LOCUS       NM_002732               1610 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit gamma
            (PRKACG), mRNA.
ACCESSION   NM_002732
VERSION     NM_002732.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Manchev,V.T., Hilpert,M., Berrou,E., Elaib,Z., Aouba,A.,
            Boukour,S., Souquere,S., Pierron,G., Rameau,P., Andrews,R.,
            Lanza,F., Bobe,R., Vainchenker,W., Rosa,J.P., Bryckaert,M.,
            Debili,N., Favier,R. and Raslova,H.
  TITLE     A new form of macrothrombocytopenia induced by a germ-line mutation
            in the PRKACG gene
  JOURNAL   Blood 124 (16), 2554-2563 (2014)
   PUBMED   25061177
  REMARK    GeneRIF: The missense p.74Ile>Met PRKACG mutation is associated
            with a marked defect in proplatelet formation and a low level in
            filamin A in megakaryocytes.
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Chung,S., Furihata,M., Tamura,K., Uemura,M., Daigo,Y., Nasu,Y.,
            Miki,T., Shuin,T., Fujioka,T., Nakamura,Y. and Nakagawa,H.
  TITLE     Overexpressing PKIB in prostate cancer promotes its aggressiveness
            by linking between PKA and Akt pathways
  JOURNAL   Oncogene 28 (32), 2849-2859 (2009)
   PUBMED   19483721
  REMARK    GeneRIF: Findings show that PKIB and PKA-C kinase can have critical
            functions of aggressive phenotype of PCs through Akt
            phosphorylation and that they should be a promising molecular
            target for PC treatment.
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Yum,J., Jeong,H.M., Kim,S., Seo,J.W., Han,Y., Lee,K.Y. and Yeo,C.Y.
  TITLE     PKA-mediated stabilization of FoxH1 negatively regulates ERalpha
            activity
  JOURNAL   Mol Cells 28 (1), 67-71 (2009)
   PUBMED   19711044
  REMARK    GeneRIF: Results suggest that PKA can negatively regulate ERalpha,
            at least in part, through FoxH1.
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Louiset,E., Stratakis,C.A., Perraudin,V., Griffin,K.J., Libe,R.,
            Cabrol,S., Feve,B., Young,J., Groussin,L., Bertherat,J. and
            Lefebvre,H.
  TITLE     The paradoxical increase in cortisol secretion induced by
            dexamethasone in primary pigmented nodular adrenocortical disease
            involves a glucocorticoid receptor-mediated effect of dexamethasone
            on protein kinase A catalytic subunits
  JOURNAL   J Clin Endocrinol Metab 94 (7), 2406-2413 (2009)
   PUBMED   19383776
  REMARK    GeneRIF: In human primary pigmented nodular adrenocortical disease
            tissues, dexamethasone paradoxically stimulates cortisol release
            through a glucocorticoid receptor-mediated effect on PKA catalytic
            subunits.
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Hofmann,B., Nishanian,P., Nguyen,T., Insixiengmay,P. and Fahey,J.L.
  TITLE     Human immunodeficiency virus proteins induce the inhibitory
            cAMP/protein kinase A pathway in normal lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6676-6680 (1993)
   PUBMED   7688126
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Foss,K.B., Simard,J., Berube,D., Beebe,S.J., Sandberg,M.,
            Grzeschik,K.H., Gagne,R., Hansson,V. and Jahnsen,T.
  TITLE     Localization of the catalytic subunit C gamma of the cAMP-dependent
            protein kinase gene (PRKACG) to human chromosome region 9q13
  JOURNAL   Cytogenet Cell Genet 60 (1), 22-25 (1992)
   PUBMED   1339328
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Hofmann,B., Nishanian,P., Baldwin,R.L., Insixiengmay,P., Nel,A. and
            Fahey,J.L.
  TITLE     HIV inhibits the early steps of lymphocyte activation, including
            initiation of inositol phospholipid metabolism
  JOURNAL   J Immunol 145 (11), 3699-3705 (1990)
   PUBMED   1978848
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC039888.1 and AL162730.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 6, 2020 this sequence version replaced NM_002732.3.
            
            Summary: Cyclic AMP-dependent protein kinase (PKA) consists of two
            catalytic subunits and a regulatory subunit dimer. This gene
            encodes the gamma form of its catalytic subunit. The gene is
            intronless and is thought to be a retrotransposon derived from the
            gene for the alpha form of the PKA catalytic subunit. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC039888.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377276.5/ ENSP00000366488.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1053              BC039888.1         11-1063
            1054-1054           AL162730.26        61796-61796         c
            1055-1585           BC039888.1         1065-1595
            1586-1610           AL162730.26        61240-61264         c
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..1610
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /note="protein kinase cAMP-activated catalytic subunit
                     gamma"
                     /db_xref="GeneID:5568"
                     /db_xref="HGNC:HGNC:9382"
                     /db_xref="MIM:176893"
     exon            1..1610
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1077
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /EC_number="2.7.11.11"
                     /note="PKA C-gamma; serine(threonine) protein kinase;
                     protein kinase, cAMP-dependent, catalytic, gamma; protein
                     kinase, cAMP-dependent, gamma catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     gamma"
                     /protein_id="NP_002723.2"
                     /db_xref="CCDS:CCDS6625.1"
                     /db_xref="GeneID:5568"
                     /db_xref="HGNC:HGNC:9382"
                     /db_xref="MIM:176893"
                     /translation="MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQF
                     ERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFP
                     FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS
                     LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK
                     AVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQV
                     DLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE
                     ELRISINEKCAKEFSEF"
     regulatory      1564..1569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /note="hexamer: AATAAA"
     polyA_site      1585
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /note="hexamer: ATTAAA"
     polyA_site      1610
                     /gene="PRKACG"
                     /gene_synonym="BDPLT19; KAPG; PKACg"
                     /note="major polyA site"
ORIGIN      
        1 gcccctgccg ccgccaccgc catgggcaac gcccccgcca agaaggacac cgagcaggag
       61 gagagcgtga acgagttcct agccaaagcc agaggagatt tcctctacag atggggaaac
      121 cccgctcaaa acaccgccag ctcggatcag ttcgaacggc tcaggacgct gggcatgggc
      181 tccttcgggc gggtgatgct ggtgaggcac caggagaccg gcggccacta cgccatgaag
      241 atcctcaaca agcagaaggt ggtgaagatg aagcaggtcg agcacatact gaacgagaag
      301 cgcatcctgc aggcgatcga ctttccgttc ctcgtcaagc tccagttctc ctttaaggac
      361 aactcctacc tgtacctggt gatggagtac gtgccgggtg gggagatgtt ctcccgccta
      421 cagcgcgtcg gaaggtttag cgagccccat gcctgtttct atgccgccca ggtcgtcctg
      481 gccgtccagt acctacactc gctcgacctc atccaccgcg acctgaagcc cgagaatctc
      541 ctcatcgacc agcagggcta cctgcaggtg acggacttcg gtttcgccaa gcgcgtgaag
      601 ggccgcactt ggaccttgtg cgggacccca gagtacctgg cccccgagat catcctgagc
      661 aaaggctaca acaaggccgt ggactggtgg gccctagggg tgctcatcta tgagatggcc
      721 gtgggcttcc cacccttcta cgccgaccag cccatccaga tctacgagaa gatcgtctct
      781 gggagggtgc ggtttccctc caaactcagc tctgacctca agcatctgct gcggagcctg
      841 ctgcaggtgg acctcaccaa gcgcttcgga aacctcagga acggggttgg cgacatcaag
      901 aaccacaagt ggttcgccac aaccagctgg atcgccatct atgagaagaa ggtggaagct
      961 cccttcatcc cgaagtacac aggccctggg gatgccagta actttgacga ctacgaggag
     1021 gaagagctcc ggatctccat caatgagaag tgtgccaagg agttttctga gttttagggg
     1081 tgtgcttgtg cccctgtggg ttttctttcc tttttgtttt tggtggtttg ggggatggga
     1141 gggttggatt gaacagccag agggccccag agttccttgt atctaatttc atcctcaccc
     1201 caccctccag ggttggggga gcaggaagcc cagatatttg gaggaacaga aacaccagct
     1261 gctccctcac ccccccccat gccttcctgg tccctctgtg cttctctctt tctcctccca
     1321 cagggtcccc cttgccccag cccccttctg cctgttttaa acgagtttct cagctctatt
     1381 caggccaggt cttgctgttg tatcaaggga cacggtgtgg aaagaggggc tcaaacttaa
     1441 ctccagccct gaacaggcac cacttactaa gagaggatga atgaaaagca cacctaccct
     1501 ttggcgtaat cctgcctggg aaggagagag gtttagtgcc atgttcagtg ggctgtttgc
     1561 tagaataaaa aattaaaaca aaaaacaatt aaaatcttat ttaagttcca
//
