LOCUS       NM_002739               3149 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens protein kinase C gamma (PRKCG), transcript variant 2,
            mRNA.
ACCESSION   NM_002739
VERSION     NM_002739.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3149)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3149)
  AUTHORS   Xu,Z., Li,Q. and Shen,X.
  TITLE     AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate genes
            affecting the severity of acute mountain sickness
  JOURNAL   BMC Med Genomics 16 (1), 28 (2023)
   PUBMED   36803152
  REMARK    GeneRIF: AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate
            genes affecting the severity of acute mountain sickness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3149)
  AUTHORS   Gan,Y., Long,J., Zeng,Y., Zhang,Y. and Tao,Y.
  TITLE     lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via
            miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway
  JOURNAL   Mediators Inflamm 2022, 9923204 (2022)
   PUBMED   36274974
  REMARK    GeneRIF: lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via
            miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3149)
  AUTHORS   Wu,Q.W. and Kapfhammer,J.P.
  TITLE     The Emerging Key Role of the mGluR1-PKCgamma Signaling Pathway in
            the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental
            Viewpoint
  JOURNAL   Int J Mol Sci 23 (16), 9169 (2022)
   PUBMED   36012439
  REMARK    GeneRIF: The Emerging Key Role of the mGluR1-PKCgamma Signaling
            Pathway in the Pathogenesis of Spinocerebellar Ataxias: A
            Neurodevelopmental Viewpoint.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3149)
  AUTHORS   Chen,D.H., Bird,T.D. and Raskind,W.H.
  TITLE     Spinocerebellar Ataxia Type 14
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301573
REFERENCE   6  (bases 1 to 3149)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   7  (bases 1 to 3149)
  AUTHORS   McSwine-Kennick,R.L., McKeegan,E.M., Johnson,M.D. and Morin,M.J.
  TITLE     Phorbol diester-induced alterations in the expression of protein
            kinase C isozymes and their mRNAs. Analysis in wild-type and
            phorbol diester-resistant HL-60 cell clones
  JOURNAL   J Biol Chem 266 (23), 15135-15143 (1991)
   PUBMED   1714454
REFERENCE   8  (bases 1 to 3149)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
REFERENCE   9  (bases 1 to 3149)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   10 (bases 1 to 3149)
  AUTHORS   Johnson,K.J., Jones,P.J., Spurr,N., Nimmo,E., Davies,J., Creed,H.,
            Weiss,M. and Williamson,R.
  TITLE     Linkage relationships of the protein kinase C gamma gene which
            exclude it as a candidate for myotonic dystrophy
  JOURNAL   Cytogenet Cell Genet 48 (1), 13-15 (1988)
   PUBMED   2460293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC318717.1, BC047876.1 and
            AC008440.9.
            
            On Nov 22, 2018 this sequence version replaced NM_002739.4.
            
            Summary: Protein kinase C (PKC) is a family of serine- and
            threonine-specific protein kinases that can be activated by calcium
            and second messenger diacylglycerol. PKC family members
            phosphorylate a wide variety of protein targets and are known to be
            involved in diverse cellular signaling pathways. PKC also serve as
            major receptors for phorbol esters, a class of tumor promoters.
            Each member of the PKC family has a specific expression profile and
            is believed to play distinct roles in cells. The protein encoded by
            this gene is one of the PKC family members. This protein kinase is
            expressed solely in the brain and spinal cord and its localization
            is restricted to neurons. It has been demonstrated that several
            neuronal functions, including long term potentiation (LTP) and long
            term depression (LTD), specifically require this kinase. Knockout
            studies in mice also suggest that this kinase may be involved in
            neuropathic pain development. Defects in this protein have been
            associated with neurodegenerative disorder spinocerebellar
            ataxia-14 (SCA14). Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.912204.1,
                                           SRR3476690.862624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263431.4/ ENSP00000263431.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               DC318717.1         14-125
            113-582             BC047876.1         1-470
            583-583             AC008440.9         28607-28607
            584-3144            BC047876.1         472-3032
            3145-3149           AC008440.9         52012-52016
FEATURES             Location/Qualifiers
     source          1..3149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3149
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /note="protein kinase C gamma"
                     /db_xref="GeneID:5582"
                     /db_xref="HGNC:HGNC:9402"
                     /db_xref="MIM:176980"
     exon            1..468
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2392
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /EC_number="2.7.11.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein kinase C gamma type"
                     /codon_start=1
                     /product="protein kinase C gamma type isoform 2"
                     /protein_id="NP_002730.1"
                     /db_xref="CCDS:CCDS12867.1"
                     /db_xref="GeneID:5582"
                     /db_xref="HGNC:HGNC:9402"
                     /db_xref="MIM:176980"
                     /translation="MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFK
                     QPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHK
                     FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGR
                     LQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKAT
                     LNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYK
                     LLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDP
                     KRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDD
                     VDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
                     KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFP
                     GTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA
                     IMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLER
                     LEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH
                     PDARSPTSPVPVPVM"
     exon            469..500
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            501..583
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            584..695
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            696..827
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            828..984
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1119
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1207
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1237
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1390
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1579
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1671
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1734
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1873
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1954
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2062
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2203
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..3149
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /note="hexamer: AATAAA"
     polyA_site      3149
                     /gene="PRKCG"
                     /gene_synonym="PKC-gamma; PKCC; PKCG; PKCgamma; PKCI(3);
                     SCA14"
                     /note="major polyA site"
ORIGIN      
        1 acatttcagc aggtgccgga gctggagctc ccaccgccgc cgcccgtgcc tccggctgcc
       61 ggcgcccctg cctttggctc ttcctcccca ctcgcccgct ccccctggcg gagccggcgc
      121 gcccggggtg ccgctccctg cctggcgcgc tccgcacctg gaggtgcctt gcccctctcc
      181 tgcccacctc ggaatttccc tgtggctcct ttgatccttc gagtctccag ctcctctccc
      241 ttccacctgt ttcccccaag aaaggcagga tcctggtccc tgctacgttt ctggggccat
      301 ggctggtctg ggccccggcg taggcgattc agagggggga ccccggcccc tgttttgcag
      361 aaagggggcc ctgaggcaga aggtggtcca cgaagtcaag agccacaagt tcaccgctcg
      421 cttcttcaag cagcccacct tctgcagcca ctgcaccgac ttcatctggg gtatcggaaa
      481 gcagggcctg caatgtcaag tctgcagctt tgtggttcat cgacgatgcc acgaatttgt
      541 gaccttcgag tgtccaggcg ctgggaaggg cccccagacg gacgaccccc ggaacaaaca
      601 caagttccgc ctgcatagct acagcagccc caccttctgc gaccactgtg gctccctcct
      661 ctacgggctt gtgcaccagg gcatgaaatg ctcctgctgc gagatgaacg tgcaccggcg
      721 ctgtgtgcgt agcgtgccct ccctgtgcgg tgtggaccac accgagcgcc gcgggcgcct
      781 gcagctggag atccgggctc ccacagcaga tgagatccac gtaactgttg gcgaggcccg
      841 taacctaatt cctatggacc ccaatggtct ctctgatccc tatgtgaaac tgaagctcat
      901 cccagaccct cggaacctga cgaaacagaa gacccgaacg gtgaaagcca cgctaaaccc
      961 tgtgtggaat gagacctttg tgttcaacct gaagccaggg gatgtggagc gccggctcag
     1021 cgtggaggtg tgggactggg accggacctc ccgcaacgac ttcatggggg ccatgtcctt
     1081 tggcgtctcg gagctgctca aggcgcccgt ggatggctgg tacaagttac tgaaccagga
     1141 ggagggcgag tattacaatg tgccggtggc cgatgctgac aactgcagcc tcctccagaa
     1201 gtttgaggct tgtaactacc ccctggaatt gtatgagcgg gtgcggatgg gcccctcttc
     1261 ctctcccatc ccctcccctt cccctagtcc caccgacccc aagcgctgct tcttcggggc
     1321 gagtccagga cgcctgcaca tctccgactt cagcttcctc atggttctag gaaaaggcag
     1381 ttttgggaag gtgatgctgg ccgagcgcag gggctctgat gagctctacg ccatcaagat
     1441 cttgaaaaag gacgtgatcg tccaggacga cgatgtggac tgcacgctgg tggagaaacg
     1501 tgtgctggcg ctggggggcc ggggtcctgg cggccggccc cacttcctca cccagctcca
     1561 ctccaccttc cagaccccgg accgcctgta tttcgtgatg gagtacgtca ccgggggaga
     1621 cttgatgtac cacattcaac agctgggcaa gtttaaggag ccccatgcag cgttctacgc
     1681 ggcagaaatc gctatcggcc tcttcttcct tcacaatcag ggcatcatct acagggacct
     1741 gaagctggac aatgtgatgc tggatgctga gggacacatc aagatcactg actttggcat
     1801 gtgtaaggag aacgtcttcc ccgggacgac aacccgcacc ttctgcggga ccccggacta
     1861 catagccccg gagatcattg cctaccagcc ctatgggaag tctgtcgatt ggtggtcctt
     1921 tggagttctg ctgtatgaga tgttggcagg acagcctccc ttcgatgggg aggacgagga
     1981 ggagctgttt caggccatca tggaacaaac tgtcacctac cccaagtcgc tttcccggga
     2041 agccgtggcc atctgcaagg ggttcctgac caagcaccca gggaagcgcc tgggctcagg
     2101 gcctgatggg gaacctacca tccgtgcaca tggctttttc cgctggattg actgggagcg
     2161 gctggaacga ttggagatcc cgcctccttt cagaccccgc ccgtgtggcc gcagcggcga
     2221 gaactttgac aagttcttca cgcgggcggc gccagcgctg acccctccag accgcctagt
     2281 cctggccagc atcgaccagg ccgatttcca gggcttcacc tacgtgaacc ccgacttcgt
     2341 gcacccggat gcccgcagcc ccaccagccc agtgcctgtg cccgtcatgt aatctcaccc
     2401 gccgccacta ggtgtcccca acgtcccctc cgccgtgccg gcggcagccc cacttcaccc
     2461 ccaacttcac caccccctgt cccattctag atcctgcacc ccagcattcc agctctgccc
     2521 ccgcgggttc tagacgcccc tcccaagcgt tcctggcctt ctgaactcca tacagcctct
     2581 acagccgtcc cgcgttcaag acttgagcgg agcccgatat tctccctgac cttagcgttc
     2641 tggactctgc cccaatcggg tccagagacc acaccactaa ccatccccaa ctccatgggg
     2701 ttcgagactc catcttggta gttctgtgcc tccccccaga ccccgcccct ggggaaatag
     2761 cctcacgggg ttggctgttc cagactcagg ttccagaaca gccctcggcc tccgaggctc
     2821 cccgcctcca ctctagttct agatgagtgg gaggcgtgcc cccctcctcc agtacgtccc
     2881 gctgctgtgc tctggggatt tctgggatat atggaggatt ctttccccag aggctcccaa
     2941 tcagcttttg ttctagactt ccccatcccg aagccatcac ttctccccgc agcccgcctg
     3001 ccgtgcatgg ctcctgtctg gctcggaccc accccaactc tccccagtgc ctgccactct
     3061 ctgggactct cctcctcccc tcctcttccc ttagcctctc ccacccggcc acagctgctg
     3121 gagaataaat ttgggatgct gatgctgaa
//
