LOCUS       NM_178013               3715 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA.
ACCESSION   NM_178013
VERSION     NM_178013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Rangel,L.P., Ferretti,G.D.S., Costa,C.L., Andrade,S.M.M.V.,
            Carvalho,R.S., Costa,D.C.F. and Silva,J.L.
  TITLE     p53 reactivation with induction of massive apoptosis-1 (PRIMA-1)
            inhibits amyloid aggregation of mutant p53 in cancer cells
  JOURNAL   J Biol Chem 294 (10), 3670-3682 (2019)
   PUBMED   30602570
  REMARK    GeneRIF: PRIMA-1 can rescue amyloid-state p53 mutants
REFERENCE   2  (bases 1 to 3715)
  AUTHORS   Bartak,B.K., Kalmar,A., Peterfia,B., Patai,A.V., Galamb,O.,
            Valcz,G., Spisak,S., Wichmann,B., Nagy,Z.B., Toth,K., Tulassay,Z.,
            Igaz,P. and Molnar,B.
  TITLE     Colorectal adenoma and cancer detection based on altered
            methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma
            samples
  JOURNAL   Epigenetics 12 (9), 751-763 (2017)
   PUBMED   28753106
  REMARK    GeneRIF: Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter
            sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma
            samples from patients with Colorectal cancer and 89.2%, 83.8%,
            81.1% and 70.3% from adenoma patients, respectively.
REFERENCE   3  (bases 1 to 3715)
  AUTHORS   Teoh,P.J., Bi,C., Sintosebastian,C., Tay,L.S., Fonseca,R. and
            Chng,W.J.
  TITLE     PRIMA-1 targets the vulnerability of multiple myeloma of
            deregulated protein homeostasis through the perturbation of ER
            stress via p73 demethylation
  JOURNAL   Oncotarget 7 (38), 61806-61819 (2016)
   PUBMED   27533450
  REMARK    GeneRIF: PRIMA-1 could cause the demethylation of TP73, through
            DNMT1 depletion, to subsequently enhance the unfolded protein
            response
REFERENCE   4  (bases 1 to 3715)
  AUTHORS   Zhang,W., Yi,B., Wang,C., Chen,D., Bae,S., Wei,S., Guo,R.J., Lu,C.,
            Nguyen,L.L., Yang,W.H., Lillard,J.W., Zhang,X., Wang,L. and Liu,R.
  TITLE     Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of
            Mutant p53 in Prostate Cancer Cells
  JOURNAL   Clin Cancer Res 22 (10), 2545-2554 (2016)
   PUBMED   26712693
  REMARK    GeneRIF: Silencing of CD24 enhanced restoration of PRIMA-1-induced
            mutant p53 in endogenous TP53(P223L/V274F) DU145 cells.
REFERENCE   5  (bases 1 to 3715)
  AUTHORS   Teschler,S., Gotthardt,J., Dammann,G. and Dammann,R.H.
  TITLE     Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline
            Personality Disorder
  JOURNAL   Int J Mol Sci 17 (1), 67 (2016)
   PUBMED   26742039
  REMARK    GeneRIF: The results suggest that aberrant methylation of rDNA and
            PRIMA1 is associated with the pathogenesis of Borderline
            Personality Disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3715)
  AUTHORS   Xie,H.Q., Choi,R.C., Leung,K.W., Chen,V.P., Chu,G.K. and Tsim,K.W.
  TITLE     Transcriptional regulation of proline-rich membrane anchor (PRiMA)
            of globular form acetylcholinesterase in neuron: an inductive
            effect of neuron differentiation
  JOURNAL   Brain Res 1265, 13-23 (2009)
   PUBMED   19368807
  REMARK    GeneRIF: These results suggested that a MAP kinase signaling
            pathway served as one of the transcriptional regulators in
            controlling PRiMA gene expression during the neuronal
            differentiation process.
REFERENCE   7  (bases 1 to 3715)
  AUTHORS   Vanaja,D.K., Ballman,K.V., Morlan,B.W., Cheville,J.C.,
            Neumann,R.M., Lieber,M.M., Tindall,D.J. and Young,C.Y.
  TITLE     PDLIM4 repression by hypermethylation as a potential biomarker for
            prostate cancer
  JOURNAL   Clin Cancer Res 12 (4), 1128-1136 (2006)
   PUBMED   16489065
REFERENCE   8  (bases 1 to 3715)
  AUTHORS   Xie,H.Q., Siow,N.L., Peng,H.B., Massoulie,J. and Tsim,K.W.
  TITLE     Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE)
            in neuron and muscle
  JOURNAL   Chem Biol Interact 157-158, 432 (2005)
   PUBMED   16429581
  REMARK    GeneRIF: PRiMA-Luc promotor-driven luciferase activity was
            increased during cell differentiation
REFERENCE   9  (bases 1 to 3715)
  AUTHORS   Perrier,N.A., Kherif,S., Perrier,A.L., Dumas,S., Mallet,J. and
            Massoulie,J.
  TITLE     Expression of PRiMA in the mouse brain: membrane anchoring and
            accumulation of 'tailed' acetylcholinesterase
  JOURNAL   Eur J Neurosci 18 (7), 1837-1847 (2003)
   PUBMED   14622217
REFERENCE   10 (bases 1 to 3715)
  AUTHORS   Perrier,A.L., Massoulie,J. and Krejci,E.
  TITLE     PRiMA: the membrane anchor of acetylcholinesterase in the brain
  JOURNAL   Neuron 33 (2), 275-285 (2002)
   PUBMED   11804574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132642.4, AY225516.1,
            AL157858.5 and BU726715.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178013.3.
            
            Summary: The product of this gene functions to organize
            acetylcholinesterase (AChE) into tetramers, and to anchor AChE at
            neural cell membranes. [provided by RefSeq, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304717.575153.1, AY225516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393140.6/ ENSP00000376848.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL132642.4         21950-22014         c
            66-106              AY225516.1         1-41
            107-107             AL132642.4         21248-21248         c
            108-157             AY225516.1         43-92
            158-158             AL132642.4         21197-21197         c
            159-975             AY225516.1         94-910
            976-3411            AL157858.5         47029-49464
            3412-3715           BU726715.1         19-322              c
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..3715
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /note="proline rich membrane anchor 1"
                     /db_xref="GeneID:145270"
                     /db_xref="HGNC:HGNC:18319"
                     /db_xref="MIM:613851"
     exon            1..76
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /inference="alignment:Splign:2.1.0"
     exon            77..200
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..569
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /note="acetylcholinesterase membrane anchor precursor
                     PRiMA"
                     /codon_start=1
                     /product="proline-rich membrane anchor 1 precursor"
                     /protein_id="NP_821092.1"
                     /db_xref="CCDS:CCDS9912.1"
                     /db_xref="GeneID:145270"
                     /db_xref="HGNC:HGNC:18319"
                     /db_xref="MIM:613851"
                     /translation="MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKV
                     TDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCA
                     SLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV"
     exon            201..336
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /inference="alignment:Splign:2.1.0"
     exon            337..466
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /inference="alignment:Splign:2.1.0"
     exon            467..3715
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /note="hexamer: AATAAA"
     polyA_site      3715
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /note="major polyA site"
ORIGIN      
        1 aaacagagct gccgcggggg gaacgcggac ctcttttccc cgagcccagg gtcggctggg
       61 gccgccgcca ggcaagttcg ccccaggagc gggcgccgct ggccgagatg ctcctccggg
      121 acttggtgct gcgccgtggc tgctgctggt cctcgctgct gctgcactgc gcgctccacc
      181 cgctctgggg cttcgtgcag gtgacgcatg gtgagcccca gaagtcctgc tccaaagtga
      241 ctgacagctg ccgacacgtc tgccagtgcc ggccccctcc cccgctgccc ccgccgcccc
      301 cacccccgcc acctcccaga ctcctctccg ccccagctcc caactctacc tcttgcccca
      361 ctgaggaaag ctggtggtcg gggctggtga tcatcattgc cgtatgctgt gcctccctgg
      421 tgtttctgac tgtgcttgtc atcatttgct acaaagccat aaaaaggaaa ccactgagaa
      481 aagacgaaaa tggcaccagc gttgctgagt atcccatgag tgcttcgcag agcaacaaag
      541 gagtagacgt gaacaacgca gtggtgtgag tctgcaggcc ctggacccgc tggccagagg
      601 gacaccttgg tggcactggt ggacatggga aagcaggtgg acatgagcta accctgagct
      661 tgtccaggac ttcattgcct cacaggccct gagcctcccg aaggagaaac cattgtcttc
      721 ccaggcttgc ccctggtcag cctgcgggcc caggcagctc ggacaccagg ctgagcccgg
      781 cgcagcacct gggcagtgtc cccaccccag gccctccaca tcctcctccc tgtctggtgt
      841 ctggtctgtc gactgccccc agctgctgtc taaagcatgc gcactggcga agccagaggg
      901 atctgtcttt ctactgtggc agggaggctt ccccctttag ccaaaagaaa gatggtccgg
      961 agcccactcc ctgccggaaa acctctcctc ctcccaggaa gcctgcctgc tccactgttc
     1021 acattctcaa cagaagccat cggcacagcc agcagacaga cgtccccttt caaaggtgct
     1081 tcccacacat ctgttcatcg ccccatctgc agttgttgtc aatcttcagg gcctgccttc
     1141 tccctcctat ccccactgac accctacacc ctaggctcct gactgcctgc catggagggc
     1201 tgtgagtcca gcctgcagaa tcccctcctg agcagacaca ggagtgcgtt tacactcggg
     1261 ggcagtgtct ggccttccgg gggcaaaacg actcactgaa cccgcagccc agggccactg
     1321 ggcaagggca gaggccactg cacctgtcct cagactcatc cccacacttg accccatagg
     1381 aactgatgca tctgtgtgag ccaggccctg ccttagtcag cagaggccac tacttgtgcc
     1441 aaatccactg tgggcctgct gtaccaggct gatgctggcc aggcgctgga tgtcccccac
     1501 agtcccctga ggcctgactg ttgtactcag gccctctccc agagtcctcc atcatctccc
     1561 cattttaccc taccccgagc cccagtcgcc aagaaggagg tgttgttctt ccagggtctt
     1621 cctttcaatg tctgtttcca cagtctcatg ctatagaagc gctgagccct ccagcgtggt
     1681 tggaggatca agggatgaaa tgggacagga ggagaggggt cctccaggct ggtgacccct
     1741 gccctgttgg cctgtctccc aagtggcagc cttccctgtg ggccacatca ggaaacccac
     1801 ggagacaggg tgattttgca tctcctggaa aatgagtggg acactcctgg ccccctggct
     1861 ctccccacca cccctacata tgtgctcaga aggagcccaa tgcattgaat ggttccactg
     1921 tcgagccctc taagacctgg tttgcctcct aaacctccag tgtgctcctc tgataggtgt
     1981 ttaagctaca ggtgagactt tgaagtccag agaagacaga cacacctgaa aaccggtccc
     2041 catttgggcc gaaccttaaa aagcccattg tcccagagtc ctagtgccca cggagctgtc
     2101 tgtgtgtcat tgtcctgccc aggtcatcag gtgtgggctg aggacaggcc cagggcatac
     2161 cctcccataa aggggttttc ttctttcctc atttccttct atttgaggac ttgtttgggg
     2221 tttagatttg aattttgctt cccctggaca cctgggcatc agcatagtgc caccccctgc
     2281 tcctgacctg gccagtactt cacagtgctc ttgaggtgcg gagccagctg acaaataggc
     2341 cagagggtgt gggccagcag caggttaaag ggggaaaccc agcagacccc accccagggc
     2401 actctcccct actgccttca gccttctggt gcctgttgaa cccccaagct gtgccctaag
     2461 cagacccctg ggcaggaccc tagccctaag cacacaccac cctgtgctgc aaccatgaga
     2521 aagtgcccat gccttgggct gtccagaagc tcaggagtga tcagagggca ccttctctaa
     2581 gaggggaggt tcctggctaa gggaccatgg agtggtgggc agcctgaagg ggctgggcac
     2641 agcccagctt tgcgcacact cgcctggtcc catcattccc taccttggct taaacctagg
     2701 aggcctggat tttgcagtta gcctaatctt ccagccccag gcgaggctcc ctggtgagga
     2761 atcagctgag ccatcaccac gttttggggc ctgtatcctc ttccctgagc cgctgacgca
     2821 tccagggctc tagtctgcac ataaattccc tctcagctgg gcttgtaaaa tcccttctca
     2881 ccccagttag caaaaatcaa gggaagagcc tagttttttt aaaagattca cttaatatcc
     2941 accccccacc tcaagcccaa gaccgcccat tcaaaaaaca agtatacggc acagcaaggg
     3001 agacccacta gattttgagc ttacagagac ataagggtac ttaaaaccct gccggcctag
     3061 tatttgagct tagaactttt atttaaaatg agccggcagt ctctagacac acaccgatcc
     3121 tcaggctagt ccgagccctg aggtcaagaa tgaaatgcac ttcccttctc attttctcaa
     3181 atagatcttt tccagccgtc tcacagttga ccccaacttt ggaactcaga tcataggatc
     3241 tcccagaggt ttcaggtgtt cctaagaagc ttctaaagga agttttggaa gaaagactaa
     3301 taggtgtaaa catataaaca tatatattat atatagctat atatatttaa agagatctct
     3361 acatatatat atatatataa atacaactac tgtactctct gcatctgtac aaagtatgag
     3421 ttaaactgcc caggtagtgt gagatacgta atgcatgaat gtgaatatcc tgaaatctgc
     3481 cttcttagca acgtgccgcg tgtactggag agaggacagt tgctcctggg agttctctca
     3541 atgggcaaat gtacaagttg atgccgtctt atccaccaac aagccattaa ggttggtttc
     3601 ctgctgagac ttttgtaccg gaagcgagac cggcagcact gggggtgtcc atatgccact
     3661 tatgaggaag aaagcaccat gactttttta ttttcaataa aaatatagag atgtc
//
