LOCUS       NM_006093                869 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2
            (PRG3), mRNA.
ACCESSION   NM_006093
VERSION     NM_006093.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Wagner,L.A., Ohnuki,L.E., Parsawar,K., Gleich,G.J. and Nelson,C.C.
  TITLE     Human eosinophil major basic protein 2: location of disulfide bonds
            and free sulfhydryl groups
  JOURNAL   Protein J 26 (1), 13-18 (2007)
   PUBMED   17136616
  REMARK    GeneRIF: contains 2 cysteine disulfide linkages (Cys20-Cys115 and
            Cys92-Cys107) and 6 cysteine residues with free sulfhydryl groups
            (Cys2, Cys23, Cys42, Cys43, Cys68, and Cys96). Amino acid positions
            are not based on the full-length protein sequence.
REFERENCE   6  (bases 1 to 869)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 869)
  AUTHORS   Plager,D.A., Weiler,D.A., Loegering,D.A., Johnson,W.B., Haley,L.,
            Eddy,R.L., Shows,T.B. and Gleich,G.J.
  TITLE     Comparative structure, proximal promoter elements, and chromosome
            location of the human eosinophil major basic protein genes
  JOURNAL   Genomics 71 (3), 271-281 (2001)
   PUBMED   11170744
REFERENCE   8  (bases 1 to 869)
  AUTHORS   Plager,D.A., Loegering,D.A., Weiler,D.A., Checkel,J.L.,
            Wagner,J.M., Clarke,N.J., Naylor,S., Page,S.M., Thomas,L.L.,
            Akerblom,I., Cocks,B., Stuart,S. and Gleich,G.J.
  TITLE     A novel and highly divergent homolog of human eosinophil granule
            major basic protein
  JOURNAL   J Biol Chem 274 (20), 14464-14473 (1999)
   PUBMED   10318872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF132209.2, AP000781.6 and AY358930.1.
            
            On May 17, 2019 this sequence version replaced NM_006093.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132209.2, AY358930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287143.2/ ENSP00000287143.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AF132209.2         1-116
            117-117             AP000781.6         136018-136018       c
            118-435             AF132209.2         118-435
            436-436             AP000781.6         134859-134859       c
            437-869             AY358930.1         417-849
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..869
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /note="proteoglycan 3, pro eosinophil major basic protein
                     2"
                     /db_xref="GeneID:10394"
                     /db_xref="HGNC:HGNC:9363"
                     /db_xref="MIM:606814"
     exon            1..37
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            38..171
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..788
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /note="prepro-major basic protein homolog; prepro-MBPH;
                     eosinophil major basic protein homolog"
                     /codon_start=1
                     /product="proteoglycan 3 precursor"
                     /protein_id="NP_006084.2"
                     /db_xref="CCDS:CCDS7954.1"
                     /db_xref="GeneID:10394"
                     /db_xref="HGNC:HGNC:9363"
                     /db_xref="MIM:606814"
                     /translation="MQCLLLLPFLLLGTVSALHLENDAPHLESLETQADLGQDLDSSK
                     EQERDLALTEEVIQAEGEEVKASACQDNFEDEEAMESDPAALDKDFQCPREEDIVEVQ
                     GSPRCKICRYLLVRTPKTFAEAQNVCSRCYGGNLVSIHDFNFNYRIQCCTSTVNQAQV
                     WIGGNLRGWFLWKRFCWTDGSHWNFAYWSPGQPGNGQGSCVALCTKGGYWRRAQCDKQ
                     LPFVCSF"
     exon            172..485
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            486..617
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            618..729
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
     exon            730..869
                     /gene="PRG3"
                     /gene_synonym="MBP2; MBPH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcactg agagtggagg tctcagactc ttggaagggg ctatactaga cacacaaaga
       61 cagccccaag aaggacggtg gagtagtgtc ctcgctaaaa gacagtagat atgcaatgcc
      121 tcttgctcct gccctttctc ctgctgggaa cagtttctgc tcttcatctg gagaatgatg
      181 ccccccatct ggagagccta gagacacagg cagacctagg ccaggatctg gatagttcaa
      241 aggagcagga gagagacttg gctctgacgg aggaggtgat tcaggcagag ggagaggagg
      301 tcaaggcttc tgcctgtcaa gacaactttg aggatgagga agccatggag tcggacccag
      361 ctgccttaga caaggacttc cagtgcccca gggaagaaga cattgttgaa gtgcagggaa
      421 gtccaaggtg caagatctgc cgctacctat tggtgcggac tcctaaaact tttgcagaag
      481 ctcagaatgt ctgcagcaga tgctacggag gcaaccttgt ctctatccat gacttcaact
      541 tcaactatcg cattcagtgc tgcactagca cagtcaacca agcccaggtc tggattggag
      601 gcaacctcag gggctggttc ctgtggaagc ggttttgctg gactgatggg agccactgga
      661 attttgctta ctggtcccca gggcaacctg ggaatgggca aggctcctgt gtggccctat
      721 gcaccaaagg aggttattgg cgacgagctc aatgcgacaa gcaactgccc ttcgtctgct
      781 ccttctaagc cagcggcacg gagaccctgc cagcagctcc ctcccgtccc ccaacctctc
      841 ctgctcataa atccagactt cccacagca
//
