LOCUS       NM_001350804            2330 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens protein kinase C zeta (PRKCZ), transcript variant 6,
            mRNA.
ACCESSION   NM_001350804 XM_017001798
VERSION     NM_001350804.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Mustafa,A., Shabbir,M., Badshah,Y., Khan,K., Abid,F.,
            Trembley,J.H., Afsar,T., Almajwal,A. and Razak,S.
  TITLE     Genetic polymorphism in untranslated regions of PRKCZ influences
            mRNA structure, stability and binding sites
  JOURNAL   BMC Cancer 24 (1), 1147 (2024)
   PUBMED   39272077
  REMARK    GeneRIF: Genetic polymorphism in untranslated regions of PRKCZ
            influences mRNA structure, stability and binding sites.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Wang,C., Zhao,X., Zhao,L., Wang,Y., Jia,Y., Zhang,X. and Ma,W.
  TITLE     PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer
            cells
  JOURNAL   Exp Cell Res 433 (2), 113823 (2023)
   PUBMED   37890607
  REMARK    GeneRIF: PKCzeta phosphorylates VASP to mediate chemotaxis in
            breast cancer cells.
REFERENCE   3  (bases 1 to 2330)
  AUTHORS   Perveen,K., Quach,A., Stark,M.J., Prescott,S., Barry,S.C., Hii,C.S.
            and Ferrante,A.
  TITLE     PKCzeta activation promotes maturation of cord blood T cells
            towards a Th1 IFN-gamma propensity
  JOURNAL   Immunology 170 (3), 359-373 (2023)
   PUBMED   37340593
  REMARK    GeneRIF: PKCzeta activation promotes maturation of cord blood T
            cells towards a Th1 IFN-gamma propensity.
REFERENCE   4  (bases 1 to 2330)
  AUTHORS   Zhang,F., Zheng,Z., Wang,L., Zeng,W., Wei,W., Zhang,C., Zhao,Z. and
            Liang,W.
  TITLE     PKC-zeta mediated reduction of the extracellular
            vesicles-associated TGF-beta1 overcomes radiotherapy resistance in
            breast cancer
  JOURNAL   Breast Cancer Res 25 (1), 38 (2023)
   PUBMED   37029374
  REMARK    GeneRIF: PKC-zeta mediated reduction of the extracellular
            vesicles-associated TGF-beta1 overcomes radiotherapy resistance in
            breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2330)
  AUTHORS   Shaha,S., Patel,K., Saadat,S., Panahi,S., de Almeida,M.M.,
            Voronova,A. and Riddell,M.
  TITLE     Human placenta and trophoblasts simultaneously express three
            isoforms of atypical protein kinase-c
  JOURNAL   Placenta 119, 39-43 (2022)
   PUBMED   35124330
  REMARK    GeneRIF: Human placenta and trophoblasts simultaneously express
            three isoforms of atypical protein kinase-c.
REFERENCE   6  (bases 1 to 2330)
  AUTHORS   Tippmer,S., Quitterer,U., Kolm,V., Faussner,A., Roscher,A.,
            Mosthaf,L., Muller-Esterl,W. and Haring,H.
  TITLE     Bradykinin induces translocation of the protein kinase C isoforms
            alpha, epsilon, and zeta
  JOURNAL   Eur J Biochem 225 (1), 297-304 (1994)
   PUBMED   7925449
REFERENCE   7  (bases 1 to 2330)
  AUTHORS   el Benna,J., Faust,L.P. and Babior,B.M.
  TITLE     The phosphorylation of the respiratory burst oxidase component
            p47phox during neutrophil activation. Phosphorylation of sites
            recognized by protein kinase C and by proline-directed kinases
  JOURNAL   J Biol Chem 269 (38), 23431-23436 (1994)
   PUBMED   8089108
REFERENCE   8  (bases 1 to 2330)
  AUTHORS   Yao,L., Kawakami,Y. and Kawakami,T.
  TITLE     The pleckstrin homology domain of Bruton tyrosine kinase interacts
            with protein kinase C
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 9175-9179 (1994)
   PUBMED   7522330
REFERENCE   9  (bases 1 to 2330)
  AUTHORS   Kawabe,J., Iwami,G., Ebina,T., Ohno,S., Katada,T., Ueda,Y.,
            Homcy,C.J. and Ishikawa,Y.
  TITLE     Differential activation of adenylyl cyclase by protein kinase C
            isoenzymes
  JOURNAL   J Biol Chem 269 (24), 16554-16558 (1994)
   PUBMED   8206971
  REMARK    Erratum:[J Biol Chem 1994 Sep 9;269(36):22912]
REFERENCE   10 (bases 1 to 2330)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB152283.1, AL645703.18,
            BC008058.2, BQ084132.1 and AI186591.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001350804.1.
            
            Summary: Protein kinase C (PKC) zeta is a member of the PKC family
            of serine/threonine kinases which are involved in a variety of
            cellular processes such as proliferation, differentiation and
            secretion. Unlike the classical PKC isoenzymes which are
            calcium-dependent, PKC zeta exhibits a kinase activity which is
            independent of calcium and diacylglycerol but not of
            phosphatidylserine. Furthermore, it is insensitive to typical PKC
            inhibitors and cannot be activated by phorbol ester. Unlike the
            classical PKC isoenzymes, it has only a single zinc finger module.
            These structural and biochemical properties indicate that the zeta
            subspecies is related to, but distinct from other isoenzymes of
            PKC. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.72077.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               CB152283.1         18-283
            267-475             AL645703.18        7448-7656
            476-717             CB152283.1         284-525
            718-1090            BC008058.2         685-1057
            1091-1361           BQ084132.1         2-272
            1362-1931           BC008058.2         1305-1874
            1932-2330           AI186591.1         14-412              c
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2330
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /note="protein kinase C zeta"
                     /db_xref="GeneID:5590"
                     /db_xref="HGNC:HGNC:9412"
                     /db_xref="MIM:176982"
     exon            1..266
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..475
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..561
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..693
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..1944
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /EC_number="2.7.11.13"
                     /note="isoform 4 is encoded by transcript variant 6;
                     protein kinase C zeta type; nPKC-zeta"
                     /codon_start=1
                     /product="protein kinase C zeta type isoform 4"
                     /protein_id="NP_001337733.1"
                     /db_xref="GeneID:5590"
                     /db_xref="HGNC:HGNC:9412"
                     /db_xref="MIM:176982"
                     /translation="MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDD
                     SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKK
                     ELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLRRLSPCRLFLVIEYVNG
                     GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLT
                     DYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF
                     DIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGF
                     SDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAI
                     KRIDQSEFEGFEYINPLLLSTEESV"
     exon            694..775
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..828
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1017
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1115
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1226
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1362
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1450
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1570
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1650
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1740
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1856
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2330
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="PRKCZ"
                     /gene_synonym="PKC-ZETA; PKC2"
                     /note="major polyA site"
ORIGIN      
        1 agctgctggc tacagcttcc cgggggagcc gggtaccacc cgggcctgga gacatgagga
       61 ggcagggatg tgaggggcgg gggacaggac agccggcctt ccgttaaata tctgctcctc
      121 gcgctcgagc ctccctgcct attgtcgggg ccggaggcga gccgacgcag catcagctcg
      181 tcaacgggaa ggaagatgcc tccctgcacg cccgccgcgc acagagcata aagaatctgc
      241 gctgaggagg caggagaaga aagccggagc ggtgccgctg gcctgtggct tctgcaggga
      301 caagtagtgg ctgtggccgg gaggcgttcg gcagctgtgc ttcagccccg gccccagctt
      361 cagctcttcg agttgctggc ttctctaagg cctgtcctga agtggcctgg agactgctga
      421 gttacttctg gaatctgcac cgtgaaagtg aaacctggac catgatgtga ggctgaatct
      481 atctaccgcc ggggagccag aagatggagg aagctgtacc gtgccaacgg ccacctcttc
      541 caagccaagc gctttaacag gagagcgtac tgcggtcagt gcagcgagag gatatggggc
      601 ctcgcgaggc aaggctacag gtgcatcaac tgcaaactgc tggtccataa gcgctgccac
      661 ggcctcgtcc cgctgacctg caggaagcat atggattctg tcatgccttc ccaagagcct
      721 ccagtagacg acaagaacga ggacgccgac cttccttccg aggagacaga tggaattgct
      781 tacatttcct catcccggaa gcatgacagc attaaagacg actcggagga ccttaagcca
      841 gttatcgatg ggatggatgg aatcaaaatc tctcaggggc ttgggctgca ggactttgac
      901 ctaatcagag tcatcgggcg cgggagctac gccaaggttc tcctggtgcg gttgaagaag
      961 aatgaccaaa tttacgccat gaaagtggtg aagaaagagc tggtgcatga tgacgaggat
     1021 attgactggg tacagacaga gaagcacgtg tttgagcagg catccagcaa ccccttcctg
     1081 gtcggattac actcctgctt ccagacgaca agtcgcctcc ggcgcctctc tccctgcagg
     1141 ttgttcctgg tcattgagta cgtcaacggc ggggacctga tgttccacat gcagaggcag
     1201 aggaagctcc ctgaggagca cgccaggttc tacgcggccg agatctgcat cgccctcaac
     1261 ttcctgcacg agagggggat catctacagg gacctgaagc tggacaacgt cctcctggat
     1321 gcggacgggc acatcaagct cacagactac ggcatgtgca aggaaggcct gggccctggt
     1381 gacacaacga gcactttctg cggaaccccg aattacatcg cccccgaaat cctgcgggga
     1441 gaggagtacg ggttcagcgt ggactggtgg gcgctgggag tcctcatgtt tgagatgatg
     1501 gccgggcgct ccccgttcga catcatcacc gacaacccgg acatgaacac agaggactac
     1561 cttttccaag tgatcctgga gaagcccatc cggatccccc ggttcctgtc cgtcaaagcc
     1621 tcccatgttt taaaaggatt tttaaataag gaccccaaag agaggctcgg ctgccggcca
     1681 cagactggat tttctgacat caagtcccac gcgttcttcc gcagcataga ctgggacttg
     1741 ctggagaaga agcaggcgct ccctccattc cagccacaga tcacagacga ctacggtctg
     1801 gacaactttg acacacagtt caccagcgag cccgtgcagc tgaccccaga cgatgaggat
     1861 gccataaaga ggatcgacca gtcagagttc gaaggctttg agtatatcaa cccattattg
     1921 ctgtccaccg aggagtcggt gtgaggccgc gtgcgtctct gtcgtggaca cgcgtgattg
     1981 accctttaac tgtatcctta accaccgcat atgcatgcca ggctgggcac ggctccgagg
     2041 gcggccaggg acagacgctt gcgccgagac cgcagaggga agcgtcagcg ggcgctgctg
     2101 ggagcagaac agtccctcac acctgggccc gggcaggcca gcttcgtgct ggaggaactt
     2161 gctgctgtgc ctgcgtcgcg gcggatccgc ggggaccctg ccgagggggc tgtcatgcgg
     2221 tttccaaggt gcacattttc cacggaaaca gaactcgatg cactgacctg ctccgccagg
     2281 aaagtgagcg tgtagcgtcc tgaggaataa aatgttccga tgatgtggaa
//
