LOCUS       NM_001316327            2682 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens protein kinase C delta (PRKCD), transcript variant 3,
            mRNA.
ACCESSION   NM_001316327 XM_006713258
VERSION     NM_001316327.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Du,Y., Guo,T., Hao,Y., Li,C., Tang,L., Li,X., Zhang,X., Li,L.,
            Yao,D., Xu,X., Si,H., Zhang,J., Zhao,N., Yu,T., Zhao,Y., Zhang,W.
            and Xu,H.
  TITLE     PKCdelta serves as a potential biomarker and therapeutic target for
            microglia-mediated neuroinflammation in Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (8), 5511-5527 (2024)
   PUBMED   38938161
  REMARK    GeneRIF: PKCdelta serves as a potential biomarker and therapeutic
            target for microglia-mediated neuroinflammation in Alzheimer's
            disease.
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Deng,Y., Hou,Z., Li,Y., Yi,M., Wu,Y., Zheng,Y., Yang,F., Zhong,G.,
            Hao,Q., Zhai,Z., Wang,M., Ma,X., Kang,H., Ji,F., Dong,C., Liu,H.
            and Dai,Z.
  TITLE     Superbinder based phosphoproteomic landscape revealed PRKCD_pY313
            mediates the activation of Src and p38 MAPK to promote TNBC
            progression
  JOURNAL   Cell Commun Signal 22 (1), 115 (2024)
   PUBMED   38347536
  REMARK    GeneRIF: Superbinder based phosphoproteomic landscape revealed
            PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote
            TNBC progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Zhang,Y., Chen,K., Wang,M., Wang,Z., Wang,D., Niu,J., Yang,E.,
            Li,Y., Sun,Y., Zhao,P., Liu,W., Lv,Y. and Hu,X.
  TITLE     Activated PRKCD-mediated neutrophil extracellular traps pathway may
            be the prothrombotic mechanism of neutrophils in polycythemia vera
            patients based on clinical retrospective analysis and
            bioinformatics study
  JOURNAL   Int Immunopharmacol 127, 111366 (2024)
   PUBMED   38128308
  REMARK    GeneRIF: Activated PRKCD-mediated neutrophil extracellular traps
            pathway may be the prothrombotic mechanism of neutrophils in
            polycythemia vera patients based on clinical retrospective analysis
            and bioinformatics study.
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Chaib,M., Holt,J.R., Fisher,E.L., Sipe,L.M., Bohm,M.S.,
            Joseph,S.C., Simmons,B.W., Eugin Simon,S., Yarbro,J.R., Tanveer,U.,
            Halle,J.L., Carson,J.A., Hollingsworth,T.J., Wei,Q., Rathmell,J.C.,
            Thomas,P.G., Hayes,D.N. and Makowski,L.
  TITLE     Protein kinase C delta regulates mononuclear phagocytes and hinders
            response to immunotherapy in cancer
  JOURNAL   Sci Adv 9 (51), eadd3231 (2023)
   PUBMED   38134280
  REMARK    GeneRIF: Protein kinase C delta regulates mononuclear phagocytes
            and hinders response to immunotherapy in cancer.
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   Yang,C.C., Lee,I.T., Lin,Y.J., Wu,W.B., Hsiao,L.D. and Yang,C.M.
  TITLE     Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human
            Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1
            Pathway Modulation
  JOURNAL   Int J Mol Sci 24 (20), 15130 (2023)
   PUBMED   37894811
  REMARK    GeneRIF: Thrombin-Induced COX-2 Expression and PGE2 Synthesis in
            Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent
            AP-1 Pathway Modulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2682)
  AUTHORS   Kasahara,K., Chida,K., Tsunenaga,M., Kohno,Y., Ikuta,T. and
            Kuroki,T.
  TITLE     Identification of lamin B2 as a substrate of protein kinase C in
            BALB/MK-2 mouse keratinocytes
  JOURNAL   J Biol Chem 266 (30), 20018-20023 (1991)
   PUBMED   1939065
REFERENCE   7  (bases 1 to 2682)
  AUTHORS   Mellor,H. and Proud,C.G.
  TITLE     A synthetic peptide substrate for initiation factor-2 kinases
  JOURNAL   Biochem Biophys Res Commun 178 (2), 430-437 (1991)
   PUBMED   1677563
REFERENCE   8  (bases 1 to 2682)
  AUTHORS   Bouvier,M., Guilbault,N. and Bonin,H.
  TITLE     Phorbol-ester-induced phosphorylation of the beta 2-adrenergic
            receptor decreases its coupling to Gs
  JOURNAL   FEBS Lett 279 (2), 243-248 (1991)
   PUBMED   1848190
REFERENCE   9  (bases 1 to 2682)
  AUTHORS   Fackler,M.J., Civin,C.I., Sutherland,D.R., Baker,M.A. and May,W.S.
  TITLE     Activated protein kinase C directly phosphorylates the CD34 antigen
            on hematopoietic cells
  JOURNAL   J Biol Chem 265 (19), 11056-11061 (1990)
   PUBMED   1694174
REFERENCE   10 (bases 1 to 2682)
  AUTHORS   Jakobovits,A., Rosenthal,A. and Capon,D.J.
  TITLE     Trans-activation of HIV-1 LTR-directed gene expression by tat
            requires protein kinase C
  JOURNAL   EMBO J 9 (4), 1165-1170 (1990)
   PUBMED   2182321
  REMARK    Erratum:[EMBO J 1990 Oct;9(10):3413]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097015.2, AK313216.1,
            BC043350.1, AK294272.1 and AW293041.1.
            
            On May 31, 2019 this sequence version replaced NM_001316327.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein kinase C family of serine- and threonine-specific protein
            kinases. The encoded protein is activated by diacylglycerol and is
            both a tumor suppressor and a positive regulator of cell cycle
            progression. Also, this protein can positively or negatively
            regulate apoptosis. Defects in this gene are a cause of autoimmune
            lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (c) is
            shorter at the N-terminus compared to isoform a. Variants 1, 2, 3,
            6, and 7 all encode the same isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313216.1, SRR14038191.986068.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC097015.2         20531-20544
            15-928              AK313216.1         1-914
            929-1640            BC043350.1         1101-1812
            1641-1981           AK294272.1         1253-1593
            1982-1982           AC097015.2         48935-48935
            1983-2056           AK294272.1         1595-1668
            2057-2057           AC097015.2         49010-49010
            2058-2327           AK294272.1         1670-1939
            2328-2617           AW293041.1         82-371              c
            2618-2682           AW293041.1         16-80               c
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..2682
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="protein kinase C delta"
                     /db_xref="GeneID:5580"
                     /db_xref="HGNC:HGNC:9399"
                     /db_xref="MIM:176977"
     exon            1..69
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            70..181
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            182..315
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2231
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /EC_number="2.7.10.2"
                     /EC_number="2.7.11.13"
                     /note="isoform c is encoded by transcript variant 3;
                     protein kinase C delta type; protein kinase C delta VIII;
                     tyrosine-protein kinase PRKCD"
                     /codon_start=1
                     /product="protein kinase C delta type isoform c"
                     /protein_id="NP_001303256.1"
                     /db_xref="CCDS:CCDS2870.1"
                     /db_xref="GeneID:5580"
                     /db_xref="HGNC:HGNC:9399"
                     /db_xref="MIM:176977"
                     /translation="MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTL
                     VQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA
                     EFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHE
                     FIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT
                     IFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKV
                     ANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTY
                     GKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVE
                     CTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRA
                     TFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
                     CGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPH
                     YPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKV
                     KSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED"
     exon            316..515
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            516..576
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            577..739
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            740..771
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            772..857
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            858..987
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1088
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1185
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1286
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1460
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1552
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1615
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1754
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1943
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2072
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2682
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="hexamer: AATAAA"
     polyA_site      2682
                     /gene="PRKCD"
                     /gene_synonym="ALPS3; CVID9; MAY1; nPKC-delta; PKCD"
                     /note="major polyA site"
ORIGIN      
        1 agttcccgtt tccgaaactg agaaactgag ccgcggtcag cgaaagtccc gccgcgccga
       61 gacctgccgg tctgcaggga actggccagg caagggggca ggcccgtttc tcctggtggt
      121 tggtgcgttg tagcagcagc gggagccagg actaaggaca agcaggagct gggagcccca
      181 gccccactgc aggccccacc atggcgccgt tcctgcgcat cgccttcaac tcctatgagc
      241 tgggctccct gcaggccgag gacgaggcga accagccctt ctgtgccgtg aagatgaagg
      301 aggcgctcag cacagagcgt gggaaaacac tggtgcagaa gaagccgacc atgtatcctg
      361 agtggaagtc gacgttcgat gcccacatct atgaggggcg cgtcatccag attgtgctaa
      421 tgcgggcagc agaggagcca gtgtctgagg tgaccgtggg tgtgtcggtg ctggccgagc
      481 gctgcaagaa gaacaatggc aaggctgagt tctggctgga cctgcagcct caggccaagg
      541 tgttgatgtc tgttcagtat ttcctggagg acgtggattg caaacagtct atgcgcagtg
      601 aggacgaggc caagttccca acgatgaacc gccgcggagc catcaaacag gccaaaatcc
      661 actacatcaa gaaccatgag tttatcgcca ccttctttgg gcaacccacc ttctgttctg
      721 tgtgcaaaga ctttgtctgg ggcctcaaca agcaaggcta caaatgcagg caatgtaacg
      781 ctgccatcca caagaaatgc atcgacaaga tcatcggcag atgcactggc accgcggcca
      841 acagccggga cactatattc cagaaagaac gcttcaacat cgacatgccg caccgcttca
      901 aggttcacaa ctacatgagc cccaccttct gtgaccactg cggcagcctg ctctggggac
      961 tggtgaagca gggattaaag tgtgaagact gcggcatgaa tgtgcaccat aaatgccggg
     1021 agaaggtggc caacctctgc ggcatcaacc agaagctttt ggctgaggcc ttgaaccaag
     1081 tcacccagag agcctcccgg agatcagact cagcctcctc agagcctgtt gggatatatc
     1141 agggtttcga gaagaagacc ggagttgctg gggaggacat gcaagacaac agtgggacct
     1201 acggcaagat ctgggagggc agcagcaagt gcaacatcaa caacttcatc ttccacaagg
     1261 tcctgggcaa aggcagcttc gggaaggtgc tgcttggaga gctgaagggc agaggagagt
     1321 actttgccat caaggccctc aagaaggatg tggtcctgat cgacgacgac gtggagtgca
     1381 ccatggttga gaagcgggtg ctgacacttg ccgcagagaa tccctttctc acccacctca
     1441 tctgcacctt ccagaccaag gaccacctgt tctttgtgat ggagttcctc aacggggggg
     1501 acctgatgta ccacatccag gacaaaggcc gctttgaact ctaccgtgcc acgttttatg
     1561 ccgctgagat aatgtgtgga ctgcagtttc tacacagcaa gggcatcatt tacagggacc
     1621 tcaaactgga caatgtgctg ctggaccggg atggccacat caagattgcc gactttggga
     1681 tgtgcaaaga gaacatattc ggggagagcc gggccagcac cttctgcggc acccctgact
     1741 atatcgcccc tgagatccta cagggcctga agtacacatt ctctgtggac tggtggtctt
     1801 tcggggtcct tctgtacgag atgctcattg gccagtcccc cttccatggt gatgatgagg
     1861 atgaactctt cgagtccatc cgtgtggaca cgccacatta tccccgctgg atcaccaagg
     1921 agtccaagga catcctggag aagctctttg aaagggaacc aaccaagagg ctgggagtga
     1981 ccggaaacat caaaatccac cccttcttca agaccataaa ctggactctg ctggaaaagc
     2041 ggaggttgga gccacctttc aggcccaaag tgaagtcacc cagagactac agtaactttg
     2101 accaggagtt cctgaacgag aaggcgcgcc tctcctacag cgacaagaac ctcatcgact
     2161 ccatggacca gtctgcattc gctggcttct cctttgtgaa ccccaaattc gagcacctcc
     2221 tggaagattg aggttcctgg acagatcagg ctagccctgc cctccaccca cacctgcccg
     2281 ctccccacga taagcaccag tgggactgtg gtgacttctg ctgctggccc cgcccctgcc
     2341 cccagagcgt ccttggctgc cgtctggccg ggctctcatg gtacttcctc tgtgaactgt
     2401 gtgtgaatct gcttttcctc tgccttcgga gggaaattgt aaatcctgtg tttcattact
     2461 tgaatgtagt tatctattga aaatatatat tatatacata gacatatata tatatataat
     2521 aggctgtata tattgctcag tagagaaaaa ccatggggga ctggtgatat gttgatcttt
     2581 ttcaaaaaaa tatatatatg acaaaaaaaa aaaaaaagga gcacaagctg tttgaaccac
     2641 caggtttatt tgtgtgtcta aataaacacc aaatagtacc aa
//
