LOCUS       NM_002742               3833 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens protein kinase D1 (PRKD1), transcript variant 2, mRNA.
ACCESSION   NM_002742
VERSION     NM_002742.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3833)
  AUTHORS   Renton,M.C., McGee,S.L. and Howlett,K.F.
  TITLE     The role of protein kinase D (PKD) in obesity: Lessons from the
            heart and other tissues
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119814 (2024)
   PUBMED   39128598
  REMARK    GeneRIF: The role of protein kinase D (PKD) in obesity: Lessons
            from the heart and other tissues.
            Review article
REFERENCE   2  (bases 1 to 3833)
  AUTHORS   Wit,M., Belykh,A. and Sumara,G.
  TITLE     Protein kinase D (PKD) on the crossroad of lipid absorption,
            synthesis and utilization
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119653 (2024)
   PUBMED   38104800
  REMARK    GeneRIF: Protein kinase D (PKD) on the crossroad of lipid
            absorption, synthesis and utilization.
            Review article
REFERENCE   3  (bases 1 to 3833)
  AUTHORS   Cilleros-Rodriguez,D., Toledo-Lobo,M.V., Martinez-Martinez,D.,
            Baquero,P., Angulo,J.C., Chiloeches,A., Iglesias,T. and Lasa,M.
  TITLE     Protein kinase D activity is a risk biomarker in prostate cancer
            that drives cell invasion by a Snail/ERK dependent mechanism
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166851 (2024)
   PUBMED   37611675
  REMARK    GeneRIF: Protein kinase D activity is a risk biomarker in prostate
            cancer that drives cell invasion by a Snail/ERK dependent
            mechanism.
REFERENCE   4  (bases 1 to 3833)
  AUTHORS   Legay,C., Doublier,S., Babajko,S. and Ricort,J.M.
  TITLE     Protein kinase D1 overexpression potentiates epidermal growth
            factor signaling pathway in MCF-7 cells
  JOURNAL   Mol Biol Rep 50 (4), 3641-3651 (2023)
   PUBMED   36800056
  REMARK    GeneRIF: Protein kinase D1 overexpression potentiates epidermal
            growth factor signaling pathway in MCF-7 cells.
REFERENCE   5  (bases 1 to 3833)
  AUTHORS   Sharma,D., Kaur,G., Bisen,S., Sharma,A., Ibrahim,A.S. and
            Singh,N.K.
  TITLE     IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin Phosphorylation
            Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced
            Vascular Leakage
  JOURNAL   Cells 12 (5), 703 (2023)
   PUBMED   36899839
  REMARK    GeneRIF: IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin
            Phosphorylation Regulates Endothelial Cell-Barrier Integrity and
            Ischemia-Induced Vascular Leakage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3833)
  AUTHORS   Johannes,F.J., Prestle,J., Eis,S., Oberhagemann,P. and
            Pfizenmaier,K.
  TITLE     PKCu is a novel, atypical member of the protein kinase C family
  JOURNAL   J Biol Chem 269 (8), 6140-6148 (1994)
   PUBMED   8119958
REFERENCE   7  (bases 1 to 3833)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
REFERENCE   8  (bases 1 to 3833)
  AUTHORS   Davis,R.J. and Czech,M.P.
  TITLE     Platelet-derived growth factor mimics phorbol diester action on
            epidermal growth factor receptor phosphorylation at threonine-654
  JOURNAL   Proc Natl Acad Sci U S A 82 (12), 4080-4084 (1985)
   PUBMED   2987962
REFERENCE   9  (bases 1 to 3833)
  AUTHORS   Davis,R.J. and Czech,M.P.
  TITLE     Tumor-promoting phorbol diesters cause the phosphorylation of
            epidermal growth factor receptors in normal human fibroblasts at
            threonine-654
  JOURNAL   Proc Natl Acad Sci U S A 82 (7), 1974-1978 (1985)
   PUBMED   2984676
REFERENCE   10 (bases 1 to 3833)
  AUTHORS   Busch,H. and Eisenhart-Rothe,B.V.
  TITLE     [Old and new dangers of blood transfusion (author's transl)]
  JOURNAL   MMW Munch Med Wochenschr 118 (22), 713-718 (1976)
   PUBMED   5668
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355053.4, X75756.1,
            CN412379.1 and BX645735.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002742.2.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase involved in many cellular processes, including Golgi
            body membrane integrity and transport, cell migration and
            differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3
            (ERK1/2) pathway signaling, cell survival, and regulation of cell
            shape and adhesion. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75756.1, AK314170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331968.11/ ENSP00000333568.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AL355053.4         27115-27268
            155-737             X75756.1           55-637
            738-1031            CN412379.1         172-465
            1032-2963           X75756.1           932-2863
            2964-3437           BX645735.1         120-593
            3438-3833           X75756.1           3338-3733
FEATURES             Location/Qualifiers
     source          1..3833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..3833
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /note="protein kinase D1"
                     /db_xref="GeneID:5587"
                     /db_xref="HGNC:HGNC:9407"
                     /db_xref="MIM:605435"
     exon            1..599
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..3074
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /EC_number="2.7.11.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein kinase C, mu; serine/threonine-protein kinase D1;
                     nPKC-D1; nPKC-mu; protein kinase C mu type"
                     /codon_start=1
                     /product="serine/threonine-protein kinase D1 isoform 2"
                     /protein_id="NP_002733.2"
                     /db_xref="CCDS:CCDS9637.1"
                     /db_xref="GeneID:5587"
                     /db_xref="HGNC:HGNC:9407"
                     /db_xref="MIM:605435"
                     /translation="MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAA
                     PVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKIL
                     LFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFC
                     DHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTS
                     SAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIH
                     SYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPG
                     AESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDA
                     NRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKC
                     ITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVV
                     NPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISV
                     SNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE
                     SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHI
                     TKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFR
                     RSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAF
                     MYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIG
                     ERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL"
     exon            600..738
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            739..870
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1031
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1242
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1320
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1525
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1649
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1727
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..2007
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2060
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2133
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2240
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2402
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2501
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2769
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2855
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3833
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /note="hexamer: ATTAAA"
     polyA_site      3368
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /note="hexamer: AATAAA"
     polyA_site      3833
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccccgt ccttccgagc gcgccaggcg gcagattctt ggcggcggcg gcgcctcccc
       61 agtgccggcg gccccgagcc ggctgccgcg ttccgggcct cagagtcctc ccgcctcggc
      121 cattttccct cctccccatc tcctcccctt agtcccctcc cctcccgatc ctcatcccct
      181 tgccctcccc cagcccaggg acttttccgg aaagttttta ttttccgtct gggctctcgg
      241 agaaagaagc tcctggctca gcggctgcaa aactttcctg ctgccgcgcc gccagccccc
      301 gccctccgct gcccggccct gcgccccgcc gagcgatgag cgcccctccg gtcctgcggc
      361 cgcccagtcc gctgctgccc gtggcggcgg cagctgccgc agcggccgcc gcactggtcc
      421 cagggtccgg gcccgggccc gcgccgttct tggctcctgt cgcggccccg gtcgggggca
      481 tctcgttcca tctgcagatc ggcctgagcc gtgagccggt gctgctgctg caggactcgt
      541 ccggggacta cagcctggcg cacgtccgcg agatggcttg ctccattgtc gaccagaagt
      601 tccctgaatg tggtttctac ggaatgtatg ataagatcct gctttttcgc catgacccta
      661 cctctgaaaa catccttcag ctggtgaaag cggccagtga tatccaggaa ggcgatctta
      721 ttgaagtggt cttgtcagct tccgccacct ttgaagactt tcagattcgt ccccacgctc
      781 tctttgttca ttcatacaga gctccagctt tctgtgatca ctgtggagaa atgctgtggg
      841 ggctggtacg tcaaggtctt aaatgtgaag ggtgtggtct gaattaccat aagagatgtg
      901 catttaaaat acccaacaat tgcagcggtg tgaggcggag aaggctctca aacgtttccc
      961 tcactggggt cagcaccatc cgcacatcat ctgctgaact ctctacaagt gcccctgatg
     1021 agccccttct gcaaaaatca ccatcagagt cgtttattgg tcgagagaag aggtcaaatt
     1081 ctcaatcata cattggacga ccaattcacc ttgacaagat tttgatgtct aaagttaaag
     1141 tgccgcacac atttgtcatc cactcctaca cccggcccac agtgtgccag tactgcaaga
     1201 agcttctgaa ggggcttttc aggcagggct tgcagtgcaa agattgcaga ttcaactgcc
     1261 ataaacgttg tgcaccgaaa gtaccaaaca actgccttgg cgaagtgacc attaatggag
     1321 atttgcttag ccctggggca gagtctgatg tggtcatgga agaagggagt gatgacaatg
     1381 atagtgaaag gaacagtggg ctcatggatg atatggaaga agcaatggtc caagatgcag
     1441 agatggcaat ggcagagtgc cagaacgaca gtggcgagat gcaagatcca gacccagacc
     1501 acgaggacgc caacagaacc atcagtccat caacaagcaa caatatccca ctcatgaggg
     1561 tagtgcagtc tgtcaaacac acgaagagga aaagcagcac agtcatgaaa gaaggatgga
     1621 tggtccacta caccagcaag gacacgctgc ggaaacggca ctattggaga ttggatagca
     1681 aatgtattac cctctttcag aatgacacag gaagcaggta ctacaaggaa attcctttat
     1741 ctgaaatttt gtctctggaa ccagtaaaaa cttcagcttt aattcctaat ggggccaatc
     1801 ctcattgttt cgaaatcact acggcaaatg tagtgtatta tgtgggagaa aatgtggtca
     1861 atccttccag cccatcacca aataacagtg ttctcaccag tggcgttggt gcagatgtgg
     1921 ccaggatgtg ggagatagcc atccagcatg cccttatgcc cgtcattccc aagggctcct
     1981 ccgtgggtac aggaaccaac ttgcacagag atatctctgt gagtatttca gtatcaaatt
     2041 gccagattca agaaaatgtg gacatcagca cagtatatca gatttttcct gatgaagtac
     2101 tgggttctgg acagtttgga attgtttatg gaggaaaaca tcgtaaaaca ggaagagatg
     2161 tagctattaa aatcattgac aaattacgat ttccaacaaa acaagaaagc cagcttcgta
     2221 atgaggttgc aattctacag aaccttcatc accctggtgt tgtaaatttg gagtgtatgt
     2281 ttgagacgcc tgaaagagtg tttgttgtta tggaaaaact ccatggagac atgctggaaa
     2341 tgatcttgtc aagtgaaaag ggcaggttgc cagagcacat aacgaagttt ttaattactc
     2401 agatactcgt ggctttgcgg caccttcatt ttaaaaatat cgttcactgt gacctcaaac
     2461 cagaaaatgt gttgctagcc tcagctgatc cttttcctca ggtgaaactt tgtgattttg
     2521 gttttgcccg gatcattgga gagaagtctt tccggaggtc agtggtgggt acccccgctt
     2581 acctggctcc tgaggtccta aggaacaagg gctacaatcg ctctctagac atgtggtctg
     2641 ttggggtcat catctatgta agcctaagcg gcacattccc atttaatgaa gatgaagaca
     2701 tacacgacca aattcagaat gcagctttca tgtatccacc aaatccctgg aaggaaatat
     2761 ctcatgaagc cattgatctt atcaacaatt tgctgcaagt aaaaatgaga aagcgctaca
     2821 gtgtggataa gaccttgagc cacccttggc tacaggacta tcagacctgg ttagatttgc
     2881 gagagctgga atgcaaaatc ggggagcgct acatcaccca tgaaagtgat gacctgaggt
     2941 gggagaagta tgcaggcgag caggggctgc agtaccccac acacctgatc aatccaagtg
     3001 ctagccacag tgacactcct gagactgaag aaacagaaat gaaagccctc ggtgagcgtg
     3061 tcagcatcct ctgagttcca tctcctataa tctgtcaaaa cactgtggaa ctaataaata
     3121 catacggtca ggtttaacat ttgccttgca gaactgccat tattttctgt cagatgagaa
     3181 caaagctgtt aaactgttag cactgttgat gtatctgagt tgccaagaca aatcaacaga
     3241 agcatttgta ttttgtgtga ccaactgtgt tgtattaaca aaagttccct gaaacacgaa
     3301 acttgttatt gtgaatgatt catgttatat ttaatgcatt aaacctgtct ccactgtgcc
     3361 tttgcaaatc agtgtttttc ttactggagc ttcattttgg taagagacag aatgtatctg
     3421 tgaagtagtt ctgtttggtg tgtcccattg gtgttgtcat tgtaaacaaa ctcttgaaga
     3481 gtcgattatt tccagtgttc tatgaacaac tccaaaaccc atgtgggaaa aaaatgaatg
     3541 aggagggtag ggaataaaat cctaagacac aaatgcatga acaagtttta atgtatagtt
     3601 ttgaatcctt tgcctgcctg gtgtgcctca gtatatttaa actcaagaca atgcacctag
     3661 ctgtgcaaga cctagtgctc ttaagcctaa atgccttaga aatgtaaact gccatatata
     3721 acagatacat ttccctcttt cttataatac tctgttgtac tatggaaaat cagctgctca
     3781 gcaacctttc acctttgtgt atttttcaat aataaaaaat attcttgtca aaa
//
