LOCUS       NM_001354679            2837 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens protein kinase C delta (PRKCD), transcript variant 6,
            mRNA.
ACCESSION   NM_001354679
VERSION     NM_001354679.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2837)
  AUTHORS   Du,Y., Guo,T., Hao,Y., Li,C., Tang,L., Li,X., Zhang,X., Li,L.,
            Yao,D., Xu,X., Si,H., Zhang,J., Zhao,N., Yu,T., Zhao,Y., Zhang,W.
            and Xu,H.
  TITLE     PKCdelta serves as a potential biomarker and therapeutic target for
            microglia-mediated neuroinflammation in Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (8), 5511-5527 (2024)
   PUBMED   38938161
  REMARK    GeneRIF: PKCdelta serves as a potential biomarker and therapeutic
            target for microglia-mediated neuroinflammation in Alzheimer's
            disease.
REFERENCE   2  (bases 1 to 2837)
  AUTHORS   Deng,Y., Hou,Z., Li,Y., Yi,M., Wu,Y., Zheng,Y., Yang,F., Zhong,G.,
            Hao,Q., Zhai,Z., Wang,M., Ma,X., Kang,H., Ji,F., Dong,C., Liu,H.
            and Dai,Z.
  TITLE     Superbinder based phosphoproteomic landscape revealed PRKCD_pY313
            mediates the activation of Src and p38 MAPK to promote TNBC
            progression
  JOURNAL   Cell Commun Signal 22 (1), 115 (2024)
   PUBMED   38347536
  REMARK    GeneRIF: Superbinder based phosphoproteomic landscape revealed
            PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote
            TNBC progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2837)
  AUTHORS   Zhang,Y., Chen,K., Wang,M., Wang,Z., Wang,D., Niu,J., Yang,E.,
            Li,Y., Sun,Y., Zhao,P., Liu,W., Lv,Y. and Hu,X.
  TITLE     Activated PRKCD-mediated neutrophil extracellular traps pathway may
            be the prothrombotic mechanism of neutrophils in polycythemia vera
            patients based on clinical retrospective analysis and
            bioinformatics study
  JOURNAL   Int Immunopharmacol 127, 111366 (2024)
   PUBMED   38128308
  REMARK    GeneRIF: Activated PRKCD-mediated neutrophil extracellular traps
            pathway may be the prothrombotic mechanism of neutrophils in
            polycythemia vera patients based on clinical retrospective analysis
            and bioinformatics study.
REFERENCE   4  (bases 1 to 2837)
  AUTHORS   Chaib,M., Holt,J.R., Fisher,E.L., Sipe,L.M., Bohm,M.S.,
            Joseph,S.C., Simmons,B.W., Eugin Simon,S., Yarbro,J.R., Tanveer,U.,
            Halle,J.L., Carson,J.A., Hollingsworth,T.J., Wei,Q., Rathmell,J.C.,
            Thomas,P.G., Hayes,D.N. and Makowski,L.
  TITLE     Protein kinase C delta regulates mononuclear phagocytes and hinders
            response to immunotherapy in cancer
  JOURNAL   Sci Adv 9 (51), eadd3231 (2023)
   PUBMED   38134280
  REMARK    GeneRIF: Protein kinase C delta regulates mononuclear phagocytes
            and hinders response to immunotherapy in cancer.
REFERENCE   5  (bases 1 to 2837)
  AUTHORS   Yang,C.C., Lee,I.T., Lin,Y.J., Wu,W.B., Hsiao,L.D. and Yang,C.M.
  TITLE     Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human
            Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1
            Pathway Modulation
  JOURNAL   Int J Mol Sci 24 (20), 15130 (2023)
   PUBMED   37894811
  REMARK    GeneRIF: Thrombin-Induced COX-2 Expression and PGE2 Synthesis in
            Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent
            AP-1 Pathway Modulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2837)
  AUTHORS   Kasahara,K., Chida,K., Tsunenaga,M., Kohno,Y., Ikuta,T. and
            Kuroki,T.
  TITLE     Identification of lamin B2 as a substrate of protein kinase C in
            BALB/MK-2 mouse keratinocytes
  JOURNAL   J Biol Chem 266 (30), 20018-20023 (1991)
   PUBMED   1939065
REFERENCE   7  (bases 1 to 2837)
  AUTHORS   Mellor,H. and Proud,C.G.
  TITLE     A synthetic peptide substrate for initiation factor-2 kinases
  JOURNAL   Biochem Biophys Res Commun 178 (2), 430-437 (1991)
   PUBMED   1677563
REFERENCE   8  (bases 1 to 2837)
  AUTHORS   Bouvier,M., Guilbault,N. and Bonin,H.
  TITLE     Phorbol-ester-induced phosphorylation of the beta 2-adrenergic
            receptor decreases its coupling to Gs
  JOURNAL   FEBS Lett 279 (2), 243-248 (1991)
   PUBMED   1848190
REFERENCE   9  (bases 1 to 2837)
  AUTHORS   Fackler,M.J., Civin,C.I., Sutherland,D.R., Baker,M.A. and May,W.S.
  TITLE     Activated protein kinase C directly phosphorylates the CD34 antigen
            on hematopoietic cells
  JOURNAL   J Biol Chem 265 (19), 11056-11061 (1990)
   PUBMED   1694174
REFERENCE   10 (bases 1 to 2837)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097015.2.
            
            On May 31, 2019 this sequence version replaced NM_001354679.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein kinase C family of serine- and threonine-specific protein
            kinases. The encoded protein is activated by diacylglycerol and is
            both a tumor suppressor and a positive regulator of cell cycle
            progression. Also, this protein can positively or negatively
            regulate apoptosis. Defects in this gene are a cause of autoimmune
            lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (c) is
            shorter at the N-terminus compared to isoform a. Variants 1, 2, 3,
            6, and 7 all encode the same isoform (c).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.592523.1,
                                           SRR14038193.684264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC097015.2         20233-20452
            221-336             AC097015.2         32517-32632
            337-470             AC097015.2         37428-37561
            471-670             AC097015.2         38601-38800
            671-731             AC097015.2         40231-40291
            732-894             AC097015.2         40468-40630
            895-926             AC097015.2         40725-40756
            927-1012            AC097015.2         42145-42230
            1013-1142           AC097015.2         42476-42605
            1143-1243           AC097015.2         43898-43998
            1244-1340           AC097015.2         44628-44724
            1341-1441           AC097015.2         44951-45051
            1442-1615           AC097015.2         45191-45364
            1616-1707           AC097015.2         45628-45719
            1708-1770           AC097015.2         46364-46426
            1771-1909           AC097015.2         47744-47882
            1910-2098           AC097015.2         48082-48270
            2099-2227           AC097015.2         48897-49025
            2228-2837           AC097015.2         51132-51741
FEATURES             Location/Qualifiers
     source          1..2837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..2837
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="protein kinase C delta"
                     /db_xref="GeneID:5580"
                     /db_xref="HGNC:HGNC:9399"
                     /db_xref="MIM:176977"
     exon            1..220
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            221..336
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            337..470
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..2386
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /EC_number="2.7.10.2"
                     /EC_number="2.7.11.13"
                     /note="isoform c is encoded by transcript variant 6;
                     protein kinase C delta type; protein kinase C delta VIII;
                     tyrosine-protein kinase PRKCD"
                     /codon_start=1
                     /product="protein kinase C delta type isoform c"
                     /protein_id="NP_001341608.1"
                     /db_xref="CCDS:CCDS2870.1"
                     /db_xref="GeneID:5580"
                     /db_xref="HGNC:HGNC:9399"
                     /db_xref="MIM:176977"
                     /translation="MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTL
                     VQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA
                     EFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHE
                     FIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT
                     IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKV
                     ANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTY
                     GKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVE
                     CTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRA
                     TFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
                     CGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPH
                     YPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKV
                     KSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED"
     exon            471..670
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            671..731
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            732..894
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            895..926
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1012
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1142
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1243
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1340
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1441
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1615
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1707
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1770
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1909
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2098
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2227
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2837
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="hexamer: AATAAA"
     polyA_site      2837
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="major polyA site"
ORIGIN      
        1 gcacttccgt gtgccgcggc gccggagccc gaggcggctg tagcccacat ctcccgagcg
       61 acccccggcg cccgcccgcc gcgcggaggc ccgggccaca cctcactggc cgcttggccc
      121 atcccagtca gcgccgcgcc gaaccccgtc cgcgcgcgcc ggggagcggc gcccccgccg
      181 ctgccgccgc gacccttggc gcctgcccct gcaacgggag tttttttcag acagagtgtc
      241 actttattga ccaggctgga gtgcagtggc aagatctcgg ctcactgcaa cctctacctc
      301 ccgggttcaa gtgattcttc tgcctcagcc tcccagcccc actgcaggcc ccaccatggc
      361 gccgttcctg cgcatcgcct tcaactccta tgagctgggc tccctgcagg ccgaggacga
      421 ggcgaaccag cccttctgtg ccgtgaagat gaaggaggcg ctcagcacag agcgtgggaa
      481 aacactggtg cagaagaagc cgaccatgta tcctgagtgg aagtcgacgt tcgatgccca
      541 catctatgag gggcgcgtca tccagattgt gctaatgcgg gcagcagagg agccagtgtc
      601 tgaggtgacc gtgggtgtgt cggtgctggc cgagcgctgc aagaagaaca atggcaaggc
      661 tgagttctgg ctggacctgc agcctcaggc caaggtgttg atgtctgttc agtatttcct
      721 ggaggacgtg gattgcaaac agtctatgcg cagtgaggac gaggccaagt tcccaacgat
      781 gaaccgccgc ggagccatca aacaggccaa aatccactac atcaagaacc atgagtttat
      841 cgccaccttc tttgggcaac ccaccttctg ttctgtgtgc aaagactttg tctggggcct
      901 caacaagcaa ggctacaaat gcaggcaatg taacgctgcc atccacaaga aatgcatcga
      961 caagatcatc ggcagatgca ctggcaccgc ggccaacagc cgggacacta tattccagaa
     1021 agaacgcttc aacatcgaca tgccgcaccg cttcaaggtt cacaactaca tgagccccac
     1081 cttctgtgac cactgcggca gcctgctctg gggactggtg aagcagggat taaagtgtga
     1141 agactgcggc atgaatgtgc accataaatg ccgggagaag gtggccaacc tctgcggcat
     1201 caaccagaag cttttggctg aggccttgaa ccaagtcacc cagagagcct cccggagatc
     1261 agactcagcc tcctcagagc ctgttgggat atatcagggt ttcgagaaga agaccggagt
     1321 tgctggggag gacatgcaag acaacagtgg gacctacggc aagatctggg agggcagcag
     1381 caagtgcaac atcaacaact tcatcttcca caaggtcctg ggcaaaggca gcttcgggaa
     1441 ggtgctgctt ggagagctga agggcagagg agagtacttt gccatcaagg ccctcaagaa
     1501 ggatgtggtc ctgatcgacg acgacgtgga gtgcaccatg gttgagaagc gggtgctgac
     1561 acttgccgca gagaatccct ttctcaccca cctcatctgc accttccaga ccaaggacca
     1621 cctgttcttt gtgatggagt tcctcaacgg gggggacctg atgtaccaca tccaggacaa
     1681 aggccgcttt gaactctacc gtgccacgtt ttatgccgct gagataatgt gtggactgca
     1741 gtttctacac agcaagggca tcatttacag ggacctcaaa ctggacaatg tgctgctgga
     1801 ccgggatggc cacatcaaga ttgccgactt tgggatgtgc aaagagaaca tattcgggga
     1861 gagccgggcc agcaccttct gcggcacccc tgactatatc gcccctgaga tcctacaggg
     1921 cctgaagtac acattctctg tggactggtg gtctttcggg gtccttctgt acgagatgct
     1981 cattggccag tcccccttcc atggtgatga tgaggatgaa ctcttcgagt ccatccgtgt
     2041 ggacacgcca cattatcccc gctggatcac caaggagtcc aaggacatcc tggagaagct
     2101 ctttgaaagg gaaccaacca agaggctggg agtgaccgga aacatcaaaa tccacccctt
     2161 cttcaagacc ataaactgga ctctgctgga aaagcggagg ttggagccac ctttcaggcc
     2221 caaagtgaag tcacccagag actacagtaa ctttgaccag gagttcctga acgagaaggc
     2281 gcgcctctcc tacagcgaca agaacctcat cgactccatg gaccagtctg cattcgctgg
     2341 cttctccttt gtgaacccca aattcgagca cctcctggaa gattgaggtt cctggacaga
     2401 tcaggctagc cctgccctcc acccacacct gcccgctccc cacgataagc accagtggga
     2461 ctgtggtgac ttctgctgct ggccccgccc ctgcccccag agcgtccttg gctgccgtct
     2521 ggccgggctc tcatggtact tcctctgtga actgtgtgtg aatctgcttt tcctctgcct
     2581 tcggagggaa attgtaaatc ctgtgtttca ttacttgaat gtagttatct attgaaaata
     2641 tatattatat acatagacat atatatatat ataataggct gtatatattg ctcagtagag
     2701 aaaaaccatg ggggactggt gatatgttga tctttttcaa aaaaatatat atatgacaaa
     2761 aaaaaaaaaa aaggagcaca agctgtttga accaccaggt ttatttgtgt gtctaaataa
     2821 acaccaaata gtaccaa
//
