LOCUS       NM_001110213            3177 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens proline rich protein HaeIII subfamily 2 (PRH2), mRNA.
ACCESSION   NM_001110213
VERSION     NM_001110213.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3177)
  AUTHORS   Sheng,N., Marell,L., Sitaram,R.T., Svensater,G., Westerlund,A. and
            Stromberg,N.
  TITLE     Human PRH1, PRH2 susceptibility and resistance and Streptococcus
            mutans virulence phenotypes specify different microbial profiles in
            caries
  JOURNAL   EBioMedicine 101, 105001 (2024)
   PUBMED   38364699
  REMARK    GeneRIF: Human PRH1, PRH2 susceptibility and resistance and
            Streptococcus mutans virulence phenotypes specify different
            microbial profiles in caries.
REFERENCE   2  (bases 1 to 3177)
  AUTHORS   Stromberg,N., Esberg,A., Sheng,N., Marell,L., Lofgren-Burstrom,A.,
            Danielsson,K. and Kallestal,C.
  TITLE     Genetic- and Lifestyle-dependent Dental Caries Defined by the
            Acidic Proline-rich Protein Genes PRH1 and PRH2
  JOURNAL   EBioMedicine 26, 38-46 (2017)
   PUBMED   29191562
  REMARK    GeneRIF: We investigated whether PRH1 and PRH2 polymorphisms in
            saliva acidic proline-rich protein (PRP) receptors for indigenous
            bacteria match and predict individual differences in the
            development of caries..They instead developed 3.9-fold more caries
            than P1 children from plaque accumulation in general when treated
            with orthodontic multibrackets; and had basic PRP polymorphisms and
            low DMBT1-mediated S. mutans adhesion
REFERENCE   3  (bases 1 to 3177)
  AUTHORS   Manconi,B., Castagnola,M., Cabras,T., Olianas,A., Vitali,A.,
            Desiderio,C., Sanna,M.T. and Messana,I.
  TITLE     The intriguing heterogeneity of human salivary proline-rich
            proteins: Short title: Salivary proline-rich protein species
  JOURNAL   J Proteomics 134, 47-56 (2016)
   PUBMED   26375204
REFERENCE   4  (bases 1 to 3177)
  AUTHORS   Tagliabracci,V.S., Wiley,S.E., Guo,X., Kinch,L.N., Durrant,E.,
            Wen,J., Xiao,J., Cui,J., Nguyen,K.B., Engel,J.L., Coon,J.J.,
            Grishin,N., Pinna,L.A., Pagliarini,D.J. and Dixon,J.E.
  TITLE     A Single Kinase Generates the Majority of the Secreted
            Phosphoproteome
  JOURNAL   Cell 161 (7), 1619-1632 (2015)
   PUBMED   26091039
REFERENCE   5  (bases 1 to 3177)
  AUTHORS   Vitorino,R., Alves,R., Barros,A., Caseiro,A., Ferreira,R.,
            Lobo,M.C., Bastos,A., Duarte,J., Carvalho,D., Santos,L.L. and
            Amado,F.L.
  TITLE     Finding new posttranslational modifications in salivary
            proline-rich proteins
  JOURNAL   Proteomics 10 (20), 3732-3742 (2010)
   PUBMED   20879038
REFERENCE   6  (bases 1 to 3177)
  AUTHORS   Kauffman,D.L., Bennick,A., Blum,M. and Keller,P.J.
  TITLE     Basic proline-rich proteins from human parotid saliva:
            relationships of the covalent structures of ten proteins from a
            single individual
  JOURNAL   Biochemistry 30 (14), 3351-3356 (1991)
   PUBMED   1849422
REFERENCE   7  (bases 1 to 3177)
  AUTHORS   Hay,D.I., Bennick,A., Schlesinger,D.H., Minaguchi,K.,
            Madapallimattam,G. and Schluckebier,S.K.
  TITLE     The primary structures of six human salivary acidic proline-rich
            proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f)
  JOURNAL   Biochem J 255 (1), 15-21 (1988)
   PUBMED   3196309
REFERENCE   8  (bases 1 to 3177)
  AUTHORS   Kim,H.S. and Maeda,N.
  TITLE     Structures of two HaeIII-type genes in the human salivary
            proline-rich protein multigene family
  JOURNAL   J Biol Chem 261 (15), 6712-6718 (1986)
   PUBMED   3009472
REFERENCE   9  (bases 1 to 3177)
  AUTHORS   Maeda,N., Kim,H.S., Azen,E.A. and Smithies,O.
  TITLE     Differential RNA splicing and post-translational cleavages in the
            human salivary proline-rich protein gene system
  JOURNAL   J Biol Chem 260 (20), 11123-11130 (1985)
   PUBMED   2993301
REFERENCE   10 (bases 1 to 3177)
  AUTHORS   Wong,R.S., Hofmann,T. and Bennick,A.
  TITLE     The complete primary structure of a proline-rich phosphoprotein
            from human saliva
  JOURNAL   J Biol Chem 254 (11), 4800-4808 (1979)
   PUBMED   438215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095488.1, BX648656.1 and
            AC006518.17.
            
            Summary: This gene encodes a member of the heterogeneous family of
            proline-rich salivary glycoproteins. The encoded preproprotein
            undergoes proteolytic processing to generate one or more mature
            isoforms before secretion from the parotid and
            submandibular/sublingual glands. In western population this locus
            is commonly biallelic and encodes proline-rich protein (PRP)
            isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1
            allele. Certain alleles of this gene are associated with
            susceptibility to dental caries. This gene is located in a cluster
            of closely related salivary proline-rich proteins on chromosome 12.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX485887.1, BX648901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396400.4/ ENSP00000379682.3
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               BC095488.1         1-233
            234-557             BX648656.1         164-487
            558-3177            AC006518.17        131137-133756
FEATURES             Location/Qualifiers
     source          1..3177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..3177
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /note="proline rich protein HaeIII subfamily 2"
                     /db_xref="GeneID:5555"
                     /db_xref="HGNC:HGNC:9367"
                     /db_xref="MIM:168790"
     exon            1..102
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..539
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /note="acidic salivary proline-rich protein, HaeIII type,
                     2; salivary acidic proline-rich phosphoprotein 1/2;
                     protein C; parotid acidic protein; parotid double-band
                     protein; parotid proline-rich protein 1/2"
                     /codon_start=1
                     /product="salivary acidic proline-rich phosphoprotein 1/2
                     preproprotein"
                     /protein_id="NP_001103683.1"
                     /db_xref="CCDS:CCDS8636.1"
                     /db_xref="GeneID:5555"
                     /db_xref="HGNC:HGNC:9367"
                     /db_xref="MIM:168790"
                     /translation="MLLILLSVALLAFSSAQDLDEDVSQEDVPLVISDGGDSEQFIDE
                     ERQGPPLGGQQSQPSAGDGNQNDGPQQGPPQQGGQQQQGPPPPQGKPQGPPQQGGHPP
                     PPQGRPQGPPQQGGHPRPPRGRPQGPPQQGGHQQGPPPPPPGKPQGPPPQGGRPQGPP
                     QGQSPQ"
     exon            103..138
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            139..557
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..3177
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      632..637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /note="hexamer: AATAAA"
     polyA_site      652
                     /gene="PRH2"
                     /gene_synonym="Pr; pr1/Pr2; PRP-1/PRP-2"
                     /note="major polyA site"
ORIGIN      
        1 agcataaagt tgggagtgac accagagcct tctgcaagat gcttctgatt ctgctgtcag
       61 tggccctgct ggccttcagc tcagctcagg acttagatga agatgtcagc caagaagacg
      121 ttcccttggt aatatcagat ggaggagact ctgagcagtt catagatgag gagcgtcagg
      181 gaccaccttt gggaggacag caatctcaac cctctgctgg tgatgggaac cagaatgatg
      241 gccctcagca gggaccaccc caacaaggag gccagcagca acaaggtcca ccacctcctc
      301 agggaaagcc acaaggacca ccccaacagg gaggccatcc ccctcctcct caaggaaggc
      361 cacaaggacc accccaacag ggaggccatc cccgtcctcc tcgaggaagg ccacaaggac
      421 caccccaaca gggaggccat cagcaaggtc ctcccccacc tcctcctgga aagccccagg
      481 gaccacctcc ccaagggggc cgcccacaag gacctccaca ggggcagtct cctcagtaat
      541 ctaggattca atgataggaa gtgaataaga agatgacagt gtttcaaatg ccttgaaaca
      601 taatgtgatc atgctctaac ttcaatatac caataaaata atcagcttgc aatttctgat
      661 tatagcatct ccttctgagt gtttgggact ctggaatctg agacccatgt tcacattgta
      721 agaacatcca ggaccccttc tccttgatgt ttccagcaag cttctttcct ccttatcctt
      781 attaagtcat ctgcctgggg aaggagttcc actgtttctt tccttctctg tcttcttagc
      841 tcgaatttaa attgcacaat tattttcagg tcatttcctg atagtctagt cagcttatga
      901 atgtaagcaa aacaggacca atgaaagaaa gtcccagaag ctgagagaaa ctttaacaag
      961 tttgagagta acttattttg ttttctagga aagtgagtat ggttctatgc ctgtattccc
     1021 cagaagccac tagacctatt ttcccctatt ttatcactga tcagttctgt ccctgcctat
     1081 gattcttacc attcttaaga aaacctgaat ggatttcatc aaggcggcag cataatttga
     1141 agggcaattg cgtgtgaaaa ttgatgtgac ttgatttaca caatagtcag aaaacatttt
     1201 agaaattgat gactttataa tgcaaccagg agtattgaaa aaaaagtaag caatgagctc
     1261 aaataattaa aaaagagaga caaaatacac ttgggagaac agaaataaga attaatgaaa
     1321 atttaaaaga ttaaatgaat gagaagaaat gattcataaa ttttgaacta acagtaataa
     1381 cttcttgaaa atccaataaa attggcaaaa gattgtgaaa attctggaag aataagggaa
     1441 acagataatc ttcagagtaa tcaggtaaag cttaaacaag tgttttaaaa gatgagtttt
     1501 tcctacattc tgaaaagcaa acatgaaaaa ctgaacacag tttttacaga tatacaatat
     1561 ggagtgactt atatacaaaa tgaccttaaa aatatattaa actcattata gtagttaata
     1621 tctaagtaaa atatgatgaa atttaataga gaattcactc ctcccaaaag caccttcatg
     1681 gaagattcct cattaacagg cagtccttta gtatgctgat ttatacaaaa tgctgaaaag
     1741 aagagaaata ccccaagttc ttgaaaaaaa attttttgat atgactactc taacagtaat
     1801 aactataaat ctcactttaa ataatttaaa acaaattaaa gtgatatatg agttaaatga
     1861 ccaagcagac ttgattccag gaatgttaag gaatgttcat tatttgtttt ggataatgaa
     1921 gtcagcagag gaaaaaaaaa tatgaccatc tcaaaagatg ccaacgttgt ctttgataat
     1981 atttaatata ttttttaaaa aacaattctt gtaaaatact tttttgatta gccttctgac
     2041 catgattaaa atggtgtacc tcaaagtagc tgctaacctt atgtgtatct gcaacaccct
     2101 gaaaaattat ctaataaaaa ggcacaaaga aaaagcttgt caatgttgtg gataattaga
     2161 aagtgaataa ttttatttaa tattagataa acaagcacat aacagagata catatattca
     2221 aatggaagga gtaaaattac caccacatgc agatctgttt ttctgtccag aaaataacaa
     2281 gagattctac tcaggtaaaa aaggaaagga aggaaaacca ttgtaattaa aataaaattt
     2341 aatacaatag ccgtttatta attcaacttc taaagaatct ttgtgattac acaatgacca
     2401 gctagtaaat ataataagaa aatgattatt cacaaaggaa ccaaaaggcc tagtcttcga
     2461 atttttaatg ccattgtgat agcaagcatc tgattatttt actctaagtt atttccactt
     2521 ctgattttaa gaacagcttc tttcccaggg atgggttccc cctagtgatg tattctcttc
     2581 accacaagag tttgcagctc tggctttctt tctgctcatc tgtaaagata actacagctc
     2641 ctctataaac catctcacca ttattaccga aatcagacaa attctggaga tagtcaaagc
     2701 tgtgaggatt cgaagatctc tttcacatct tgacccagtc aattccgttc accagtgtta
     2761 tgaatccatt ccccaaaatt ccaattagga attatatatt tattattata atgaggatac
     2821 tatacaaggc atttagcatg gctgcaaaga gagagctcca atgtctaaat gcaacgctga
     2881 caatttcttc atctatcaca tgtacctgtt atacatactt attaattgga tgtgcagtta
     2941 atttcttcct ttaaaaaaaa aactataggc tcaatatgaa agtagaaagc actaaggtgt
     3001 actaatgaat gggcacatag cttttttcac aaaaagatta ttttgcccca gacagctatc
     3061 tgcattctga tccagatact gtatgttctt aacataaagt gaaatttctc atacttcatg
     3121 atgaaagaaa aaactgaatt ctcattgtta ataaacaaat aaagacaatt ctctgca
//
