LOCUS       XM_011532980            5921 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C epsilon (PRKCE),
            transcript variant X14, mRNA.
ACCESSION   XM_011532980
VERSION     XM_011532980.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011532980.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 40% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..5921
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /note="protein kinase C epsilon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 21 ESTs, 677 long SRA reads, 3 Proteins, and 87%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
     CDS             1049..2812
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /codon_start=1
                     /product="protein kinase C epsilon type isoform X4"
                     /protein_id="XP_011531282.1"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
                     /translation="MRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVI
                     GKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV
                     PTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTP
                     DKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALS
                     FDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAE
                     LKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFF
                     VMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA
                     EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
                     MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNG
                     EDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI
                     VKQINQEEFKGFSYFGEDLMP"
ORIGIN      
        1 gaaatttccc gggattatgt ttcggaaagg taggtaagcg ccgggcgcgg cgcccgcttt
       61 cccgcagtcc ggagccggag agccagcgag gcggcgaggc agcccccgcg gcttgcagcg
      121 gagccgacag ctcgtcttct cttctggagg tgcagctggt ggtcgggggg agagacttgc
      181 tccaaacacg gacatccccc agctctcccc cctccctgtt ttccgttagg aacccggcga
      241 ggaaatacat gcactggctg agaatcgccc gcgccagggc gcaacgccac aaggtgtagg
      301 gagtgtgcgg ggtggggcga aaggggaccc aagagtccct gtggctcgga gtgccgggcc
      361 gtcggttctt cattcctgcc ctcggggcag acggagtgac cccggccccc actccccgcc
      421 ccgaccatgg tagtgttcaa tggccttctt aagatcaaaa tctgcgaggc cgtgagcttg
      481 aagcccacag cctggtcgct gcgccatgcg gtgggacccc ggccgcagac tttccttctc
      541 gacccctaca ttgccctcaa tgtggacgac tcgcgcatcg gccaaacggc caccaagcag
      601 aagaccaaca gcccggcctg gcacgacgag ttcgtcaccg atgtgtgcaa cggacgcaag
      661 atcgagctgg ctgtctttca cgatgccccc ataggctacg acgacttcgt ggccaactgc
      721 accatccagt ttgaggagct gctgcagaac gggagccgcc acttcgagga ctgggggctg
      781 gtgagggtca gcactagtgg tgagaattct ggagaacatt ttctttaccc agaaacttaa
      841 aatcatggac tcttggggag aaaggaatga gaaaaggcag catgcggaat taccagtttg
      901 ttatttggtt cccatctgga tttaaaaccg aagatcccaa actcagattg atctggagcc
      961 agaaggaaga gtgtatgtga tcatcgatct ctcagggtcg tcgggtgaag cccctaaaga
     1021 caatgaagag cgtgtgttca gggaacgcat gcggccgagg aagcggcagg gggccgtcag
     1081 gcgcagggtc catcaggtca acggccacaa gttcatggcc acctatcttc ggcagcccac
     1141 ctactgctcc cattgcagag acttcatctg gggtgtcata ggaaagcagg gataccagtg
     1201 tcaagtctgc acctgcgtgg tccacaagcg gtgccacgag ctcataatca caaagtgtgc
     1261 tgggttaaag aagcaggaga cccccgacca ggtgggctcc cagcggttca gcgtcaacat
     1321 gccccacaag ttcggtatcc acaactacaa ggtccctacc ttctgcgatc actgtgggtc
     1381 cctgctctgg ggactcttgc ggcagggttt gcagtgtaaa gtctgcaaaa tgaatgttca
     1441 ccgtcgatgt gagaccaacg tggctcccaa ctgtggagtg gatgccagag gaatcgccaa
     1501 agtactggcc gacctgggcg ttaccccaga caaaatcacc aacagcggcc agagaaggaa
     1561 aaagctcatt gctggtgccg agtccccgca gcctgcttct ggaagctcac catctgagga
     1621 agatcgatcc aagtcagcac ccacctcccc ttgtgaccag gaaataaaag aacttgagaa
     1681 caacattcgg aaagccttgt catttgacaa ccgaggagag gagcaccggg cagcatcgtc
     1741 tcctgatggc cagctgatga gccccggtga gaatggcgaa gtccggcaag gccaggccaa
     1801 gcgcctgggc ctggatgagt tcaacttcat caaggtgttg ggcaaaggca gctttggcaa
     1861 ggtcatgttg gcagaactca agggcaaaga tgaagtatat gctgtgaagg tcttaaagaa
     1921 ggacgtcatc cttcaggatg atgacgtgga ctgcacaatg acagagaaga ggattttggc
     1981 tctggcacgg aaacacccgt accttaccca actctactgc tgcttccaga ccaaggaccg
     2041 cctctttttc gtcatggaat atgtaaatgg tggagacctc atgtttcaga ttcagcgctc
     2101 ccgaaaattc gacgagcctc gttcacggtt ctatgctgca gaggtcacat cggccctcat
     2161 gttcctccac cagcatggag tcatctacag ggatttgaaa ctggacaaca tccttctgga
     2221 tgcagaaggt cactgcaagc tggctgactt cgggatgtgc aaggaaggga ttctgaatgg
     2281 tgtgacgacc accacgttct gtgggactcc tgactacata gctcctgaga tcctgcagga
     2341 gttggagtat ggcccctccg tggactggtg ggccctgggg gtgctgatgt acgagatgat
     2401 ggctggacag cctccctttg aggccgacaa tgaggacgac ctatttgagt ccatcctcca
     2461 tgacgacgtg ctgtacccag tctggctcag caaggaggct gtcagcatct tgaaagcttt
     2521 catgacgaag aatccccaca agcgcctggg ctgtgtggca tcgcagaatg gcgaggacgc
     2581 catcaagcag cacccattct tcaaagagat tgactgggtg ctcctggagc agaagaagat
     2641 caagccaccc ttcaaaccac gcattaaaac caaaagagac gtcaataatt ttgaccaaga
     2701 ctttacccgg gaagagccgg tactcaccct tgtggacgaa gcaattgtaa agcagatcaa
     2761 ccaggaggaa ttcaaaggtt tctcctactt tggtgaagac ctgatgccct gagagcccac
     2821 tgcagttgga ctttgccgat gctgcaagaa ggggtgcaga gaagactcct gtgttggaga
     2881 cactcagcag gtcttgaact acttctcctc ctcggagccc cagtcccatg tccactgtct
     2941 atttattgca ttcccttgcc ccaggccacc tcctccccct cccacctggt gaccagaagg
     3001 cgctctcggt tcttgtctca ccagtaatgc agactcattg ggtcagcaat tagctgtata
     3061 cactgccgtg tttggaccat tggcaagcct ggttccactc ctcaggggct cctggcagtg
     3121 aagcaacttc agttctttta ctgcaaagaa cagaaaaaag aaagaaagca aacaagaaga
     3181 ctccggctct gctatcggac acagatcctg atccctcttg cttcttttcc ctcctgcacc
     3241 gcagcttgcc atccctgccc ttctgtcctg gagaagagac tggtgcttct ccgcacacac
     3301 gagggagggc gcccttgagg catgccctct gagggaggga gaccagagat gcagggattg
     3361 gccagctggg ttggtttgct ctggaatggc taactcttgc ctgctttggt tttagctttt
     3421 cagcatgcca aagtcatgta agtttgtgtc ttgtggaaga aatcctcttt gtggaaaaag
     3481 aaacagggtt ttgaactctg ttaacatttg aaaaatatat tttcaaattc actttctaat
     3541 tggccaaaag agatgagttc cagtctgaat acaggtagat attaaagggc taataaaaaa
     3601 tgagaaaccg gtcgtccaag gtggatgctg tcaatgcccg agtgacacat gagagctgta
     3661 tgaattgaga gaaaaggcaa caagtagcat tcttcatcat tcaagttcta cctggacaca
     3721 aaggcgagga ccctggggtt ccaacaaagc tcagctccca gattctcttt ccagtttcat
     3781 cctaagttcc tagcataaac actatttatt ttctgcagca gtgtgttatt tttgcgcact
     3841 tatacaaaat ggtagtacta ctgtgttgtg gtttttaaac attaaacatg taaagttata
     3901 tacgaaatat ctgcttttgg aataagcaga atgaggctaa acatgggtta tacaaagggt
     3961 atctggaaac tgaagagcaa cttgttagaa aactgacaat gtcgcaagat gtactcagtt
     4021 ttgtttctgt gtgacatgca atggcaactc atgtggacac tattgaaggg atgtgacatt
     4081 acctcctgta gatatgctaa cagtgttatt ctttcatttc caagggttct ctgtggcttt
     4141 gtgtatatgt ttcccagagg tcatttgatt acctaattta ctgaactgat ttagcaggga
     4201 atggaatcca ttccaactat tgcacgtgga tttcccagct gcccctaaat atatatactt
     4261 gtgagtggca aagtggcact aatgaagctt ttgccttttg tacatttgag atttttgtat
     4321 atagtgtttg ctgcaaggcc tgtggaatta attcgttgca tatagaggta tcaactgctg
     4381 catgttcagg catattataa aactttagtc tatgaaagaa taattataat aatgtccagg
     4441 tgcaatactc tgtaagtcta ttggttcaag ttaccgagag ataggtgtgt tcctttatgg
     4501 gggatggggg ggtgtgttgg ggattctttg tattgtttat ttcattttgg tttattttaa
     4561 aagatgtaaa catatattaa gctatattaa atctcacata cagttcttct gtgctctatt
     4621 ataccctgat agagatgggg gagagaaagg aatgtttttg atggtggttt caaagctcgg
     4681 acagtaacta tcttgagccc attagagagt ctgtgtccat atttgcatct ggctggtcat
     4741 agcctttgtt actaatgatg acattcagtt ctcttttgtt tttatttttt aaaaactcag
     4801 gtgtaattat tatctgttct taagataatt gcaaatatta aatattatga tatatcaatt
     4861 catgtgtttg gcataccagt gaatgatgaa gaacatgaga ttaatttaat ttatcttcgg
     4921 taacttgaca ttctggagag agactatctt ctggagttga gtacaagcac agaaacatct
     4981 ttacggtggc atcatctcat tttttaggaa gacatgataa tactgcccat catattcatg
     5041 tgtaactact gttctttctt ctgctttctt caccataata aactttggac aaccaagcaa
     5101 gctctaaccg caatgccaga tggccttgtc cgagggccta gtgtttgcac ggcagtggga
     5161 actgggcctt tcctacagga caactggcaa gtttgctggg aagtcaaata atacattcca
     5221 cctggcagct gaaggcagcc agtcagtctg tcccagaaag ggcccttttc agcacccaaa
     5281 gctgggctgg ctgggatgcc tctggctggt gaagttctca cataggctga tttaaatcca
     5341 gcaaaggtct atagaaaaag gcttgcgtgt tcgttgagta atcattgttt cattttcatt
     5401 tttacgagag tttgaaaata gacacactgt taacacttct gccagttttt tctgatcttt
     5461 ccagccccac cccctttctc tttctctctc tctctcaaag aaaaaaaaaa tgggagtgca
     5521 aaaaaaacaa agccaaaaaa tatatgaagg atagctgttc ttctgtgttc tctcattatg
     5581 gactttgtga agtagaaaca taattttttt tcctccaaag gtgaaaaaac aatgcattct
     5641 tgctttaaaa aaaaaaaaga aggctaaaaa attacctctt tttaaattat gtgcaaaata
     5701 attctggcta actgtaaaat gtattcaatt ttaggatttt ttttttttgt attgtgatgc
     5761 tttatttgta catttttttc ctttctggat gtaattttaa tctcttgcca ttcattagtg
     5821 ttatttcatt gtaaacgtta ttgtgccaaa tgtactgtat tcaaaaggat gtgaatgtgt
     5881 attgtttcag aacctaataa atacaatgac gttaagtctt a
//
