LOCUS       XM_005264428            5945 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C epsilon (PRKCE),
            transcript variant X1, mRNA.
ACCESSION   XM_005264428
VERSION     XM_005264428.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005264428.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..5945
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /note="protein kinase C epsilon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 7
                     mRNAs, 30 ESTs, 741 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 35 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
     CDS             623..2836
                     /gene="PRKCE"
                     /gene_synonym="nPKC-epsilon; PKCE"
                     /codon_start=1
                     /product="protein kinase C epsilon type isoform X1"
                     /protein_id="XP_005264485.1"
                     /db_xref="GeneID:5581"
                     /db_xref="HGNC:HGNC:9401"
                     /db_xref="MIM:176975"
                     /translation="MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIAL
                     NVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF
                     EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV
                     RRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT
                     KCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVC
                     KMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPAS
                     GSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGEN
                     GEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV
                     DCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPR
                     SRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT
                     FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDV
                     LYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIK
                     PPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP"
ORIGIN      
        1 gcagtccctg ccccgccgcc gcgctgcgca ccgcccggtg ctggcctgcg cccccgagcc
       61 ggatcggcgg ccgcccggac tccgagcccg cgcggatgtg agattccggg ctcctggcgc
      121 ctcccgatcg ccggctccgg cgcggcgctg cttcgcccag gaggcggcgg ccccggctgg
      181 ccgtggggct tgtggatttt taaaaatttg gctccgagga ggaccatttc ctctcgacat
      241 gcatccctcc ggatagactg aacatccctc cgttcacccc cccgccccgc gcggtcagag
      301 gcaggcgctg agtgtgcgaa gaggatccgg gttgaaatct gcgcccccgg ttctcgtccc
      361 cgccccgtcc caccgcccca tccccctccc ggagtcgaaa tttcccggga ttatgtttcg
      421 gaaaggaacc cggcgaggaa atacatgcac tggctgagaa tcgcccgcgc cagggcgcaa
      481 cgccacaagg tgtagggagt gtgcggggtg gggcgaaagg ggacccaaga gtccctgtgg
      541 ctcggagtgc cgggccgtcg gttcttcatt cctgccctcg gggcagacgg agtgaccccg
      601 gcccccactc cccgccccga ccatggtagt gttcaatggc cttcttaaga tcaaaatctg
      661 cgaggccgtg agcttgaagc ccacagcctg gtcgctgcgc catgcggtgg gaccccggcc
      721 gcagactttc cttctcgacc cctacattgc cctcaatgtg gacgactcgc gcatcggcca
      781 aacggccacc aagcagaaga ccaacagccc ggcctggcac gacgagttcg tcaccgatgt
      841 gtgcaacgga cgcaagatcg agctggctgt ctttcacgat gcccccatag gctacgacga
      901 cttcgtggcc aactgcacca tccagtttga ggagctgctg cagaacggga gccgccactt
      961 cgaggactgg attgatctgg agccagaagg aagagtgtat gtgatcatcg atctctcagg
     1021 gtcgtcgggt gaagccccta aagacaatga agagcgtgtg ttcagggaac gcatgcggcc
     1081 gaggaagcgg cagggggccg tcaggcgcag ggtccatcag gtcaacggcc acaagttcat
     1141 ggccacctat cttcggcagc ccacctactg ctcccattgc agagacttca tctggggtgt
     1201 cataggaaag cagggatacc agtgtcaagt ctgcacctgc gtggtccaca agcggtgcca
     1261 cgagctcata atcacaaagt gtgctgggtt aaagaagcag gagacccccg accaggtggg
     1321 ctcccagcgg ttcagcgtca acatgcccca caagttcggt atccacaact acaaggtccc
     1381 taccttctgc gatcactgtg ggtccctgct ctggggactc ttgcggcagg gtttgcagtg
     1441 taaagtctgc aaaatgaatg ttcaccgtcg atgtgagacc aacgtggctc ccaactgtgg
     1501 agtggatgcc agaggaatcg ccaaagtact ggccgacctg ggcgttaccc cagacaaaat
     1561 caccaacagc ggccagagaa ggaaaaagct cattgctggt gccgagtccc cgcagcctgc
     1621 ttctggaagc tcaccatctg aggaagatcg atccaagtca gcacccacct ccccttgtga
     1681 ccaggaaata aaagaacttg agaacaacat tcggaaagcc ttgtcatttg acaaccgagg
     1741 agaggagcac cgggcagcat cgtctcctga tggccagctg atgagccccg gtgagaatgg
     1801 cgaagtccgg caaggccagg ccaagcgcct gggcctggat gagttcaact tcatcaaggt
     1861 gttgggcaaa ggcagctttg gcaaggtcat gttggcagaa ctcaagggca aagatgaagt
     1921 atatgctgtg aaggtcttaa agaaggacgt catccttcag gatgatgacg tggactgcac
     1981 aatgacagag aagaggattt tggctctggc acggaaacac ccgtacctta cccaactcta
     2041 ctgctgcttc cagaccaagg accgcctctt tttcgtcatg gaatatgtaa atggtggaga
     2101 cctcatgttt cagattcagc gctcccgaaa attcgacgag cctcgttcac ggttctatgc
     2161 tgcagaggtc acatcggccc tcatgttcct ccaccagcat ggagtcatct acagggattt
     2221 gaaactggac aacatccttc tggatgcaga aggtcactgc aagctggctg acttcgggat
     2281 gtgcaaggaa gggattctga atggtgtgac gaccaccacg ttctgtggga ctcctgacta
     2341 catagctcct gagatcctgc aggagttgga gtatggcccc tccgtggact ggtgggccct
     2401 gggggtgctg atgtacgaga tgatggctgg acagcctccc tttgaggccg acaatgagga
     2461 cgacctattt gagtccatcc tccatgacga cgtgctgtac ccagtctggc tcagcaagga
     2521 ggctgtcagc atcttgaaag ctttcatgac gaagaatccc cacaagcgcc tgggctgtgt
     2581 ggcatcgcag aatggcgagg acgccatcaa gcagcaccca ttcttcaaag agattgactg
     2641 ggtgctcctg gagcagaaga agatcaagcc acccttcaaa ccacgcatta aaaccaaaag
     2701 agacgtcaat aattttgacc aagactttac ccgggaagag ccggtactca cccttgtgga
     2761 cgaagcaatt gtaaagcaga tcaaccagga ggaattcaaa ggtttctcct actttggtga
     2821 agacctgatg ccctgagagc ccactgcagt tggactttgc cgatgctgca agaaggggtg
     2881 cagagaagac tcctgtgttg gagacactca gcaggtcttg aactacttct cctcctcgga
     2941 gccccagtcc catgtccact gtctatttat tgcattccct tgccccaggc cacctcctcc
     3001 ccctcccacc tggtgaccag aaggcgctct cggttcttgt ctcaccagta atgcagactc
     3061 attgggtcag caattagctg tatacactgc cgtgtttgga ccattggcaa gcctggttcc
     3121 actcctcagg ggctcctggc agtgaagcaa cttcagttct tttactgcaa agaacagaaa
     3181 aaagaaagaa agcaaacaag aagactccgg ctctgctatc ggacacagat cctgatccct
     3241 cttgcttctt ttccctcctg caccgcagct tgccatccct gcccttctgt cctggagaag
     3301 agactggtgc ttctccgcac acacgaggga gggcgccctt gaggcatgcc ctctgaggga
     3361 gggagaccag agatgcaggg attggccagc tgggttggtt tgctctggaa tggctaactc
     3421 ttgcctgctt tggttttagc ttttcagcat gccaaagtca tgtaagtttg tgtcttgtgg
     3481 aagaaatcct ctttgtggaa aaagaaacag ggttttgaac tctgttaaca tttgaaaaat
     3541 atattttcaa attcactttc taattggcca aaagagatga gttccagtct gaatacaggt
     3601 agatattaaa gggctaataa aaaatgagaa accggtcgtc caaggtggat gctgtcaatg
     3661 cccgagtgac acatgagagc tgtatgaatt gagagaaaag gcaacaagta gcattcttca
     3721 tcattcaagt tctacctgga cacaaaggcg aggaccctgg ggttccaaca aagctcagct
     3781 cccagattct ctttccagtt tcatcctaag ttcctagcat aaacactatt tattttctgc
     3841 agcagtgtgt tatttttgcg cacttataca aaatggtagt actactgtgt tgtggttttt
     3901 aaacattaaa catgtaaagt tatatacgaa atatctgctt ttggaataag cagaatgagg
     3961 ctaaacatgg gttatacaaa gggtatctgg aaactgaaga gcaacttgtt agaaaactga
     4021 caatgtcgca agatgtactc agttttgttt ctgtgtgaca tgcaatggca actcatgtgg
     4081 acactattga agggatgtga cattacctcc tgtagatatg ctaacagtgt tattctttca
     4141 tttccaaggg ttctctgtgg ctttgtgtat atgtttccca gaggtcattt gattacctaa
     4201 tttactgaac tgatttagca gggaatggaa tccattccaa ctattgcacg tggatttccc
     4261 agctgcccct aaatatatat acttgtgagt ggcaaagtgg cactaatgaa gcttttgcct
     4321 tttgtacatt tgagattttt gtatatagtg tttgctgcaa ggcctgtgga attaattcgt
     4381 tgcatataga ggtatcaact gctgcatgtt caggcatatt ataaaacttt agtctatgaa
     4441 agaataatta taataatgtc caggtgcaat actctgtaag tctattggtt caagttaccg
     4501 agagataggt gtgttccttt atgggggatg ggggggtgtg ttggggattc tttgtattgt
     4561 ttatttcatt ttggtttatt ttaaaagatg taaacatata ttaagctata ttaaatctca
     4621 catacagttc ttctgtgctc tattataccc tgatagagat gggggagaga aaggaatgtt
     4681 tttgatggtg gtttcaaagc tcggacagta actatcttga gcccattaga gagtctgtgt
     4741 ccatatttgc atctggctgg tcatagcctt tgttactaat gatgacattc agttctcttt
     4801 tgtttttatt ttttaaaaac tcaggtgtaa ttattatctg ttcttaagat aattgcaaat
     4861 attaaatatt atgatatatc aattcatgtg tttggcatac cagtgaatga tgaagaacat
     4921 gagattaatt taatttatct tcggtaactt gacattctgg agagagacta tcttctggag
     4981 ttgagtacaa gcacagaaac atctttacgg tggcatcatc tcatttttta ggaagacatg
     5041 ataatactgc ccatcatatt catgtgtaac tactgttctt tcttctgctt tcttcaccat
     5101 aataaacttt ggacaaccaa gcaagctcta accgcaatgc cagatggcct tgtccgaggg
     5161 cctagtgttt gcacggcagt gggaactggg cctttcctac aggacaactg gcaagtttgc
     5221 tgggaagtca aataatacat tccacctggc agctgaaggc agccagtcag tctgtcccag
     5281 aaagggccct tttcagcacc caaagctggg ctggctggga tgcctctggc tggtgaagtt
     5341 ctcacatagg ctgatttaaa tccagcaaag gtctatagaa aaaggcttgc gtgttcgttg
     5401 agtaatcatt gtttcatttt catttttacg agagtttgaa aatagacaca ctgttaacac
     5461 ttctgccagt tttttctgat ctttccagcc ccaccccctt tctctttctc tctctctctc
     5521 aaagaaaaaa aaaatgggag tgcaaaaaaa acaaagccaa aaaatatatg aaggatagct
     5581 gttcttctgt gttctctcat tatggacttt gtgaagtaga aacataattt tttttcctcc
     5641 aaaggtgaaa aaacaatgca ttcttgcttt aaaaaaaaaa aagaaggcta aaaaattacc
     5701 tctttttaaa ttatgtgcaa aataattctg gctaactgta aaatgtattc aattttagga
     5761 tttttttttt ttgtattgtg atgctttatt tgtacatttt tttcctttct ggatgtaatt
     5821 ttaatctctt gccattcatt agtgttattt cattgtaaac gttattgtgc caaatgtact
     5881 gtattcaaaa ggatgtgaat gtgtattgtt tcagaaccta ataaatacaa tgacgttaag
     5941 tctta
//
