LOCUS       NM_198859               9947 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens prickle planar cell polarity protein 2 (PRICKLE2),
            transcript variant 1, mRNA.
ACCESSION   NM_198859 XM_093799
VERSION     NM_198859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9947)
  AUTHORS   Bayat,A., Iqbal,S., Borredy,K., Amiel,J., Zweier,C., Barcia,G.,
            Kraus,C., Weyhreter,H., Bassuk,A.G., Chopra,M., Rubboli,G. and
            Moller,R.S.
  TITLE     PRICKLE2 revisited-further evidence implicating PRICKLE2 in
            neurodevelopmental disorders
  JOURNAL   Eur J Hum Genet 29 (8), 1235-1244 (2021)
   PUBMED   34092786
  REMARK    GeneRIF: PRICKLE2 revisited-further evidence implicating PRICKLE2
            in neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 9947)
  AUTHORS   Arenas,E.
  TITLE     Wnt signaling in midbrain dopaminergic neuron development and
            regenerative medicine for Parkinson's disease
  JOURNAL   J Mol Cell Biol 6 (1), 42-53 (2014)
   PUBMED   24431302
  REMARK    Review article
REFERENCE   3  (bases 1 to 9947)
  AUTHORS   Sowers,L.P., Loo,L., Wu,Y., Campbell,E., Ulrich,J.D., Wu,S.,
            Paemka,L., Wassink,T., Meyer,K., Bing,X., El-Shanti,H.,
            Usachev,Y.M., Ueno,N., Manak,J.R., Shepherd,A.J., Ferguson,P.J.,
            Darbro,B.W., Richerson,G.B., Mohapatra,D.P., Wemmie,J.A. and
            Bassuk,A.G.
  TITLE     Disruption of the non-canonical Wnt gene PRICKLE2 leads to
            autism-like behaviors with evidence for hippocampal synaptic
            dysfunction
  JOURNAL   Mol Psychiatry 18 (10), 1077-1089 (2013)
   PUBMED   23711981
  REMARK    GeneRIF: 2 autism-spectrum-disorder patients had distinct,
            paternally inherited, heterozygous, non-synonymous PRICKLE2
            variants (p.E8Q and p.V153I) shared by their affected siblings.
            These variants had deficits in morphological and
            electrophysiological assays.
            Erratum:[Mol Psychiatry. 2014 Jun;19(6):742. Manak, R J [corrected
            to Manak, J R]]
REFERENCE   4  (bases 1 to 9947)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9947)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   6  (bases 1 to 9947)
  AUTHORS   Daulat,A.M., Luu,O., Sing,A., Zhang,L., Wrana,J.L., McNeill,H.,
            Winklbauer,R. and Angers,S.
  TITLE     Mink1 regulates beta-catenin-independent Wnt signaling via Prickle
            phosphorylation
  JOURNAL   Mol Cell Biol 32 (1), 173-185 (2012)
   PUBMED   22037766
  REMARK    GeneRIF: MINK1 interacts with and phosphorylates PRICKLE1 and
            PRICKLE2.
REFERENCE   7  (bases 1 to 9947)
  AUTHORS   Tanaka,T., Scheet,P., Giusti,B., Bandinelli,S., Piras,M.G.,
            Usala,G., Lai,S., Mulas,A., Corsi,A.M., Vestrini,A., Sofi,F.,
            Gori,A.M., Abbate,R., Guralnik,J., Singleton,A., Abecasis,G.R.,
            Schlessinger,D., Uda,M. and Ferrucci,L.
  TITLE     Genome-wide association study of vitamin B6, vitamin B12, folate,
            and homocysteine blood concentrations
  JOURNAL   Am J Hum Genet 84 (4), 477-482 (2009)
   PUBMED   19303062
  REMARK    Erratum:[Am J Hum Genet. 2009 May;84(5):712]
REFERENCE   8  (bases 1 to 9947)
  AUTHORS   Maurer-Stroh,S., Koranda,M., Benetka,W., Schneider,G., Sirota,F.L.
            and Eisenhaber,F.
  TITLE     Towards complete sets of farnesylated and geranylgeranylated
            proteins
  JOURNAL   PLoS Comput Biol 3 (4), e66 (2007)
   PUBMED   17411337
REFERENCE   9  (bases 1 to 9947)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human PRICKLE1 and PRICKLE2
            genes as well as mouse Prickle1 and Prickle2 genes homologous to
            Drosophila tissue polarity gene prickle
  JOURNAL   Int J Mol Med 11 (2), 249-256 (2003)
   PUBMED   12525887
  REMARK    GeneRIF: PRICKLE1 and PRICKLE2 mRNAs were expressed together in
            brain, eye and testis.
REFERENCE   10 (bases 1 to 9947)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136275.1, AL833539.1,
            BC119002.1 and AC092040.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198859.3.
            
            Summary: This gene encodes a homolog of Drosophila prickle. The
            exact function of this gene is not known, however, studies in mice
            suggest that it may be involved in seizure prevention. Mutations in
            this gene are associated with progressive myoclonic epilepsy type
            5. [provided by RefSeq, Dec 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833539.1, BC119002.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638394.2/ ENSP00000492363.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC136275.1         3818-3828           c
            12-30               AL833539.1         2-20
            31-1412             BC119002.1         1-1382
            1413-1413           AC092040.2         75970-75970
            1414-3710           BC119002.1         1384-3680
            3711-8333           AC092040.2         125172-129794
            8334-9947           AC092040.2         129795-131408
FEATURES             Location/Qualifiers
     source          1..9947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..9947
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="prickle planar cell polarity protein 2"
                     /db_xref="GeneID:166336"
                     /db_xref="HGNC:HGNC:20340"
                     /db_xref="MIM:608501"
     exon            1..557
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            558..741
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..3132
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="prickle homolog 2"
                     /codon_start=1
                     /product="prickle-like protein 2"
                     /protein_id="NP_942559.1"
                     /db_xref="CCDS:CCDS2902.1"
                     /db_xref="GeneID:166336"
                     /db_xref="HGNC:HGNC:20340"
                     /db_xref="MIM:608501"
                     /translation="MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGL
                     KPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELK
                     LFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCF
                     VCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMK
                     HFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHW
                     HATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKES
                     RRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDP
                     IWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPK
                     RSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEE
                     EEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEH
                     LSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQL
                     SNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRF
                     RPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGS
                     RRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQP
                     ARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCIIS"
     exon            742..855
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            856..993
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1197
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1384
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..2257
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..9947
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8295..8300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="hexamer: AATAAA"
     regulatory      8311..8316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="hexamer: AAGAAA"
     polyA_site      8316
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="major polyA site"
     polyA_site      8333
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
     regulatory      9319..9324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="hexamer: ATTAAA"
     polyA_site      9336
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
     regulatory      9921..9926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
                     /note="hexamer: AATAAA"
     polyA_site      9947
                     /gene="PRICKLE2"
                     /gene_synonym="EPM5"
ORIGIN      
        1 actgcaacag cgacttctca ggcaccacca gcagcgccac cgagagttat tattattttt
       61 tgaccaagca gcacatttcc tggttcagtg gcttgagctc tgtgagcagc tgactagtca
      121 ccccgggtct ggctcaggat cagctggtga cgctgggctg gagtctatga cttcttcctt
      181 cagattgtca tgaagaaggg gagttaagag gaaactgggg gtcctccgga aggcgatctg
      241 agcactcagg ctgatctaga ggaagagtag aagtcatact ttttttctct tgcttggtga
      301 attccccagc agagtctgga tccagcagtg ctgttttccc tgagggaatg tggagcagct
      361 cggcttgagt ctgttgccag cttcaggaag ggttcagact gaaaaggggg tttgaggaga
      421 agatgctttg gctgcctgag gtcctgcttg cgttcttaga agtcagatcc agggagaaag
      481 tgaactggga caattgacaa gctccaaggg tctggcagaa gcttcctccg agactgggca
      541 tttcatcctc cctggaggaa gatctgcctg cactgcaagt gtccccagga ggagcacatg
      601 gtgacagtga tgccgctgga gatggagaag accatcagca aactcatgtt tgactttcag
      661 aggaactcga cctcagatga tgactcaggc tgtgctttgg aagagtatgc ctgggtcccg
      721 ccgggtctga agcctgaaca ggtacaccag tactatagct gtctcccaga agagaaagtc
      781 ccttatgtca acagtcctgg agagaaactg cgaatcaagc agctactaca ccagctgccg
      841 ccacatgaca atgaggttcg atattgcaac tccctggatg aggaagagaa gagggagctg
      901 aagcttttca gcagccagag gaaacgcgaa aacttgggcc gcgggaatgt caggcctttc
      961 ccagtcacca tgacaggagc tatttgtgaa cagtgcggag gccagatcaa tggtggagac
     1021 atcgctgtgt ttgcgtcacg cgctggccac ggcgtttgct ggcacccgcc gtgcttcgta
     1081 tgcactgtct gcaatgagct cctggtggat ctgatctact tttaccaaga tgggaagata
     1141 tactgtggca ggcaccatgc tgagtgcctg aagccgcgct gtgctgcctg cgatgagatc
     1201 atctttgcag atgaatgcac agaagctgag gggcgacact ggcacatgaa acacttttgc
     1261 tgcttcgagt gtgagacagt gctgggcggc cagcgctaca tcatgaagga gggaagaccc
     1321 tactgttgcc actgcttcga gtccttgtat gcagaatatt gtgacacctg tgcccaacat
     1381 ataggtatcg accaaggtca aatgacctat gatggccaac actggcatgc cactgagacc
     1441 tgtttctgct gtgctcactg caagaaatcc ctcctggggc ggccattcct cccgaagcag
     1501 ggccagatat tctgctcacg ggcctgcagt gctggggaag accccaatgg ttctgactcc
     1561 tctgattccg ccttccagaa cgccagggcc aaggagtccc ggcgcagtgc caaaattggc
     1621 aagaacaagg gcaagacgga ggagcccatg ctgaaccagc acagccagct gcaagtgagt
     1681 tctaaccggc tgtcagccga cgtagacccc ctgtcactgc agatggacat gctcagcctg
     1741 tccagccaga cacccagcct caaccgggac cccatctgga ggagccggga agagccctac
     1801 cattatggga acaagatgga gcagaaccag acccagagcc ctctgcagct cctcagccag
     1861 tgcaacatca gaacttccta cagtccagga gggcaagggg ctggggccca gcccgaaatg
     1921 tggggcaagc acttcagcaa ccccaaaagg agctcgtcac tggccatgac aggacatgct
     1981 ggcagcttca tcaaggaatg ccgagaagac tattacccgg ggaggctgag atctcaggag
     2041 agctacagtg atatgtctag tcagagtttc agtgagaccc gaggcagcat ccaagtcccc
     2101 aaatatgagg aggaagagga agaggaaggg ggcttgtcca ctcagcagtg tcggacccgt
     2161 catcccatca gttccctgaa atacacagag gacatgacgc ccacagagca gacccctcgg
     2221 ggctccatgg aatccctggc cctgtctaat gcaacaggcc tctctgctga tggtggtgcc
     2281 aagcgccagg agcacctatc ccgattttcc atgcctgacc tcagcaaaga ctctggaatg
     2341 aatgtgtctg agaagctgag caacatgggc actcttaact cgtccatgca gttccggagc
     2401 gcagagtcag ttcgcagcct gctctctgcc cagcagtacc aggagatgga gggaaacctc
     2461 caccagctca gcaaccccat tggctacaga gacctgcagt cccacggaag gatgcatcag
     2521 agctttgatt ttgatggagg gatggcgggc agcaagctgc cagggcagga gggcgtgagg
     2581 atccagccca tgagtgaacg cacccggaga agagctactt cacgcgacga caaccgccgt
     2641 ttccgacctc acaggtccag gcgttcccga cgctctcgct ccgacaacgc cctccacctg
     2701 gccagcgaac gcgaggccat ctcccggtta aaagataggc cccctctgag agccagggag
     2761 gactatgacc aatttatgcg ccagcggagc ttccaggaga gcatggggca tgggtcccgg
     2821 agggacctgt acggccagtg ccctaggact gtgtcggacc tggctttgca gaatgccttt
     2881 ggggaccgct ggggacccta cttcgccgag tatgattggt gttccacctg ctcctcctct
     2941 tcagagtctg acaacgaggg ctatttccta ggagaaccca tcccccagcc agcgcgcctg
     3001 cgatacgtca caagcgatga gctgctgcac aaatacagct cctacggcct ccccaaatct
     3061 tccacattag gtggcagagg acagttgcac agcaggaaaa gacagaagag caaaaactgt
     3121 atcatttctt aatatgattg ggatcaggga atgggagaag atgggagcta agaatgtaaa
     3181 gtcagaaact tgcactgttt taaatgttaa agcgcttttg ggggtggctt atgggggaga
     3241 aaagggaaaa tgctgtcagt agatggaggc aaggttacag gttgactcaa taggtagtca
     3301 cagttcttgg catgttgaat attatttgca catttcactt tggaaacaca gtagactcta
     3361 tcgaggccag gcttggtcac ttccttccca tcagttctgt gttgagttgc catctctcaa
     3421 gatggtaaat tgtttcctgc tcgcttttat cctctctggt tctcttactt ttaggaccct
     3481 tttttcagta agtaatttgt ttattagcca ggacccaaga ctaagttatt tacatgtcca
     3541 ttgtaaatgc aatgtaaatg agagttctga taaaatattt ttgtattttg taatatcaaa
     3601 ggaatttcta tatcgtagga ctcagtgggg acttgcatgc acatccacca ttgtctctga
     3661 gtagtattga aatgtggccc ggtaccacct tttttttttt tttttttttt tctatacaaa
     3721 tttgttacat gtcagtgaga cctttttcaa aggaacatat tcaatttggc tttttgtggc
     3781 tgaaaaaaca taactgttag acccaaagca ttttatgctc cgttccatct taaggagcca
     3841 tccttaagtc tgctcccacc ctcagtagaa tttattttct acaaagtggt agtaattttt
     3901 ttttaaattg caaatgtaat ttttgccaat tagagaaacc aaccggtgtc agtaaaattc
     3961 tgtgagaaat gccatccctg ctgggaatgt tgaagttact taatgttgat ctatcccttg
     4021 gggaaagtaa aagtgactgt gagtggtgcc attgtgtgat gtcagcatga cgttgttttg
     4081 aatgtggcat tatgttctgg tgctcatgtt tcctggattg tattatctgc tttcctttac
     4141 caaggcagac agaactgctg ccttagcctg acaaccggtt gtcctcaaag caaatgaact
     4201 taagcatttg ggattgaggg acagaaggat tctgaggggg ctctgcgagg gacggtgtgt
     4261 gacatgtcat gcctggagaa ggaacaaggc tatttgaaaa cagaaggcag gtcaagggta
     4321 gaagttaaag gagaatctga aggcaggtca gggaaaagaa gaactggaaa tgaaacagag
     4381 gacaggtgac aaccacctcg aagagctccc agagattgta gaaagagtcc agtgtaacca
     4441 gcttagtaac cagagtatct ggattaccca ggaaggttga gctgctgaga tttcagtggt
     4501 gcaatgtctt taaaaaaaca ggctttgttg ggagggtatt tccattttga actttgagga
     4561 ctgttggtca gaaaatgggc tcaaaagtga gtttgcttaa tgaagacatt taacggttgt
     4621 gctgtttata gtaaaataaa actccctacc ttgcttcagt taaaaatgaa gcacttggtt
     4681 tcttccatcc tcctcctccc cttaatggat tgtggcagtt gaaataatcc atcggatgac
     4741 ccacctgtag tgagatgtac tgtcgatgta gtgcccggtg tatctcagtg gccatctgcc
     4801 atggtgaggt gagcgtgatc tcttttcagt atagtagtta acattttcta gtatttttta
     4861 tggagagaat gtcaaaagtg gcatttcaga ccccgtccca gatgggtctg aggaaaggaa
     4921 ggctgtaaag gacatggtaa tggcactcca ttcgggatgt attaaaataa tttgcttttc
     4981 aggtattaat atgacatttg tcattgtcac tgattttttt aaaaaagcaa tgcacatgtt
     5041 ggttgtggct gttttccgca tgctatcttc atatctaaat gcttcattaa ttatccgagc
     5101 ctccggagaa ttaactctat tacgtttgta tagtaagttt gtaaactgct tggcaaactg
     5161 attaagaaat aatttgcaat accgtgctac taaagtggca ggtttctggt agaaattgtg
     5221 cgagtccaat ttggagtttt aagttccttg attgatgaaa ctaaaaaggc aattttggaa
     5281 aaagagaggg ggaaaagtag atcacttatc ttagcaaacg gttgaaaata tgtctgtcct
     5341 ctgtggcccc aaatccagtg aaagaaattc tcccagtaaa agttgcttcc taactctgtt
     5401 tttctcagaa tacctcttac ctttctcaaa gaaagcttca accaccatca tcagaaagaa
     5461 ggtggcctaa aaactgacac atggccagtg cccggagggg tctggaggca taagtctaga
     5521 tgcccagaga gcatccaggc actgaactgc tcagagcttg agatgaaatg acatacaagc
     5581 ttcagggtaa aactgtctac tagcaagatt acctccctca attctaccat tgcagatttc
     5641 ttctgacccc aaatgcaacc ttacagagaa tgctgaatga ggaaggccaa ttccttacaa
     5701 tgatggcaga acccccaagc gaatgcccta ttgaggagaa ggacatcact gtatttggaa
     5761 ttctgcctgc tagtgatagc tcacacatca catcccagaa tcccactccc aatgcattat
     5821 ttcctgaggc aagaacttaa ggtcctcacc taattcctcc atcacaacca ttaactctta
     5881 ttggacaagc tcctcctgtg agtagggcct gtactcactt cctcttagat cataattcca
     5941 tcttcaagag actgatttcc agaatagtaa tctttttcca gcgttctctc ttctccaatg
     6001 ccctggttgt tatttttccc acctctccta atattgatct tcttgtcttt tggttagaac
     6061 tgcaacttcg gagttgagtt catttcctat tgctgctcaa ttcagtagca acatagctgg
     6121 cttgttccca gacccaggaa gtataagtca ttgacagttt cctgagtggc tctgccaatc
     6181 cataccaccc ttggtactgt gaaaaggctt cttggcagcc aggtggcatt gaggatggta
     6241 ttcagggcgc tttccttctg tcatatagtt gtgggatctc taccaagtgt gaaggtgaat
     6301 gaggtaaggg agatcagaac catgcttcct ggtttttcat acatccaagg aagaagtcct
     6361 ggtgtgggtt gtttgacacc ttctttccac tttcaccttt tattttttat tccttccttt
     6421 ctacccccaa ccagtcgagc aaatgagcaa ttttgtgttt ctaatacagg atctggaagt
     6481 agtgctttct aatcctcatt tcctgtagga tgttcctgca ctataacaag attatgtttt
     6541 cttccttctg cagcagcttt ctgcttcttg ggtactacta gctattgttc aattcaggtg
     6601 aggcctgtga tgacatatat gtagcatgtg ctctgcgctc cctgcaagct gagcagatac
     6661 aaccaatgca tcactgtata ctcttgctga gaatgtggat gcagcctcac agatctttgc
     6721 aacactccaa ccagccagga ccagttgatc agaactgatc ttattggtct gataaccaat
     6781 cttatttgtg aactgattca tatctgtctt tccactcttg gttctcttgc cgtagaacaa
     6841 aaacagttta ggaagcataa ttacgaacat ttaggaacca atatgtataa gtaattcgga
     6901 gactccaatt cacctgcccc tcccccatcc caggttgtgg aggctcgagg aagctgactt
     6961 cttaggctaa aggacaaaaa aatctcttta cctccttggc cattttcatg ttctctgcca
     7021 attactatag gcagtcttca ttttgcagag gtgaggtaag acttcatctt attcttcatg
     7081 taatcccacc ttctaacaaa aaataaataa atatttaaat tccaaggaga agtgttcttt
     7141 gtgtatttct agcagaaaac agatgcttaa gcctaagaag gaagatccgt ccatgacaaa
     7201 ggaaagtgga aaactgaacc agttatctga atacttcatg ccaggacagt tgctattagc
     7261 aactgttttg caccttcagg gctttaaaat gggctctgca gacagcattt gcatatgcaa
     7321 gactcagtag ccaagcctcc actgccaatt gttgaaggca gtttcagatc gccacctttt
     7381 gaggtacatt tctttaagca caagagaagt agaaatggcc tttgccttgt ctccagtggt
     7441 ttgtccctct ggtgcctcag cagataccag agcttattct tatgaccatt tggaagtagt
     7501 cctcaaagta aagatcaaga aaaaattgga ttctttttcc attttctcat aatagtagcc
     7561 tagtcaacac aagactccca taaaatatga ctcactattg ggagccatac tattttataa
     7621 gcttacttcc tgctgacaaa actagctttc ctcaaggaaa tataaaggag gggaaagtca
     7681 catagtgtta ggaaaacatt cctgtgtttt gaatacgatg aatccatagg atagagaaaa
     7741 atctgcttgt tctattctga gagttctctg agatatccct tcactctgct tggcatttgg
     7801 ccattgatat tcaacaggtc actgaccaag cttttctaaa tttttcagag agagttactt
     7861 accagtaagg tctgttctta aacctaccta gttgattttc atatctttcc ataaagtgtc
     7921 atgattctgt catagaccct gacttaacat tgtaaggact atgagtcctc cattttttaa
     7981 ttaatttttt tttagcaaat taggacttcg gcaggttttc ctctcctaaa ctcattcttt
     8041 cctccacagg attgctttgt ccatctcctg ctttcatttc aagtgcataa acaaaacctc
     8101 aaagggcctg ggaaggtgag gcaggccaga gtctgtgttc tgtgttgagt gtcaagctat
     8161 ttgttaagaa ggtctgcaac aggcctttgg tgtgggctct gccagagact gttctgaaca
     8221 ctttgcttga gatccgtgcc ctgtaaaatg gatatgatgt tttactgatg tctgtaatac
     8281 atttgtaaac ttccaataaa atttgaataa aagaaatgtt gccattcttc tcagccctcc
     8341 ctcactttcc agattttagg ggtggtctct gcctttgagc atttcaacaa agaaaagaaa
     8401 ggacacaggt atggagggat gagttttact atgaaatatt aacctgattg tttaaatcag
     8461 ggtttctaag cctcagcaat attgacgtct tgtgctagtt aattctcggt tgcagagggc
     8521 tgtcctgtgc attgtaggat gtttagcaac atcgctgact tctactcact agatgccagt
     8581 agcagccccc agaaactgtg acaactaaaa atgtctccca tcacaaccat taggatggca
     8641 gttattaaaa ataacaacaa atgtgggtga ggatgtggag caattggaac acttgtacac
     8701 tgttggtggg aatgtaaaat gatgtagtgc tgtggaaaac agtatggcag ttcctcaaaa
     8761 aaaattaaaa atagaattac taccatatgc tacttctggg ctatacccaa aagaattgac
     8821 agcagggtct ccaaagagat acttgtacac ccatattcat aaaagcagca ttcacaatat
     8881 ccaaaaagtg ggagcaaccc aaatgtccac tgatggatga atgtgtaaac aaggtgtggt
     8941 gtatacatac aatggaatat tattcagcct taaaacggaa ggaaattctg acacatgcta
     9001 caacatggat gaaccttgag gacattttgc taagtgagat aagccagtca caaaaagaca
     9061 agtgtatgat tccatttatc tgaggcacct agagtcaaat tcatagagac agaatgtaga
     9121 agagtggttg gttgtcaggg actgaaggga ggagggaatg gggagttact atttaatggg
     9181 tatagagttt cattatggca agatgaaaag agttctggag acgggttgca gaacaatgca
     9241 gatgaactta atactactga actgtacact taaaagtggt taagatggta aattttatat
     9301 tatgtttatt taaccacaat taaaaatgtc tccacacatt gtcaatgtct ccctgttgag
     9361 aaccactggt ttcaatgcat tgccttctta gtgtctttgt tccttgagaa ttcttgaaac
     9421 tgattcctac ccaggccaca cagttaattt tcagttatta gcaagaattg aaagcagcag
     9481 atgacccaaa aatatttgtg tttgctttta agcaaataat aagtggtctg tctggagaat
     9541 tacatccatg tctgtgttct ggttagggca gcattaacac tgactgggag ccaggaccaa
     9601 ggcagcatgt aaattcaatt tccccgtgtc tgatccacaa cattagggac ttgctggatg
     9661 ctataatatc atctattcat tcattcaaca aatatttatc aaaaggcttt ctctagccag
     9721 gaaccgttct aggtgcttgg aatacaataa tgtgcaaaac aaacaaaaat ccctacctta
     9781 aaggagttta caaactttac tttcaactag gcaagacatt cggaatagta agtagtctta
     9841 cccaccctag ctaatcacaa ggacttggga gtggcagaca acaagagttg tttcattgta
     9901 agacattcta agagcttttg aataaaaact tgaactggaa atggcaa
//
