LOCUS       NM_001375572            1844 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 22, mRNA.
ACCESSION   NM_001375572 XM_017001709
VERSION     NM_001375572.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 1844)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 1844)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 1844)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_017001709.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.276935.1,
                                           SRR3476690.711358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL450063.14        35267-35384
            119-142             AL450063.14        44291-44314
            143-166             AL450063.14        45995-46018
            167-228             AL450063.14        50139-50200
            229-357             AL450063.14        53162-53290
            358-456             AL450063.14        54999-55097
            457-539             AL450063.14        56062-56144
            540-666             AL450063.14        67578-67704
            667-762             AL450063.14        68691-68786
            763-885             AL450063.14        73645-73767
            886-1844            AL450063.14        75441-76399
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1844
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..118
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..897
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 22 is encoded by transcript variant 22;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 22"
                     /protein_id="NP_001362501.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MGLSRKSSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAG
                     LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA
                     VNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE
                     YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK
                     GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKQNF"
     exon            119..142
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            143..166
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            167..228
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            229..357
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            358..456
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            457..539
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            540..666
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            667..762
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            763..885
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1844
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: AATAAA"
     polyA_site      1704
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      1844
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
ORIGIN      
        1 acacagcatt ttaatatcag tgaggtccac agctagcagt aagagctggt gtaattgaaa
       61 gacgtttagg tgcaatcatt ctgctgtttg ctccttgcca ggttcaacat gggattgtca
      121 cgcaaatcat cagatgcatc tgcttgctcc tcttcagaaa tatctgtgaa agagtttcta
      181 gccaaagcca aagaagactt tttgaaaaaa tgggagaatc caactcagaa taatgccgga
      241 cttgaagatt ttgaaaggaa aaaaaccctt ggaacaggtt catttggaag agtcatgttg
      301 gtaaaacaca aagccactga acagtattat gccatgaaga tcttagataa gcagaaggtt
      361 gttaaactga agcaaataga gcatactttg aatgagaaaa gaatattaca ggcagtgaat
      421 tttcctttcc ttgttcgact ggagtatgct tttaaggata attctaattt atacatggtt
      481 atggaatatg tccctggggg tgaaatgttt tcacatctaa gaagaattgg aaggttcagt
      541 gagccccatg cacggttcta tgcagctcag atagtgctaa cattcgagta cctccattca
      601 ctagacctca tctacagaga tctaaaacct gaaaatctct taattgacca tcaaggctat
      661 atccaggtca cagactttgg gtttgccaaa agagttaaag gcagaacttg gacattatgt
      721 ggaactccag agtatttggc tccagaaata attctcagca agggctacaa taaggcagtg
      781 gattggtggg cattaggagt gctaatctat gaaatggcag ctggctatcc cccattcttt
      841 gcagaccaac caattcagat ttatgaaaag attgtttctg gaaagcagaa cttttgatat
      901 gaacaaaaca aaactttgag aaaaattaac agacaaggca gtgatttatt tttgaagaat
      961 ttgagaagtg tagactctca agaggactaa aggtcatatg aagaatgatg agagaaccaa
     1021 aatacattaa aatcacaaat ggaagaagaa tattttacta atacaaaaac taagaatgta
     1081 aatgttataa taattgtttc aaatcattta attgacagta attataaagt tcttgaatct
     1141 ttactatatt acttttattt atattcatat aagaaatcca attttctaac aaggatactg
     1201 tcataactaa atttacattt attaagaaaa actgctttag ttaaaattaa tgtgtcttca
     1261 tttttatgca ttggcctcga tttgccaatc attctctatt ggttaaattt tatattcagc
     1321 tgtttatgaa tatatattca ttttatatca aactttaaaa ttttgtatct aataatcagc
     1381 atatattcta aaatcataac agtctaaatc ctgggcacct tagaagaatg acaccagaaa
     1441 accttattat atcacaatat tctgttttcc ccttcattta tttagaaata tgacaggata
     1501 tttggtgtac ttttgttttt taactaaaag taccagatta tctctcccca tgtgggatat
     1561 aaaattatcc ccatctctta ctccctttac tcatctaaag tagaagtcat gaaagtggaa
     1621 tttttgccat taaaaggctc tgtattatgt gaagttagat tgtattaacc atttcccaat
     1681 aaatcatctg tttcaaaact caaattcaaa ctagaatgtg tctctattca cattgcaaaa
     1741 atattattgt ctctctggtt agtggctaaa agccaaattg gaaactaact agttttttaa
     1801 attttttaaa ttgtgcaaat tattaaaaat ccaatttggt ctta
//
