LOCUS       NM_001375560            4571 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 13, mRNA.
ACCESSION   NM_001375560 XM_006710758
VERSION     NM_001375560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14.
            
            On Oct 29, 2019 this sequence version replaced XM_006710758.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.21772.1,
                                           SRR14372079.3681217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL450063.14        35656-35975
            321-344             AL450063.14        44291-44314
            345-368             AL450063.14        45995-46018
            369-430             AL450063.14        50139-50200
            431-559             AL450063.14        53162-53290
            560-658             AL450063.14        54999-55097
            659-741             AL450063.14        56062-56144
            742-868             AL450063.14        67578-67704
            869-964             AL450063.14        68691-68786
            965-1087            AL450063.14        73645-73767
            1088-1252           AL450063.14        85115-85279
            1253-4571           AL450063.14        106142-109460
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4571
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..320
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1378
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 13 is encoded by transcript variant 13;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 13"
                     /protein_id="NP_001362489.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MSARKSSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGL
                     EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAV
                     NFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY
                     LHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG
                     YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL
                     LQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDY
                     EEEDIRVSITEKCAKEFGEF"
     exon            321..344
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            345..368
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            369..430
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..559
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            560..658
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            659..741
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            742..868
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            869..964
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1087
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1252
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..4571
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4544..4549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4571
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa
       61 ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc
      121 taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc
      181 gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta
      241 gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag
      301 gttggttttc atcatgagtg cacgcaaatc atcagatgca tctgcttgct cctcttcaga
      361 aatatctgtg aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa
      421 tccaactcag aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg
      481 ttcatttgga agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa
      541 gatcttagat aagcagaagg ttgttaaact gaagcaaata gagcatactt tgaatgagaa
      601 aagaatatta caggcagtga attttccttt ccttgttcga ctggagtatg cttttaagga
      661 taattctaat ttatacatgg ttatggaata tgtccctggg ggtgaaatgt tttcacatct
      721 aagaagaatt ggaaggttca gtgagcccca tgcacggttc tatgcagctc agatagtgct
      781 aacattcgag tacctccatt cactagacct catctacaga gatctaaaac ctgaaaatct
      841 cttaattgac catcaaggct atatccaggt cacagacttt gggtttgcca aaagagttaa
      901 aggcagaact tggacattat gtggaactcc agagtatttg gctccagaaa taattctcag
      961 caagggctac aataaggcag tggattggtg ggcattagga gtgctaatct atgaaatggc
     1021 agctggctat cccccattct ttgcagacca accaattcag atttatgaaa agattgtttc
     1081 tggaaaggtc cgattcccat cccacttcag ttcagatctc aaggaccttc tacggaacct
     1141 gctgcaggtg gatttgacca agagatttgg aaatctaaag aatggtgtca gtgatataaa
     1201 aactcacaag tggtttgcca cgacagattg gattgctatt taccagagga aggttgaagc
     1261 tccattcata ccaaagttta gaggctctgg agataccagc aactttgatg actatgaaga
     1321 agaagatatc cgtgtctcta taacagaaaa atgtgcaaaa gaatttggtg aattttaaag
     1381 aggaacaaga tgacatctga gctcacactc agtgtttgca ctctgttgag agataaggta
     1441 gagctgagac cgtccttgtt gaagcagtta cctagttcct tcattccaac gactgagtga
     1501 ggtctttatt gccatcatcc cgtgtgcgca ctctgcatcc acctatgtaa caaggcaccg
     1561 ctaagcaagc attgtctgtg ccataacaca gtactagacc actttcttac ttctctttgg
     1621 gttgtctttc tcctctccta tatccatttc ttccttttcc aatttcattg gttttctcta
     1681 aacagtgctc cattttattt tgttggtgtt tcagatgggc agtgttatgg ctacgtgata
     1741 tttgaaggga aggataagtg ttgctttcag tagttattgc caatattgtt gttggtcaat
     1801 ggcttgaaga taaactttct aataattatt atttctttga gtagctcaga cttggttttg
     1861 ccaaaactct tggtaatttt tgaagataga ctgtcttatc accaaggaaa tttatacaaa
     1921 ttaagactaa ctttcttgga attcactatt ctggcaataa attttggtag actaatacag
     1981 tacagctaga cccagaaatt tggaaggctg tagatcagag gttctagttc cctttccctc
     2041 cttttatatc ctcctctcct tgagtaatga agtgaccagc ctgtgtagtg tgacaaacgt
     2101 gtctcattca gcaggaaaaa ctaatgatat ggatcatcac ccagattctc tcacttggta
     2161 ccagcatttc tgtaggtatt agagaagagt tctaagtttt ctaaacctta actgttcctt
     2221 aaggatttta gccagtattt taatagaaca tgattaatga aagtgacaaa ttttaaattt
     2281 tctctaatag tcctcatcat aaacttttta aaggaaaata agcaaactaa aaagaacatt
     2341 ggtttagata aatacttata ctttgcaaag tcaaaaatgg cttgattttt ggaaacaata
     2401 tagaggtatt catatttaaa tgagggttta catttgtttt gttttgtaac cgttaaaaag
     2461 aagttgtttc cagctaatta ttgtggtgta ctatatttgt gagcctaggg taggggcact
     2521 gctgcaactt ctgctttcat cccatgcctc atcaatgagg aaagggaaca aagtgtataa
     2581 aactgccaca attgtatttt aattttgagg tatgatattt tcagatattt cataatttct
     2641 aacctctgtt ctctcagtaa acagaatgtc tgatcgatca tgcagataca atgttggtat
     2701 ttgagaggtt agtttttttc ctacactttt ttttgccaac tgacttaaca acattgctgt
     2761 caggtggaaa tttcaagcac ttttgcacat ttagttcagt gtttgttgag aatccatggc
     2821 ttaacccact tgttttgcta tttttttctt tgcttttaat tttccccatc tgattttatc
     2881 tctgcgtttc agtgacctac cttaaaacaa cacacgagaa gagttaaact gggttcattt
     2941 taatgatcaa tttacctgca tataaaattt atttttaatc aagctgatct taatgtatat
     3001 aatcattcta tttgctttat tatcggtgca ggtaggtcat taacaccact tcttttcatc
     3061 tgtaccacac cctggtgaaa cctttgaaga cataaaaaaa acctgtctga gatgttcttt
     3121 ctaccaatct atatgtcttt cggttatcaa gtgtttctgc atggtaatgt catgtaaatg
     3181 ctgatattga tttcactggt ccatctatat ttaaaacgtg caagaaaaaa ataaaatact
     3241 ctgctctagc aagttttgtg taacaaaggc atatcgtcat gttaataaat ttaaaacatc
     3301 attcgtataa aatattttaa ttttcttgta tttcatttag acccaagaac atgctgacca
     3361 atgtgttcta tatgtaaact acaaattcta tggtagcttt gttgtatatt attgtaaaat
     3421 tattttaata agtcatgggg atgacaattt gattattaca atttagtttt cagtaatcaa
     3481 aaagatttct atgaattcta aaaaatattt ttttctatga aattactagt gcccagctgt
     3541 agaatctacc ttaggtagat gatccctaga catacgttgg ttttgagggc tattcagcca
     3601 ttccatttta ctctctattt aaaggccgtg agcaagcttg tcatgagcaa atatgtcaag
     3661 ggagtcaatt tctgaccaat caagtacact aaattagaat atttttaaag tatgtaacat
     3721 tcccagtttc agccacaatt tagccaagaa taagataaaa acttgaataa gaagtaagta
     3781 gcataaatca gtatttaacc taaaattaca tatttgaaac agaagatatt atgttatgct
     3841 cagtaaataa ttaagagatg gcattgtgta agaaggagcc ctagactgaa agtcaagaca
     3901 tctgaatttc aggctggaaa actatcagta tgatctcagc ctcagttctc ttgtctgtaa
     3961 aatggaagaa ctggattagg cagtttgtaa gattcctcct aactttcaca gtcgatgaca
     4021 agattgtctt tttatctgat attttgaagg gtatattgct ttgaagtaag tctcaataag
     4081 gcaatatatt ttagggcatc tttcttctta tctctgacag tgttcttaaa attatttgaa
     4141 tatcataaga gccttggtgt ctgtcctaat tcctttctca ctcaccgatg ctgaataccc
     4201 agttgaatca aactgtcaac ctaccaaaaa cgatattgtg gcttatgggt attgctgtct
     4261 cattcttggt atattcttgt gttaactgcc cattggcctg aaaatactca ttgtaagcct
     4321 gaaaaaaaaa atctttccca ctgttttttc tgcttgttgt aagaatcaaa tgaaataatg
     4381 tatgtgaaag caccttgtaa actgtaacct atcaatgtaa aatgttaagg tgtgttgtta
     4441 tttcattaat tacttctttg tttagaatgg aatttcctat gcactactgt agctaggaaa
     4501 tgctgaaaac aactgtgttt tttaattaat caataactgc aaaattaaag taccttcaat
     4561 ggataagaca a
//
