LOCUS       NM_001242859            4369 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 6, mRNA.
ACCESSION   NM_001242859
VERSION     NM_001242859.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4369)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4369)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4369)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4369)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4369)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4369)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4369)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4369)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4369)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4369)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450063.14 and BX641026.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001242859.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Transcript Variant: This variant (6) differs in the 5' exon
            structure, compared to variant 1. The encoded isoform (6) has a
            distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936631.1, SRR1660809.18138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL450063.14        35267-35384
            119-142             AL450063.14        44291-44314
            143-166             AL450063.14        45995-46018
            167-228             AL450063.14        50139-50200
            229-357             AL450063.14        53162-53290
            358-456             AL450063.14        54999-55097
            457-539             AL450063.14        56062-56144
            540-666             AL450063.14        67578-67704
            667-762             AL450063.14        68691-68786
            763-885             AL450063.14        73645-73767
            886-1050            AL450063.14        85115-85279
            1051-1439           AL450063.14        106142-106530
            1440-3553           BX641026.1         1551-3664
            3554-3554           AL450063.14        108645-108645
            3555-4369           BX641026.1         3666-4480
FEATURES             Location/Qualifiers
     source          1..4369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4369
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..118
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1176
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 6 is encoded by transcript variant 6;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 6"
                     /protein_id="NP_001229788.1"
                     /db_xref="CCDS:CCDS55610.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MGLSRKSSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAG
                     LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA
                     VNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE
                     YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK
                     GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN
                     LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDD
                     YEEEDIRVSITEKCAKEFGEF"
     exon            119..142
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            143..166
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            167..228
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            229..357
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            358..456
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            457..539
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            540..666
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            667..762
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            763..885
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1050
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..4369
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4369
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 acacagcatt ttaatatcag tgaggtccac agctagcagt aagagctggt gtaattgaaa
       61 gacgtttagg tgcaatcatt ctgctgtttg ctccttgcca ggttcaacat gggattgtca
      121 cgcaaatcat cagatgcatc tgcttgctcc tcttcagaaa tatctgtgaa agagtttcta
      181 gccaaagcca aagaagactt tttgaaaaaa tgggagaatc caactcagaa taatgccgga
      241 cttgaagatt ttgaaaggaa aaaaaccctt ggaacaggtt catttggaag agtcatgttg
      301 gtaaaacaca aagccactga acagtattat gccatgaaga tcttagataa gcagaaggtt
      361 gttaaactga agcaaataga gcatactttg aatgagaaaa gaatattaca ggcagtgaat
      421 tttcctttcc ttgttcgact ggagtatgct tttaaggata attctaattt atacatggtt
      481 atggaatatg tccctggggg tgaaatgttt tcacatctaa gaagaattgg aaggttcagt
      541 gagccccatg cacggttcta tgcagctcag atagtgctaa cattcgagta cctccattca
      601 ctagacctca tctacagaga tctaaaacct gaaaatctct taattgacca tcaaggctat
      661 atccaggtca cagactttgg gtttgccaaa agagttaaag gcagaacttg gacattatgt
      721 ggaactccag agtatttggc tccagaaata attctcagca agggctacaa taaggcagtg
      781 gattggtggg cattaggagt gctaatctat gaaatggcag ctggctatcc cccattcttt
      841 gcagaccaac caattcagat ttatgaaaag attgtttctg gaaaggtccg attcccatcc
      901 cacttcagtt cagatctcaa ggaccttcta cggaacctgc tgcaggtgga tttgaccaag
      961 agatttggaa atctaaagaa tggtgtcagt gatataaaaa ctcacaagtg gtttgccacg
     1021 acagattgga ttgctattta ccagaggaag gttgaagctc cattcatacc aaagtttaga
     1081 ggctctggag ataccagcaa ctttgatgac tatgaagaag aagatatccg tgtctctata
     1141 acagaaaaat gtgcaaaaga atttggtgaa ttttaaagag gaacaagatg acatctgagc
     1201 tcacactcag tgtttgcact ctgttgagag ataaggtaga gctgagaccg tccttgttga
     1261 agcagttacc tagttccttc attccaacga ctgagtgagg tctttattgc catcatcccg
     1321 tgtgcgcact ctgcatccac ctatgtaaca aggcaccgct aagcaagcat tgtctgtgcc
     1381 ataacacagt actagaccac tttcttactt ctctttgggt tgtctttctc ctctcctata
     1441 tccatttctt ccttttccaa tttcattggt tttctctaaa cagtgctcca ttttattttg
     1501 ttggtgtttc agatgggcag tgttatggct acgtgatatt tgaagggaag gataagtgtt
     1561 gctttcagta gttattgcca atattgttgt tggtcaatgg cttgaagata aactttctaa
     1621 taattattat ttctttgagt agctcagact tggttttgcc aaaactcttg gtaatttttg
     1681 aagatagact gtcttatcac caaggaaatt tatacaaatt aagactaact ttcttggaat
     1741 tcactattct ggcaataaat tttggtagac taatacagta cagctagacc cagaaatttg
     1801 gaaggctgta gatcagaggt tctagttccc tttccctcct tttatatcct cctctccttg
     1861 agtaatgaag tgaccagcct gtgtagtgtg acaaacgtgt ctcattcagc aggaaaaact
     1921 aatgatatgg atcatcaccc agattctctc acttggtacc agcatttctg taggtattag
     1981 agaagagttc taagttttct aaaccttaac tgttccttaa ggattttagc cagtatttta
     2041 atagaacatg attaatgaaa gtgacaaatt ttaaattttc tctaatagtc ctcatcataa
     2101 actttttaaa ggaaaataag caaactaaaa agaacattgg tttagataaa tacttatact
     2161 ttgcaaagtc aaaaatggct tgatttttgg aaacaatata gaggtattca tatttaaatg
     2221 agggtttaca tttgttttgt tttgtaaccg ttaaaaagaa gttgtttcca gctaattatt
     2281 gtggtgtact atatttgtga gcctagggta ggggcactgc tgcaacttct gctttcatcc
     2341 catgcctcat caatgaggaa agggaacaaa gtgtataaaa ctgccacaat tgtattttaa
     2401 ttttgaggta tgatattttc agatatttca taatttctaa cctctgttct ctcagtaaac
     2461 agaatgtctg atcgatcatg cagatacaat gttggtattt gagaggttag tttttttcct
     2521 acactttttt ttgccaactg acttaacaac attgctgtca ggtggaaatt tcaagcactt
     2581 ttgcacattt agttcagtgt ttgttgagaa tccatggctt aacccacttg ttttgctatt
     2641 tttttctttg cttttaattt tccccatctg attttatctc tgcgtttcag tgacctacct
     2701 taaaacaaca cacgagaaga gttaaactgg gttcatttta atgatcaatt tacctgcata
     2761 taaaatttat ttttaatcaa gctgatctta atgtatataa tcattctatt tgctttatta
     2821 tcggtgcagg taggtcatta acaccacttc ttttcatctg taccacaccc tggtgaaacc
     2881 tttgaagaca taaaaaaaac ctgtctgaga tgttctttct accaatctat atgtctttcg
     2941 gttatcaagt gtttctgcat ggtaatgtca tgtaaatgct gatattgatt tcactggtcc
     3001 atctatattt aaaacgtgca agaaaaaaat aaaatactct gctctagcaa gttttgtgta
     3061 acaaaggcat atcgtcatgt taataaattt aaaacatcat tcgtataaaa tattttaatt
     3121 ttcttgtatt tcatttagac ccaagaacat gctgaccaat gtgttctata tgtaaactac
     3181 aaattctatg gtagctttgt tgtatattat tgtaaaatta ttttaataag tcatggggat
     3241 gacaatttga ttattacaat ttagttttca gtaatcaaaa agatttctat gaattctaaa
     3301 aaatattttt ttctatgaaa ttactagtgc ccagctgtag aatctacctt aggtagatga
     3361 tccctagaca tacgttggtt ttgagggcta ttcagccatt ccattttact ctctatttaa
     3421 aggccgtgag caagcttgtc atgagcaaat atgtcaaggg agtcaatttc tgaccaatca
     3481 agtacactaa attagaatat ttttaaagta tgtaacattc ccagtttcag ccacaattta
     3541 gccaagaata agataaaaac ttgaataaga agtaagtagc ataaatcagt atttaaccta
     3601 aaattacata tttgaaacag aagatattat gttatgctca gtaaataatt aagagatggc
     3661 attgtgtaag aaggagccct agactgaaag tcaagacatc tgaatttcag gctggaaaac
     3721 tatcagtatg atctcagcct cagttctctt gtctgtaaaa tggaagaact ggattaggca
     3781 gtttgtaaga ttcctcctaa ctttcacagt cgatgacaag attgtctttt tatctgatat
     3841 tttgaagggt atattgcttt gaagtaagtc tcaataaggc aatatatttt agggcatctt
     3901 tcttcttatc tctgacagtg ttcttaaaat tatttgaata tcataagagc cttggtgtct
     3961 gtcctaattc ctttctcact caccgatgct gaatacccag ttgaatcaaa ctgtcaacct
     4021 accaaaaacg atattgtggc ttatgggtat tgctgtctca ttcttggtat attcttgtgt
     4081 taactgccca ttggcctgaa aatactcatt gtaagcctga aaaaaaaaat ctttcccact
     4141 gttttttctg cttgttgtaa gaatcaaatg aaataatgta tgtgaaagca ccttgtaaac
     4201 tgtaacctat caatgtaaaa tgttaaggtg tgttgttatt tcattaatta cttctttgtt
     4261 tagaatggaa tttcctatgc actactgtag ctaggaaatg ctgaaaacaa ctgtgttttt
     4321 taattaatca ataactgcaa aattaaagta ccttcaatgg ataagacaa
//
