LOCUS       XM_017004492            6007 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C epsilon (PRKCE),
            transcript variant X18, mRNA.
ACCESSION   XM_017004492
VERSION     XM_017004492.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017004492.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6007
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..6007
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /note="protein kinase C epsilon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 26
                     ESTs, 74 long SRA reads, and 93% coverage of the annotated
                     genomic feature by RNAseq alignments, including 39 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
     CDS             427..1872
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /codon_start=1
                     /product="protein kinase C epsilon type isoform X7"
                     /protein_id="XP_016859981.1"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
                     /translation="MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIAL
                     NVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF
                     EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV
                     RRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT
                     KCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVC
                     KMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPAS
                     GSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGEN
                     GEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV
                     DCTMTEKRILALARKHPYLTQLYCCFQTKRQ"
     polyA_site      6007
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaaatttccc gggattatgt ttcggaaagg taggtaagcg ccgggcgcgg cgcccgcttt
       61 cccgcagtcc ggagccggag agccagcgag gcggcgaggc agcccccgcg gcttgcagcg
      121 gagccgacag ctcgtcttct cttctggagg tgcagctggt ggtcgggggg agagacttgc
      181 tccaaacacg gacatccccc agctctcccc cctccctgtt ttccgttagg aacccggcga
      241 ggaaatacat gcactggctg agaatcgccc gcgccagggc gcaacgccac aaggtgtagg
      301 gagtgtgcgg ggtggggcga aaggggaccc aagagtccct gtggctcgga gtgccgggcc
      361 gtcggttctt cattcctgcc ctcggggcag acggagtgac cccggccccc actccccgcc
      421 ccgaccatgg tagtgttcaa tggccttctt aagatcaaaa tctgcgaggc cgtgagcttg
      481 aagcccacag cctggtcgct gcgccatgcg gtgggacccc ggccgcagac tttccttctc
      541 gacccctaca ttgccctcaa tgtggacgac tcgcgcatcg gccaaacggc caccaagcag
      601 aagaccaaca gcccggcctg gcacgacgag ttcgtcaccg atgtgtgcaa cggacgcaag
      661 atcgagctgg ctgtctttca cgatgccccc ataggctacg acgacttcgt ggccaactgc
      721 accatccagt ttgaggagct gctgcagaac gggagccgcc acttcgagga ctggattgat
      781 ctggagccag aaggaagagt gtatgtgatc atcgatctct cagggtcgtc gggtgaagcc
      841 cctaaagaca atgaagagcg tgtgttcagg gaacgcatgc ggccgaggaa gcggcagggg
      901 gccgtcaggc gcagggtcca tcaggtcaac ggccacaagt tcatggccac ctatcttcgg
      961 cagcccacct actgctccca ttgcagagac ttcatctggg gtgtcatagg aaagcaggga
     1021 taccagtgtc aagtctgcac ctgcgtggtc cacaagcggt gccacgagct cataatcaca
     1081 aagtgtgctg ggttaaagaa gcaggagacc cccgaccagg tgggctccca gcggttcagc
     1141 gtcaacatgc cccacaagtt cggtatccac aactacaagg tccctacctt ctgcgatcac
     1201 tgtgggtccc tgctctgggg actcttgcgg cagggtttgc agtgtaaagt ctgcaaaatg
     1261 aatgttcacc gtcgatgtga gaccaacgtg gctcccaact gtggagtgga tgccagagga
     1321 atcgccaaag tactggccga cctgggcgtt accccagaca aaatcaccaa cagcggccag
     1381 agaaggaaaa agctcattgc tggtgccgag tccccgcagc ctgcttctgg aagctcacca
     1441 tctgaggaag atcgatccaa gtcagcaccc acctcccctt gtgaccagga aataaaagaa
     1501 cttgagaaca acattcggaa agccttgtca tttgacaacc gaggagagga gcaccgggca
     1561 gcatcgtctc ctgatggcca gctgatgagc cccggtgaga atggcgaagt ccggcaaggc
     1621 caggccaagc gcctgggcct ggatgagttc aacttcatca aggtgttggg caaaggcagc
     1681 tttggcaagg tcatgttggc agaactcaag ggcaaagatg aagtatatgc tgtgaaggtc
     1741 ttaaagaagg acgtcatcct tcaggatgat gacgtggact gcacaatgac agagaagagg
     1801 attttggctc tggcacggaa acacccgtac cttacccaac tctactgctg cttccagacc
     1861 aagaggcaat aggaagttga agcctccact tttgacctca ttggagcatt ttgtttttac
     1921 catgacgttc cagggagaat gccaggaagg atcatgggca aaaagaattc tctcagtccg
     1981 cctccttagt gtggcaggag gtacaaatta attcctttgt tgggtcagta tgatattcac
     2041 ctgggattca tcagcagtat gtaatccatt ttatcgggaa cacttgtgtg cgggttgcta
     2101 ggaagctaag cttattacct ggctctggct cttagagctg agcctgctgg tgctaacaga
     2161 tttgggcctg agaagtttgt ggccttccct ggacttcaga aggagggtgg aaggtccagt
     2221 aaagtgtcca aggatgagag tgaatgggga aaatgacttt tgttctcagt gtttctttca
     2281 ccatttatcc aacctatccc catgtgtttt tggtattttt ttttcttttt caggtaagag
     2341 tttaaatcca acctccttta tcaagcccca gtttatgaaa actttctaga ttcaccagtg
     2401 ttaacactaa aaacatacca acacaaccaa aggaaacacg ttgtcatgaa tggtgaaata
     2461 cttctaccat ccaatttgcc cagagtttta ttcccttggg agagcttctt aaagatctag
     2521 gaagtatctt ttgatgtaca taactcagag attaaacaca cttcacaaag tataggtagg
     2581 ctccactgaa agaaagctcg aaaatttgac tgtaaaaaaa aacaaatgta ggtgtgattg
     2641 ttgaccttgc aaaagctaac tcctattata aaatgtttac aaaagaattc acgagagaac
     2701 tcccggggtt ggcaagatcc atttggattg ccagacgtgg tgactgaggt gcagcagtgc
     2761 taggcagagt aactgaaccc tgaagtgtta aaaaacagct gtgcaggagc agtaccaggg
     2821 aacgtaagac atctggaaca cacaccccca gccagggacg aagtgttctg cttcagtata
     2881 cattagacaa ccagtatttt ttttagtacc tggtacggta tgtcttcaac ttaatatcag
     2941 gtattccagg gatagaaaaa gacacaatcc ttgttcaaag aactgctggt ccacctaggg
     3001 aggttaggct aataggtgaa ccagagaatg aaaatcagag gaagagatga gtgggctgac
     3061 tagtaggtat actcctacaa attggaggaa actgaggcac aagcgttgaa gtgccccttc
     3121 cgggtcacat acacgctcat gtgctccctc tctctccctt gctctcactc tctccctctg
     3181 tcactctctc gctgtctcat aagggacttt gtcacaggaa taagaaccct gggttccacc
     3241 taccccacag gagcacagtg gcaaggtccc atctgattca aggaaattgg ctttgtaggg
     3301 ttgttattgt gtgaaaagga gcaagccctg tccaaggcag atctggatgt ttgtgtagtt
     3361 cagatccatt tagctccctg gccagtgttg atctctgctg ctttaaacca cattaatctc
     3421 tgggagggca aactgaccca tcactatggg aaccagagtg agcctgtgtc ctgggtacta
     3481 ggtaaacact ggaagtcagt acctggtaga cgccataggc agaagcaaac tggggccttc
     3541 caaaagctga aaatgatcaa tagatatgat tcttgtgcat ccatatccca ggaaggaggg
     3601 attctgttta gctctttgag ctaattgtta attttcaaat cttgaagaca ctattgagca
     3661 tgaaatgcag atattcaaat acccctttct ccttggtagg aaatggtact aacagtctgc
     3721 aggatcatgg gagtaaaaag cgcagtctaa gcacataggc attcatgggg agagtatacg
     3781 aagttagagg gtataaaagc tatgtggatg gttcaaagat taaggtaaag atgtgaaacc
     3841 taaaatctca attctctaga atgggacatt tagacttcat gggtagagga ggacaagaat
     3901 cgggagtatg ggcagttaga caaaatcaga aagaagcgta gaagactatg cagaaacatt
     3961 aagaatgtag tggtggaaat gttacctttt tggaagatgg tatcatgcag aaggtttgaa
     4021 tgcatttctc tgatctttaa ttctaccaaa agtgtcactc tgatgtaaga aaatatttag
     4081 gttgaaaagg tgaggaactg gccacagctt tcctaaatgt ggttgacaac ctgtatccaa
     4141 gagaacagaa tgaattggtc gatttgctgt gtcatgacat tttagggatg tttttgggat
     4201 gtttaaggga tgtttttgaa ggggatttat aagagagtaa atgagacccc ttaaacacag
     4261 agatctgagg cataagagct ggtaatttta aaagatacac agctgactac agaaggaaag
     4321 aagcaagtcc cagaatagac atgtagcata tttccatttc tataaaaccc ccaaacaggc
     4381 gagactaaac aatattctta ggaggaaaca catgggtgat gaaactgtaa agaaaagcaa
     4441 ggggccgggt gtggtggttc atgtctgtag tcccaacatt gggaggccaa ggcaggagga
     4501 ttgcttgagc cctgggaaca tagtgagacc ctgtctctac aaaaaattgt tttaaattag
     4561 cctggcacgg tgatgtgtgc ctgttgtccc agctactctg gaggctaagg tgggaggatc
     4621 gcttgagcct aggaagtcaa ggctgcagtg agccataatc atgccactgt actccagcct
     4681 gagcaacaga gcaagaccct gtctcaaaaa taaataaaag aattagccag ggatggtggc
     4741 acacacctgt agtcccagct attcgggagg ctgaggtagg agggtaggtt gagcccagga
     4801 ggttgaggct gcagtgaagc atgattgtac cacttgtact tcatcctggg catcagagtg
     4861 agaccctatc tcaaaaaaga aagaaaaaga aaagaaaaac aagatcatga ttaccaggga
     4921 agtccaaata gggactgaat gaggatgggg agagaggttg caattaaaga gagttaaagg
     4981 ggtttcaaag gccagcaacc atgttctatc tgtcaaggtg ggtcacagct aaaagtgagt
     5041 cttatttgat ctttaaaatg catatgcata ttttacatat tctcattcgt aggtatattt
     5101 tacaataagg cagggaaggg gaacaagaac atgaaagcat ccaaactgtc ataggcacta
     5161 gcattttaaa tgatgacatg ctctccaaaa attcgaactt taacaaaaaa ctgagcttgt
     5221 gcactacctc tgtgtatcat tcttttgcca ctaaagtttc gattttcctg ttcttttggc
     5281 agtatgatct gtctcaagga caagaagtgt ggtgactggt cccatggcct atttagctgg
     5341 aagaatgaag cgtagtccct atcctctttc caagaccaag gccaagatgg ggctcaagac
     5401 cagggggtta tctacagaac tgctggccca ccttccacct accctggggg acctccctct
     5461 tgaaggttgg gattcttttt tttctttttt ttttttgaga tggagtcggg ctctgtggcc
     5521 cagactggag tgcagtggca agatcttagc tcactgcagc ctccgcctcc cgggttcacg
     5581 tgattctcct gcctcagcct cccgagtagc tgggattaca ggctcccacc actgcacccg
     5641 gctgactttt gtgtttttag tagagacggg gttttgccat gctggccagg ccggtctcaa
     5701 actcttgacc tcaagtgatc cgcccgtctc agcctcccaa agtgctggaa ttacaggcgt
     5761 gagccaccgc gtccggccga aggttgggat tcttaaagag taacctagcc cagcctcact
     5821 ctttcagcaa gcagctctga gttggggggt aaactttctt cactgccaca acatttgtgt
     5881 tttgcaacat gtttttaaac catgttttat aactaagaag atgccaaaca tttcatttgg
     5941 cagtttgtat tatgaaaacc atagttatct ttccattttc acctataaag tgatgttata
     6001 aattgaa
//
