LOCUS       NM_002725               5769 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens proline and arginine rich end leucine rich repeat
            protein (PRELP), transcript variant 1, mRNA.
ACCESSION   NM_002725
VERSION     NM_002725.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5769)
  AUTHORS   Ding,F., Zheng,P., Yan,X.Y., Chen,H.J., Fang,H.T., Luo,Y.Y.,
            Peng,Y.X., Zhang,L. and Yan,Y.E.
  TITLE     Adipocyte-secreted PRELP promotes adipocyte differentiation and
            adipose tissue fibrosis by binding with p75NTR to activate FAK/MAPK
            signaling
  JOURNAL   Int J Biol Macromol 279 (Pt 4), 135376 (2024)
   PUBMED   39244119
  REMARK    GeneRIF: Adipocyte-secreted PRELP promotes adipocyte
            differentiation and adipose tissue fibrosis by binding with
            p75[NTR] to activate FAK/MAPK signaling.
REFERENCE   2  (bases 1 to 5769)
  AUTHORS   Sun,X., Chai,L., Wang,B. and Zhou,J.
  TITLE     PRELP inhibits the progression of oral squamous cell carcinoma via
            inactivation of the NF-kappaB pathway
  JOURNAL   Arch Oral Biol 167, 106068 (2024)
   PUBMED   39151326
  REMARK    GeneRIF: PRELP inhibits the progression of oral squamous cell
            carcinoma via inactivation of the NF-kappaB pathway.
REFERENCE   3  (bases 1 to 5769)
  AUTHORS   Gui,Y., Deng,X., Li,N. and Zhao,L.
  TITLE     PRELP reduce cell stiffness and adhesion to promote the growth and
            metastasis of colorectal cancer cells by binding to integrin alpha5
  JOURNAL   Exp Cell Res 441 (1), 114151 (2024)
   PUBMED   38992455
  REMARK    GeneRIF: PRELP reduce cell stiffness and adhesion to promote the
            growth and metastasis of colorectal cancer cells by binding to
            integrin alpha5.
REFERENCE   4  (bases 1 to 5769)
  AUTHORS   Schafer,H., Subbarayan,K., Massa,C., Vaxevanis,C., Mueller,A. and
            Seliger,B.
  TITLE     Correlation of the tumor escape phenotype with loss of PRELP
            expression in melanoma
  JOURNAL   J Transl Med 21 (1), 643 (2023)
   PUBMED   37730606
  REMARK    GeneRIF: Correlation of the tumor escape phenotype with loss of
            PRELP expression in melanoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5769)
  AUTHORS   Shozu,K., Kaneko,S., Shinkai,N., Dozen,A., Kosuge,H., Nakakido,M.,
            Machino,H., Takasawa,K., Asada,K., Komatsu,M., Tsumoto,K.,
            Ohnuma,S.I. and Hamamoto,R.
  TITLE     Repression of the PRELP gene is relieved by histone deacetylase
            inhibitors through acetylation of histone H2B lysine 5 in bladder
            cancer
  JOURNAL   Clin Epigenetics 14 (1), 147 (2022)
   PUBMED   36371227
  REMARK    GeneRIF: Repression of the PRELP gene is relieved by histone
            deacetylase inhibitors through acetylation of histone H2B lysine 5
            in bladder cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5769)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5769)
  AUTHORS   Bengtsson,E., Morgelin,M., Sasaki,T., Timpl,R., Heinegard,D. and
            Aspberg,A.
  TITLE     The leucine-rich repeat protein PRELP binds perlecan and collagens
            and may function as a basement membrane anchor
  JOURNAL   J Biol Chem 277 (17), 15061-15068 (2002)
   PUBMED   11847210
REFERENCE   8  (bases 1 to 5769)
  AUTHORS   Grover,J. and Roughley,P.J.
  TITLE     Characterization of the human proline/arginine-rich end
            leucine-rich repeat protein (PRELP) gene promoter and
            identification of a repressor element
  JOURNAL   Biochem J 336 (Pt 1) (Pt 1), 77-82 (1998)
   PUBMED   9806887
REFERENCE   9  (bases 1 to 5769)
  AUTHORS   Grover,J., Chen,X.N., Korenberg,J.R., Recklies,A.D. and
            Roughley,P.J.
  TITLE     The gene organization, chromosome location, and expression of a
            55-kDa matrix protein (PRELP) of human articular cartilage
  JOURNAL   Genomics 38 (2), 109-117 (1996)
   PUBMED   8954791
REFERENCE   10 (bases 1 to 5769)
  AUTHORS   Bengtsson,E., Neame,P.J., Heinegard,D. and Sommarin,Y.
  TITLE     The primary structure of a basic leucine-rich repeat protein,
            PRELP, found in connective tissues
  JOURNAL   J Biol Chem 270 (43), 25639-25644 (1995)
   PUBMED   7592739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA393630.1, BC032498.1,
            AL391817.18 and BQ010158.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002725.3.
            
            Summary: The protein encoded by this gene is a leucine-rich repeat
            protein present in connective tissue extracellular matrix. This
            protein functions as a molecule anchoring basement membranes to the
            underlying connective tissue. This protein has been shown to bind
            type I collagen to basement membranes and type II collagen to
            cartilage. It also binds the basement membrane heparan sulfate
            proteoglycan perlecan. This protein is suggested to be involved in
            the pathogenesis of Hutchinson-Gilford progeria (HGP), which is
            reported to lack the binding of collagen in basement membranes and
            cartilage. Alternatively spliced transcript variants encoding the
            same protein have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the same protein as variant 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.47604.1,
                                           SRR1803615.154831.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343110.3/ ENSP00000343924.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CA393630.1         4-34
            32-1580             BC032498.1         1-1549
            1581-5765           AL391817.18        45797-49981
            5766-5769           BQ010158.1         14-17               c
FEATURES             Location/Qualifiers
     source          1..5769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..5769
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /note="proline and arginine rich end leucine rich repeat
                     protein"
                     /db_xref="GeneID:5549"
                     /db_xref="HGNC:HGNC:9357"
                     /db_xref="MIM:601914"
     exon            1..133
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     exon            134..1122
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1298
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /note="prolargin proteoglycan; 55 kDa leucine-rich repeat
                     protein of articular cartilage; proline-arginine-rich end
                     leucine-rich repeat protein"
                     /codon_start=1
                     /product="prolargin precursor"
                     /protein_id="NP_002716.1"
                     /db_xref="CCDS:CCDS1438.1"
                     /db_xref="GeneID:5549"
                     /db_xref="HGNC:HGNC:9357"
                     /db_xref="MIM:601914"
                     /translation="MRSPLCWLLPLLILASVAQGQPTRRPRPGTGPGRRPRPRPRPTP
                     SFPQPDEPAEPTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPVIPP
                     RIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKN
                     QLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFH
                     GLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYN
                     KLTDRGLPKNSFNISNLLVLHLSHNRISSVPAINNRLEHLYLNNNSIEKINGTQICPN
                     DLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRLLQSVVI"
     exon            1123..5769
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /note="hexamer: AATAAA"
     polyA_site      4032
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /note="major polyA site"
     regulatory      5743..5748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
                     /note="hexamer: AATAAA"
     polyA_site      5769
                     /gene="PRELP"
                     /gene_synonym="MST161; MSTP161; SLRR2A"
ORIGIN      
        1 aaacacaagc acgcacacac cactgggaga tcagatcttc tagctggctc tctgctgcca
       61 cagctccgcc gaagggaggg ggtggaagag gaggactaaa ctcagagctg agaggagagg
      121 caggtgtgtg caggtgcatc acctggatca tgaggtcacc cctctgctgg ctcctcccac
      181 ttctcatctt ggcctcagtg gcccaaggcc agccaacaag acgaccaaga cccgggactg
      241 ggcccgggcg cagacccagg cccaggccca ggcccacacc cagctttcct cagcctgatg
      301 aaccagcaga gccaacagac ctgcctcctc ccctccctcc aggccctcca tctatcttcc
      361 ctgactgtcc ccgcgaatgc tactgccccc ctgatttccc atctgccctc tactgtgata
      421 gccgcaacct gcgaaaggtc cctgtcatcc cgccccgcat ccattacctc tatctccaga
      481 acaacttcat cactgagctc ccggtggagt ccttccagaa tgccacaggc ctgcgatgga
      541 ttaacctgga caacaaccga atccgcaaga tagaccagag ggtgctggag aaactgcccg
      601 gcctggtgtt cctctacatg gagaagaacc agttggaaga ggtcccctcg gccctgcccc
      661 ggaacctgga gcagctgagg ctgagccaga accacatctc cagaatcccg cctggtgtct
      721 tcagcaagct ggagaacctg ctgctcctgg atctccagca caacaggctg agcgacggcg
      781 tcttcaagcc cgacaccttc catggcctca agaacctcat gcagctcaac ctggcccaca
      841 acatcctgag aaagatgccg cccagggtcc ccaccgccat tcaccagctc tacctggaca
      901 gtaacaagat tgagaccatc cctaacggat acttcaagag ctttcccaat cttgccttca
      961 ttcggcttaa ctacaacaag ctgacagaca ggggactccc caagaactcc tttaatatct
     1021 ccaacctgct tgtgctccac ctgtcccaca acaggatcag cagtgtgccc gccatcaaca
     1081 acaggctgga acacctgtac ctcaacaaca atagcatcga gaaaatcaac ggaacccaga
     1141 tttgccccaa cgacctagtg gcgttccatg acttctcctc ggacctggag aacgtgccac
     1201 acctgcgcta cctgcggctg gatggaaact acttgaagcc gcccatcccg ctggacctca
     1261 tgatgtgctt ccgcctcctg cagtccgtgg tcatctaggc cctactccgc caccggatct
     1321 gctctgaccg cacttgaagg ctggggccca ggcacctgtg ccggccattc gttttctctc
     1381 tctccctttc tttctcccag ctttgcctcc cttatcccac cctcgaggca gggaaaagcc
     1441 atctattctt ctgcagcctc aggagcgaga cttcaaggac tcagtttggt tccacccagt
     1501 tgaaagacac ccagtgcaca cccaaactcc tggccttctg tggtttccct ttgctccaga
     1561 aacacagatg tgtctaaaga cttggtgtcc ccttctctct cctcccccac ccgccactcc
     1621 tgggtacatc tgggccgtgg actatctgat cttggtcctg gccgagcaaa cagcccggag
     1681 gtaaggttca gaaagtcccc ctggggactc ctccatcttc ggcagctctg gctcaaagag
     1741 gccgagaaac ccagttctcc tgggccaagg atcccttctg gcaaagctgc tgctccgccg
     1801 cttggttccc cggcaccaga catcgccctg gccctgctgg cccgggtatc gggaaggagg
     1861 agcgagggaa tgacggaggt agggtgcagg gtcagggctc ccgcaggggc ctgcatctgg
     1921 ccagcaggac acagggatgc gcagggcgcc cccttctgtt ccagggtgaa catagcacac
     1981 gccctcctgg ctgggcctca ggaggaacag ccaaggagaa gaatggccca aggaactagg
     2041 aagcagccat gggagagggg aagggttcaa gcccgggatg ggcccgcgtg acgtcgatgg
     2101 gtcctgcggc ccccttgccc aacctcgggt ttagggagga gggttcacag tgtttttgtg
     2161 ggggcggggg aaggaagagg cagccccgcc cccgccatct gttctccatc agtgtgcgcg
     2221 gcccagccat ttccaccctc gggaggcggc tcctgagaaa cagggaggaa ggggcggagc
     2281 acctggacgt ctcccagaag cccctccacg tttgaaaatg cgcctcctcc tcggagacag
     2341 acgcatcggt gccacctagt ggctggtggg agtaacagct ggtcccagtc ttgcgcctgg
     2401 ccctcttcct ggggtgattt tcctcggtgg aggaggcccg tggggtccca acacggaaga
     2461 gccatgggcc gtgtgcatgg tgtcgctctc ctctagggtc tagcgggcac aaacgtcccc
     2521 aggctgggct cattcccatc gtgagtgagc ccaggtgagg acatagtcgg ctcccgtttg
     2581 ttgtaggccc ttcccaggtg ccttctcagc tccctcatct gtaaaccgag gaggtggata
     2641 agatgctccc ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga
     2701 ggcgggcaga ttattgcctg agctcaggag ttcgaaacca ccctgggcaa catggtgaaa
     2761 cccccgtctc tactaaaata caaaaaaatt agccaggcat agtggcgcgc gcctataatc
     2821 ccagctactg ggaggctgag gcgggagaat cgcttgagcc ggggaggcgg aggttgcagt
     2881 gaggcgagat tgtgccactg cactccagct tgggcgacag agtgagactc cgtctcaaaa
     2941 aagaaaaaaa aaagatgctc ctctgaggtc cctccggcgc tcatgttccg agtctgcagc
     3001 tccacacttt aaatcatact cgaatgcagg acaagtccta aatatttgcc ccttcccttg
     3061 cagtaattta ttttctgtat ggactgtccc tcccccagag gcttccccac cctccattgc
     3121 ctggcccagg tgagcagctt ggcaggtctc caagtggaac ccggtccaga cagggctgcc
     3181 tcgacttcac ctttccccct aacttcctcc aagggatgct gccccttctc agccccctgc
     3241 gtgtgtatat tggtgggagg catagaggat ggatgttcta gaaatgagta agacacagtg
     3301 cccaccccca agttaggatg aaaaaagttc cagaggtttt taagaaattg gattaagctg
     3361 ggtccctaac ttcaagaaat tcccattatg ctccttctca cctttctttt ttgctaatta
     3421 tggaaaatag ggcccatttc atcatagcct ccttcccccg tgctccacta caatcgccgc
     3481 attctttcta gctgcagctg gtttcttcaa ggctcctgct taaagtccac acgttattat
     3541 ggccgaaagc aacctggtgc ttcggcctgg ataagagccc cttctgcatc ttattcacag
     3601 cttgcagcct cagccccttt gatgaggccc tcaggggaga ggtcattacc ttgatcctgc
     3661 aaacccagac tcgttgagca gcaacgcaat caccatcatc ccactgccca atctagaata
     3721 tgtctgctct cctttgctct ctgcagctgt aagccagagg ggattcaagg taaataggct
     3781 ttacaggctc ccctcctcca aacacacaca gaatgggctg gtttctttca agtttaaaaa
     3841 aagccccctt ctccatgcac aagttcattc cctccatgct gtcgtcatcg acatatacag
     3901 gtgtgtacgt aggtgtatgt gtgtactctg cacgtatatc tcttctgtct tgaagaccct
     3961 gttaactttg tgaaataact tccacatttc aacacacttc acagtacagg aaataaagta
     4021 atatgaaaaa caccctgcgt gaactcaacg gtgtgaacag gtcaagaata acacttcaaa
     4081 gtcatcttgc cagccaggcg tggtggatca cgcctgtaat cccagcactc tgggaggcca
     4141 aagcgggcag atcacctgag gtcaggagtt caagaccagc ctggccaaca tagtgaaacc
     4201 ccttgtttac tcaaaataca aaaattggct gggtgcggtg gtacatgcct gtagtcccag
     4261 ctacttggga ggctgaggca ggagaattgc ttgaaccctg gaggcagaag ttgcagtgag
     4321 ccgagatcgc accactgcac tccagcctag gagacaaaac gagacttcat ttaaaaaaaa
     4381 taaaaataaa aataaaaata aagtcatctt gccacccacc ccctaccatt gagccaccat
     4441 gcccagcccc aaagcctctt aattgctcta acaagatgag tggggaaaag attatactct
     4501 taagaaattc ctacgaaagc tatccaaaag ccttttcttt cctcttttct tattattttt
     4561 aaatagaggc agggtctcat tatgttgccc aggctggtct ggaactcctg gcctcaagtg
     4621 atcctcccac cttggcctcc ccagagtgct gggattacac acgtgagtca ccatgcccag
     4681 ccccaaagcc atttcttgaa gaatttctcg caaactcaca accctcatga aaaattaatc
     4741 ctcagttcca cgagactgcc cacccacaga caaaaaaata tatatattcc taaagtcgga
     4801 ccagaaatct gacagctgcc tttgaaaccc aaagcctcgg gttctttcaa gctacatgta
     4861 ctaaattgtc gaaggtctcc caggagctct gtactgaggc agacacagaa agacacaaaa
     4921 cggtcgtctt tcctgcccaa gtaaagctta cagactaact ggggagatgt agtgtgcata
     4981 caaaacagta aaagagccat ctcaaggaca gagagcatag accaagtcat ctggaatggt
     5041 ctacatgcca tgcggaagtc caccgaaggg ttagaacagg gtgtcccaga ctctctcttc
     5101 tgagggaagg ttggttgcaa aagtgggatt catgaccctc ccaggctaca ccatcttctt
     5161 tagaatgaga actgccaggt gacgccctcg ctgctcctac ctggctacta aacatcgact
     5221 tcggttcact tcacggatgt tcagtggata tcggtcacat gccaggtccc cagctacgca
     5281 ttcaaggatg gataatatac atagcagcac atccttgagg aactcatacc ttggtaaagg
     5341 gaaagaaatc catgaatgga tacctctgtg tcctaagtgt ttgtaataat gctgtgtgtc
     5401 aggcctctga gcccaagcta agccatcata tcccctgtga cctgcatgtg cacatccaga
     5461 cggctggttc ctaccttaac tgatgatatt ccaccacaaa agaagtgaaa atggctggtc
     5521 cctgccttaa ctgatgacat taccttgtga aattccttct cctggctcat cctggctcaa
     5581 aagctccccc actgaacacc ttgcaacccc cacccctggc caccagagaa caaccccctt
     5641 tgactgtaat tttccattac ctacccacat cttataaaat ggccccatcc ctatctccct
     5701 tcgctgactc ttttcggact cagcccgcct gcacccaggt gaaataaaca gccttgttgc
     5761 tcacacaaa
//
