LOCUS       XM_024450830            8624 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C alpha (PRKCA), transcript
            variant X4, mRNA.
ACCESSION   XM_024450830
VERSION     XM_024450830.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024450830.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..8624
                     /gene="PRKCA"
                     /gene_synonym="AAG6; PKC-alpha; PKCA; PKCalpha; PKCI+/-;
                     PRKACA"
                     /note="protein kinase C alpha; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 9
                     mRNAs, 25 ESTs, 1629 long SRA reads, 4 Proteins, and 98%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 12 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5578"
                     /db_xref="HGNC:HGNC:9393"
                     /db_xref="MIM:176960"
     CDS             158..1918
                     /gene="PRKCA"
                     /gene_synonym="AAG6; PKC-alpha; PKCA; PKCalpha; PKCI+/-;
                     PRKACA"
                     /codon_start=1
                     /product="protein kinase C alpha type isoform X3"
                     /protein_id="XP_024306598.1"
                     /db_xref="GeneID:5578"
                     /db_xref="HGNC:HGNC:9393"
                     /db_xref="MIM:176960"
                     /translation="MLSVSSWDSNDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGM
                     KCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDP
                     NGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWD
                     WDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQK
                     FEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE
                     ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
                     NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIK
                     IADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQP
                     PFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREH
                     AFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSD
                     FEGFSYVNPQFVHPILQSAV"
ORIGIN      
        1 cctgagacct gccgtgtgat cggacatctt ccaaataaaa gagcactgtc acctcccaga
       61 atgctacatg aatgaaacat acccacccat ctgagaactc tccttcgccc aacagtgtga
      121 tgagaaagtt gtctgttgca gatatctaca ctgctgcatg ctaagtgtgt catcctggga
      181 ttcaaacgac cccaggagca agcacaagtt caaaatccac acttacggaa gccccacctt
      241 ctgcgatcac tgtgggtcac tgctctatgg acttatccat caagggatga aatgtgacac
      301 ctgcgatatg aacgttcaca agcaatgcgt catcaatgtc cccagcctct gcggaatgga
      361 tcacactgag aagagggggc ggatttacct aaaggctgag gttgctgatg aaaagctcca
      421 tgtcacagta cgagatgcaa aaaatctaat ccctatggat ccaaacgggc tttcagatcc
      481 ttatgtgaag ctgaaactta ttcctgatcc caagaatgaa agcaagcaaa aaaccaaaac
      541 catccgctcc acactaaatc cgcagtggaa tgagtccttt acattcaaat tgaaaccttc
      601 agacaaagac cgacgactgt ctgtagaaat ctgggactgg gatcgaacaa caaggaatga
      661 cttcatggga tccctttcct ttggagtttc ggagctgatg aagatgccgg ccagtggatg
      721 gtacaagttg cttaaccaag aagaaggtga gtactacaac gtacccattc cggaagggga
      781 cgaggaagga aacatggaac tcaggcagaa attcgagaaa gccaaacttg gccctgctgg
      841 caacaaagtc atcagtccct ctgaagacag gaaacaacct tccaacaacc ttgaccgagt
      901 gaaactcacg gacttcaatt tcctcatggt gttgggaaag gggagttttg gaaaggtgat
      961 gcttgccgac aggaagggca cagaagaact gtatgcaatc aaaatcctga agaaggatgt
     1021 ggtgattcag gatgatgacg tggagtgcac catggtagaa aagcgagtct tggccctgct
     1081 tgacaaaccc ccgttcttga cgcagctgca ctcctgcttc cagacagtgg atcggctgta
     1141 cttcgtcatg gaatatgtca acggtgggga cctcatgtac cacattcagc aagtaggaaa
     1201 atttaaggaa ccacaagcag tattctatgc ggcagagatt tccatcggat tgttctttct
     1261 tcataaaaga ggaatcattt atagggatct gaagttagat aacgtcatgt tggattcaga
     1321 aggacatatc aaaattgctg actttgggat gtgcaaggaa cacatgatgg atggagtcac
     1381 gaccaggacc ttctgtggga ctccagatta tatcgcccca gagataatcg cttatcagcc
     1441 gtatggaaaa tctgtggact ggtgggccta tggcgtcctg ttgtatgaaa tgcttgccgg
     1501 gcagcctcca tttgatggtg aagatgaaga cgagctattt cagtctatca tggagcacaa
     1561 cgtttcctat ccaaaatcct tgtccaagga ggctgtttct gtctgcaaag gactgatgac
     1621 caaacaccca gccaagcggc tgggctgtgg gcctgagggg gagagggacg tgagagagca
     1681 tgccttcttc cggaggatcg actgggaaaa actggagaac agggagatcc agccaccatt
     1741 caagcccaaa gtgtgtggca aaggagcaga gaactttgac aagttcttca cacgaggaca
     1801 gcccgtctta acaccacctg atcagctggt tattgctaac atagaccagt ctgattttga
     1861 agggttctcg tatgtcaacc cccagtttgt gcaccccatc ttacagagtg cagtatgaaa
     1921 ctcaccagcg agaacaaaca cctccccagc ccccagccct ccccgcagtg ggaagtgaat
     1981 ccttaaccct aaaattttaa ggccacggcc ttgtgtctga ttccatatgg aggcctgaaa
     2041 attgtagggt tattagtcca aatgtgatca actgttcagg gtctctctct tacaaccaag
     2101 aacattatct tagtggaaga tggtacgtca tgctcagtgt ccagtttaat tctgtagaag
     2161 ttacgtctgg ctctaggtta acccttccta gaaagcaagc agactgttgc cccattttgg
     2221 gtacaatttg atatactttc cataccctcc atctgtggat ttttcagcat tggaatcccc
     2281 caaccagaga tgttaaagtg agcctgtccc aggaaacatc tccacccaag acgtctttgg
     2341 aatccaagaa caggaagcca agagagtgag cagggaggga ttgggggtgg gggaggcctc
     2401 aaaataccga ctgcgtccat tctctgcctc catggaaaca gcccctagaa tctgaaaggc
     2461 cgggataaac ctaatcactg ttcccaaaca ttgacaaatc ctaacccaac catggtccag
     2521 cagttaccag tttaaacaaa aaaacctcag atgagtgttg ggtgaatctg tcatctggta
     2581 ccctccttgg ttgataactg tcttgatact tttcattctt tgtaagaggc caaatcgtct
     2641 aaggacgttg ctgaacaagc gtgtgaaatc atttcagatc aaggataagc cagtgtgtac
     2701 atatgttcat tttaatctct gggagattat ttttccatcc agggtgccat cagtaatcat
     2761 gccactactc accagtgttg ttcaccaaca cccaccccca cacacaccaa cattttgctg
     2821 cctaccttgt tatccttctc aagaagctga agtgtacgcc ctctcccctt ttgtgcttat
     2881 ttatttaata ggctgcagtg tcgcttatga aagtacgatg tacagtaact taatggaagt
     2941 gctgactcta gcatcagcct ctaccgattg attttcctcc cttctctagc cctggatgtc
     3001 cacttaggga taaaaagaat atggttttgg ttcccatttc tagttcacgt tgaatgacag
     3061 gcctggagct gtagaatcag gaaacccgga tgcctaacag ctcaaagatg ttttgttaat
     3121 agaaggattt taatacgttt tgcaaatgca tcatgcaatg aattttgcat gtttataata
     3181 aaccttaata acaagtgaat ctatattatt gatataatcg tatcaagtat aaagagagta
     3241 ttataataat tttataagac acaattgtgc tctatttgtg caggttcttg tttctaatcc
     3301 tcttttctaa ttaagtttta gctgaatccc ttgcttctgt gctttccctc cctgcacatg
     3361 ggcactgtat cagatagatt actttttaaa tgtagataaa atttcaaaaa tgaatggcta
     3421 gtttacgtga tagattaggc tcttactaca tatgtgtgtg tatatatatg tatttgattc
     3481 tacctgcaaa caaattttta ttggtgagga ctatttttga gctgacactc cctcttagtt
     3541 tcttcatgtc acctttcgtc ctggttcctc cgccactctt cctcttgggg acaacaggaa
     3601 gtgtctgatt ccagtctgcc tagtacgttg gtacacacgt ggcattgccg cagcacctgg
     3661 gctgaccttt gtgtgtgcgt gtgtgtgtgt ttccttcttc ccttcagcct gtgactgttg
     3721 ctgactccag gggtgggagg gatggggaga ctcccctctt gctgtgtgta ctggacacgc
     3781 aggaagcatg ctgtcttgct gcctctgcaa cgacctgtcg tttgctccag catgcacaaa
     3841 cttcgtgaga ccaacacagc cgtgccctgc aggcaccagc acgtgctttt cagaggctgc
     3901 ggactttctt ccagccattg tggcattggc ctttccagtc ttgggaggag cgcgctgctt
     3961 tggtgagaca cccccatgca aggtcctcag agtagccggg ttctaccaca aacagaaaca
     4021 gaatgaaagt agctgtcagt ccttgtagag agccgctctg tttcctccca gaagcatctc
     4081 ccagctaagc tcgcattatt tttctcctct ggctgtttgc ctgaagttca cagaacacac
     4141 aaccatgaaa ggctttttga ggtgagaggc ccaggtggtc ctggcaaccc tgagtagaag
     4201 gagagacggg gtagggaacg ggcccggcca gaaaagaacc atttcttctg ccatctttta
     4261 tgcaccatag acatcgagac tccagggggt cctggctccc ctgtccctgc agccctgcag
     4321 gtcagtgcat gatctgggtt cgtgtcctga ccaggtgctc ctcctttgat ccgaggggaa
     4381 agggactggt ttatagaaag agcctaggag acaaaagggc cagtccccct gcccagaatg
     4441 gagcagcagc aggacagacc cccacgaggc cccccagaga ggaggaagat cccacggagg
     4501 aacacatgag gttagggacc cttgttcagc accccaaaca gcctgcctgt ttaaagcagg
     4561 cagcaggctt aggccttccc tgcaacccca acacccacaa gtttgtttct ctaggaaaca
     4621 cattcactgt ctcagctggc tgttactctc tcagaccata tggcaaagtt ttccaagaaa
     4681 atgccccgac aggggtgccc agcacactgc ctgagggaca acagacatca gaacaaaccc
     4741 ccagagagaa acagtcaaaa tcagggcccg gtgcagtgtt gtcatgtgga acctgcttta
     4801 tccattgctg agtgttgaat gtgggtaatg gttagggctt tccagatctc agcagccaaa
     4861 gacagttatt gttggaagac tgtcatgtag ataaccatga gcaatggctc gcctcagaat
     4921 cagttcataa aattctatgg tactggcccc ttcgtgggta ttgtgtgaaa tgagatggtg
     4981 gcgaggggtg cgctgtggaa ctgccgcagc cacgcaggag gtccctgggg gatgctttgg
     5041 gaagtccttg cccctgagca ctgcctgatt gccagggcct gtggaggtct aggccgcctg
     5101 gcagaatcta gcaccgtccg aatccccgca ggacccatgg agctatgacc acaccaggcc
     5161 attcaaatgg ctctgcatta tcttcccttg gaaggtggcc actcctcggt ggcagggcct
     5221 ttccctgagg ctgcaggccg tgggctggca gcccgtctct tggcatttca attgaaggtc
     5281 accaggtgct gggtttgaaa ggaagtcact ggagtgctgc caggggccgc cctccaaggt
     5341 taatgagagg cccacatcca ggcaagaact aattcaaaag gcagatcaga aaccacagga
     5401 gtcaaaatta ttgctccggc agtgcttccc ttcctttcat ccactggcct cgtgtggtcc
     5461 atgcagggcc actgtctgcc ctttctgatg ccacgtatta ggctttctta ctcagaattt
     5521 tgatagaaaa ccatggggcc aagagctctg gaagcctggc cggaaagacc aaggttcatg
     5581 cagcccaaca aatgattgtt gagcacctct cggagccaaa gtccttaggc gagtgtggtg
     5641 acttcctgga aggaggatgc agacttccag agagcccccc caacggacgt gctgagaagg
     5701 gagagggagg cgggggctgt agtcaggaag gagccagaga agaacagggt ttgggtgcat
     5761 ccagaaatat gcctgcagta ggagggagag gaaggggtgc caccgtcaac ggcttcccat
     5821 cggaggtggt tggtgcagat ggaagtttct gtctgctggc cctcaagaga gtgttttgcc
     5881 agggacacag tctgttcctc ctcagaaaac accccccaaa tgctaacaac atccccacca
     5941 gctgctagaa gcccctttcc cctccccacc ttgaagtagc tcatagttct ctgggcagag
     6001 ccagaccatc cagtgtaccc cagaggccag taggttcctg cccattttcc tctctggctt
     6061 cctgccaaga attatggcag ctgaggatga atggagaagt aaaaacaact aacaccgcac
     6121 aactaacaac taacaccgca gttcccacct gggttccact tagcaggaga catttcggag
     6181 ggtttttttt gtttttgttc ctgttttttt tttttttgct ggaatttgtt ttctcagtac
     6241 tgaaaagaga aaaagtgaca atcttgtatt tttaaaagcc tcggaaaggt gataccatct
     6301 gacagtcatt ttctcacgtt ggtcttctaa agtcacctat ttcttgtgtg tgcacatcac
     6361 accatttcct gtttctttat aacccgacaa gggtaggagt gcctgtttcc cctgctgggc
     6421 acaccagaca atcgtaatca caaaacagac actgagccag gggcccaaag ggtgtgatca
     6481 tgagagttac cgggacagca gtaggcatga cagtcaccag gaaggacaag ggtgctctgt
     6541 tgttagtggc cacacaccaa tttgacaagg agtgttgcga aatttttatt tatttattta
     6601 tttattttga gatggagttt cactcttgtt gcccaggctg gagtgcggtg gtacaatctc
     6661 ggctcactgc aacctccacc tcccaggttc aagcgattct cctgcctcag cctcccaagt
     6721 acctgggact acaggtgcgt gccaccacac ccagctaaat tttgtgtttt tagtagagat
     6781 ggggtttcac catgttggcc aggatggtct tgaacccctg acctcatgat ctgcctgcct
     6841 cggcctccca aagtgctggg attacaggca tgagccacca cgcccagcca aaatattttt
     6901 ttaaagtcat tttccttaag ctgcttgggc tacatgtgaa atacactgga cggtcaacat
     6961 tcctgtctcc tcccatttgg gctgatgcag cagatccagg gaatgttacc tgtttctgct
     7021 gctagaagat ccaggaaatt gggaaggtta cctgacgcac acatggatga aggccatcat
     7081 ctagaaatgg ggtcaaccac aattgtgtta attccgtagt gtcagggatt cttcgggaag
     7141 gtcaacagta tgaaggattc tgacccctgt gcctcccatt tatgtgatca ggtgacagtt
     7201 aataaccgtg gaggtcacac tcagccatcc aacagcctta cagtgaccct acacaaaagc
     7261 ccccaaattc caaagacttt ttcttaacct aaaggaagaa attatttgtt aattccagta
     7321 gagcaactga atatactggg ctatttgtac ttttttatag agaactttaa taataattct
     7381 ttaaaaatga gtttttagaa caaagcaact gacgatttcc taagattcca atgccctgga
     7441 gcttgtagga ggacttagcc tgggtcagct ggagcacccc cgacctgatc tcccactgcc
     7501 agattttccc atgctcctag ggtatggagt ccacgtggga atgactgcaa gttcaggtgg
     7561 aacttggccg actgatgctc tgcgagtttt taatagacac tggggacaac tgcttaaggt
     7621 ttagaaactt ccaaaccaca ggaaagacat ttttagtgtc ccccatccag aggcagccct
     7681 ggaataggat tcccaggggt ttctgggacc cctttccttg ctccgtgagg ctctgtggcc
     7741 atcttttggc aggaggagga tgcttccttg gctctgtgcc cagacccgcc tggtccccag
     7801 gtctctcacc ttgggtgaag attcagagat gccctgtaag gattttgccc actgggcaac
     7861 tcagaaatac ttcgatctcc caagatataa gaggcagcag caaacgtgcc tattgacgtc
     7921 tgtttcatag ttaccactta cgcgagtaga cagaactcgg cttttcagaa aataggtgtc
     7981 aagtccactt tataagaacc tttttttcta aaataagata aaaggtggct ttgcattttc
     8041 tgattaaacg actgtgtctt tgtcacctct gcttaacttt aggagtatcc attcctgtga
     8101 ttgtagactt ttgttgatat tcttcctgga agaatatcat tcttttcttg aagggttggt
     8161 ttactagaat attcaaaatc aatcatgaag gcagttacta ttttgagtct aaaggttttc
     8221 taaaaattaa cctcacatcc cttctgttag ggtctttcag aatatctttt ataaacagaa
     8281 gcatttgaag tcattgcttt tgctacatga tttgtgtgtg tgaaggacat accacgttta
     8341 aatcattaat tgaaaaacat catataagcc ccaactttgt ttggaggaag agacggaggt
     8401 tgaggttttt ccttctgtat aagcacctac tgacaaaatg tagaggccat tcaaccgtca
     8461 aacaccattt ggttatatcg cagaggagac ggatgtgtaa attactgcat tgcttttttt
     8521 ttcagtttgt ataacctcta atctccgttt gcatgatacg ctttgttaga aacattaatt
     8581 gtagtttgga agcaagtgtg tatgaataaa gataatgatc attc
//
