LOCUS       XM_017024836            3966 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein kinase C alpha (PRKCA), transcript
            variant X1, mRNA.
ACCESSION   XM_017024836
VERSION     XM_017024836.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017024836.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..3966
                     /gene="PRKCA"
                     /gene_synonym="AAG6; PKC-alpha; PKCA; PKCalpha; PKCI+/-;
                     PRKACA"
                     /note="protein kinase C alpha; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 8 ESTs, 46 long SRA reads, 9 Proteins, and 98%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 16 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5578"
                     /db_xref="HGNC:HGNC:9393"
                     /db_xref="MIM:176960"
     CDS             240..2177
                     /gene="PRKCA"
                     /gene_synonym="AAG6; PKC-alpha; PKCA; PKCalpha; PKCI+/-;
                     PRKACA"
                     /codon_start=1
                     /product="protein kinase C alpha type isoform X1"
                     /protein_id="XP_016880325.1"
                     /db_xref="GeneID:5578"
                     /db_xref="HGNC:HGNC:9393"
                     /db_xref="MIM:176960"
                     /translation="MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFF
                     KQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKH
                     KFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRG
                     RIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRST
                     LNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYK
                     LLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRV
                     KLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA
                     LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG
                     LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE
                     IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAV
                     SVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVTLCTKM
                     HWLQWASRSSVSTFPEPWVTK"
ORIGIN      
        1 gtcagtgagc ctggggccag cgggcgagcc agcggctccg gctcccgctc ccgctccgcg
       61 cagcaccagc ccgactctcc ccggcccccg ccgcgccccc tcgccgcgac ctcggccacc
      121 ggcccgcgcc ccgcgcccgg ggtcgccccg agcccgcacc tctcccccgc cgcccccgcc
      181 cacccggccc tccgcggccg cagctccccg gcggaggcaa gaggtggttg ggggggacca
      241 tggctgacgt tttcccgggc aacgactcca cggcgtctca ggacgtggcc aaccgcttcg
      301 cccgcaaagg ggcgctgagg cagaagaacg tgcacgaggt gaaggaccac aaattcatcg
      361 cgcgcttctt caagcagccc accttctgca gccactgcac cgacttcatc tgggggtttg
      421 ggaaacaagg cttccagtgc caagtttgct gttttgtggt ccacaagagg tgccatgaat
      481 ttgttacttt ttcttgtccg ggtgcggata agggacccga cactgatgac cccaggagca
      541 agcacaagtt caaaatccac acttacggaa gccccacctt ctgcgatcac tgtgggtcac
      601 tgctctatgg acttatccat caagggatga aatgtgacac ctgcgatatg aacgttcaca
      661 agcaatgcgt catcaatgtc cccagcctct gcggaatgga tcacactgag aagagggggc
      721 ggatttacct aaaggctgag gttgctgatg aaaagctcca tgtcacagta cgagatgcaa
      781 aaaatctaat ccctatggat ccaaacgggc tttcagatcc ttatgtgaag ctgaaactta
      841 ttcctgatcc caagaatgaa agcaagcaaa aaaccaaaac catccgctcc acactaaatc
      901 cgcagtggaa tgagtccttt acattcaaat tgaaaccttc agacaaagac cgacgactgt
      961 ctgtagaaat ctgggactgg gatcgaacaa caaggaatga cttcatggga tccctttcct
     1021 ttggagtttc ggagctgatg aagatgccgg ccagtggatg gtacaagttg cttaaccaag
     1081 aagaaggtga gtactacaac gtacccattc cggaagggga cgaggaagga aacatggaac
     1141 tcaggcagaa attcgagaaa gccaaacttg gccctgctgg caacaaagtc atcagtccct
     1201 ctgaagacag gaaacaacct tccaacaacc ttgaccgagt gaaactcacg gacttcaatt
     1261 tcctcatggt gttgggaaag gggagttttg gaaaggtgat gcttgccgac aggaagggca
     1321 cagaagaact gtatgcaatc aaaatcctga agaaggatgt ggtgattcag gatgatgacg
     1381 tggagtgcac catggtagaa aagcgagtct tggccctgct tgacaaaccc ccgttcttga
     1441 cgcagctgca ctcctgcttc cagacagtgg atcggctgta cttcgtcatg gaatatgtca
     1501 acggtgggga cctcatgtac cacattcagc aagtaggaaa atttaaggaa ccacaagcag
     1561 tattctatgc ggcagagatt tccatcggat tgttctttct tcataaaaga ggaatcattt
     1621 atagggatct gaagttagat aacgtcatgt tggattcaga aggacatatc aaaattgctg
     1681 actttgggat gtgcaaggaa cacatgatgg atggagtcac gaccaggacc ttctgtggga
     1741 ctccagatta tatcgcccca gagataatcg cttatcagcc gtatggaaaa tctgtggact
     1801 ggtgggccta tggcgtcctg ttgtatgaaa tgcttgccgg gcagcctcca tttgatggtg
     1861 aagatgaaga cgagctattt cagtctatca tggagcacaa cgtttcctat ccaaaatcct
     1921 tgtccaagga ggctgtttct gtctgcaaag gactgatgac caaacaccca gccaagcggc
     1981 tgggctgtgg gcctgagggg gagagggacg tgagagagca tgccttcttc cggaggatcg
     2041 actgggaaaa actggagaac agggagatcc agccaccatt caagcccaaa gtgactttgt
     2101 gtaccaaaat gcactggctt cagtgggcct ccaggtcttc ggtgagcacg tttccagaac
     2161 cttgggtgac taaatgagca aactaacccc actttataac ccttaaccgt gtgcccctgc
     2221 ttgtgttggt catgcacgta gcccgttccc tgagcatgct aatcttcaga gaaagggcag
     2281 accaatggcc agaccccttt gctggatagc tccttagtat ggacattacc tcccaggaag
     2341 cccaagtgaa atgcaccagc ccatttctgc tgttatttaa cttaaaagaa gacgctgtgc
     2401 aaccacaagt cagagagctg tgcagatggt ggcgatgcgg ttgctaaggc gctccactgt
     2461 accccagcac tgggacctga atacaagtga gggttcccct acgatgaagt acctcctgca
     2521 tttggtcatc gtaaggggta gctcccacct cgttaggttt cctttctcca tagtcttgca
     2581 acatcccttt actctttatt tgttctgcat ctttcctctt cttctgggtt ttgtttggtt
     2641 ttgcttttta acagcagtgt tttgagctac tcatatttcc cataattccc atagctgaga
     2701 ccatggggtt gtattctaca tgactgagac gccgaggtaa agggcagggg tgagaccaac
     2761 acgtgtattg ctcatgctca gaggcctctc ccaggtaaga atcagccacg aagccaactc
     2821 ctgcattgca tctcagtctc ccccacaccc tatcacagaa tgaaaggggc tgtgagcaat
     2881 gtgtttgcca cacaaggctc cagtgggggc acactgcaat cccagattcc acccagagtc
     2941 cgtgtcattc atgttttgta acatctttac caatgcctga tttctcttgg gtccgttgca
     3001 ttcattgaag tttgaccaaa tgggtaggaa tatcaaaaac gacaaaggag ttcattcctg
     3061 aatccagaga tcagaaagag ggaggtagct tattaataac gttccttcgt ccctcagaga
     3121 tcgatcacat gccttttaca tgctagtgct tgcttcgcag ggtgtaccct atgtctgtcc
     3181 tgcctcctcg ctgaggaagg gcctcatgcc cactagttcc ctggatcctc acaacagcct
     3241 gggaaggtgg atggtcacat caccatctta ccttcgcaga gagatgcact gagtttgcca
     3301 aagctatata cattggggct cttgatctct ggccacatcc ttctcccctc tgtgtcccca
     3361 ctttcccttg ggtgccgaca tcgcctggtc tcagggagtt cagcagtcac acgctgactg
     3421 gttgggtctg accaccccag tgccctcttc ccctttatct ctgtcccata cccatcgtgt
     3481 ggtacgtcac atcccagagg gcaaaagcct cagtcggcaa aaggcgcggg tgacctttgg
     3541 aggtggagac agtgcgcacc cagcccagtt ttgctcacaa ggtataaatg ttacttttag
     3601 tggccatgtg ctgttgggtg gcctacagct ctgaggccat ggacagccac acctgcccgc
     3661 tgtcacagac tgctgtagag gctgcccttc caatggaggt ggtgatccac ctgcctgcct
     3721 catccctgag gagtggcggg aggctgcctg cagtcatctt ttactcattc acttggcgtt
     3781 catgcagtca tgctaggtgc cccctcagcc ctttagcctc tttgcttctt cttgctccct
     3841 gctcagctcc aagatggcac ccgaggccat tgcccatcaa gctcatggtg atgagtaagg
     3901 ttagatcatt gatagtagga agaatctctt ccacattagg aatgcagtac cttcttgaat
     3961 ctactg
//
