LOCUS       NM_002731               4496 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 2, mRNA.
ACCESSION   NM_002731
VERSION     NM_002731.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4496)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4496)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4496)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4496)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4496)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4496)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4496)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4496)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4496)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4496)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY160843.1, M34181.1,
            BC035058.1, BX537705.1 and BX641026.1.
            
            On Aug 13, 2020 this sequence version replaced NM_002731.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Transcript Variant: This variant (2) differs in the 5' exon
            structure, compared to variant 1. The encoded isoform (2, also
            known as Cbeta1) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035058.1, SRR1660809.856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               HY160843.1         105-309
            206-1445            M34181.1           6-1245
            1446-3594           BC035058.1         1468-3616
            3595-4065           BX537705.1         3580-4050
            4066-4496           BX641026.1         4050-4480
FEATURES             Location/Qualifiers
     source          1..4496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4496
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..293
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1303
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 2"
                     /protein_id="NP_002722.1"
                     /db_xref="CCDS:CCDS691.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDF
                     ERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP
                     FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS
                     LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK
                     AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV
                     DLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE
                     DIRVSITEKCAKEFGEF"
     exon            294..355
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            356..484
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            485..583
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            584..666
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            667..793
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            794..889
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1012
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1177
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..4496
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4469..4474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4496
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 actgctgctg ccaccgccgt cgccgccgcc gccgccgccg ccgctgctgc tgccggtgct
       61 aaggagttcg ctggagccct ttcctcagac ccggcccggt cttcgcgccc ggactcctgg
      121 cgccagcgct aggcgcactc accgctctga cgggtgcaga cgcgggagtt gtcccagact
      181 gtggagtggc gggcacggcc ccagcccccc ttcccttccc tgaccccttc ttgccatcgc
      241 cccagacatg gggaacgcgg cgaccgccaa gaaaggcagc gaggtggaga gcgtgaaaga
      301 gtttctagcc aaagccaaag aagacttttt gaaaaaatgg gagaatccaa ctcagaataa
      361 tgccggactt gaagattttg aaaggaaaaa aacccttgga acaggttcat ttggaagagt
      421 catgttggta aaacacaaag ccactgaaca gtattatgcc atgaagatct tagataagca
      481 gaaggttgtt aaactgaagc aaatagagca tactttgaat gagaaaagaa tattacaggc
      541 agtgaatttt cctttccttg ttcgactgga gtatgctttt aaggataatt ctaatttata
      601 catggttatg gaatatgtcc ctgggggtga aatgttttca catctaagaa gaattggaag
      661 gttcagtgag ccccatgcac ggttctatgc agctcagata gtgctaacat tcgagtacct
      721 ccattcacta gacctcatct acagagatct aaaacctgaa aatctcttaa ttgaccatca
      781 aggctatatc caggtcacag actttgggtt tgccaaaaga gttaaaggca gaacttggac
      841 attatgtgga actccagagt atttggctcc agaaataatt ctcagcaagg gctacaataa
      901 ggcagtggat tggtgggcat taggagtgct aatctatgaa atggcagctg gctatccccc
      961 attctttgca gaccaaccaa ttcagattta tgaaaagatt gtttctggaa aggtccgatt
     1021 cccatcccac ttcagttcag atctcaagga ccttctacgg aacctgctgc aggtggattt
     1081 gaccaagaga tttggaaatc taaagaatgg tgtcagtgat ataaaaactc acaagtggtt
     1141 tgccacgaca gattggattg ctatttacca gaggaaggtt gaagctccat tcataccaaa
     1201 gtttagaggc tctggagata ccagcaactt tgatgactat gaagaagaag atatccgtgt
     1261 ctctataaca gaaaaatgtg caaaagaatt tggtgaattt taaagaggaa caagatgaca
     1321 tctgagctca cactcagtgt ttgcactctg ttgagagata aggtagagct gagaccgtcc
     1381 ttgttgaagc agttacctag ttccttcatt ccaacgactg agtgaggtct ttattgccat
     1441 catcccgtgt gcgcactctg catccaccta tgtaacaagg caccgctaag caagcattgt
     1501 ctgtgccata acacagtact agaccacttt cttacttctc tttgggttgt ctttctcctc
     1561 tcctatatcc atttcttcct tttccaattt cattggtttt ctctaaacag tgctccattt
     1621 tattttgttg gtgtttcaga tgggcagtgt tatggctacg tgatatttga agggaaggat
     1681 aagtgttgct ttcagtagtt attgccaata ttgttgttgg tcaatggctt gaagataaac
     1741 tttctaataa ttattatttc tttgagtagc tcagacttgg ttttgccaaa actcttggta
     1801 atttttgaag atagactgtc ttatcaccaa ggaaatttat acaaattaag actaactttc
     1861 ttggaattca ctattctggc aataaatttt ggtagactaa tacagtacag ctagacccag
     1921 aaatttggaa ggctgtagat cagaggttct agttcccttt ccctcctttt atatcctcct
     1981 ctccttgagt aatgaagtga ccagcctgtg tagtgtgaca aacgtgtctc attcagcagg
     2041 aaaaactaat gatatggatc atcacccaga ttctctcact tggtaccagc atttctgtag
     2101 gtattagaga agagttctaa gttttctaaa ccttaactgt tccttaagga ttttagccag
     2161 tattttaata gaacatgatt aatgaaagtg acaaatttta aattttctct aatagtcctc
     2221 atcataaact ttttaaagga aaataagcaa actaaaaaga acattggttt agataaatac
     2281 ttatactttg caaagtcaaa aatggcttga tttttggaaa caatatagag gtattcatat
     2341 ttaaatgagg gtttacattt gttttgtttt gtaaccgtta aaaagaagtt gtttccagct
     2401 aattattgtg gtgtactata tttgtgagcc tagggtaggg gcactgctgc aacttctgct
     2461 ttcatcccat gcctcatcaa tgaggaaagg gaacaaagtg tataaaactg ccacaattgt
     2521 attttaattt tgaggtatga tattttcaga tatttcataa tttctaacct ctgttctctc
     2581 agtaaacaga atgtctgatc gatcatgcag atacaatgtt ggtatttgag aggttagttt
     2641 ttttcctaca cttttttttg ccaactgact taacaacatt gctgtcaggt ggaaatttca
     2701 agcacttttg cacatttagt tcagtgtttg ttgagaatcc atggcttaac ccacttgttt
     2761 tgctattttt ttctttgctt ttaattttcc ccatctgatt ttatctctgc gtttcagtga
     2821 cctaccttaa aacaacacac gagaagagtt aaactgggtt cattttaatg atcaatttac
     2881 ctgcatataa aatttatttt taatcaagct gatcttaatg tatataatca ttctatttgc
     2941 tttattatcg gtgcaggtag gtcattaaca ccacttcttt tcatctgtac cacaccctgg
     3001 tgaaaccttt gaagacataa aaaaaacctg tctgagatgt tctttctacc aatctatatg
     3061 tctttcggtt atcaagtgtt tctgcatggt aatgtcatgt aaatgctgat attgatttca
     3121 ctggtccatc tatatttaaa acgtgcaaga aaaaaataaa atactctgct ctagcaagtt
     3181 ttgtgtaaca aaggcatatc gtcatgttaa taaatttaaa acatcattcg tataaaatat
     3241 tttaattttc ttgtatttca tttagaccca agaacatgct gaccaatgtg ttctatatgt
     3301 aaactacaaa ttctatggta gctttgttgt atattattgt aaaattattt taataagtca
     3361 tggggatgac aatttgatta ttacaattta gttttcagta atcaaaaaga tttctatgaa
     3421 ttctaaaaaa tatttttttc tatgaaatta ctagtgccca gctgtagaat ctaccttagg
     3481 tagatgatcc ctagacatac gttggttttg agggctattc agccattcca ttttactctc
     3541 tatttaaagg ccgtgagcaa gcttgtcatg agcaaatatg tcaagggagt caatttctga
     3601 ccaatcaagt acactaaatt agaatatttt taaagtatgt aacattccca gtttcagcca
     3661 caatttagcc aagaataaga taaaaacttg aataagaagt aagtagcata aatcagtatt
     3721 taacctaaaa ttacatattt gaaacagaag atattatgtt atgctcagta aataattaag
     3781 agatggcatt gtgtaagaag gagccctaga ctgaaagtca agacatctga atttcaggct
     3841 ggaaaactat cagtatgatc tcagcctcag ttctcttgtc tgtaaaatgg aagaactgga
     3901 ttaggcagtt tgtaagattc ctcctaactt tcacagtcga tgacaagatt gtctttttat
     3961 ctgatatttt gaagggtata ttgctttgaa gtaagtctca ataaggcaat atattttagg
     4021 gcatctttct tcttatctct gacagtgttc ttaaaattat ttgaatatca taagagcctt
     4081 ggtgtctgtc ctaattcctt tctcactcac cgatgctgaa tacccagttg aatcaaactg
     4141 tcaacctacc aaaaacgata ttgtggctta tgggtattgc tgtctcattc ttggtatatt
     4201 cttgtgttaa ctgcccattg gcctgaaaat actcattgta agcctgaaaa aaaaaatctt
     4261 tcccactgtt ttttctgctt gttgtaagaa tcaaatgaaa taatgtatgt gaaagcacct
     4321 tgtaaactgt aacctatcaa tgtaaaatgt taaggtgtgt tgttatttca ttaattactt
     4381 ctttgtttag aatggaattt cctatgcact actgtagcta ggaaatgctg aaaacaactg
     4441 tgttttttaa ttaatcaata actgcaaaat taaagtacct tcaatggata agacaa
//
