LOCUS       NM_001242858            4321 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens protein kinase cAMP-activated catalytic subunit beta
            (PRKACB), transcript variant 5, mRNA.
ACCESSION   NM_001242858
VERSION     NM_001242858.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Tanaka,M., Takeshita,K., Kunita,A., Hasegawa,K. and Ushiku,T.
  TITLE     PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic
            Papillary Neoplasms Including Those With Atypical Morphology: An
            Analysis of 22 Cases Expanding Morphologic Spectrum
  JOURNAL   Am J Surg Pathol 48 (8), 1032-1040 (2024)
   PUBMED   38841868
  REMARK    GeneRIF: PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal
            Oncocytic Papillary Neoplasms Including Those With Atypical
            Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   3  (bases 1 to 4321)
  AUTHORS   Itoh,T., Omori,Y., Seino,M., Hirose,K., Date,F., Ono,Y.,
            Mizukami,Y., Aoki,S., Ishida,M., Mizuma,M., Morikawa,T.,
            Higuchi,R., Honda,G., Okamura,Y., Kinoshita,K., Unno,M. and
            Furukawa,T.
  TITLE     Gene Rearrangement and Expression of PRKACA and PRKACB Govern
            Morphobiology of Pancreatobiliary Oncocytic Neoplasms
  JOURNAL   Mod Pathol 37 (1), 100358 (2024)
   PUBMED   37871652
  REMARK    GeneRIF: Gene Rearrangement and Expression of PRKACA and PRKACB
            Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
REFERENCE   4  (bases 1 to 4321)
  AUTHORS   Maimaitiaili,Y., Fukumura,Y., Hirabayashi,K., Kinowaki,Y.,
            Naito,Y., Saito,A., Rong,L., Nakahodo,J. and Yao,T.
  TITLE     Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors
            of the pancreatobiliary and other systems
  JOURNAL   Virchows Arch 481 (6), 865-876 (2022)
   PUBMED   36152045
  REMARK    GeneRIF: Investigation of -PRKACA/-PRKACB fusion genes in oncocytic
            tumors of the pancreatobiliary and other systems.
REFERENCE   5  (bases 1 to 4321)
  AUTHORS   Orstavik,S., Reinton,N., Frengen,E., Langeland,B.T., Jahnsen,T. and
            Skalhegg,B.S.
  TITLE     Identification of novel splice variants of the human catalytic
            subunit Cbeta of cAMP-dependent protein kinase
  JOURNAL   Eur J Biochem 268 (19), 5066-5073 (2001)
   PUBMED   11589697
REFERENCE   6  (bases 1 to 4321)
  AUTHORS   Scarpetta,M.A. and Uhler,M.D.
  TITLE     Evidence for two additional isoforms of the endogenous protein
            kinase inhibitor of cAMP-dependent protein kinase in mouse
  JOURNAL   J Biol Chem 268 (15), 10927-10931 (1993)
   PUBMED   7684369
REFERENCE   7  (bases 1 to 4321)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   8  (bases 1 to 4321)
  AUTHORS   Simard,J., Berube,D., Sandberg,M., Grzeschik,K.H., Gagne,R.,
            Hansson,V. and Jahnsen,T.
  TITLE     Assignment of the gene encoding the catalytic subunit C beta of
            cAMP-dependent protein kinase to the p36 band on chromosome 1
  JOURNAL   Hum Genet 88 (6), 653-657 (1992)
   PUBMED   1551670
REFERENCE   9  (bases 1 to 4321)
  AUTHORS   Beebe,S.J., Oyen,O., Sandberg,M., Froysa,A., Hansson,V. and
            Jahnsen,T.
  TITLE     Molecular cloning of a tissue-specific protein kinase (C gamma)
            from human testis--representing a third isoform for the catalytic
            subunit of cAMP-dependent protein kinase
  JOURNAL   Mol Endocrinol 4 (3), 465-475 (1990)
   PUBMED   2342480
REFERENCE   10 (bases 1 to 4321)
  AUTHORS   Taylor,S.S., Buechler,J.A. and Yonemoto,W.
  TITLE     cAMP-dependent protein kinase: framework for a diverse family of
            regulatory enzymes
  JOURNAL   Annu Rev Biochem 59, 971-1005 (1990)
   PUBMED   2165385
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC322547.1, AK304375.1,
            BX641026.1 and AL450063.14.
            
            On Aug 14, 2020 this sequence version replaced NM_001242858.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. The encoded protein is a
            catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase,
            which mediates signalling though cAMP. cAMP signaling is important
            to a number of processes, including cell proliferaton and
            differentiation. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been observed. [provided by RefSeq,
            Jul 2014].
            
            Transcript Variant: This variant (5) differs in the 5' exon
            structure, compared to variant 1. The encoded isoform (5, also
            known as Cbeta3) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1861663.1,
                                           SRR14038195.560656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                DC322547.1         123-199
            78-1368             AK304375.1         1-1291
            1369-1390           BX641026.1         1528-1549
            1391-1391           AL450063.14        106530-106530
            1392-3505           BX641026.1         1551-3664
            3506-3506           AL450063.14        108645-108645
            3507-4321           BX641026.1         3666-4480
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4321
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
     exon            1..118
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1128
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /EC_number="2.7.11.11"
                     /note="isoform 5 is encoded by transcript variant 5;
                     protein kinase A catalytic subunit beta; protein kinase,
                     cAMP-dependent, catalytic, beta; protein kinase,
                     cAMP-dependent, beta catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta isoform 5"
                     /protein_id="NP_001229787.1"
                     /db_xref="CCDS:CCDS72813.1"
                     /db_xref="GeneID:5567"
                     /db_xref="HGNC:HGNC:9381"
                     /db_xref="MIM:176892"
                     /translation="MGLLKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFG
                     RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDN
                     SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN
                     LLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIY
                     EMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG
                     VSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAK
                     EFGEF"
     exon            119..180
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            181..309
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            310..408
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            409..491
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            492..618
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            619..714
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            715..837
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1002
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..4321
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4294..4299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="hexamer: ATTAAA"
     polyA_site      4321
                     /gene="PRKACB"
                     /gene_synonym="CAFD2; PKA C-beta; PKACB"
                     /note="major polyA site"
ORIGIN      
        1 acacagcatt ttaatatcag tgaggtccac agctagcagt aagagctggt gtaattgaaa
       61 gacgtttagg tgcaatcatt ctgctgtttg ctccttgcca ggttcaacat gggattgttg
      121 aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa tccaactcag
      181 aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga
      241 agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa gatcttagat
      301 aagcagaagg ttgttaaact gaagcaaata gagcatactt tgaatgagaa aagaatatta
      361 caggcagtga attttccttt ccttgttcga ctggagtatg cttttaagga taattctaat
      421 ttatacatgg ttatggaata tgtccctggg ggtgaaatgt tttcacatct aagaagaatt
      481 ggaaggttca gtgagcccca tgcacggttc tatgcagctc agatagtgct aacattcgag
      541 tacctccatt cactagacct catctacaga gatctaaaac ctgaaaatct cttaattgac
      601 catcaaggct atatccaggt cacagacttt gggtttgcca aaagagttaa aggcagaact
      661 tggacattat gtggaactcc agagtatttg gctccagaaa taattctcag caagggctac
      721 aataaggcag tggattggtg ggcattagga gtgctaatct atgaaatggc agctggctat
      781 cccccattct ttgcagacca accaattcag atttatgaaa agattgtttc tggaaaggtc
      841 cgattcccat cccacttcag ttcagatctc aaggaccttc tacggaacct gctgcaggtg
      901 gatttgacca agagatttgg aaatctaaag aatggtgtca gtgatataaa aactcacaag
      961 tggtttgcca cgacagattg gattgctatt taccagagga aggttgaagc tccattcata
     1021 ccaaagttta gaggctctgg agataccagc aactttgatg actatgaaga agaagatatc
     1081 cgtgtctcta taacagaaaa atgtgcaaaa gaatttggtg aattttaaag aggaacaaga
     1141 tgacatctga gctcacactc agtgtttgca ctctgttgag agataaggta gagctgagac
     1201 cgtccttgtt gaagcagtta cctagttcct tcattccaac gactgagtga ggtctttatt
     1261 gccatcatcc cgtgtgcgca ctctgcatcc acctatgtaa caaggcaccg ctaagcaagc
     1321 attgtctgtg ccataacaca gtactagacc actttcttac ttctctttgg gttgtctttc
     1381 tcctctccta tatccatttc ttccttttcc aatttcattg gttttctcta aacagtgctc
     1441 cattttattt tgttggtgtt tcagatgggc agtgttatgg ctacgtgata tttgaaggga
     1501 aggataagtg ttgctttcag tagttattgc caatattgtt gttggtcaat ggcttgaaga
     1561 taaactttct aataattatt atttctttga gtagctcaga cttggttttg ccaaaactct
     1621 tggtaatttt tgaagataga ctgtcttatc accaaggaaa tttatacaaa ttaagactaa
     1681 ctttcttgga attcactatt ctggcaataa attttggtag actaatacag tacagctaga
     1741 cccagaaatt tggaaggctg tagatcagag gttctagttc cctttccctc cttttatatc
     1801 ctcctctcct tgagtaatga agtgaccagc ctgtgtagtg tgacaaacgt gtctcattca
     1861 gcaggaaaaa ctaatgatat ggatcatcac ccagattctc tcacttggta ccagcatttc
     1921 tgtaggtatt agagaagagt tctaagtttt ctaaacctta actgttcctt aaggatttta
     1981 gccagtattt taatagaaca tgattaatga aagtgacaaa ttttaaattt tctctaatag
     2041 tcctcatcat aaacttttta aaggaaaata agcaaactaa aaagaacatt ggtttagata
     2101 aatacttata ctttgcaaag tcaaaaatgg cttgattttt ggaaacaata tagaggtatt
     2161 catatttaaa tgagggttta catttgtttt gttttgtaac cgttaaaaag aagttgtttc
     2221 cagctaatta ttgtggtgta ctatatttgt gagcctaggg taggggcact gctgcaactt
     2281 ctgctttcat cccatgcctc atcaatgagg aaagggaaca aagtgtataa aactgccaca
     2341 attgtatttt aattttgagg tatgatattt tcagatattt cataatttct aacctctgtt
     2401 ctctcagtaa acagaatgtc tgatcgatca tgcagataca atgttggtat ttgagaggtt
     2461 agtttttttc ctacactttt ttttgccaac tgacttaaca acattgctgt caggtggaaa
     2521 tttcaagcac ttttgcacat ttagttcagt gtttgttgag aatccatggc ttaacccact
     2581 tgttttgcta tttttttctt tgcttttaat tttccccatc tgattttatc tctgcgtttc
     2641 agtgacctac cttaaaacaa cacacgagaa gagttaaact gggttcattt taatgatcaa
     2701 tttacctgca tataaaattt atttttaatc aagctgatct taatgtatat aatcattcta
     2761 tttgctttat tatcggtgca ggtaggtcat taacaccact tcttttcatc tgtaccacac
     2821 cctggtgaaa cctttgaaga cataaaaaaa acctgtctga gatgttcttt ctaccaatct
     2881 atatgtcttt cggttatcaa gtgtttctgc atggtaatgt catgtaaatg ctgatattga
     2941 tttcactggt ccatctatat ttaaaacgtg caagaaaaaa ataaaatact ctgctctagc
     3001 aagttttgtg taacaaaggc atatcgtcat gttaataaat ttaaaacatc attcgtataa
     3061 aatattttaa ttttcttgta tttcatttag acccaagaac atgctgacca atgtgttcta
     3121 tatgtaaact acaaattcta tggtagcttt gttgtatatt attgtaaaat tattttaata
     3181 agtcatgggg atgacaattt gattattaca atttagtttt cagtaatcaa aaagatttct
     3241 atgaattcta aaaaatattt ttttctatga aattactagt gcccagctgt agaatctacc
     3301 ttaggtagat gatccctaga catacgttgg ttttgagggc tattcagcca ttccatttta
     3361 ctctctattt aaaggccgtg agcaagcttg tcatgagcaa atatgtcaag ggagtcaatt
     3421 tctgaccaat caagtacact aaattagaat atttttaaag tatgtaacat tcccagtttc
     3481 agccacaatt tagccaagaa taagataaaa acttgaataa gaagtaagta gcataaatca
     3541 gtatttaacc taaaattaca tatttgaaac agaagatatt atgttatgct cagtaaataa
     3601 ttaagagatg gcattgtgta agaaggagcc ctagactgaa agtcaagaca tctgaatttc
     3661 aggctggaaa actatcagta tgatctcagc ctcagttctc ttgtctgtaa aatggaagaa
     3721 ctggattagg cagtttgtaa gattcctcct aactttcaca gtcgatgaca agattgtctt
     3781 tttatctgat attttgaagg gtatattgct ttgaagtaag tctcaataag gcaatatatt
     3841 ttagggcatc tttcttctta tctctgacag tgttcttaaa attatttgaa tatcataaga
     3901 gccttggtgt ctgtcctaat tcctttctca ctcaccgatg ctgaataccc agttgaatca
     3961 aactgtcaac ctaccaaaaa cgatattgtg gcttatgggt attgctgtct cattcttggt
     4021 atattcttgt gttaactgcc cattggcctg aaaatactca ttgtaagcct gaaaaaaaaa
     4081 atctttccca ctgttttttc tgcttgttgt aagaatcaaa tgaaataatg tatgtgaaag
     4141 caccttgtaa actgtaacct atcaatgtaa aatgttaagg tgtgttgtta tttcattaat
     4201 tacttctttg tttagaatgg aatttcctat gcactactgt agctaggaaa tgctgaaaac
     4261 aactgtgttt tttaattaat caataactgc aaaattaaag taccttcaat ggataagaca
     4321 a
//
