LOCUS       NM_001393989             712 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens proline rich protein HaeIII subfamily 1 (PRH1),
            transcript variant 4, mRNA.
ACCESSION   NM_001393989
VERSION     NM_001393989.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 712)
  AUTHORS   Sheng,N., Marell,L., Sitaram,R.T., Svensater,G., Westerlund,A. and
            Stromberg,N.
  TITLE     Human PRH1, PRH2 susceptibility and resistance and Streptococcus
            mutans virulence phenotypes specify different microbial profiles in
            caries
  JOURNAL   EBioMedicine 101, 105001 (2024)
   PUBMED   38364699
  REMARK    GeneRIF: Human PRH1, PRH2 susceptibility and resistance and
            Streptococcus mutans virulence phenotypes specify different
            microbial profiles in caries.
REFERENCE   2  (bases 1 to 712)
  AUTHORS   Stromberg,N., Esberg,A., Sheng,N., Marell,L., Lofgren-Burstrom,A.,
            Danielsson,K. and Kallestal,C.
  TITLE     Genetic- and Lifestyle-dependent Dental Caries Defined by the
            Acidic Proline-rich Protein Genes PRH1 and PRH2
  JOURNAL   EBioMedicine 26, 38-46 (2017)
   PUBMED   29191562
  REMARK    GeneRIF: We investigated whether PRH1 and PRH2 polymorphisms in
            saliva acidic proline-rich protein (PRP) receptors for indigenous
            bacteria match and predict individual differences in the
            development of caries..They instead developed 3.9-fold more caries
            than P1 children from plaque accumulation in general when treated
            with orthodontic multibrackets; and had basic PRP polymorphisms and
            low DMBT1-mediated S. mutans adhesion
REFERENCE   3  (bases 1 to 712)
  AUTHORS   Manconi,B., Castagnola,M., Cabras,T., Olianas,A., Vitali,A.,
            Desiderio,C., Sanna,M.T. and Messana,I.
  TITLE     The intriguing heterogeneity of human salivary proline-rich
            proteins: Short title: Salivary proline-rich protein species
  JOURNAL   J Proteomics 134, 47-56 (2016)
   PUBMED   26375204
REFERENCE   4  (bases 1 to 712)
  AUTHORS   Tagliabracci,V.S., Wiley,S.E., Guo,X., Kinch,L.N., Durrant,E.,
            Wen,J., Xiao,J., Cui,J., Nguyen,K.B., Engel,J.L., Coon,J.J.,
            Grishin,N., Pinna,L.A., Pagliarini,D.J. and Dixon,J.E.
  TITLE     A Single Kinase Generates the Majority of the Secreted
            Phosphoproteome
  JOURNAL   Cell 161 (7), 1619-1632 (2015)
   PUBMED   26091039
REFERENCE   5  (bases 1 to 712)
  AUTHORS   Levine,M.
  TITLE     Susceptibility to dental caries and the salivary proline-rich
            proteins
  JOURNAL   Int J Dent 2011, 953412 (2011)
   PUBMED   22190937
REFERENCE   6  (bases 1 to 712)
  AUTHORS   Inzitari,R., Cabras,T., Onnis,G., Olmi,C., Mastinu,A., Sanna,M.T.,
            Pellegrini,M.G., Castagnola,M. and Messana,I.
  TITLE     Different isoforms and post-translational modifications of human
            salivary acidic proline-rich proteins
  JOURNAL   Proteomics 5 (3), 805-815 (2005)
   PUBMED   15693058
REFERENCE   7  (bases 1 to 712)
  AUTHORS   Kauffman,D.L., Bennick,A., Blum,M. and Keller,P.J.
  TITLE     Basic proline-rich proteins from human parotid saliva:
            relationships of the covalent structures of ten proteins from a
            single individual
  JOURNAL   Biochemistry 30 (14), 3351-3356 (1991)
   PUBMED   1849422
REFERENCE   8  (bases 1 to 712)
  AUTHORS   Maeda,N., Kim,H.S., Azen,E.A. and Smithies,O.
  TITLE     Differential RNA splicing and post-translational cleavages in the
            human salivary proline-rich protein gene system
  JOURNAL   J Biol Chem 260 (20), 11123-11130 (1985)
   PUBMED   2993301
REFERENCE   9  (bases 1 to 712)
  AUTHORS   Wong,R.S., Hofmann,T. and Bennick,A.
  TITLE     The complete primary structure of a proline-rich phosphoprotein
            from human saliva
  JOURNAL   J Biol Chem 254 (11), 4800-4808 (1979)
   PUBMED   438215
REFERENCE   10 (bases 1 to 712)
  AUTHORS   Friedman,R.D. and Merritt,A.D.
  TITLE     Partial purification and characterization of a polymorphic protein
            (Pa) in human parotid saliva
  JOURNAL   Am J Hum Genet 27 (3), 304-314 (1975)
   PUBMED   803013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006518.17.
            
            Summary: This gene encodes a member of the heterogeneous family of
            proline-rich salivary glycoproteins. The encoded preproprotein
            undergoes proteolytic processing to generate one or more mature
            isoforms before secretion from the parotid and
            submandibular/sublingual glands. Multiple distinct alleles of this
            locus including the parotid isoelectric-focusing variant slow
            (PIF-s), the parotid acidic protein (Pa), and the double band slow
            (Db-s) isoforms have been characterized. The reference genome
            encodes the Db-s allele. Certain alleles of this gene are
            associated with susceptibility to dental caries. This gene is
            located in a cluster of closely related salivary proline-rich
            proteins on chromosome 12. Co-transcription of this gene with
            adjacent genes has been observed. Alternate splicing of this gene
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064553.1, SRR1163655.363287.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543626.5/ ENSP00000479168.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC006518.17        83065-83166         c
            103-138             AC006518.17        81972-82007         c
            139-620             AC006518.17        81128-81609         c
            621-712             AC006518.17        79876-79967         c
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..712
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /note="proline rich protein HaeIII subfamily 1"
                     /db_xref="GeneID:5554"
                     /db_xref="HGNC:HGNC:9366"
                     /db_xref="MIM:168730"
     exon            1..102
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..602
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 4; protein C; parotid acidic protein; parotid
                     double-band protein; parotid proline-rich protein 1/2;
                     parotid isoelectric focusing variant protein; salivary
                     acidic proline-rich phosphoprotein 1/2"
                     /codon_start=1
                     /product="salivary acidic proline-rich phosphoprotein 1/2
                     isoform a preproprotein"
                     /protein_id="NP_001380918.1"
                     /db_xref="CCDS:CCDS76533.1"
                     /db_xref="GeneID:5554"
                     /db_xref="HGNC:HGNC:9366"
                     /db_xref="MIM:168730"
                     /translation="MLLILLSVALLAFSSAQDLNEDVSQEDVPLVISDGGDSEQFLDE
                     ERQGPPLGGQQSQPSAGDGNQDDGPQQGPPQQGGQQQQGPPPPQGKPQGPPQQGGQQQ
                     QGPPPPQGKPQGPPQQGGHPPPPQGRPQGPPQQGGHPRPPRGRPQGPPQQGGHQQGPP
                     PPPPGKPQGPPPQGGRPQGPPQGQSPQ"
     exon            103..138
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            139..620
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..712
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /note="hexamer: AATAAA"
     polyA_site      712
                     /gene="PRH1"
                     /gene_synonym="Db-s; PA; PIF-S; Pr1/Pr2; PRH2;
                     PRP-1/PRP-2"
                     /note="major polyA site"
ORIGIN      
        1 agcacaaagt tgggagtgac accagagcct cctgcaagat gcttctgatt ctgctgtcag
       61 tggccctgct ggccttcagc tcagctcagg atttaaatga agatgtcagc caggaagatg
      121 ttcccctcgt aatatcagat ggaggagact ctgagcagtt cctagatgag gagcgtcagg
      181 gaccaccttt gggaggacag caatctcaac cctctgctgg tgatgggaac caggatgatg
      241 gccctcagca gggaccaccc caacaaggag gccagcagca acaaggtcca ccacctcctc
      301 agggaaagcc acaaggacca ccccaacaag gaggccagca gcaacaaggt ccaccacctc
      361 ctcagggaaa gccacaagga ccaccccaac agggaggcca tccccctcct cctcaaggaa
      421 ggccacaagg accaccccaa cagggaggcc atccccgtcc tcctcgagga aggccacaag
      481 gaccacccca acagggaggc catcagcaag gtcctccccc acctcctcct ggaaagcccc
      541 agggaccacc tccccaaggg ggccgcccac aaggacctcc acaggggcag tctcctcagt
      601 aatctaggat tcaatgacag gaagtgaata agaagataac agtgtttcaa atgccgtgaa
      661 acatggcatc atgctctaac ttcagtatac caataaaaca atcagcttgc aa
//
