LOCUS       NM_001375579            1998 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 29, mRNA.
ACCESSION   NM_001375579 XM_017001719
VERSION     NM_001375579.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 1998)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_017001719.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.16160.1,
                                           SRR1803612.484043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL450063.14        35656-35975
            321-382             AL450063.14        50139-50200
            383-511             AL450063.14        53162-53290
            512-610             AL450063.14        54999-55097
            611-693             AL450063.14        56062-56144
            694-820             AL450063.14        67578-67704
            821-916             AL450063.14        68691-68786
            917-1039            AL450063.14        73645-73767
            1040-1998           AL450063.14        75441-76399
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1998
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..320
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1051
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isforom 29 is encoded by transcript variant 29;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isforom 29"
                     /protein_id="NP_001362508.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MSVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGR
                     VMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNS
                     NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENL
                     LIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE
                     MAAGYPPFFADQPIQIYEKIVSGKQNF"
     exon            321..382
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            383..511
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            512..610
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            611..693
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            694..820
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            821..916
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1039
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1998
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: AATAAA"
     polyA_site      1858
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      1998
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
ORIGIN      
        1 gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa
       61 ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc
      121 taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc
      181 gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta
      241 gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag
      301 gttggttttc atcatgagtg tgaaagagtt tctagccaaa gccaaagaag actttttgaa
      361 aaaatgggag aatccaactc agaataatgc cggacttgaa gattttgaaa ggaaaaaaac
      421 ccttggaaca ggttcatttg gaagagtcat gttggtaaaa cacaaagcca ctgaacagta
      481 ttatgccatg aagatcttag ataagcagaa ggttgttaaa ctgaagcaaa tagagcatac
      541 tttgaatgag aaaagaatat tacaggcagt gaattttcct ttccttgttc gactggagta
      601 tgcttttaag gataattcta atttatacat ggttatggaa tatgtccctg ggggtgaaat
      661 gttttcacat ctaagaagaa ttggaaggtt cagtgagccc catgcacggt tctatgcagc
      721 tcagatagtg ctaacattcg agtacctcca ttcactagac ctcatctaca gagatctaaa
      781 acctgaaaat ctcttaattg accatcaagg ctatatccag gtcacagact ttgggtttgc
      841 caaaagagtt aaaggcagaa cttggacatt atgtggaact ccagagtatt tggctccaga
      901 aataattctc agcaagggct acaataaggc agtggattgg tgggcattag gagtgctaat
      961 ctatgaaatg gcagctggct atcccccatt ctttgcagac caaccaattc agatttatga
     1021 aaagattgtt tctggaaagc agaacttttg atatgaacaa aacaaaactt tgagaaaaat
     1081 taacagacaa ggcagtgatt tatttttgaa gaatttgaga agtgtagact ctcaagagga
     1141 ctaaaggtca tatgaagaat gatgagagaa ccaaaataca ttaaaatcac aaatggaaga
     1201 agaatatttt actaatacaa aaactaagaa tgtaaatgtt ataataattg tttcaaatca
     1261 tttaattgac agtaattata aagttcttga atctttacta tattactttt atttatattc
     1321 atataagaaa tccaattttc taacaaggat actgtcataa ctaaatttac atttattaag
     1381 aaaaactgct ttagttaaaa ttaatgtgtc ttcattttta tgcattggcc tcgatttgcc
     1441 aatcattctc tattggttaa attttatatt cagctgttta tgaatatata ttcattttat
     1501 atcaaacttt aaaattttgt atctaataat cagcatatat tctaaaatca taacagtcta
     1561 aatcctgggc accttagaag aatgacacca gaaaacctta ttatatcaca atattctgtt
     1621 ttccccttca tttatttaga aatatgacag gatatttggt gtacttttgt tttttaacta
     1681 aaagtaccag attatctctc cccatgtggg atataaaatt atccccatct cttactccct
     1741 ttactcatct aaagtagaag tcatgaaagt ggaatttttg ccattaaaag gctctgtatt
     1801 atgtgaagtt agattgtatt aaccatttcc caataaatca tctgtttcaa aactcaaatt
     1861 caaactagaa tgtgtctcta ttcacattgc aaaaatatta ttgtctctct ggttagtggc
     1921 taaaagccaa attggaaact aactagtttt ttaaattttt taaattgtgc aaattattaa
     1981 aaatccaatt tggtctta
//
