LOCUS       NM_001242861            4472 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 8, mRNA.
ACCESSION   NM_001242861
VERSION     NM_001242861.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4472)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4472)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4472)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4472)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4472)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4472)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4472)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4472)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4472)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4472)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA188681.1, AK091420.1,
            AL450063.14 and BX641026.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001242861.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Transcript Variant: This variant (8) differs in the 5' exon
            structure, compared to variant 1. The encoded isoform (8, also
            known as Cbeta4ab) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091420.1, SRR1803613.152659.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMN03267759
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               DA188681.1         55-326
            273-1541            AK091420.1         1-1269
            1542-1542           AL450063.14        106530-106530
            1543-3656           BX641026.1         1551-3664
            3657-3657           AL450063.14        108645-108645
            3658-4472           BX641026.1         3666-4480
FEATURES             Location/Qualifiers
     source          1..4472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4472
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..320
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1279
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 8 is encoded by transcript variant 8;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 8"
                     /protein_id="NP_001229790.1"
                     /db_xref="CCDS:CCDS55611.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MSARKSSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGL
                     EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKDNSNLYMVMEYVPGGEMFSH
                     LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK
                     RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY
                     EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAI
                     YQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF"
     exon            321..344
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            345..368
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            369..430
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..559
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            560..642
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            643..769
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            770..865
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            866..988
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1153
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..4472
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4445..4450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4472
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa
       61 ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc
      121 taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc
      181 gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta
      241 gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag
      301 gttggttttc atcatgagtg cacgcaaatc atcagatgca tctgcttgct cctcttcaga
      361 aatatctgtg aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa
      421 tccaactcag aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg
      481 ttcatttgga agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa
      541 gatcttagat aagcagaagg ataattctaa tttatacatg gttatggaat atgtccctgg
      601 gggtgaaatg ttttcacatc taagaagaat tggaaggttc agtgagcccc atgcacggtt
      661 ctatgcagct cagatagtgc taacattcga gtacctccat tcactagacc tcatctacag
      721 agatctaaaa cctgaaaatc tcttaattga ccatcaaggc tatatccagg tcacagactt
      781 tgggtttgcc aaaagagtta aaggcagaac ttggacatta tgtggaactc cagagtattt
      841 ggctccagaa ataattctca gcaagggcta caataaggca gtggattggt gggcattagg
      901 agtgctaatc tatgaaatgg cagctggcta tcccccattc tttgcagacc aaccaattca
      961 gatttatgaa aagattgttt ctggaaaggt ccgattccca tcccacttca gttcagatct
     1021 caaggacctt ctacggaacc tgctgcaggt ggatttgacc aagagatttg gaaatctaaa
     1081 gaatggtgtc agtgatataa aaactcacaa gtggtttgcc acgacagatt ggattgctat
     1141 ttaccagagg aaggttgaag ctccattcat accaaagttt agaggctctg gagataccag
     1201 caactttgat gactatgaag aagaagatat ccgtgtctct ataacagaaa aatgtgcaaa
     1261 agaatttggt gaattttaaa gaggaacaag atgacatctg agctcacact cagtgtttgc
     1321 actctgttga gagataaggt agagctgaga ccgtccttgt tgaagcagtt acctagttcc
     1381 ttcattccaa cgactgagtg aggtctttat tgccatcatc ccgtgtgcgc actctgcatc
     1441 cacctatgta acaaggcacc gctaagcaag cattgtctgt gccataacac agtactagac
     1501 cactttctta cttctctttg ggttgtcttt ctcctctcct atatccattt cttccttttc
     1561 caatttcatt ggttttctct aaacagtgct ccattttatt ttgttggtgt ttcagatggg
     1621 cagtgttatg gctacgtgat atttgaaggg aaggataagt gttgctttca gtagttattg
     1681 ccaatattgt tgttggtcaa tggcttgaag ataaactttc taataattat tatttctttg
     1741 agtagctcag acttggtttt gccaaaactc ttggtaattt ttgaagatag actgtcttat
     1801 caccaaggaa atttatacaa attaagacta actttcttgg aattcactat tctggcaata
     1861 aattttggta gactaataca gtacagctag acccagaaat ttggaaggct gtagatcaga
     1921 ggttctagtt ccctttccct ccttttatat cctcctctcc ttgagtaatg aagtgaccag
     1981 cctgtgtagt gtgacaaacg tgtctcattc agcaggaaaa actaatgata tggatcatca
     2041 cccagattct ctcacttggt accagcattt ctgtaggtat tagagaagag ttctaagttt
     2101 tctaaacctt aactgttcct taaggatttt agccagtatt ttaatagaac atgattaatg
     2161 aaagtgacaa attttaaatt ttctctaata gtcctcatca taaacttttt aaaggaaaat
     2221 aagcaaacta aaaagaacat tggtttagat aaatacttat actttgcaaa gtcaaaaatg
     2281 gcttgatttt tggaaacaat atagaggtat tcatatttaa atgagggttt acatttgttt
     2341 tgttttgtaa ccgttaaaaa gaagttgttt ccagctaatt attgtggtgt actatatttg
     2401 tgagcctagg gtaggggcac tgctgcaact tctgctttca tcccatgcct catcaatgag
     2461 gaaagggaac aaagtgtata aaactgccac aattgtattt taattttgag gtatgatatt
     2521 ttcagatatt tcataatttc taacctctgt tctctcagta aacagaatgt ctgatcgatc
     2581 atgcagatac aatgttggta tttgagaggt tagttttttt cctacacttt tttttgccaa
     2641 ctgacttaac aacattgctg tcaggtggaa atttcaagca cttttgcaca tttagttcag
     2701 tgtttgttga gaatccatgg cttaacccac ttgttttgct atttttttct ttgcttttaa
     2761 ttttccccat ctgattttat ctctgcgttt cagtgaccta ccttaaaaca acacacgaga
     2821 agagttaaac tgggttcatt ttaatgatca atttacctgc atataaaatt tatttttaat
     2881 caagctgatc ttaatgtata taatcattct atttgcttta ttatcggtgc aggtaggtca
     2941 ttaacaccac ttcttttcat ctgtaccaca ccctggtgaa acctttgaag acataaaaaa
     3001 aacctgtctg agatgttctt tctaccaatc tatatgtctt tcggttatca agtgtttctg
     3061 catggtaatg tcatgtaaat gctgatattg atttcactgg tccatctata tttaaaacgt
     3121 gcaagaaaaa aataaaatac tctgctctag caagttttgt gtaacaaagg catatcgtca
     3181 tgttaataaa tttaaaacat cattcgtata aaatatttta attttcttgt atttcattta
     3241 gacccaagaa catgctgacc aatgtgttct atatgtaaac tacaaattct atggtagctt
     3301 tgttgtatat tattgtaaaa ttattttaat aagtcatggg gatgacaatt tgattattac
     3361 aatttagttt tcagtaatca aaaagatttc tatgaattct aaaaaatatt tttttctatg
     3421 aaattactag tgcccagctg tagaatctac cttaggtaga tgatccctag acatacgttg
     3481 gttttgaggg ctattcagcc attccatttt actctctatt taaaggccgt gagcaagctt
     3541 gtcatgagca aatatgtcaa gggagtcaat ttctgaccaa tcaagtacac taaattagaa
     3601 tatttttaaa gtatgtaaca ttcccagttt cagccacaat ttagccaaga ataagataaa
     3661 aacttgaata agaagtaagt agcataaatc agtatttaac ctaaaattac atatttgaaa
     3721 cagaagatat tatgttatgc tcagtaaata attaagagat ggcattgtgt aagaaggagc
     3781 cctagactga aagtcaagac atctgaattt caggctggaa aactatcagt atgatctcag
     3841 cctcagttct cttgtctgta aaatggaaga actggattag gcagtttgta agattcctcc
     3901 taactttcac agtcgatgac aagattgtct ttttatctga tattttgaag ggtatattgc
     3961 tttgaagtaa gtctcaataa ggcaatatat tttagggcat ctttcttctt atctctgaca
     4021 gtgttcttaa aattatttga atatcataag agccttggtg tctgtcctaa ttcctttctc
     4081 actcaccgat gctgaatacc cagttgaatc aaactgtcaa cctaccaaaa acgatattgt
     4141 ggcttatggg tattgctgtc tcattcttgg tatattcttg tgttaactgc ccattggcct
     4201 gaaaatactc attgtaagcc tgaaaaaaaa aatctttccc actgtttttt ctgcttgttg
     4261 taagaatcaa atgaaataat gtatgtgaaa gcaccttgta aactgtaacc tatcaatgta
     4321 aaatgttaag gtgtgttgtt atttcattaa ttacttcttt gtttagaatg gaatttccta
     4381 tgcactactg tagctaggaa atgctgaaaa caactgtgtt ttttaattaa tcaataactg
     4441 caaaattaaa gtaccttcaa tggataagac aa
//
