LOCUS       NM_002736               3689 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein kinase cAMP-dependent type II regulatory
            subunit beta (PRKAR2B), mRNA.
ACCESSION   NM_002736
VERSION     NM_002736.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Palencia-Campos,A., Aoto,P.C., Machal,E.M.F., Rivera-Barahona,A.,
            Soto-Bielicka,P., Bertinetti,D., Baker,B., Vu,L.,
            Piceci-Sparascio,F., Torrente,I., Boudin,E., Peeters,S., Van
            Hul,W., Huber,C., Bonneau,D., Hildebrand,M.S., Coleman,M.,
            Bahlo,M., Bennett,M.F., Schneider,A.L., Scheffer,I.E., Kibaek,M.,
            Kristiansen,B.S., Issa,M.Y., Mehrez,M.I., Ismail,S., Tenorio,J.,
            Li,G., Skalhegg,B.S., Otaify,G.A., Temtamy,S., Aglan,M.,
            Jonch,A.E., De Luca,A., Mortier,G., Cormier-Daire,V., Ziegler,A.,
            Wallis,M., Lapunzina,P., Herberg,F.W., Taylor,S.S. and
            Ruiz-Perez,V.L.
  TITLE     Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple
            Congenital Malformation Syndrome
  JOURNAL   Am J Hum Genet 107 (5), 977-988 (2020)
   PUBMED   33058759
REFERENCE   4  (bases 1 to 3689)
  AUTHORS   Xia,L., Sun,J., Xie,S., Chi,C., Zhu,Y., Pan,J., Dong,B., Huang,Y.,
            Xia,W., Sha,J. and Xue,W.
  TITLE     PRKAR2B-HIF-1alpha loop promotes aerobic glycolysis and tumour
            growth in prostate cancer
  JOURNAL   Cell Prolif 53 (11), e12918 (2020)
   PUBMED   33025691
  REMARK    GeneRIF: PRKAR2B-HIF-1alpha loop promotes aerobic glycolysis and
            tumour growth in prostate cancer.
REFERENCE   5  (bases 1 to 3689)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 3689)
  AUTHORS   Luo,Z., Singh,I.S., Fujihira,T. and Erlichman,J.
  TITLE     Characterization of a minimal promoter element required for
            transcription of the mouse type II beta regulatory subunit (RII
            beta) of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 267 (34), 24738-24747 (1992)
   PUBMED   1332964
REFERENCE   7  (bases 1 to 3689)
  AUTHORS   Solberg,R., Sistonen,P., Traskelin,A.L., Berube,D., Simard,J.,
            Krajci,P., Jahnsen,T. and de la Chapelle,A.
  TITLE     Mapping of the regulatory subunits RI beta and RII beta of
            cAMP-dependent protein kinase genes on human chromosome 7
  JOURNAL   Genomics 14 (1), 63-69 (1992)
   PUBMED   1358799
REFERENCE   8  (bases 1 to 3689)
  AUTHORS   Rios,R.M., Celati,C., Lohmann,S.M., Bornens,M. and Keryer,G.
  TITLE     Identification of a high affinity binding protein for the
            regulatory subunit RII beta of cAMP-dependent protein kinase in
            Golgi enriched membranes of human lymphoblasts
  JOURNAL   EMBO J 11 (5), 1723-1731 (1992)
   PUBMED   1582408
REFERENCE   9  (bases 1 to 3689)
  AUTHORS   Hofmann,B., Nishanian,P., Baldwin,R.L., Insixiengmay,P., Nel,A. and
            Fahey,J.L.
  TITLE     HIV inhibits the early steps of lymphocyte activation, including
            initiation of inositol phospholipid metabolism
  JOURNAL   J Immunol 145 (11), 3699-3705 (1990)
   PUBMED   1978848
REFERENCE   10 (bases 1 to 3689)
  AUTHORS   Tortora,G., Clair,T. and Cho-Chung,Y.S.
  TITLE     An antisense oligodeoxynucleotide targeted against the type II beta
            regulatory subunit mRNA of protein kinase inhibits cAMP-induced
            differentiation in HL-60 leukemia cells without affecting phorbol
            ester effects
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 705-708 (1990)
   PUBMED   1689049
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006387.3, CF593944.1,
            AL559918.3, M31158.1, CA405423.1, AK128639.1 and BQ022817.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002736.2.
            
            Summary: cAMP is a signaling molecule important for a variety of
            cellular functions. cAMP exerts its effects by activating the
            cAMP-dependent protein kinase, which transduces the signal through
            phosphorylation of different target proteins. The inactive kinase
            holoenzyme is a tetramer composed of two regulatory and two
            catalytic subunits. cAMP causes the dissociation of the inactive
            holoenzyme into a dimer of regulatory subunits bound to four cAMP
            and two free monomeric catalytic subunits. Four different
            regulatory subunits and three catalytic subunits have been
            identified in humans. The protein encoded by this gene is one of
            the regulatory subunits. This subunit can be phosphorylated by the
            activated catalytic subunit. This subunit has been shown to
            interact with and suppress the transcriptional activity of the cAMP
            responsive element binding protein 1 (CREB1) in activated T cells.
            Knockout studies in mice suggest that this subunit may play an
            important role in regulating energy balance and adiposity. The
            studies also suggest that this subunit may mediate the gene
            induction and cataleptic behavior induced by haloperidol. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075800.1, SRR1660809.100739.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265717.5/ ENSP00000265717.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC006387.3         28791-28818
            29-121              CF593944.1         30-122
            122-328             AL559918.3         172-378
            329-1225            M31158.1           292-1188
            1226-1825           CA405423.1         75-674
            1826-2520           AK128639.1         1608-2302
            2521-3297           M31158.1           2483-3259
            3298-3688           AK128639.1         3080-3470
            3689-3689           BQ022817.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..3689
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /note="protein kinase cAMP-dependent type II regulatory
                     subunit beta"
                     /db_xref="GeneID:5577"
                     /db_xref="HGNC:HGNC:9392"
                     /db_xref="MIM:176912"
     exon            1..510
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1460
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /EC_number="2.7.11.1"
                     /note="cAMP-dependent protein kinase type II-beta
                     regulatory chain; H_RG363E19.2; protein kinase,
                     cAMP-dependent, regulatory subunit type II beta;
                     WUGSC:H_RG363E19.2; protein kinase, cAMP-dependent,
                     regulatory, type II, beta"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type II-beta
                     regulatory subunit"
                     /protein_id="NP_002727.2"
                     /db_xref="CCDS:CCDS5740.1"
                     /db_xref="GeneID:5577"
                     /db_xref="HGNC:HGNC:9392"
                     /db_xref="MIM:176912"
                     /translation="MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENE
                     RKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFN
                     APVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP
                     EQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNR
                     GSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPF
                     LKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE
                     ENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIM
                     KRNIATYEEQLVALFGTNMDIVEPTA"
     exon            511..546
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            547..599
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            600..683
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            684..790
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            791..944
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1046
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1121
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1187
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1326
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..3689
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /note="major polyA site"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
                     /note="hexamer: ATTAAA"
     polyA_site      3689
                     /gene="PRKAR2B"
                     /gene_synonym="PRKAR2; RII-BETA"
ORIGIN      
        1 cgctcagccg ccgccaccac acggagcaga cgcgcgccgg gagccgcggg ccgggccagc
       61 cgggccgccg gggcccagtg cgccgcgctc gcagccggta gcgcgccagc gccgtaggcg
      121 ctcgctcggc agccgcgggg ccctaggccg tgccggggag ggggcgaggg cggcgcccag
      181 gcgcctgccg ccccggaggc aggatgagca tcgagatccc ggcgggactg acggagctgc
      241 tgcagggctt cacggtggag gtgctgaggc accagcccgc ggacctgctg gagttcgcgc
      301 tgcagcactt cacccgcctg cagcaggaga acgagcgcaa aggcaccgcg cgcttcggcc
      361 atgagggcag gacctggggg gacctgggcg ccgctgccgg gggcggcacc cccagcaagg
      421 gggtcaactt cgccgaggag cccatgcagt ccgactccga ggacggggag gaggaggagg
      481 cggcgcccgc ggacgcaggg gcgttcaatg ctccagtaat aaaccgattc acaaggcgtg
      541 cctcagtatg tgcagaagct tataatcctg atgaagaaga agatgatgca gagtccagga
      601 ttatacatcc aaaaactgat gatcaaagaa ataggttgca agaggcttgc aaagacatcc
      661 tgctgtttaa gaatctggat ccggagcaga tgtctcaagt attagatgcc atgtttgaaa
      721 aattggtcaa agatggggag catgtaattg atcaaggtga cgatggtgac aacttttatg
      781 taattgatag aggcacattt gatatttatg tgaaatgtga tggtgttgga agatgtgttg
      841 gtaactatga taatcgtggg agtttcggcg aactggcctt aatgtacaat acacccagag
      901 cagctacaat cactgctacc tctcctggtg ctctgtgggg tttggacagg gtaaccttca
      961 ggagaataat tgtgaaaaac aatgccaaaa agagaaaaat gtatgaaagc tttattgagt
     1021 cactgccatt ccttaaatct ttggagtttt ctgaacgcct gaaagtagta gatgtgatag
     1081 gcaccaaagt atacaacgat ggagaacaaa tcattgctca gggagattcg gctgattctt
     1141 ttttcattgt agaatctgga gaagtgaaaa ttactatgaa aagaaagggt aaatcagaag
     1201 tggaagagaa tggtgcagta gaaatcgctc gatgctcgcg gggacagtac tttggagagc
     1261 ttgccctggt aactaacaaa cctcgagcag cttctgccca cgccattggg actgtcaaat
     1321 gtttagcaat ggatgtgcaa gcatttgaaa ggcttctggg accttgcatg gaaattatga
     1381 aaaggaacat cgctacctat gaagaacagt tagttgccct gtttggaacg aacatggata
     1441 ttgttgaacc cactgcatga agcaaaagta tggagcaaga cctgtagtga caaaattaca
     1501 cagtagtggt tagtccactg agaatgtgtt tgtgtagatg ccaagcattt tctgtgattt
     1561 caggtttttt ccttttttta catttacaac gtatcaataa acagtagtga tttaatagtc
     1621 aataggcttt aacatcactt tctaaagagt agttcataaa aaaatcaaca tactgataaa
     1681 atgactttgt actccacaaa attatgactg aaaggtttat taaaatgatt gtaatatata
     1741 gaaagtatct gtgtttaaga agataattaa aggatgttat cataggctat atgtgtttta
     1801 cttattcaga ctgataatca tattagtgac tatccccatg taagagggca cttggcaatt
     1861 aaacatgcta cacagcatgg catcactttt ttttataact cattaaacac agtaaaattt
     1921 taatcatttt tgttttaaag ttttctagct tgataagtta tgtgctggcc ttggcctatt
     1981 ggtgaaatgg tataaaatat catatgcagt tttaaaactt tttatatttt tgcaataaag
     2041 tacattttga ctttgttggc ataatgtcag taacatacat attccagtgg ttttatggac
     2101 aggcaattta gtcattatga taataaggaa aacagtgttt tagatgagag atcattaatg
     2161 catttttccc tcatcaagca tatatctgct tttttttatt ttgcaattct ctgtattcta
     2221 tgtctttaaa aatttgatct tgacatttaa tgtcacaaag ttttgttttt ttaaaaagtg
     2281 atttaaactt aagatccgac attttttgta ttctttaaga ttttacacct aaaaaatctc
     2341 tcctatccca aaaataatgt gggatcctta tcagcatgcc cacagtttat ttctttgttc
     2401 ttcactaggc ctgcataata cagtcctatg tagacatctg ttcccttggg tttccgttct
     2461 ttcttaggat ggttgccaac ccacaatctc attgatcagc agccaatatg ggtttgtttg
     2521 gtttttttaa ttcttaaaaa catcctctag aggaatagaa acaaattttt atgagcataa
     2581 ccctatataa agacaaaatg aatttctgac cttaccatat ataccattag gccttgccat
     2641 tgctttaatg tagactcata gttgaaatta gtgcagaaag aactcagatg tactagattt
     2701 tcattgttca ttgatatgct cagtatgctg ccacataaga tgaatttaat tatattcaac
     2761 caaagcaata tactcttaca tgatttctag gccccatgac ccagtgtcta gagacattaa
     2821 ttctaaccag ttgtttgctt ttaaatgagt gatttcattt tgggaaacag gtttcaaatg
     2881 aatatatata catgggtaaa attactctgt gctagtgtag tcttactaga gaatgtttat
     2941 ggtcccactt gtatatgaaa atgtggttag aatgttaatt ggataatgta tatataagaa
     3001 gttaaagtat gtaaagtata acttcagcca catttttaga acactgttta acatttttgc
     3061 aaaaccttct tgtaggaaaa gagagctctc tacatgaaga tgacttgttt tatatttcag
     3121 attttatttt aaaagccatg tctgttaaac aagaaaaaac acaaaagaac tccagattcc
     3181 tggttcatca ttctgtattc ttactcactt tttcaagtta tctattttgt tgcataaact
     3241 aattgttaac tattcatgga acagcaaacg cctgtttaat aaagaacttt gaccaaggct
     3301 ataaatgcca cgtacattat tttcagtatt gttggttata tttaaatttt ccttacaata
     3361 aagcacactt ttataataaa atacatgaat tattgttttt catacttttt tgcttgtttc
     3421 tttaaagttt tctgacgtgc ataatgcata attcattgaa aagcatgata gcaatgtggc
     3481 atgtggaagc gaacccccag ggcataacat agtaagaaag tatggttctg tatggcaata
     3541 ggtttttaaa attattagct attcatcatg tgtgggagaa ataattgtgg tgtgttgcag
     3601 atttatttgg ccatttagaa taaccaaatc aatctggcta actaggaatt tatgtgtaaa
     3661 attatctgat taaaacagct caagtttga
//
