LOCUS       NM_002740               4887 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens protein kinase C iota (PRKCI), mRNA.
ACCESSION   NM_002740
VERSION     NM_002740.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4887)
  AUTHORS   Tyagi,K., Roy,A. and Mandal,S.
  TITLE     Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR
            signalling in high grade serous ovarian cancer
  JOURNAL   Mol Biol Rep 51 (1), 983 (2024)
   PUBMED   39276277
  REMARK    GeneRIF: Protein kinase C iota promotes glycolysis via
            PI3K/AKT/mTOR signalling in high grade serous ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4887)
  AUTHORS   Muta,Y., Linares,J.F., Martinez-Ordonez,A., Duran,A., Cid-Diaz,T.,
            Kinoshita,H., Zhang,X., Han,Q., Nakanishi,Y., Nakanishi,N.,
            Cordes,T., Arora,G.K., Ruiz-Martinez,M., Reina-Campos,M.,
            Kasashima,H., Yashiro,M., Maeda,K., Albaladejo-Gonzalez,A.,
            Torres-Moreno,D., Garcia-Solano,J., Conesa-Zamora,P., Inghirami,G.,
            Metallo,C.M., Osborne,T.F., Diaz-Meco,M.T. and Moscat,J.
  TITLE     Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota
            deficiency in intestinal epithelial cells promotes aggressive
            serrated tumorigenesis
  JOURNAL   Nat Commun 14 (1), 8075 (2023)
   PUBMED   38092754
  REMARK    GeneRIF: Enhanced SREBP2-driven cholesterol biosynthesis by
            PKClambda/iota deficiency in intestinal epithelial cells promotes
            aggressive serrated tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4887)
  AUTHORS   Jiao,J., Ruan,L., Cheng,C.S., Wang,F., Yang,P. and Chen,Z.
  TITLE     Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth
            and metastasis via enhancing NF-kappaB/JNK/ERK phosphorylation
  JOURNAL   Mol Med 29 (1), 47 (2023)
   PUBMED   37016317
  REMARK    GeneRIF: Paired protein kinases PRKCI-RIPK2 promote pancreatic
            cancer growth and metastasis via enhancing NF-kappaB/JNK/ERK
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4887)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 4887)
  AUTHORS   Shah,H., Khan,K., Badshah,Y., Mahmood Ashraf,N., Shabbir,M.,
            Trembley,J.H., Afsar,T., Abusharha,A. and Razak,S.
  TITLE     Investigation of UTR Variants by Computational Approaches Reveal
            Their Functional Significance in PRKCI Gene Regulation
  JOURNAL   Genes (Basel) 14 (2), 247 (2023)
   PUBMED   36833174
  REMARK    GeneRIF: Investigation of UTR Variants by Computational Approaches
            Reveal Their Functional Significance in PRKCI Gene Regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4887)
  AUTHORS   Conant,K., Ma,M., Nath,A. and Major,E.O.
  TITLE     Extracellular human immunodeficiency virus type 1 Tat protein is
            associated with an increase in both NF-kappa B binding and protein
            kinase C activity in primary human astrocytes
  JOURNAL   J Virol 70 (3), 1384-1389 (1996)
   PUBMED   8627654
REFERENCE   7  (bases 1 to 4887)
  AUTHORS   Diaz-Meco,M.T., Municio,M.M., Sanchez,P., Lozano,J. and Moscat,J.
  TITLE     Lambda-interacting protein, a novel protein that specifically
            interacts with the zinc finger domain of the atypical protein
            kinase C isotype lambda/iota and stimulates its kinase activity in
            vitro and in vivo
  JOURNAL   Mol Cell Biol 16 (1), 105-114 (1996)
   PUBMED   8524286
REFERENCE   8  (bases 1 to 4887)
  AUTHORS   Mazzarella,R., Ciccodicola,A., Esposito,T., Arcucci,A.,
            Migliaccio,C., Jones,C., Schlessinger,D., D'Urso,M. and
            D'Esposito,M.
  TITLE     Human protein kinase C Iota gene (PRKCI) is closely linked to the
            BTK gene in Xq21.3
  JOURNAL   Genomics 26 (3), 629-631 (1995)
   PUBMED   7607695
REFERENCE   9  (bases 1 to 4887)
  AUTHORS   Selbie,L.A., Schmitz-Peiffer,C., Sheng,Y. and Biden,T.J.
  TITLE     Molecular cloning and characterization of PKC iota, an atypical
            isoform of protein kinase C derived from insulin-secreting cells
  JOURNAL   J Biol Chem 268 (32), 24296-24302 (1993)
   PUBMED   8226978
REFERENCE   10 (bases 1 to 4887)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023891.28, CN412350.1,
            BC022016.2, L33881.1 and AC073288.27.
            
            On Nov 22, 2018 this sequence version replaced NM_002740.5.
            
            Summary: This gene encodes a member of the protein kinase C (PKC)
            family of serine/threonine protein kinases. The PKC family
            comprises at least eight members, which are differentially
            expressed and are involved in a wide variety of cellular processes.
            This protein kinase is calcium-independent and
            phospholipid-dependent. It is not activated by phorbolesters or
            diacylglycerol. This kinase can be recruited to vesicle tubular
            clusters (VTCs) by direct interaction with the small GTPase RAB2,
            where this kinase phosphorylates glyceraldehyde-3-phosphate
            dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics
            in the early secretory pathway. This kinase is found to be
            necessary for BCL-ABL-mediated resistance to drug-induced apoptosis
            and therefore protects leukemia cells against drug-induced
            apoptosis. There is a single exon pseudogene mapped on chromosome
            X. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.32160.1,
                                           SRR1803616.69458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295797.5/ ENSP00000295797.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC023891.28        120950-120957
            9-15                CN412350.1         1-7
            16-1698             BC022016.2         3-1685
            1699-2305           L33881.1           1630-2236
            2306-4887           AC073288.27        59733-62314
FEATURES             Location/Qualifiers
     source          1..4887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..4887
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /note="protein kinase C iota"
                     /db_xref="GeneID:5584"
                     /db_xref="HGNC:HGNC:9404"
                     /db_xref="MIM:600539"
     exon            1..347
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..2037
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /EC_number="2.7.11.13"
                     /note="atypical protein kinase C-lambda/iota;
                     aPKC-lambda/iota; PRKC-lambda/iota"
                     /codon_start=1
                     /product="protein kinase C iota type"
                     /protein_id="NP_002731.4"
                     /db_xref="CCDS:CCDS3212.2"
                     /db_xref="GeneID:5584"
                     /db_xref="HGNC:HGNC:9404"
                     /db_xref="MIM:600539"
                     /translation="MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPS
                     ISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELL
                     IHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDR
                     IWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIP
                     YNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKT
                     DRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEY
                     VNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI
                     KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGR
                     SPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCH
                     PQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPD
                     DDDIVRKIDQSEFEGFEYINPLLMSAEECV"
     exon            348..469
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            470..559
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            560..610
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            611..696
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            697..837
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            838..892
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            893..951
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1128
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1226
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1313
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1449
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1537
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1663
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1743
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1833
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1949
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..4887
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4868..4873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /note="hexamer: AATAAA"
     polyA_site      4887
                     /gene="PRKCI"
                     /gene_synonym="DXS1179E; nPKC-iota; PKCI"
                     /note="major polyA site"
ORIGIN      
        1 gacgcaggag gtgtcttggg cccgggcggc tgtagaggcg gcggcgccta cgggcagtgg
       61 gaggagccgc gcggttccgg ctgctccggc gaggcgaccc ttgggtcggc gctgcgggcg
      121 aggtgggcag gtaggtgggc ggacggccgc ggttctccgg caagcgcagg cggcggagtc
      181 ccccacggcg cccgaagcgc ccccccgcac ccccggcctc cagcgttgag gcgggggagt
      241 gaggagatgc cgacccagag ggacagcagc accatgtccc acacggtcgc aggcggcggc
      301 agcggggacc attcccacca ggtccgggtg aaagcctact accgcgggga tatcatgata
      361 acacattttg aaccttccat ctcctttgag ggcctttgca atgaggttcg agacatgtgt
      421 tcttttgaca acgaacagct cttcaccatg aaatggatag atgaggaagg agacccgtgt
      481 acagtatcat ctcagttgga gttagaagaa gcctttagac tttatgagct aaacaaggat
      541 tctgaactct tgattcatgt gttcccttgt gtaccagaac gtcctgggat gccttgtcca
      601 ggagaagata aatccatcta ccgtagaggt gcacgccgct ggagaaagct ttattgtgcc
      661 aatggccaca ctttccaagc caagcgtttc aacaggcgtg ctcactgtgc catctgcaca
      721 gaccgaatat ggggacttgg acgccaagga tataagtgca tcaactgcaa actcttggtt
      781 cataagaagt gccataaact cgtcacaatt gaatgtgggc ggcattcttt gccacaggaa
      841 ccagtgatgc ccatggatca gtcatccatg cattctgacc atgcacagac agtaattcca
      901 tataatcctt caagtcatga gagtttggat caagttggtg aagaaaaaga ggcaatgaac
      961 accagggaaa gtggcaaagc ttcatccagt ctaggtcttc aggattttga tttgctccgg
     1021 gtaataggaa gaggaagtta tgccaaagta ctgttggttc gattaaaaaa aacagatcgt
     1081 atttatgcaa tgaaagttgt gaaaaaagag cttgttaatg atgatgagga tattgattgg
     1141 gtacagacag agaagcatgt gtttgagcag gcatccaatc atcctttcct tgttgggctg
     1201 cattcttgct ttcagacaga aagcagattg ttctttgtta tagagtatgt aaatggagga
     1261 gacctaatgt ttcatatgca gcgacaaaga aaacttcctg aagaacatgc cagattttac
     1321 tctgcagaaa tcagtctagc attaaattat cttcatgagc gagggataat ttatagagat
     1381 ttgaaactgg acaatgtatt actggactct gaaggccaca ttaaactcac tgactacggc
     1441 atgtgtaagg aaggattacg gccaggagat acaaccagca ctttctgtgg tactcctaat
     1501 tacattgctc ctgaaatttt aagaggagaa gattatggtt tcagtgttga ctggtgggct
     1561 cttggagtgc tcatgtttga gatgatggca ggaaggtctc catttgatat tgttgggagc
     1621 tccgataacc ctgaccagaa cacagaggat tatctcttcc aagttatttt ggaaaaacaa
     1681 attcgcatac cacgttctct gtctgtaaaa gctgcaagtg ttctgaagag ttttcttaat
     1741 aaggacccta aggaacgatt gggttgtcat cctcaaacag gatttgctga tattcaggga
     1801 cacccgttct tccgaaatgt tgattgggat atgatggagc aaaaacaggt ggtacctccc
     1861 tttaaaccaa atatttctgg ggaatttggt ttggacaact ttgattctca gtttactaat
     1921 gaacctgtcc agctcactcc agatgacgat gacattgtga ggaagattga tcagtctgaa
     1981 tttgaaggtt ttgagtatat caatcctctt ttgatgtctg cagaagaatg tgtctgatcc
     2041 tcatttttca accatgtatt ctactcatgt tgccatttaa tgcatggata aacttgctgc
     2101 aagcctggat acaattaacc attttatatt tgccacctac aaaaaaacac ccaatatctt
     2161 ctcttgtaga ctatatgaat caattattac atctgtttta ctatgaaaaa aaaattaata
     2221 ctactagctt ccagacaatc atgtcaaaat ttagttgaac tggtttttca gtttttaaaa
     2281 ggcctacaga tgagtaatga agttatcttt tttgtttaaa aaaaaaaaaa acactgcatt
     2341 aaaaaagtat ctgttgcatt aaggcacata gtgggattac atcataaacc tcccataatt
     2401 tttgtcattc tgtgttaaat catttcaggg tttaattttg aaataaaaga ttaatataaa
     2461 atgcaacaac tttttatatt acctattagt tttggagttc tttatgttta aaaattcagg
     2521 tgtaaatttt attgccttgg ataaataaat tattgatctt ttttaaggca gcagttatta
     2581 aattggtaat agaagatgct gcttgcttag aattgggaaa ttcggctggg tgcagtgact
     2641 caatgcctgt gatcccagta ctttgggagg ttgaggcggg cagatcactt gaggtcagga
     2701 gtttgagatt ggcctggtca acatggtgaa atcctgtctc tactaaaaat acaaaaatta
     2761 gctgggcatg gtggcacata cctgtaatcc cagctactcg ggaggctgaa acaggagaat
     2821 cgcttgaacc caggagatgg agttggcagt gagccaagat tagcctgggc aacagtgagt
     2881 gagactcggt ctcaaacaaa aaccaaattg ggaaattctt cttgagttaa aaaagacact
     2941 ttttattatg aatcagattc caaatcatta actatttttg caaaactggc acaagtggtt
     3001 tttcttttta agtatattaa cagggtagct cctgagcctt tccctttatt ggaaacttta
     3061 actgcagtgt taatatatac actgcaaaag accaaggatg cagttgaatg gaaaattact
     3121 cagtgtatag aaaggaaaaa aaccagaaat ttaaaataga tacagaaaag tacactggta
     3181 atatttttat ttcctattgg agagtgaatc cccacagttg ctttttgtga cttgattcaa
     3241 atgaggcact cattattgtt accaaacttg taaaagcatt ccatgtattc agtggaggca
     3301 gaatgtataa tattttttcc ttataattta gcatacagga aaagtattta ttttttaagt
     3361 agggtatctt aattatgctc atttcttccc ctaaaccaca ttatctatat gattggaccc
     3421 tttagtgaaa tcagaaaaat aaagtaggca tgaataaatg ttcaggacac acacatacac
     3481 tcacacacat cacagtatca gctctttcag tgagttttta ttaactagat aacacatgta
     3541 atacatagta gaatacattt cagaggcaga gttcctcgga ttatttttta tggatattag
     3601 tgttcagcag cttattattt aaaggggtgc caaatatagc atccttctgt tgtttatttt
     3661 aaatatattt ttaatgaaaa gggacttaaa aagtaaacat gattatctaa attacttaaa
     3721 attttttaat cttagtaaaa attttaggaa agttatctag tttaaatttc aaatgtttta
     3781 aaatttgtag gcatttaata aattatcttt ttttggaggg gtggatgctg catttcattg
     3841 gaaatgtcat ttttccaaag tttctagcta tatactctct ttccttcaaa taacataagt
     3901 ctgaaagcaa tgaaaacgtc aaaggaaaat gtttatatac atccacatgt ttatttaata
     3961 tgtttctctt aacacctgaa acttgtttta aaacaaaaag cagtattcac ttcaaatcat
     4021 aaacttagaa ttctgtatct catgtcagaa atatgtttat ggccttgctt ttaagtggtg
     4081 ctgtttccca tagggcatta gttctcagat tttggaatgt gaaataatca cctaggaagt
     4141 tggtttaaaa tgcacactag tgagcccacc ttagacttct tttggggcct tcgacctcac
     4201 tttgagaaat accttcttca ggttattctt tatgtttgtc ctgtggttaa atattagagt
     4261 attcatgata aaacattttg agaaggggta agcagtgagt tattacccac aatttaaagc
     4321 aaattttgaa tgaatcttta agttaggtat ctaccttccc accagccccc caaaaaacct
     4381 ctcagtagtt tctttcagtg tacaaaatga tgagcatttt tctatgatga ggttttaacc
     4441 attattcagg gtggtctttt gtttttaaat ctttttttaa ctaataagat ttacggtgtg
     4501 tattttatac agaaatgcat tataaatgtt tttaattgtg ttctgttttt tgcagtcttt
     4561 aagtgccatg ccaattgttc ttatattcta tagaagttcg ctcaaaatac tcaacagggg
     4621 aataggcagc ggacagtcag aatggttgga attttggctt tctaagaaaa actttatttt
     4681 gcataagcat gtggtcagat cattttgtgc atatgcagcc tggattggat gttaagtaaa
     4741 tgcttgttca gtgccggtac atttacttaa atctgttttt atttttgtca tgtagaatac
     4801 tactgtggtc atcataatgt aatctatttc tgtacctttt tttttttttt ttactttgaa
     4861 gtctttaaat aaaatgtata ataccca
//
