LOCUS       XM_005264431           10326 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C epsilon (PRKCE),
            transcript variant X16, mRNA.
ACCESSION   XM_005264431
VERSION     XM_005264431.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005264431.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..10326
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /note="protein kinase C epsilon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 27
                     ESTs, 175 long SRA reads, and 98% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     40 samples with support for all annotated introns"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
     CDS             427..1917
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /codon_start=1
                     /product="protein kinase C epsilon type isoform X6"
                     /protein_id="XP_005264488.1"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
                     /translation="MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIAL
                     NVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF
                     EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV
                     RRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT
                     KCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVC
                     KMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPAS
                     GSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGEN
                     GEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV
                     DCTMTEKRILALARKHPYLTQLYCCFQTKGTGFSIQGCACEGMREL"
     polyA_site      10326
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaaatttccc gggattatgt ttcggaaagg taggtaagcg ccgggcgcgg cgcccgcttt
       61 cccgcagtcc ggagccggag agccagcgag gcggcgaggc agcccccgcg gcttgcagcg
      121 gagccgacag ctcgtcttct cttctggagg tgcagctggt ggtcgggggg agagacttgc
      181 tccaaacacg gacatccccc agctctcccc cctccctgtt ttccgttagg aacccggcga
      241 ggaaatacat gcactggctg agaatcgccc gcgccagggc gcaacgccac aaggtgtagg
      301 gagtgtgcgg ggtggggcga aaggggaccc aagagtccct gtggctcgga gtgccgggcc
      361 gtcggttctt cattcctgcc ctcggggcag acggagtgac cccggccccc actccccgcc
      421 ccgaccatgg tagtgttcaa tggccttctt aagatcaaaa tctgcgaggc cgtgagcttg
      481 aagcccacag cctggtcgct gcgccatgcg gtgggacccc ggccgcagac tttccttctc
      541 gacccctaca ttgccctcaa tgtggacgac tcgcgcatcg gccaaacggc caccaagcag
      601 aagaccaaca gcccggcctg gcacgacgag ttcgtcaccg atgtgtgcaa cggacgcaag
      661 atcgagctgg ctgtctttca cgatgccccc ataggctacg acgacttcgt ggccaactgc
      721 accatccagt ttgaggagct gctgcagaac gggagccgcc acttcgagga ctggattgat
      781 ctggagccag aaggaagagt gtatgtgatc atcgatctct cagggtcgtc gggtgaagcc
      841 cctaaagaca atgaagagcg tgtgttcagg gaacgcatgc ggccgaggaa gcggcagggg
      901 gccgtcaggc gcagggtcca tcaggtcaac ggccacaagt tcatggccac ctatcttcgg
      961 cagcccacct actgctccca ttgcagagac ttcatctggg gtgtcatagg aaagcaggga
     1021 taccagtgtc aagtctgcac ctgcgtggtc cacaagcggt gccacgagct cataatcaca
     1081 aagtgtgctg ggttaaagaa gcaggagacc cccgaccagg tgggctccca gcggttcagc
     1141 gtcaacatgc cccacaagtt cggtatccac aactacaagg tccctacctt ctgcgatcac
     1201 tgtgggtccc tgctctgggg actcttgcgg cagggtttgc agtgtaaagt ctgcaaaatg
     1261 aatgttcacc gtcgatgtga gaccaacgtg gctcccaact gtggagtgga tgccagagga
     1321 atcgccaaag tactggccga cctgggcgtt accccagaca aaatcaccaa cagcggccag
     1381 agaaggaaaa agctcattgc tggtgccgag tccccgcagc ctgcttctgg aagctcacca
     1441 tctgaggaag atcgatccaa gtcagcaccc acctcccctt gtgaccagga aataaaagaa
     1501 cttgagaaca acattcggaa agccttgtca tttgacaacc gaggagagga gcaccgggca
     1561 gcatcgtctc ctgatggcca gctgatgagc cccggtgaga atggcgaagt ccggcaaggc
     1621 caggccaagc gcctgggcct ggatgagttc aacttcatca aggtgttggg caaaggcagc
     1681 tttggcaagg tcatgttggc agaactcaag ggcaaagatg aagtatatgc tgtgaaggtc
     1741 ttaaagaagg acgtcatcct tcaggatgat gacgtggact gcacaatgac agagaagagg
     1801 attttggctc tggcacggaa acacccgtac cttacccaac tctactgctg cttccagacc
     1861 aagggcacag gattttccat tcaaggttgt gcttgtgaag ggatgagaga gctgtagaat
     1921 tctttgcagc cagagttgga caaagccaaa tggctaaact cactgtttgc tcattggaaa
     1981 aaccaacaag tgtggttagt ccttgctctg ctcctaactt tctatcacta atcaaatcac
     2041 ttaacttcta agttattttc atgtcatatg aaaaagagta aaggccacct taatctcttc
     2101 taatctgtgt aatgtcatct gaaataaagg atgtgaacaa atgcttaaaa tttcatagtg
     2161 aaacacaaat ataaggcagc atttttaatt taccgcatag gtgtctggga accagaaggt
     2221 ggcagtaaag aaacaaagat aatccataac tccatggtag agtctgactc gagtattatt
     2281 aactaatttg ttacctgttt ttagtaaaga aacagcaatg ttcttcatga agctctaatt
     2341 ttgttatcct ttttgagggg ttgggaggag ttaaagtctt ttaggatcat tatggatgtt
     2401 tgtagtattt tgcttcttga gaaggcaaag acagacatca cctgaaactc ctagctgtgg
     2461 cttatgtgga acccagaccc tgagggtgac atcatggaga ggtgatacct tgcttctggg
     2521 tgtattctca tctccatgtc attttgaatg ccagtttttc cacttaaaat tcaatagtta
     2581 ttcattgagt catttggcaa acttttcttt tattatattt cattatatcc ttcccgtgta
     2641 tctgatgcca tgccaggtgc tggagataca gtggtgaact agactagtcc ctgacctcat
     2701 ggagtttaca ttatctttgg tacaccgttt cccagagagg atttctcaga accccaatca
     2761 cttgagcagc tgtaagaaga aaggactctg tgacccatag ttggagtcac tgcaaacgta
     2821 acctctctta gtctcaacac acgtatgttt attagcatcc ttgaggagac ctgcaatgaa
     2881 aacaaaatta cctttgttta atctactttt ccgaacttat ttgatcccag ggtcccccat
     2941 ctctctctta cacacacata cacatgcacc cacacacaca caatgcccat tccatactga
     3001 ggaaccctga tccagtggaa tttttcctat ccttctgatc tctcaggaga ataagaaata
     3061 tcgtctgaaa atctggaaat cattctgctt atctttcaag atggacacat atttctttgt
     3121 ctacgaaact ttcctcagag accactattt aataggaatc tatccctttt tctgcacaag
     3181 tataagaatt actaactctt ctcatttttc atgtgtgttg tgtaatgcct aatatttatg
     3241 ggtttgtgtg tgtacagaat cctgaataat agagactcag tgatggagtt aactttcttc
     3301 ttttttccac tagagcataa ttttagattc atgagaaatg tatcatattt tgtattttcc
     3361 atggtgccta tcacagggcc tcacacttga caggtaccca cggacagaat caaagacttg
     3421 gaagattttt tcaaagtcac cttatctttc tttatctctc tctcttttcc tttcttttct
     3481 tttccttttt ttttttcttt tctttccttt tggtaccagt gagaaaattg ggtttcagag
     3541 aagtaaaact attttgctca taggcactcc atcttggcag agtcagacct ggcatctcat
     3601 ctagtctcag ggactcccaa ggtagtgggg ccttgctctg attcacattg ctagtttctt
     3661 gtgcctgatc cagcacaggg tcccttctgt tggaggaacc ctcccacttc cccctgtccc
     3721 cagcaggtag ccctccctct cactatctga ggtggctttc caggcaggga gccactctgg
     3781 caagttttct ttacaccatt atcaagaagc ccaacatcct aggaggggtc cagtttagtt
     3841 gtgagggctc tatggagccc ctgtacgtgg tggatcatgg gaagccacgt tgaaggtcag
     3901 cttggtgaat gagtgaggga gtgggaatgg atgtcttcaa tgtcagcagt gttctccttt
     3961 gtgcgttgta gaataacaag gctaaggatt cctcatcata tggcagcttt tggagcacaa
     4021 aatggtgttg aataacacca gggatttctt ttatggcaga acagtgatca agctaacatg
     4081 gatgttgtca tggatggctg tagggtgagg atgggcagag aaggagcttc ctctgtagtt
     4141 cagatattta ctatcttttc tcaggccact gtcaggcagc cacagtcaca ggagcagctt
     4201 tgcaccaact ctctcatgcc acctcagttt catagaatac ttagctttat gtaacagatg
     4261 catattcact gaatttttct aaactgaatc atattttaac ctcatagaag gatcttaact
     4321 tacttatgaa aggaacctga tgaagaatca gcttataaac cttcaactta actttttaaa
     4381 aatgtgactt tccctatgac aaaccaacag tttatcatag ttttaaagag tagctattat
     4441 tcacctgact ctgaggtaga tgctggggtt attaaccaaa ggaagacagt tctcacgtgg
     4501 aaggattcac tgataataga ttgggaggtt attctaaatt ccacaagcta agagggagta
     4561 gcaaacagca ttgaatagtt atgttctaga tgggagtatt caaaccaaga agactcaggg
     4621 gagggggtct tccctacgat ctagtggaag aagtgcgatc aagccaggct ttgaaaggta
     4681 gagaggattt ggacaggatt tgggaatagc agctgggttt ggtagccaca gaattcagtc
     4741 ttgattgagt ttcacttttc ctgaaaacaa aggacagttc ctctgagcca ccttaaacct
     4801 ggtttccact aagactctga tacaacattc aggaacacaa agacccgatt gcaatcctat
     4861 taagatttct ttcatgcttg tttaattatg acatacagaa cagcaataat attaagtcga
     4921 gtttaattat ttttaggtga gcctttattt ttcaatatat cggaaaaaaa tggtcctttt
     4981 ggaaacattc ctttgagaac ttcttctgag agattagaca ttgcttcaga ctgcacacta
     5041 catacaagtt gcctggaaag actcagaagt gtgtaaagtg atgtcaccat atctaatacg
     5101 gtgaccaatg gcaatggtca tatgaaccca ttggcatcag tcatgatgac atagtcaggt
     5161 tcaggtctgg tcagtgcagc ccagtgaagg gccaacttac agctgaagag agatttgggc
     5221 ttttctttac tgagcccgcc tacccttggc tcatgtgctc catccgctcc atgggatcta
     5281 gaaaggcaaa aagcaaataa aatggctcca gctttccagg gctagtgaga aaaagcagac
     5341 agaacaacaa attaagccag tggttttaat ttcagtcaaa ttcaaaccag tgtgtctttg
     5401 ggatgcaaga gtaacctgaa ccatgtaggg aattctacca aacttgattt aatttactgt
     5461 caaaatataa agtacagaaa gaggaataaa gaacttctaa ttccagtcaa gatcaagtag
     5521 ccacattcgt cccaggtcct ccctcttaca actaaaaatc cctggacata attcttattt
     5581 tataaaggta gggtgcttat cagcttatca aaattggcat agtcacaaaa aactgtatct
     5641 gttgatgtga atgaaagacc aaaattttta tatttaaaaa ttctagaaga cttttaagtg
     5701 ggtaacattg tcagtagtgt ttaatatttt cttgcatatg agaaaaaaaa ttttttatac
     5761 atccacagtt gtttcttgct ataaaaaaat tatggcctat aattgtttca attacaagtc
     5821 tttattgtta agcatctatg tgctagacac tgtgctagat tctagggcta caaagctaaa
     5881 agataccaac tctgaactca tgccaattac tgcctagtag agagatagac atgcaaggag
     5941 gcagtcagga aggtttcctg atggaggtag aacctaccct ggacctggaa gcatgggtgg
     6001 catttgcaag agggtagggg taaagacatg gctgctgaaa cctagaaatt atttccaaat
     6061 ctcatttgta ttatttttcc aatgcttgaa ctcccaacca atgctatctc ctacttcttc
     6121 caaggaaatg ataatggcta aaccagagca aagaaggaag aggagaaagg gagggtattt
     6181 ggaaaataag gagacagatt cctgcatcta caagatcaga tgcctatcgg tagaggaggg
     6241 aggtaatgct gtgagccctc cttattggac tgctaggctc taaaacttag gggcttggtc
     6301 agggtttgtg ggggaagtga cttttggaat tgcctctccc agttcccagg ttcccattca
     6361 ggcattgact acaagggata ggagaaccac tgagaggtag ttttgttttt tttttctgga
     6421 agttacagga aatgaaattc ccagattttt agagtctgtg catttgtatt tatgaccccc
     6481 attgttgaaa ccattctctc caacaggatc ccacaaaacc tgtcttgaat aatttcatga
     6541 tttttcctct ttaaaaattt catctctaca caattctacc catcccccac cctttggcat
     6601 ttcctgccag gcctgggaag ccaaattctg gagggctttg ctgcaaagga aacaaagggt
     6661 gaactagaga atctccctta gccaatctcc cttgctgccc tagggaaaat gcagcatgga
     6721 aacatcctta caaagcaacg ggagacgttt ttcaaatgcg tttgaatcat ctgtgtgagc
     6781 acggggagaa gtgagaaaag gagtgttaac aacgtaggag caaaagtgtc atttcaagga
     6841 actcaactct gaagaacaga aacactaaac caaaaaaaaa aaaaaaaaaa aaacgaagta
     6901 aaaattaggc cattggtaga ttttgttcta aagagacagc tatgtcagat taaatctaaa
     6961 cgagctgaca gagccgttga ggatgggtct ctttcctgct agaccatact gtctacctga
     7021 ggcaccacta ctactccgaa ggagttggag agtgtgtgag caggtttggt gagtgctttt
     7081 cgagaagaga ttgagatgct caacacaatg agttggtttg tgggtcaggc agccacctgg
     7141 gaatcaatat gctcgccagt aacagattac aagcagagat agcctcagta atttgcaatg
     7201 gattttagag aaatgagatc cgtggtagag gttacaggct tagtgttggc agaatcagtt
     7261 attaatagaa tcagactcca gggaagtcca tctctttact tctgaagacc atctttgctt
     7321 gatagtgggc tggacagcaa tgccatttat tctaatcagc caattaacac atctttagtg
     7381 agcacctatg gtgtgcaaat cactgcaaga tgtgacaaga cttttatggc aggacctttg
     7441 gtcaaactag ttgaggggta agctctactc tcttgtgaag gaatgcacgg gtgtatgtgt
     7501 gtggtggcgt gtgtctgtgt agatgagctg gcggttctct ggccggtcag agaaagatcg
     7561 tcactggttt ccacgatcaa gcaaggcttc atggagcaag acaacttcac ccaggtcttg
     7621 aagcataaca ggattcattc tgtgtgataa aggaaaagtt gtggagtttg ttaatgctca
     7681 tgtgtcccag gggcagagaa ggatgtgttg gctcttaatc taactgctgc agcttcgtgt
     7741 aacctctttg catataagga aaccttacat ttgaatagga cctttgcttt taaaagtgcc
     7801 ctgactggct aggtgcagtg gctcatgcct gtaaccccag cactttggga ggccgaggca
     7861 ggtggatcac ctgaggtcag gaattcgaga ccagcctgac caatttgatg ataccccatc
     7921 tttactaaaa atacaaaaat tatccggaca cggtggcggg cacctgtaat cccagctact
     7981 caggaggcta aggcaggaga atcgcttgaa cccaggaggc agaggttgca gtgagccgag
     8041 atcgtcccac tgcactccag cctggggcaa tagagctaga ctctgtctca aaaaaaaaaa
     8101 aaaaaagaaa gaaaaaagcc ctgacttaga tcagccattt tataactgcc taatgatgtc
     8161 tctatgaatt cacctaccat actctatggt tattcactcc cccttttttt tttcggaatt
     8221 tgttattgtg gtaaaataca cataatataa aacgtgccat cttaaccgtt tttaagtgta
     8281 cagttcagtg gtattaaatg cattcataat gtccatccat cacccctctc catctccatg
     8341 cctcttttca ccttacaacc ctgaaactca atacccatta aacagtacct tcctattccc
     8401 tctccccaca gcccttggca acagccactc tgtcagtctc aataatcttg actactctag
     8461 gtacctctta taagtggaat catacaataa tgtctttctg tgactagtat atttcattta
     8521 gcagaatgtc ctcaaggttc atccatgatg taacgtatgt cataatttcc ttccttttaa
     8581 aggccaaata ctattctatc atgtgtataa tatcacattt cacttatcat ctatggatgg
     8641 acattttgac ttccacgttt tggctactat gaataatgct gctgtgaaca tggttgtctg
     8701 aatatttctt tgaggcctta ctttcaattc ttttagctat atacctagaa gtgggattcc
     8761 tggatcatat agtaattctc tttttaattt tttgaggaac cgctatactg ttttccataa
     8821 tgactgaact attttacatt cccatcaaca gtgcaccagg gttctgatct gatttctcta
     8881 ttactttgcc caacacttat ttctttattt gatagtagcc attctgatgg gtgtgaggta
     8941 gtatctcatt atagttttaa tgtgcatttc cctagtgatt tgtggtcact catttttaca
     9001 gataagaaaa ccaaggccca gtcaagtctt ataatttgtt tgcaacagaa cccagattgg
     9061 aataaaggtt tcccaacagt ctttgttgtt caccatgtat ttctgtctcc ttctctgtcc
     9121 tcctgtccaa attctccact tcaaatagcc tcacctccaa atcccctctt ccccaattcc
     9181 tgtcacacac atgaaaaagg gtctgaaggg gtgtcagctc aattttacat gaactcaatg
     9241 aggctgggat taaaaaatat taatgtccct taagctggca agaggagcag ggttgatcag
     9301 cctgtttctg gaaatgtttc tgttttctga aagcgtaaga gagaaaggag gaaaaagggg
     9361 gcatgggcac aggaacgatc caaaatgggc tggagtagga tgaggccctc acacttgtct
     9421 gtttagccat tgcttactga gcacctgcta tgtgccgtgc catggggcat catggggcgc
     9481 catgctgcct gctgaggaac acaggtgtgg ggaaaggtag gtaggagtcc cggccttgtg
     9541 aacttgaagc ctcatgggag cgtaaaactg ctggcctcta cagaggttac agtgagccga
     9601 gatcccgcca ctgccctcca gcctgggcca cagagtgaaa ctccatctca aaaaaaaaaa
     9661 tttttttaaa aaaagccctt ctggcctcta tacagtgccc agaactcagt gctttatttt
     9721 ccttcagaaa ctgttggcct gatcttcttt tgtaaattgt gttttaatca caaagattat
     9781 ttattaattg tagaaatttt ggaaaagtca caagaggaca aaaaagaaaa taagaacaat
     9841 tcacatgact actactaaca tttcgatgtg tatcattcca gttttagaaa agtacatgtc
     9901 tgttcataca tatatattta taacatcagt atcatactct atgtaaactg tttcacttag
     9961 taatatagta gagctatttt ccttgtcact aaatattctt cagccaaatg atttctaggg
    10021 ttctacagta tctgagggcg tctcgtagac attctgcatc gggggttgca ggtggctggt
    10081 aagtgcctgg cttcctccca gctgatgtta gcagtgaatg gaccgcatgc tctgcccagt
    10141 gctggccagt gatggtgctg cgctctctgc agcagaactg cctccttcta tttttatttc
    10201 tctctgtaac atcaacctga gtacaacatg taaataacct atttggcatt gacataatgc
    10261 aaactaagac ttaaatgtct ttaacattaa atatgtgtgt atacagcagg tctttgaata
    10321 acctga
//
