LOCUS       NM_016045               2503 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens PRELI domain containing 3B (PRELID3B), transcript
            variant 1, mRNA.
ACCESSION   NM_016045
VERSION     NM_016045.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Liu,X., Yuan,R., Peng,J., Xu,A., Nie,X., Tang,R. and Li,G.
  TITLE     SLMO2 is a potential prognostic and immunological biomarker in
            human pan-cancer
  JOURNAL   Sci Rep 14 (1), 1070 (2024)
   PUBMED   38212657
  REMARK    GeneRIF: SLMO2 is a potential prognostic and immunological
            biomarker in human pan-cancer.
            Erratum:[Sci Rep. 2024 Mar 13;14(1):6087. doi:
            10.1038/s41598-024-55384-z.. PMID: 38480750]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Miliara,X., Tatsuta,T., Berry,J.L., Rouse,S.L., Solak,K.,
            Chorev,D.S., Wu,D., Robinson,C.V., Matthews,S. and Langer,T.
  TITLE     Structural determinants of lipid specificity within Ups/PRELI lipid
            transfer proteins
  JOURNAL   Nat Commun 10 (1), 1130 (2019)
   PUBMED   30850607
  REMARK    GeneRIF: Structural determinants of lipid specificity within
            Ups/PRELI lipid transfer proteins has been reported.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Qayyum,R., Snively,B.M., Ziv,E., Nalls,M.A., Liu,Y., Tang,W.,
            Yanek,L.R., Lange,L., Evans,M.K., Ganesh,S., Austin,M.A.,
            Lettre,G., Becker,D.M., Zonderman,A.B., Singleton,A.B.,
            Harris,T.B., Mohler,E.R., Logsdon,B.A., Kooperberg,C., Folsom,A.R.,
            Wilson,J.G., Becker,L.C. and Reiner,A.P.
  TITLE     A meta-analysis and genome-wide association study of platelet count
            and mean platelet volume in african americans
  JOURNAL   PLoS Genet 8 (3), e1002491 (2012)
   PUBMED   22423221
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2503)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF151865.1 and BC010649.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016045.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1019099.1,
                                           SRR3476690.374941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355937.9/ ENSP00000348206.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AF151865.1         29-657
            630-757             AF151865.1         659-786
            758-2499            AF151865.1         788-2529
            2500-2503           BC010649.1         2505-2508
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..2503
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="PRELI domain containing 3B"
                     /db_xref="GeneID:51012"
                     /db_xref="HGNC:HGNC:15892"
                     /db_xref="MIM:620754"
     exon            1..88
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..641
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein slowmo homolog 2; PRELI domain containing protein
                     3B"
                     /codon_start=1
                     /product="PRELI domain containing protein 3B isoform 1"
                     /protein_id="NP_057129.2"
                     /db_xref="CCDS:CCDS42893.1"
                     /db_xref="GeneID:51012"
                     /db_xref="HGNC:HGNC:15892"
                     /db_xref="MIM:620754"
                     /translation="MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHID
                     PSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTN
                     MVSVDERLIYKPHPQDPEKTVLTQEAIITVKGVSLSSYLEGLMASTISSNASKGREAM
                     EWVIHKLNAEIEELTASARGTIRTPMAAAAFAEK"
     exon            89..257
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..347
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            348..418
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..521
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..2503
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="hexamer: AATAAA"
     polyA_site      2472
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="major polyA site"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="PRELID3B"
                     /gene_synonym="C20orf45; dJ543J19.5; SLMO2; UPS2"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtgcct cgttgtcccc tggcgctacc cggacatctc tcagggtgcc ggcaccatga
       61 agatctggac ttcggagcac gtctttgacc acccgtggga aactgttaca acagctgcaa
      121 tgcagaaata cccaaaccct atgaacccaa gtgtggttgg agttgatgtg ttggacagac
      181 atatagatcc ctctggaaag ttgcacagcc acagacttct cagcacagag tggggactgc
      241 cttccattgt gaagtctctt attggtgcag caagaacgaa aacatatgtg caagaacatt
      301 ctgtagttga tcctgtagag aaaacaatgg aacttaaatc tactaatatt tcatttacaa
      361 acatggtttc agtagatgag agacttatat acaaaccaca tcctcaggat ccagaaaaaa
      421 ctgttttgac acaagaagcc ataattaccg tgaaaggagt tagcctcagc agttaccttg
      481 aaggactgat ggcaagtacg atatcctcaa atgctagtaa aggccgagaa gcaatggaat
      541 gggtaataca taaattaaat gctgagattg aagaactgac agcctcagca agaggaacca
      601 taaggactcc aatggcagca gcagcgtttg cagagaagtg atcgtgacag ttggtagaca
      661 acatcgggta ctccaggtct ctccaaactg actatatatt tatttgttat tttaaaaata
      721 caactatatt ttgggtagtt tttttttttt tttttttgat aagttggtgt aaggctatgt
      781 gacttgatca aaacagatgc agggcctcta aataaaaggg atcatctgaa attaatgttg
      841 tttgaaatta ctatctgatt ttgagggttc cagtatttct gtgaaaattc aacaagaact
      901 ccttggaaac tggtattgat attcagtctc cttaaggtag atttttcaag cttttcatac
      961 attggaactc cacctgactt tggaccaacc ccagaacaga gcagagccac ctcctataga
     1021 cgcccattgc cctgctgctg tacacttcag cagcttgcac aagggagctc acttaaaagg
     1081 agaaattgtg tagttttaaa atatattttg tgtaaaatac cttactatgc tataaaccac
     1141 cattaaaaac cagtgttttg atttggtact taaatatttt tggagtgaaa attatcacta
     1201 aagtaacatg actccaacaa aagtatggtt tcattataaa agagtactgt attgatttgc
     1261 ccaagttttg taacttagta aaggtattaa cttccttgga tttgtacttt gtgatttagt
     1321 atgctgtatc gtgggctggt tatgttaact gaaaaaaata aagtcattac ctgagttttg
     1381 cagtgctcta acttaaacag aagaacagct gttcacatct tttagcattt tacatttgcc
     1441 taacttaaaa attgccatgt gtcaaaatca tggttttgta attgctaagg catgatatgt
     1501 caggttattt gaatataatt actttttgaa gtaattgtga ccacaaaaca tcttttttac
     1561 atgaaggagc tgtgtatcat ttgaaattac tcaaatgatg tcttgctctg aggcataaat
     1621 cccaggtact tagtgttttt aataatatgg tgccactgca ggatttgggg gcggtgggga
     1681 agaacaagca taatggtagg gggaggcttg gcctgaaact aaccactgag tgaattgcac
     1741 tgcaggtttt acttaacggg aattccttat ttgggatgtc aagagggcag ctgcaaactg
     1801 aaaaacaatc cagtaaatgt actttgtttt atgtattgta gcaggcaatt aactactaaa
     1861 taatagcttt gacatttgca attgttgcat agagactatt tttgctagaa gatgattagc
     1921 tcttgccttt attttacagt gcttagtgtg ataaacttct agtcatgttt cctatccaag
     1981 agaccagtta atatatgtac ataaaccaca gaaatagtat aacacactat ttttaaatta
     2041 tcgttttcct acttaaattt tgtttagctt aagacttctt aggacatttg taaaagcagg
     2101 ttaaatttaa taaggtttct gatttttttt tgtaaccgga gatagttttt acaagtgaaa
     2161 taacatttca gctaaataaa acatcgctaa ataattgata tttgatgaaa atctgctttg
     2221 tataatttct gtaaattatc cttgttctga aaaaggtgta atgccctaat atttttaaat
     2281 ccttatcctt tgatttttta aaaactgacc tattgataaa actataaatt ttcattttcc
     2341 agtgcagtta gttacctttt taaacataaa tgcacaacaa gcaaatgaat ttaagagaac
     2401 taaactggaa taagtgttca taaatgaaac ccttggacta tttaataaag ttgaaatgtg
     2461 aattaaggaa aacttttgtt aataaaaact ttcttttaag tga
//
