LOCUS       XM_011532981            5044 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C epsilon (PRKCE),
            transcript variant X12, mRNA.
ACCESSION   XM_011532981
VERSION     XM_011532981.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011532981.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..5044
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /note="protein kinase C epsilon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 19 ESTs, 671 long SRA reads, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 8 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
     CDS             172..1935
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /codon_start=1
                     /product="protein kinase C epsilon type isoform X4"
                     /protein_id="XP_011531283.1"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
                     /translation="MRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVI
                     GKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV
                     PTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP
                     DKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALS
                     FDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAE
                     LKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFF
                     VMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA
                     EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
                     MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNG
                     EDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI
                     VKQINQEEFKGFSYFGEDLMP"
ORIGIN      
        1 ttaagcgcct taaggcctca tttaacttga gttaaagaag tgtgattttg gaggacccaa
       61 agattttcca ctggtgtagg gaatgtctcc tcccggctct gagagacttc ctccaatcca
      121 caacctaccg cagcccctaa agacaatgaa gagcgtgtgt tcagggaacg catgcggccg
      181 aggaagcggc agggggccgt caggcgcagg gtccatcagg tcaacggcca caagttcatg
      241 gccacctatc ttcggcagcc cacctactgc tcccattgca gagacttcat ctggggtgtc
      301 ataggaaagc agggatacca gtgtcaagtc tgcacctgcg tggtccacaa gcggtgccac
      361 gagctcataa tcacaaagtg tgctgggtta aagaagcagg agacccccga ccaggtgggc
      421 tcccagcggt tcagcgtcaa catgccccac aagttcggta tccacaacta caaggtccct
      481 accttctgcg atcactgtgg gtccctgctc tggggactct tgcggcaggg tttgcagtgt
      541 aaagtctgca aaatgaatgt tcaccgtcga tgtgagacca acgtggctcc caactgtgga
      601 gtggatgcca gaggaatcgc caaagtactg gccgacctgg gcgttacccc agacaaaatc
      661 accaacagcg gccagagaag gaaaaagctc attgctggtg ccgagtcccc gcagcctgct
      721 tctggaagct caccatctga ggaagatcga tccaagtcag cacccacctc cccttgtgac
      781 caggaaataa aagaacttga gaacaacatt cggaaagcct tgtcatttga caaccgagga
      841 gaggagcacc gggcagcatc gtctcctgat ggccagctga tgagccccgg tgagaatggc
      901 gaagtccggc aaggccaggc caagcgcctg ggcctggatg agttcaactt catcaaggtg
      961 ttgggcaaag gcagctttgg caaggtcatg ttggcagaac tcaagggcaa agatgaagta
     1021 tatgctgtga aggtcttaaa gaaggacgtc atccttcagg atgatgacgt ggactgcaca
     1081 atgacagaga agaggatttt ggctctggca cggaaacacc cgtaccttac ccaactctac
     1141 tgctgcttcc agaccaagga ccgcctcttt ttcgtcatgg aatatgtaaa tggtggagac
     1201 ctcatgtttc agattcagcg ctcccgaaaa ttcgacgagc ctcgttcacg gttctatgct
     1261 gcagaggtca catcggccct catgttcctc caccagcatg gagtcatcta cagggatttg
     1321 aaactggaca acatccttct ggatgcagaa ggtcactgca agctggctga cttcgggatg
     1381 tgcaaggaag ggattctgaa tggtgtgacg accaccacgt tctgtgggac tcctgactac
     1441 atagctcctg agatcctgca ggagttggag tatggcccct ccgtggactg gtgggccctg
     1501 ggggtgctga tgtacgagat gatggctgga cagcctccct ttgaggccga caatgaggac
     1561 gacctatttg agtccatcct ccatgacgac gtgctgtacc cagtctggct cagcaaggag
     1621 gctgtcagca tcttgaaagc tttcatgacg aagaatcccc acaagcgcct gggctgtgtg
     1681 gcatcgcaga atggcgagga cgccatcaag cagcacccat tcttcaaaga gattgactgg
     1741 gtgctcctgg agcagaagaa gatcaagcca cccttcaaac cacgcattaa aaccaaaaga
     1801 gacgtcaata attttgacca agactttacc cgggaagagc cggtactcac ccttgtggac
     1861 gaagcaattg taaagcagat caaccaggag gaattcaaag gtttctccta ctttggtgaa
     1921 gacctgatgc cctgagagcc cactgcagtt ggactttgcc gatgctgcaa gaaggggtgc
     1981 agagaagact cctgtgttgg agacactcag caggtcttga actacttctc ctcctcggag
     2041 ccccagtccc atgtccactg tctatttatt gcattccctt gccccaggcc acctcctccc
     2101 cctcccacct ggtgaccaga aggcgctctc ggttcttgtc tcaccagtaa tgcagactca
     2161 ttgggtcagc aattagctgt atacactgcc gtgtttggac cattggcaag cctggttcca
     2221 ctcctcaggg gctcctggca gtgaagcaac ttcagttctt ttactgcaaa gaacagaaaa
     2281 aagaaagaaa gcaaacaaga agactccggc tctgctatcg gacacagatc ctgatccctc
     2341 ttgcttcttt tccctcctgc accgcagctt gccatccctg cccttctgtc ctggagaaga
     2401 gactggtgct tctccgcaca cacgagggag ggcgcccttg aggcatgccc tctgagggag
     2461 ggagaccaga gatgcaggga ttggccagct gggttggttt gctctggaat ggctaactct
     2521 tgcctgcttt ggttttagct tttcagcatg ccaaagtcat gtaagtttgt gtcttgtgga
     2581 agaaatcctc tttgtggaaa aagaaacagg gttttgaact ctgttaacat ttgaaaaata
     2641 tattttcaaa ttcactttct aattggccaa aagagatgag ttccagtctg aatacaggta
     2701 gatattaaag ggctaataaa aaatgagaaa ccggtcgtcc aaggtggatg ctgtcaatgc
     2761 ccgagtgaca catgagagct gtatgaattg agagaaaagg caacaagtag cattcttcat
     2821 cattcaagtt ctacctggac acaaaggcga ggaccctggg gttccaacaa agctcagctc
     2881 ccagattctc tttccagttt catcctaagt tcctagcata aacactattt attttctgca
     2941 gcagtgtgtt atttttgcgc acttatacaa aatggtagta ctactgtgtt gtggttttta
     3001 aacattaaac atgtaaagtt atatacgaaa tatctgcttt tggaataagc agaatgaggc
     3061 taaacatggg ttatacaaag ggtatctgga aactgaagag caacttgtta gaaaactgac
     3121 aatgtcgcaa gatgtactca gttttgtttc tgtgtgacat gcaatggcaa ctcatgtgga
     3181 cactattgaa gggatgtgac attacctcct gtagatatgc taacagtgtt attctttcat
     3241 ttccaagggt tctctgtggc tttgtgtata tgtttcccag aggtcatttg attacctaat
     3301 ttactgaact gatttagcag ggaatggaat ccattccaac tattgcacgt ggatttccca
     3361 gctgccccta aatatatata cttgtgagtg gcaaagtggc actaatgaag cttttgcctt
     3421 ttgtacattt gagatttttg tatatagtgt ttgctgcaag gcctgtggaa ttaattcgtt
     3481 gcatatagag gtatcaactg ctgcatgttc aggcatatta taaaacttta gtctatgaaa
     3541 gaataattat aataatgtcc aggtgcaata ctctgtaagt ctattggttc aagttaccga
     3601 gagataggtg tgttccttta tgggggatgg gggggtgtgt tggggattct ttgtattgtt
     3661 tatttcattt tggtttattt taaaagatgt aaacatatat taagctatat taaatctcac
     3721 atacagttct tctgtgctct attataccct gatagagatg ggggagagaa aggaatgttt
     3781 ttgatggtgg tttcaaagct cggacagtaa ctatcttgag cccattagag agtctgtgtc
     3841 catatttgca tctggctggt catagccttt gttactaatg atgacattca gttctctttt
     3901 gtttttattt tttaaaaact caggtgtaat tattatctgt tcttaagata attgcaaata
     3961 ttaaatatta tgatatatca attcatgtgt ttggcatacc agtgaatgat gaagaacatg
     4021 agattaattt aatttatctt cggtaacttg acattctgga gagagactat cttctggagt
     4081 tgagtacaag cacagaaaca tctttacggt ggcatcatct cattttttag gaagacatga
     4141 taatactgcc catcatattc atgtgtaact actgttcttt cttctgcttt cttcaccata
     4201 ataaactttg gacaaccaag caagctctaa ccgcaatgcc agatggcctt gtccgagggc
     4261 ctagtgtttg cacggcagtg ggaactgggc ctttcctaca ggacaactgg caagtttgct
     4321 gggaagtcaa ataatacatt ccacctggca gctgaaggca gccagtcagt ctgtcccaga
     4381 aagggccctt ttcagcaccc aaagctgggc tggctgggat gcctctggct ggtgaagttc
     4441 tcacataggc tgatttaaat ccagcaaagg tctatagaaa aaggcttgcg tgttcgttga
     4501 gtaatcattg tttcattttc atttttacga gagtttgaaa atagacacac tgttaacact
     4561 tctgccagtt ttttctgatc tttccagccc cacccccttt ctctttctct ctctctctca
     4621 aagaaaaaaa aaatgggagt gcaaaaaaaa caaagccaaa aaatatatga aggatagctg
     4681 ttcttctgtg ttctctcatt atggactttg tgaagtagaa acataatttt ttttcctcca
     4741 aaggtgaaaa aacaatgcat tcttgcttta aaaaaaaaaa agaaggctaa aaaattacct
     4801 ctttttaaat tatgtgcaaa ataattctgg ctaactgtaa aatgtattca attttaggat
     4861 tttttttttt tgtattgtga tgctttattt gtacattttt ttcctttctg gatgtaattt
     4921 taatctcttg ccattcatta gtgttatttc attgtaaacg ttattgtgcc aaatgtactg
     4981 tattcaaaag gatgtgaatg tgtattgttt cagaacctaa taaatacaat gacgttaagt
     5041 ctta
//
