaaatatc cttgaaagaa tagtagcaaa cagtatgcag tactcctgtg
     5161 ttctaagttc ttttatgttt tagtttaccc tcacagcagc catagtgtta agtcattatg
     5221 agcttcatct taaagataag aaaactgagg caaggggaga ttaacttact gccaaatttc
     5281 aaacagttag tagtatttga gaccagtagt atggctctaa tcttaccctt agccctccca
     5341 accattatgc tgtactatct acccataaat acctccagga aacattcccc tcttggtaat
     5401 ttgtccttct atagaagctt caaagattaa atcaaattaa ttttcaaaaa aaattttttt
     5461 ttagaaatgt tattttccct gtgatagagg atgacttccc agtttcacca aagtctgttt
     5521 atatcaacac acacaaaatg gaataattct gagtcactag gcaatcaatc tactgtggtt
     5581 ttactatgta aggtgaaaat taactggaac gatgtttgtt tgctatactt acatagtcaa
     5641 actttacaag ccatgaaatt aattgcactc tttgtatttg ttgttaaatg cctaagaagt
     5701 tttctaaaaa ttttgtaaag gcactgtcag agaatctgga gttgaatgat tattccagat
     5761 actgtataac ctgcataact ttttgtcttt aagtcgtgtt tgtaaaagaa gtaattgcta
     5821 gaaacatttg ataatgtaca aagtagtcta taatgactgt tcagtacatt tttaatattt
     5881 ttttggttat atccaacttt ttgtaaatat actggaagct tgataataaa atgtatttcc
     5941 tatcaccata cttttccatg tgaaaacctg agcctatttc tagtataagt atccaaagaa
     6001 aagtttgacc tggttgtgtt attttaccag accttggtaa aagaactatt ttggaaacag
     6061 tatttgtaaa tggaactaat gctatattta aaaacactga ttttttttta acctgccaaa
     6121 aataaaaaaa agctcatttt ataattttct actaaa
//
