LOCUS       NM_002726               7250 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens prolyl endopeptidase (PREP), mRNA.
ACCESSION   NM_002726
VERSION     NM_002726.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7250)
  AUTHORS   Venditti,M., Arcaniolo,D., De Sio,M. and Minucci,S.
  TITLE     Preliminary Investigation on the Involvement of
            Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular
            Disorders
  JOURNAL   Int J Mol Sci 22 (15), 8094 (2021)
   PUBMED   34360857
  REMARK    GeneRIF: Preliminary Investigation on the Involvement of
            Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular
            Disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7250)
  AUTHORS   Etelainen,T., Kulmala,V., Svarcbahs,R., Jantti,M. and Myohanen,T.T.
  TITLE     Prolyl oligopeptidase inhibition reduces oxidative stress via
            reducing NADPH oxidase activity by activating protein phosphatase
            2A
  JOURNAL   Free Radic Biol Med 169, 14-23 (2021)
   PUBMED   33838285
  REMARK    GeneRIF: Prolyl oligopeptidase inhibition reduces oxidative stress
            via reducing NADPH oxidase activity by activating protein
            phosphatase 2A.
REFERENCE   3  (bases 1 to 7250)
  AUTHORS   Julku,U.H., Jantti,M., Svarcbahs,R. and Myohanen,T.T.
  TITLE     Prolyl Oligopeptidase Regulates Dopamine Transporter
            Oligomerization and Phosphorylation in a PKC- and ERK-Independent
            Manner
  JOURNAL   Int J Mol Sci 22 (4), 1777 (2021)
   PUBMED   33579026
  REMARK    GeneRIF: Prolyl Oligopeptidase Regulates Dopamine Transporter
            Oligomerization and Phosphorylation in a PKC- and ERK-Independent
            Manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7250)
  AUTHORS   Kucukkose,C., Taskin,A.A., Marada,A., Brummer,T., Dennerlein,S. and
            Vogtle,F.N.
  TITLE     Functional coupling of presequence processing and degradation in
            human mitochondria
  JOURNAL   FEBS J 288 (2), 600-613 (2021)
   PUBMED   32491259
REFERENCE   5  (bases 1 to 7250)
  AUTHORS   Venditti,M., Fasano,C., Minucci,S., Serino,I., Sinisi,A.A., Dale,B.
            and Di Matteo,L.
  TITLE     DAAM1 and PREP are involved in human spermatogenesis
  JOURNAL   Reprod Fertil Dev 32 (5), 484-494 (2020)
   PUBMED   31972124
  REMARK    GeneRIF: DAAM1 and PREP are involved in human spermatogenesis.
REFERENCE   6  (bases 1 to 7250)
  AUTHORS   Mentlein,R.
  TITLE     Proline residues in the maturation and degradation of peptide
            hormones and neuropeptides
  JOURNAL   FEBS Lett 234 (2), 251-256 (1988)
   PUBMED   3292288
  REMARK    Review article
REFERENCE   7  (bases 1 to 7250)
  AUTHORS   Momand,J. and Clarke,S.
  TITLE     Rapid degradation of D- and L-succinimide-containing peptides by a
            post-proline endopeptidase from human erythrocytes
  JOURNAL   Biochemistry 26 (24), 7798-7805 (1987)
   PUBMED   3480758
REFERENCE   8  (bases 1 to 7250)
  AUTHORS   Checler,F., Vincent,J.P. and Kitabgi,P.
  TITLE     Purification and characterization of a novel neurotensin-degrading
            peptidase from rat brain synaptic membranes
  JOURNAL   J Biol Chem 261 (24), 11274-11281 (1986)
   PUBMED   3525564
REFERENCE   9  (bases 1 to 7250)
  AUTHORS   Swanson,A.A., Davis,R.M. and Meinhardt,N.C.
  TITLE     Proteases in human lenses and their possible significance
  JOURNAL   Curr Eye Res 4 (1), 43-48 (1985)
   PUBMED   2858361
REFERENCE   10 (bases 1 to 7250)
  AUTHORS   Koida,M. and Walter,R.
  TITLE     Post-proline cleaving enzyme. Purification of this endopeptidase by
            affinity chromatography
  JOURNAL   J Biol Chem 251 (23), 7593-7599 (1976)
   PUBMED   12173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314195.1, BC030636.2 and
            AL133406.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002726.4.
            
            Summary: The protein encoded by this gene is a cytosolic prolyl
            endopeptidase that cleaves peptide bonds on the C-terminal side of
            prolyl residues within peptides that are up to approximately 30
            amino acids long. Prolyl endopeptidases have been reported to be
            involved in the maturation and degradation of peptide hormones and
            neuropeptides. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030636.2, AB020018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652536.2/ ENSP00000499089.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AK314195.1         21-220
            201-2749            BC030636.2         203-2751
            2750-7250           AL133406.14        46156-50656
FEATURES             Location/Qualifiers
     source          1..7250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..7250
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="prolyl endopeptidase"
                     /db_xref="GeneID:5550"
                     /db_xref="HGNC:HGNC:9358"
                     /db_xref="MIM:600400"
     exon            1..236
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2324
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /EC_number="3.4.21.26"
                     /note="prolyl oligopeptidase; post-proline cleaving
                     enzyme; dJ355L5.1 (prolyl endopeptidase)"
                     /codon_start=1
                     /product="prolyl endopeptidase"
                     /protein_id="NP_002717.3"
                     /db_xref="CCDS:CCDS5053.1"
                     /db_xref="GeneID:5550"
                     /db_xref="HGNC:HGNC:9358"
                     /db_xref="MIM:600400"
                     /translation="MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVE
                     AQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYV
                     QDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDG
                     AKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTD
                     QSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGI
                     LKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHE
                     KDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDT
                     EIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKI
                     PMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGG
                     EYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQ
                     RPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPE
                     ADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGA
                     GKPTAKVIEEVSDMFAFIARCLNVDWIP"
     exon            237..311
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..445
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..576
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            577..786
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            787..908
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1014
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1206
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1404
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1508
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1645
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1740
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1872
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2029
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..7250
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="major polyA site"
     regulatory      2728..2733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="hexamer: AATAAA"
     polyA_site      2749
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="major polyA site"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="hexamer: AATAAA"
     polyA_site      2840
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
     regulatory      2887..2892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="hexamer: AATAAG"
     polyA_site      2903
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
     regulatory      7230..7235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
                     /note="hexamer: AATAAA"
     polyA_site      7250
                     /gene="PREP"
                     /gene_synonym="PE; PEP"
ORIGIN      
        1 gctttctgca cgtcctcgcc gccgcgccgc cagtccgttt gtgctagctc tggccgtgag
       61 ccggccgccc gctgccgccg gccgccccgc agctgcctgc gccccagccg cgcctcgcgg
      121 ccagcccggc tagctcaggt ccgctcccgg agcccgcgcc cctccacgct gccccctgcc
      181 tgtccccggc catgctgtcc cttcagtacc ccgacgtgta ccgcgacgag accgccgtac
      241 aggattatca tggtcataaa atttgtgacc cttacgcctg gcttgaagac cccgacagtg
      301 aacagactaa ggcctttgtg gaggcccaga ataagattac tgtgccattt cttgagcagt
      361 gtcccatcag aggtttatac aaagagagaa tgactgaact atatgattat cccaagtata
      421 gttgccactt caagaaagga aaacggtatt tttattttta caatacaggt ttgcagaacc
      481 agcgagtatt atatgtacag gattccttag agggtgaggc cagagtgttc ctggacccca
      541 acatactgtc tgacgatggc acagtggcac tccgaggtta tgcgttcagc gaagatggtg
      601 aatattttgc ctatggtctg agtgccagtg gctcagactg ggtgacaatc aagttcatga
      661 aagttgatgg tgccaaagag cttccagatg tgcttgaaag agtcaagttc agctgtatgg
      721 cctggaccca tgatgggaag ggaatgttct acaactcata ccctcaacag gatggaaaaa
      781 gtgatggcac agagacatct accaatctcc accaaaagct ctactaccat gtcttgggaa
      841 ccgatcagtc agaagatatt ttgtgtgctg agtttcctga tgaacctaaa tggatgggtg
      901 gagctgagtt atctgatgat ggccgctatg tcttgttatc aataagggaa ggatgtgatc
      961 cagtaaaccg actctggtac tgtgacctac agcaggaatc cagtggcatc gcgggaatcc
     1021 tgaagtgggt aaaactgatt gacaactttg aaggggaata tgactacgtg accaatgagg
     1081 ggacggtgtt cacattcaag acgaatcgcc agtctcccaa ctatcgcgtg atcaacattg
     1141 acttcaggga tcctgaagag tctaagtgga aagtacttgt tcctgagcat gagaaagatg
     1201 tcttagaatg gatagcttgt gtcaggtcca acttcttggt cttatgctac ctccatgacg
     1261 tcaagaacat tctgcagctc catgacctga ctactggtgc tctccttaag accttcccgc
     1321 tcgatgtcgg cagcattgta gggtacagcg gtcagaagaa ggacactgaa atcttctatc
     1381 agtttacttc ctttttatct ccaggtatca tttatcactg tgatcttacc aaagaggagc
     1441 tggagccaag agttttccga gaggtgaccg taaaaggaat tgatgcttct gattaccaga
     1501 cagtccagat tttctaccct agcaaggatg gtacgaagat tccaatgttc attgtgcata
     1561 aaaaaggcat aaaattggat ggctctcatc cagctttctt atatggctat ggcggcttca
     1621 acatatccat cacacccaac tacagtgttt ccaggcttat ttttgtgaga cacatgggtg
     1681 gtatcctggc agtggccaac atcagaggag gtggcgaata tggagagacg tggcataaag
     1741 gtggtatctt ggccaacaaa caaaactgct ttgatgactt tcagtgtgct gctgagtatc
     1801 tgatcaagga aggttacaca tctcccaaga ggctgactat taatggaggt tcaaatggag
     1861 gcctcttagt ggctgcttgt gcaaatcaga gacctgacct ctttggttgt gttattgccc
     1921 aagttggagt aatggacatg ctgaagtttc ataaatatac catcggccat gcttggacca
     1981 ctgattatgg gtgctcggac agcaaacaac actttgaatg gcttgtcaaa tactctccat
     2041 tgcataatgt gaagttacca gaagcagatg acatccagta cccgtccatg ctgctcctca
     2101 ctgctgacca tgatgaccgc gtggtcccgc ttcactccct gaagttcatt gccacccttc
     2161 agtacatcgt gggccgcagc aggaagcaaa gcaaccccct gcttatccac gtggacacca
     2221 aggcgggcca cggggcgggg aagcccacag ccaaagtgat agaggaagtc tcagacatgt
     2281 ttgcgttcat cgcgcggtgc ctgaacgtcg actggattcc ataaacagtt ttcgtgcttc
     2341 ctcctgacag cgacagaaaa cctcaagggc tttcccacgt tgacaccaag aaaccactgg
     2401 gcataatgct tccccacggg aacattattc ctgcactcac aggctacagt tgaacagaac
     2461 tgccgtggga attttatctt ttttaggctt ctccttttta gcaaggcctt ggtgtttctt
     2521 tttccaccct gtctaggcac atgtggtttt ttggtgtttt ttttaagggc atgttgggat
     2581 aaatagctaa atggcaacaa acacattgtg aatattagat tgctgaatta aggatcatag
     2641 tcgggcatac ttatctatat ccataacctc tatatcttta aataaatgtg agaactgttc
     2701 tcatggagaa gacttctttg caacaataat aaatgttatt taagaatgac aggcttttac
     2761 ttccggtttc ttcatattga ggggcaactc cagaagtgga gttttctgtg agaataaagc
     2821 atttcacctt tctgcaacaa gttagttttc aagcagttaa gtcatagaat gtttgttagc
     2881 tttgaaaata agttgttcat ccactctgtc tcccttgttt gtttgtttgt tagaggtgat
     2941 gaagctgtca gagggggttc actgtcataa acaaacactg accacttagt tgggtaaaaa
     3001 tctgatctgg ggctcttttg gtttggatgc ctcctttcaa aaatcactgg gctggaaaat
     3061 tcagattatt cacctatttg tatattgatt tgtttacaaa gtattcctag aaatcagagt
     3121 tccttggatc caaggatcct tggttccaag agatcacatg agtaaattat ccaaacaaac
     3181 agatacatat atccaagcat ttcttacagt cagaaatttc agcatttccc aagctgtttc
     3241 tcctgcatag atcactcctg gaaatagaaa tagtcatact tacttactgg aaaaaaaaaa
     3301 aaaaaagttt tggtttgccc acccccaaga tttttaagat atactattcc ttaaactttc
     3361 atccataaaa tttttttcaa ggcatatatt ttaacatttc atgaaacaat gttcctttga
     3421 gtatcagttt gggaaatgct gatctaactt aaaacagttt tttttccttt gtcttgcttt
     3481 atcagatgat atgataaaaa ttattatttt atatagtatc ttaaccttat ataaaatagc
     3541 ttaaaagatt acttcattat tccaataatt tgtacttttc caagtaagtc ccatcttcca
     3601 agttgtatat gtatgtgctt ttaagagcac tctctcattc tctacgtttc aagttatggt
     3661 caaaaattag acataccatt ttctatcaag catatcactg cataccaagc atattgaaag
     3721 acagctatat ggcttggttt ttctctactg gaatcatgtt ttccgttact atttagtacg
     3781 gtacataata cagttgtcat tgagtataag attcaccata actcctctgg aaacaaagtg
     3841 tgccagtagc tagtgttgca tgctgagact ctgtcgtcat caccatctac tcagatactg
     3901 atactagcta gctttggtgt aactgctgac cagcatggca ggaaagaaag aaaatacatt
     3961 tgcatggtca agccagaggc agcctctttc ctagactagc tgtgtggtgt gaagtacaaa
     4021 tagctgagtt ggacccactg agtccagagc attttcaagg ttgcacagaa tctaaccata
     4081 ctttctgagg tctgctttac agcagaaaat acagtgtgta gtgtgtgagc ttcagatatc
     4141 aggactgggt tcaaatccca aatgtcactt agcaactgat gaggaggagg aggaatacag
     4201 taatacgttt ttaatgccta gcatgattgg cctccagtta cgagttctct tttccaacct
     4261 aatttttgtg tctagatttt cacaggacaa ctaatcccac caactaaagg tattttgggg
     4321 agtaggggga gctttaaaca ttagaaataa gacttgagat tgggctccta cccagaactc
     4381 taagggattc ttctctattt gatcccactt ttctgtatcc tgtgctctgc cctttggctc
     4441 tttcttatga ttactctctt ctagctattt tgaaatgcac agtagattat tgtaaactat
     4501 agacacccta ctgatctaac actaggtctt ctttcaaact gtatatttgt aggcattaat
     4561 ctcttcatcc tccctttctc tgcctgcttt tttagctccc acatgagtgg agaacatggg
     4621 atatttgtct tcctgtgcct ggcttatttc acttaccata ttgaccttca gttccatcca
     4681 tgttgctgca aatgacagga tctcagtctt tttcatggct aaatcatatt ccattgtata
     4741 tatgtaccac attttcttca tctgttcatc tgctgatggg cacgtgggtt gattccctat
     4801 cttggctgtt gtggatagtg ctgcagtaga cacaggagtg cagatatctt tttgatatac
     4861 tgatttcctt tcttttggat tcatacccag tagtggaatt gctcgatcac agaggactta
     4921 tatgtttagt ttttttagga ctgttttgaa aaagaaaaag ttgtacatgt tgcacaggtg
     4981 gcctcactgc tttgtcacaa ggccctgcta agcacaccag agcatttgtt accttagcaa
     5041 gataaagtca catttatgtt cactatggac ttacctggaa tattataaaa ctttccaatt
     5101 aatcatgttt cttaaatact cccactaaag cttaagcagc tacacacaca tggtgctaca
     5161 agtttgaaaa ggataagttt caactaagga agcctgtcac cagtctctca aggtttgtca
     5221 gttttaccag cctctggaag ttcccagcag gccacatagc taatgcccag aaggagttgc
     5281 aaagactcaa aggcaggtta aggacaggct ggaaagctgt ggaggttgct gtaaagaggc
     5341 aaaggtcata ctgttggggt ggtcaggcca gtgggatgag gactgaggcc cttgaaggag
     5401 gaacattgag ccattctcat cctccatatc tcaggggctg aaggtgcaga gagaaaatgt
     5461 cctgccctca tccagttgat attccaggga ggagacagat ggtaaattat cttgctcatg
     5521 tttaccctgt gccacccgct gcaagcactc tgtgtggatg aatgtttgtc ctcacacaac
     5581 cttaggaagc acataatacc ttttccccat ttggcaaagg tccaagttcc ccagccagga
     5641 ggtgggcagg cagggcagta accccaggag ctgggccttg gatactgcac tctttttttg
     5701 ggatggagtt ttgctgttac ggcccaggct ggagtgcaat ggcgctatct cagcttactg
     5761 caacctccac ctcttgggtt cacgtgattc tcctgcctca gccttcccag tagctggtat
     5821 tacaggcgca taccatcatt cccggctaat ctttttgtat ttttagtaga gatggggttt
     5881 caccatgttg gccaggctgg tcttgaactc ctgacctcag gtgatccacc cacctcagcc
     5941 tcccaaaatg ctgggattac aggcatgagc caccatgccc agccgaaaca gctctcttac
     6001 tgctgttgtc tgagtgttta tgtcctcccc gaaatgtata tgttgaaatc gtaaatccca
     6061 aagtgatgga attaggaggc agggccttca ggaggcgatg ggtcatgaga gcggaatcct
     6121 catgaatggg actggtgcct ttatattaga gcccaaggag agaccccccc gccccatccc
     6181 ttccaccatg tgaggacaca ggagacggtg tcacctatga accaggaagc aaccctcatt
     6241 agacaccaaa tctgccagtg ccttgatctt agatgtccca gactctagga ctgtgagaga
     6301 gcaatttctg ttgttgacaa cccaccagtt tatggtattt tcttatagca gcttaaacag
     6361 actaagatac ccacgagtct attaacaaga taataaacaa agtataattt caggaattaa
     6421 caagaaacag gaataaaaag agctgtgaag aaacaaagtg gggcaaatga atagtccgtg
     6481 agaaggaatg ctatttgagt cgaggtcagg gtgcctcttt caggaagcaa cattcggaca
     6541 aagacccgaa cggaatgagg ggacaaacaa tgggcaacgt tttgggggtt ggtgaggaca
     6601 gcagcaatgg gcagagcctg aggcaggaac cagccaggcc tttggaggaa gagcaggaag
     6661 ccagtgtggg gggaacaggg agccaggcga ggcctggagg atacactaga gatggcaggc
     6721 agctcagtca ggtgaagcca ctgagagatg aaagccgaca acactgtggg aaactgacag
     6781 caggagagcc tagggaaaag cggggtggtt attcaaagag caggttgctt agcaccttta
     6841 aggaattttg ggggtggggg cagcaggaac ccaccatcac aaaaatcact gacatgccat
     6901 atcatggatg aatctcaaaa acattataag tgaaagaagc cagacacaaa tgactgggta
     6961 tagtctgatt aagtgaaata tcctgaaaag gcagttctat aaagatagaa tgtagattag
     7021 tgggtacctg gagttggtgg tgaagatggt aattaactac ttgggcataa aggatctaac
     7081 cgggatgaca aaaatgttct aaaactggat ttcagtaacg gttgcacaac ctggtaaatg
     7141 tattaaaaag tcattgaatt gtacacttga aatgtatgaa ttttatggtt tgtaaatcat
     7201 aatgttatcg aaataatctc tggtagtgaa ataaagagaa aaaagagcaa
//
