LOCUS       NM_001375564            4547 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 17, mRNA.
ACCESSION   NM_001375564 XM_005271018
VERSION     NM_001375564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4547)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4547)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4547)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4547)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4547)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4547)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4547)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4547)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4547)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4547)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_005271018.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.207017.1,
                                           SRR1803612.249258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL450063.14        35656-35975
            321-344             AL450063.14        45995-46018
            345-406             AL450063.14        50139-50200
            407-535             AL450063.14        53162-53290
            536-634             AL450063.14        54999-55097
            635-717             AL450063.14        56062-56144
            718-844             AL450063.14        67578-67704
            845-940             AL450063.14        68691-68786
            941-1063            AL450063.14        73645-73767
            1064-1228           AL450063.14        85115-85279
            1229-4547           AL450063.14        106142-109460
FEATURES             Location/Qualifiers
     source          1..4547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4547
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..320
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1354
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 17 is encoded by transcript variant 17;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 17"
                     /protein_id="NP_001362493.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MSACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKT
                     LGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRL
                     EYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY
                     RDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW
                     ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR
                     FGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVS
                     ITEKCAKEFGEF"
     exon            321..344
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            345..406
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            407..535
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            536..634
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            635..717
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            718..844
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            845..940
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1063
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1228
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..4547
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4547
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa
       61 ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc
      121 taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc
      181 gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta
      241 gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag
      301 gttggttttc atcatgagtg cttgctcctc ttcagaaata tctgtgaaag agtttctagc
      361 caaagccaaa gaagactttt tgaaaaaatg ggagaatcca actcagaata atgccggact
      421 tgaagatttt gaaaggaaaa aaacccttgg aacaggttca tttggaagag tcatgttggt
      481 aaaacacaaa gccactgaac agtattatgc catgaagatc ttagataagc agaaggttgt
      541 taaactgaag caaatagagc atactttgaa tgagaaaaga atattacagg cagtgaattt
      601 tcctttcctt gttcgactgg agtatgcttt taaggataat tctaatttat acatggttat
      661 ggaatatgtc cctgggggtg aaatgttttc acatctaaga agaattggaa ggttcagtga
      721 gccccatgca cggttctatg cagctcagat agtgctaaca ttcgagtacc tccattcact
      781 agacctcatc tacagagatc taaaacctga aaatctctta attgaccatc aaggctatat
      841 ccaggtcaca gactttgggt ttgccaaaag agttaaaggc agaacttgga cattatgtgg
      901 aactccagag tatttggctc cagaaataat tctcagcaag ggctacaata aggcagtgga
      961 ttggtgggca ttaggagtgc taatctatga aatggcagct ggctatcccc cattctttgc
     1021 agaccaacca attcagattt atgaaaagat tgtttctgga aaggtccgat tcccatccca
     1081 cttcagttca gatctcaagg accttctacg gaacctgctg caggtggatt tgaccaagag
     1141 atttggaaat ctaaagaatg gtgtcagtga tataaaaact cacaagtggt ttgccacgac
     1201 agattggatt gctatttacc agaggaaggt tgaagctcca ttcataccaa agtttagagg
     1261 ctctggagat accagcaact ttgatgacta tgaagaagaa gatatccgtg tctctataac
     1321 agaaaaatgt gcaaaagaat ttggtgaatt ttaaagagga acaagatgac atctgagctc
     1381 acactcagtg tttgcactct gttgagagat aaggtagagc tgagaccgtc cttgttgaag
     1441 cagttaccta gttccttcat tccaacgact gagtgaggtc tttattgcca tcatcccgtg
     1501 tgcgcactct gcatccacct atgtaacaag gcaccgctaa gcaagcattg tctgtgccat
     1561 aacacagtac tagaccactt tcttacttct ctttgggttg tctttctcct ctcctatatc
     1621 catttcttcc ttttccaatt tcattggttt tctctaaaca gtgctccatt ttattttgtt
     1681 ggtgtttcag atgggcagtg ttatggctac gtgatatttg aagggaagga taagtgttgc
     1741 tttcagtagt tattgccaat attgttgttg gtcaatggct tgaagataaa ctttctaata
     1801 attattattt ctttgagtag ctcagacttg gttttgccaa aactcttggt aatttttgaa
     1861 gatagactgt cttatcacca aggaaattta tacaaattaa gactaacttt cttggaattc
     1921 actattctgg caataaattt tggtagacta atacagtaca gctagaccca gaaatttgga
     1981 aggctgtaga tcagaggttc tagttccctt tccctccttt tatatcctcc tctccttgag
     2041 taatgaagtg accagcctgt gtagtgtgac aaacgtgtct cattcagcag gaaaaactaa
     2101 tgatatggat catcacccag attctctcac ttggtaccag catttctgta ggtattagag
     2161 aagagttcta agttttctaa accttaactg ttccttaagg attttagcca gtattttaat
     2221 agaacatgat taatgaaagt gacaaatttt aaattttctc taatagtcct catcataaac
     2281 tttttaaagg aaaataagca aactaaaaag aacattggtt tagataaata cttatacttt
     2341 gcaaagtcaa aaatggcttg atttttggaa acaatataga ggtattcata tttaaatgag
     2401 ggtttacatt tgttttgttt tgtaaccgtt aaaaagaagt tgtttccagc taattattgt
     2461 ggtgtactat atttgtgagc ctagggtagg ggcactgctg caacttctgc tttcatccca
     2521 tgcctcatca atgaggaaag ggaacaaagt gtataaaact gccacaattg tattttaatt
     2581 ttgaggtatg atattttcag atatttcata atttctaacc tctgttctct cagtaaacag
     2641 aatgtctgat cgatcatgca gatacaatgt tggtatttga gaggttagtt tttttcctac
     2701 actttttttt gccaactgac ttaacaacat tgctgtcagg tggaaatttc aagcactttt
     2761 gcacatttag ttcagtgttt gttgagaatc catggcttaa cccacttgtt ttgctatttt
     2821 tttctttgct tttaattttc cccatctgat tttatctctg cgtttcagtg acctacctta
     2881 aaacaacaca cgagaagagt taaactgggt tcattttaat gatcaattta cctgcatata
     2941 aaatttattt ttaatcaagc tgatcttaat gtatataatc attctatttg ctttattatc
     3001 ggtgcaggta ggtcattaac accacttctt ttcatctgta ccacaccctg gtgaaacctt
     3061 tgaagacata aaaaaaacct gtctgagatg ttctttctac caatctatat gtctttcggt
     3121 tatcaagtgt ttctgcatgg taatgtcatg taaatgctga tattgatttc actggtccat
     3181 ctatatttaa aacgtgcaag aaaaaaataa aatactctgc tctagcaagt tttgtgtaac
     3241 aaaggcatat cgtcatgtta ataaatttaa aacatcattc gtataaaata ttttaatttt
     3301 cttgtatttc atttagaccc aagaacatgc tgaccaatgt gttctatatg taaactacaa
     3361 attctatggt agctttgttg tatattattg taaaattatt ttaataagtc atggggatga
     3421 caatttgatt attacaattt agttttcagt aatcaaaaag atttctatga attctaaaaa
     3481 atattttttt ctatgaaatt actagtgccc agctgtagaa tctaccttag gtagatgatc
     3541 cctagacata cgttggtttt gagggctatt cagccattcc attttactct ctatttaaag
     3601 gccgtgagca agcttgtcat gagcaaatat gtcaagggag tcaatttctg accaatcaag
     3661 tacactaaat tagaatattt ttaaagtatg taacattccc agtttcagcc acaatttagc
     3721 caagaataag ataaaaactt gaataagaag taagtagcat aaatcagtat ttaacctaaa
     3781 attacatatt tgaaacagaa gatattatgt tatgctcagt aaataattaa gagatggcat
     3841 tgtgtaagaa ggagccctag actgaaagtc aagacatctg aatttcaggc tggaaaacta
     3901 tcagtatgat ctcagcctca gttctcttgt ctgtaaaatg gaagaactgg attaggcagt
     3961 ttgtaagatt cctcctaact ttcacagtcg atgacaagat tgtcttttta tctgatattt
     4021 tgaagggtat attgctttga agtaagtctc aataaggcaa tatattttag ggcatctttc
     4081 ttcttatctc tgacagtgtt cttaaaatta tttgaatatc ataagagcct tggtgtctgt
     4141 cctaattcct ttctcactca ccgatgctga atacccagtt gaatcaaact gtcaacctac
     4201 caaaaacgat attgtggctt atgggtattg ctgtctcatt cttggtatat tcttgtgtta
     4261 actgcccatt ggcctgaaaa tactcattgt aagcctgaaa aaaaaaatct ttcccactgt
     4321 tttttctgct tgttgtaaga atcaaatgaa ataatgtatg tgaaagcacc ttgtaaactg
     4381 taacctatca atgtaaaatg ttaaggtgtg ttgttatttc attaattact tctttgttta
     4441 gaatggaatt tcctatgcac tactgtagct aggaaatgct gaaaacaact gtgtttttta
     4501 attaatcaat aactgcaaaa ttaaagtacc ttcaatggat aagacaa
//
