LOCUS       NM_001375576            1971 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 25, mRNA.
ACCESSION   NM_001375576 XM_017001713
VERSION     NM_001375576.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 1971)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359504.29 and AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_017001713.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2543897.1,
                                           SRR11853559.1664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AL359504.29        10273-10565
            294-355             AL450063.14        50139-50200
            356-484             AL450063.14        53162-53290
            485-583             AL450063.14        54999-55097
            584-666             AL450063.14        56062-56144
            667-793             AL450063.14        67578-67704
            794-889             AL450063.14        68691-68786
            890-1012            AL450063.14        73645-73767
            1013-1971           AL450063.14        75441-76399
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1971
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..293
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1024
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 25 is encoded by transcript variant 25;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 25"
                     /protein_id="NP_001362505.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDF
                     ERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP
                     FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS
                     LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK
                     AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKQNF"
     exon            294..355
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            356..484
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            485..583
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            584..666
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            667..793
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            794..889
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1012
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1971
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: AATAAA"
     polyA_site      1831
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      1971
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
ORIGIN      
        1 actgctgctg ccaccgccgt cgccgccgcc gccgccgccg ccgctgctgc tgccggtgct
       61 aaggagttcg ctggagccct ttcctcagac ccggcccggt cttcgcgccc ggactcctgg
      121 cgccagcgct aggcgcactc accgctctga cgggtgcaga cgcgggagtt gtcccagact
      181 gtggagtggc gggcacggcc ccagcccccc ttcccttccc tgaccccttc ttgccatcgc
      241 cccagacatg gggaacgcgg cgaccgccaa gaaaggcagc gaggtggaga gcgtgaaaga
      301 gtttctagcc aaagccaaag aagacttttt gaaaaaatgg gagaatccaa ctcagaataa
      361 tgccggactt gaagattttg aaaggaaaaa aacccttgga acaggttcat ttggaagagt
      421 catgttggta aaacacaaag ccactgaaca gtattatgcc atgaagatct tagataagca
      481 gaaggttgtt aaactgaagc aaatagagca tactttgaat gagaaaagaa tattacaggc
      541 agtgaatttt cctttccttg ttcgactgga gtatgctttt aaggataatt ctaatttata
      601 catggttatg gaatatgtcc ctgggggtga aatgttttca catctaagaa gaattggaag
      661 gttcagtgag ccccatgcac ggttctatgc agctcagata gtgctaacat tcgagtacct
      721 ccattcacta gacctcatct acagagatct aaaacctgaa aatctcttaa ttgaccatca
      781 aggctatatc caggtcacag actttgggtt tgccaaaaga gttaaaggca gaacttggac
      841 attatgtgga actccagagt atttggctcc agaaataatt ctcagcaagg gctacaataa
      901 ggcagtggat tggtgggcat taggagtgct aatctatgaa atggcagctg gctatccccc
      961 attctttgca gaccaaccaa ttcagattta tgaaaagatt gtttctggaa agcagaactt
     1021 ttgatatgaa caaaacaaaa ctttgagaaa aattaacaga caaggcagtg atttattttt
     1081 gaagaatttg agaagtgtag actctcaaga ggactaaagg tcatatgaag aatgatgaga
     1141 gaaccaaaat acattaaaat cacaaatgga agaagaatat tttactaata caaaaactaa
     1201 gaatgtaaat gttataataa ttgtttcaaa tcatttaatt gacagtaatt ataaagttct
     1261 tgaatcttta ctatattact tttatttata ttcatataag aaatccaatt ttctaacaag
     1321 gatactgtca taactaaatt tacatttatt aagaaaaact gctttagtta aaattaatgt
     1381 gtcttcattt ttatgcattg gcctcgattt gccaatcatt ctctattggt taaattttat
     1441 attcagctgt ttatgaatat atattcattt tatatcaaac tttaaaattt tgtatctaat
     1501 aatcagcata tattctaaaa tcataacagt ctaaatcctg ggcaccttag aagaatgaca
     1561 ccagaaaacc ttattatatc acaatattct gttttcccct tcatttattt agaaatatga
     1621 caggatattt ggtgtacttt tgttttttaa ctaaaagtac cagattatct ctccccatgt
     1681 gggatataaa attatcccca tctcttactc cctttactca tctaaagtag aagtcatgaa
     1741 agtggaattt ttgccattaa aaggctctgt attatgtgaa gttagattgt attaaccatt
     1801 tcccaataaa tcatctgttt caaaactcaa attcaaacta gaatgtgtct ctattcacat
     1861 tgcaaaaata ttattgtctc tctggttagt ggctaaaagc caaattggaa actaactagt
     1921 tttttaaatt ttttaaattg tgcaaattat taaaaatcca atttggtctt a
//
