LOCUS       NM_182948               4481 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 1, mRNA.
ACCESSION   NM_182948
VERSION     NM_182948.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4481)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4481)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4481)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4481)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4481)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX485407.1, M34181.1,
            BC035058.1, BX537705.1 and BX641026.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_182948.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as Cbeta2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX641026.1, SRR1803612.267708.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370685.7/ ENSP00000359719.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               BX485407.1         5-536
            533-1430            M34181.1           348-1245
            1431-3579           BC035058.1         1468-3616
            3580-4050           BX537705.1         3580-4050
            4051-4481           BX641026.1         4050-4480
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4481
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..278
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1288
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 1"
                     /protein_id="NP_891993.1"
                     /db_xref="CCDS:CCDS693.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MAAYREPPCNQYTGTTTALQKLEGFASRLFHRHSKGTAHDQKTA
                     LENDSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSF
                     GRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKD
                     NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPE
                     NLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLI
                     YEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKN
                     GVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCA
                     KEFGEF"
     exon            279..340
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            341..469
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            470..568
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            569..651
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            652..778
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            779..874
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            875..997
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1162
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..4481
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4454..4459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4481
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 acatgcatag ctcttagctt ctgtgtaaga agttgtgagc tccttctgga aacatttgca
       61 gttacattaa gtaaagtgta aatgcacatg aatggcagct tatagagaac caccttgtaa
      121 ccagtataca ggtacaacta cagctcttca gaaattggaa ggttttgcta gccggttatt
      181 tcatagacac tctaaaggta ctgcacatga tcagaaaaca gctctggaaa atgacagcct
      241 tcatttctct gaacatactg ccttatggga cagatcaatg aaagagtttc tagccaaagc
      301 caaagaagac tttttgaaaa aatgggagaa tccaactcag aataatgccg gacttgaaga
      361 ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga agagtcatgt tggtaaaaca
      421 caaagccact gaacagtatt atgccatgaa gatcttagat aagcagaagg ttgttaaact
      481 gaagcaaata gagcatactt tgaatgagaa aagaatatta caggcagtga attttccttt
      541 ccttgttcga ctggagtatg cttttaagga taattctaat ttatacatgg ttatggaata
      601 tgtccctggg ggtgaaatgt tttcacatct aagaagaatt ggaaggttca gtgagcccca
      661 tgcacggttc tatgcagctc agatagtgct aacattcgag tacctccatt cactagacct
      721 catctacaga gatctaaaac ctgaaaatct cttaattgac catcaaggct atatccaggt
      781 cacagacttt gggtttgcca aaagagttaa aggcagaact tggacattat gtggaactcc
      841 agagtatttg gctccagaaa taattctcag caagggctac aataaggcag tggattggtg
      901 ggcattagga gtgctaatct atgaaatggc agctggctat cccccattct ttgcagacca
      961 accaattcag atttatgaaa agattgtttc tggaaaggtc cgattcccat cccacttcag
     1021 ttcagatctc aaggaccttc tacggaacct gctgcaggtg gatttgacca agagatttgg
     1081 aaatctaaag aatggtgtca gtgatataaa aactcacaag tggtttgcca cgacagattg
     1141 gattgctatt taccagagga aggttgaagc tccattcata ccaaagttta gaggctctgg
     1201 agataccagc aactttgatg actatgaaga agaagatatc cgtgtctcta taacagaaaa
     1261 atgtgcaaaa gaatttggtg aattttaaag aggaacaaga tgacatctga gctcacactc
     1321 agtgtttgca ctctgttgag agataaggta gagctgagac cgtccttgtt gaagcagtta
     1381 cctagttcct tcattccaac gactgagtga ggtctttatt gccatcatcc cgtgtgcgca
     1441 ctctgcatcc acctatgtaa caaggcaccg ctaagcaagc attgtctgtg ccataacaca
     1501 gtactagacc actttcttac ttctctttgg gttgtctttc tcctctccta tatccatttc
     1561 ttccttttcc aatttcattg gttttctcta aacagtgctc cattttattt tgttggtgtt
     1621 tcagatgggc agtgttatgg ctacgtgata tttgaaggga aggataagtg ttgctttcag
     1681 tagttattgc caatattgtt gttggtcaat ggcttgaaga taaactttct aataattatt
     1741 atttctttga gtagctcaga cttggttttg ccaaaactct tggtaatttt tgaagataga
     1801 ctgtcttatc accaaggaaa tttatacaaa ttaagactaa ctttcttgga attcactatt
     1861 ctggcaataa attttggtag actaatacag tacagctaga cccagaaatt tggaaggctg
     1921 tagatcagag gttctagttc cctttccctc cttttatatc ctcctctcct tgagtaatga
     1981 agtgaccagc ctgtgtagtg tgacaaacgt gtctcattca gcaggaaaaa ctaatgatat
     2041 ggatcatcac ccagattctc tcacttggta ccagcatttc tgtaggtatt agagaagagt
     2101 tctaagtttt ctaaacctta actgttcctt aaggatttta gccagtattt taatagaaca
     2161 tgattaatga aagtgacaaa ttttaaattt tctctaatag tcctcatcat aaacttttta
     2221 aaggaaaata agcaaactaa aaagaacatt ggtttagata aatacttata ctttgcaaag
     2281 tcaaaaatgg cttgattttt ggaaacaata tagaggtatt catatttaaa tgagggttta
     2341 catttgtttt gttttgtaac cgttaaaaag aagttgtttc cagctaatta ttgtggtgta
     2401 ctatatttgt gagcctaggg taggggcact gctgcaactt ctgctttcat cccatgcctc
     2461 atcaatgagg aaagggaaca aagtgtataa aactgccaca attgtatttt aattttgagg
     2521 tatgatattt tcagatattt cataatttct aacctctgtt ctctcagtaa acagaatgtc
     2581 tgatcgatca tgcagataca atgttggtat ttgagaggtt agtttttttc ctacactttt
     2641 ttttgccaac tgacttaaca acattgctgt caggtggaaa tttcaagcac ttttgcacat
     2701 ttagttcagt gtttgttgag aatccatggc ttaacccact tgttttgcta tttttttctt
     2761 tgcttttaat tttccccatc tgattttatc tctgcgtttc agtgacctac cttaaaacaa
     2821 cacacgagaa gagttaaact gggttcattt taatgatcaa tttacctgca tataaaattt
     2881 atttttaatc aagctgatct taatgtatat aatcattcta tttgctttat tatcggtgca
     2941 ggtaggtcat taacaccact tcttttcatc tgtaccacac cctggtgaaa cctttgaaga
     3001 cataaaaaaa acctgtctga gatgttcttt ctaccaatct atatgtcttt cggttatcaa
     3061 gtgtttctgc atggtaatgt catgtaaatg ctgatattga tttcactggt ccatctatat
     3121 ttaaaacgtg caagaaaaaa ataaaatact ctgctctagc aagttttgtg taacaaaggc
     3181 atatcgtcat gttaataaat ttaaaacatc attcgtataa aatattttaa ttttcttgta
     3241 tttcatttag acccaagaac atgctgacca atgtgttcta tatgtaaact acaaattcta
     3301 tggtagcttt gttgtatatt attgtaaaat tattttaata agtcatgggg atgacaattt
     3361 gattattaca atttagtttt cagtaatcaa aaagatttct atgaattcta aaaaatattt
     3421 ttttctatga aattactagt gcccagctgt agaatctacc ttaggtagat gatccctaga
     3481 catacgttgg ttttgagggc tattcagcca ttccatttta ctctctattt aaaggccgtg
     3541 agcaagcttg tcatgagcaa atatgtcaag ggagtcaatt tctgaccaat caagtacact
     3601 aaattagaat atttttaaag tatgtaacat tcccagtttc agccacaatt tagccaagaa
     3661 taagataaaa acttgaataa gaagtaagta gcataaatca gtatttaacc taaaattaca
     3721 tatttgaaac agaagatatt atgttatgct cagtaaataa ttaagagatg gcattgtgta
     3781 agaaggagcc ctagactgaa agtcaagaca tctgaatttc aggctggaaa actatcagta
     3841 tgatctcagc ctcagttctc ttgtctgtaa aatggaagaa ctggattagg cagtttgtaa
     3901 gattcctcct aactttcaca gtcgatgaca agattgtctt tttatctgat attttgaagg
     3961 gtatattgct ttgaagtaag tctcaataag gcaatatatt ttagggcatc tttcttctta
     4021 tctctgacag tgttcttaaa attatttgaa tatcataaga gccttggtgt ctgtcctaat
     4081 tcctttctca ctcaccgatg ctgaataccc agttgaatca aactgtcaac ctaccaaaaa
     4141 cgatattgtg gcttatgggt attgctgtct cattcttggt atattcttgt gttaactgcc
     4201 cattggcctg aaaatactca ttgtaagcct gaaaaaaaaa atctttccca ctgttttttc
     4261 tgcttgttgt aagaatcaaa tgaaataatg tatgtgaaag caccttgtaa actgtaacct
     4321 atcaatgtaa aatgttaagg tgtgttgtta tttcattaat tacttctttg tttagaatgg
     4381 aatttcctat gcactactgt agctaggaaa tgctgaaaac aactgtgttt tttaattaat
     4441 caataactgc aaaattaaag taccttcaat ggataagaca a
//
