LOCUS       NM_001375575            2043 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 24, mRNA.
ACCESSION   NM_001375575 XM_017001712
VERSION     NM_001375575.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 2043)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_017001712.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.728943.1,
                                           SRR1803617.385022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL450063.14        35656-35975
            321-344             AL450063.14        44291-44314
            345-368             AL450063.14        45995-46018
            369-430             AL450063.14        50139-50200
            431-559             AL450063.14        53162-53290
            560-658             AL450063.14        54999-55097
            659-741             AL450063.14        56062-56144
            742-868             AL450063.14        67578-67704
            869-964             AL450063.14        68691-68786
            965-1087            AL450063.14        73645-73767
            1088-2043           AL450063.14        75444-76399
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2043
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..320
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1096
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 24 is encoded by transcript variant 24;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 24"
                     /protein_id="NP_001362504.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MSARKSSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGL
                     EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAV
                     NFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY
                     LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG
                     YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKNF"
     exon            321..344
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            345..368
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            369..430
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..559
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            560..658
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            659..741
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            742..868
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            869..964
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1087
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..2043
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      2043
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
ORIGIN      
        1 gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa
       61 ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc
      121 taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc
      181 gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta
      241 gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag
      301 gttggttttc atcatgagtg cacgcaaatc atcagatgca tctgcttgct cctcttcaga
      361 aatatctgtg aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa
      421 tccaactcag aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg
      481 ttcatttgga agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa
      541 gatcttagat aagcagaagg ttgttaaact gaagcaaata gagcatactt tgaatgagaa
      601 aagaatatta caggcagtga attttccttt ccttgttcga ctggagtatg cttttaagga
      661 taattctaat ttatacatgg ttatggaata tgtccctggg ggtgaaatgt tttcacatct
      721 aagaagaatt ggaaggttca gtgagcccca tgcacggttc tatgcagctc agatagtgct
      781 aacattcgag tacctccatt cactagacct catctacaga gatctaaaac ctgaaaatct
      841 cttaattgac catcaaggct atatccaggt cacagacttt gggtttgcca aaagagttaa
      901 aggcagaact tggacattat gtggaactcc agagtatttg gctccagaaa taattctcag
      961 caagggctac aataaggcag tggattggtg ggcattagga gtgctaatct atgaaatggc
     1021 agctggctat cccccattct ttgcagacca accaattcag atttatgaaa agattgtttc
     1081 tggaaagaac ttttgatatg aacaaaacaa aactttgaga aaaattaaca gacaaggcag
     1141 tgatttattt ttgaagaatt tgagaagtgt agactctcaa gaggactaaa ggtcatatga
     1201 agaatgatga gagaaccaaa atacattaaa atcacaaatg gaagaagaat attttactaa
     1261 tacaaaaact aagaatgtaa atgttataat aattgtttca aatcatttaa ttgacagtaa
     1321 ttataaagtt cttgaatctt tactatatta cttttattta tattcatata agaaatccaa
     1381 ttttctaaca aggatactgt cataactaaa tttacattta ttaagaaaaa ctgctttagt
     1441 taaaattaat gtgtcttcat ttttatgcat tggcctcgat ttgccaatca ttctctattg
     1501 gttaaatttt atattcagct gtttatgaat atatattcat tttatatcaa actttaaaat
     1561 tttgtatcta ataatcagca tatattctaa aatcataaca gtctaaatcc tgggcacctt
     1621 agaagaatga caccagaaaa ccttattata tcacaatatt ctgttttccc cttcatttat
     1681 ttagaaatat gacaggatat ttggtgtact tttgtttttt aactaaaagt accagattat
     1741 ctctccccat gtgggatata aaattatccc catctcttac tccctttact catctaaagt
     1801 agaagtcatg aaagtggaat ttttgccatt aaaaggctct gtattatgtg aagttagatt
     1861 gtattaacca tttcccaata aatcatctgt ttcaaaactc aaattcaaac tagaatgtgt
     1921 ctctattcac attgcaaaaa tattattgtc tctctggtta gtggctaaaa gccaaattgg
     1981 aaactaacta gttttttaaa ttttttaaat tgtgcaaatt attaaaaatc caatttggtc
     2041 tta
//
