LOCUS       NM_205846               4817 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens PRELI domain containing 2 (PRELID2), transcript
            variant 2, mRNA.
ACCESSION   NM_205846
VERSION     NM_205846.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4817)
  AUTHORS   Lin,X. and Zhi,Y.
  TITLE     CircPRELID2 functions as a promoter of renal cell carcinoma through
            the miR-22-3p/ETV1 cascade
  JOURNAL   BMC Urol 24 (1), 104 (2024)
   PUBMED   38730434
  REMARK    GeneRIF: CircPRELID2 functions as a promoter of renal cell
            carcinoma through the miR-22-3p/ETV1 cascade.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4817)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4817)
  AUTHORS   Gao,M., Liu,Q., Zhang,F., Han,Z., Gu,T., Tian,W., Chen,Y. and Wu,Q.
  TITLE     Conserved expression of the PRELI domain containing 2 gene
            (Prelid2) during mid-later-gestation mouse embryogenesis
  JOURNAL   J Mol Histol 40 (3), 227-233 (2009)
   PUBMED   19847657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB266840.1, BQ645893.1 and AC011355.6.
            
            On Jun 2, 2019 this sequence version replaced NM_205846.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The encoded isoform
            (b) is shorter, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.24807.1,
                                           SRR14372080.3378192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511, SAMN03267751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683046.1/ ENSP00000506938.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB266840.1         30-43
            15-651              BQ645893.1         12-648
            652-4817            AC011355.6         65781-69946         c
FEATURES             Location/Qualifiers
     source          1..4817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4817
                     /gene="PRELID2"
                     /note="PRELI domain containing 2"
                     /db_xref="GeneID:153768"
                     /db_xref="HGNC:HGNC:28306"
                     /db_xref="MIM:620750"
     exon            1..166
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..625
                     /gene="PRELID2"
                     /note="isoform b is encoded by transcript variant 2; PRELI
                     domain-containing protein 2; CTC-806A22.1"
                     /codon_start=1
                     /product="PRELI domain-containing protein 2 isoform b"
                     /protein_id="NP_995318.1"
                     /db_xref="CCDS:CCDS34261.1"
                     /db_xref="GeneID:153768"
                     /db_xref="HGNC:HGNC:28306"
                     /db_xref="MIM:620750"
                     /translation="MGVSVDVHQVYKYPFEQVVASFLRKYPNPMDKNVISVKIMEEKR
                     DESTGVIYRKRIAICQNVVPEILRKVSILKVPNIQLEEESWLNPRERNMAIRSHCLTW
                     TQYASMKEESVFRESMENPNWTEFIQRGRISITGVGFLNCVLETFASTFLRQGAQKGI
                     RIMEMLLKEQCGAPLAE"
     exon            167..224
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     exon            225..298
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..459
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..565
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..635
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..4817
                     /gene="PRELID2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID2"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="PRELID2"
                     /note="major polyA site"
     regulatory      4598..4603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID2"
                     /note="hexamer: AATAAA"
     polyA_site      4618
                     /gene="PRELID2"
                     /note="major polyA site"
     regulatory      4798..4803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID2"
                     /note="hexamer: AATAAA"
     polyA_site      4817
                     /gene="PRELID2"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtgggc gcctccgggc ctctgcggag ccctgggcag ctctgagctc gcggaggcgt
       61 ggccggtgcg cggggcccgc ggcgcgcggg gatgggggtc tcggtggatg tgcaccaggt
      121 gtacaagtac cccttcgagc aggtggtcgc cagctttctc cgaaagtacc ccaaccccat
      181 ggataaaaat gtcatctcag taaaaatcat ggaggaaaaa agagatgaat caacaggggt
      241 catctacaga aagaggattg caatctgtca gaacgtggtt ccagaaattt taaggaaggt
      301 gagcattttg aaagtaccta atatccaatt agaagaggag tcatggctca atcctcggga
      361 aagaaacatg gccatacgga gtcactgcct tacgtggaca cagtatgcat ccatgaagga
      421 agagtctgtc ttccgggaaa gtatggaaaa cccaaattgg acagagttca ttcaaagagg
      481 caggatttca atcacagggg ttggatttct caactgtgtt ttagaaactt ttgccagcac
      541 attcttacga cagggagccc agaagggaat tagaatcatg gagatgctgc taaaggaaca
      601 gtgtggtgcc cccttagctg aataaagaat catcagagag ctgtatccat gtctacttat
      661 ttatttattt attttttttt tgagaatcac ttcttggcca cagcacatca cagacacagt
      721 ttctggaata caggtttgag gatacagtgt tggcagcttc aagaagagaa gaccttcttg
      781 ccaggacata aaatgatacc ctcctctggg agcctgcttc gaatagtggg actcagggag
      841 ataagacctt cttgctggat ttttatgaca caatctcttt ataattttac aaataaagga
      901 aaaaagaacc atgtaagata tgtgtgccct tcctcagggt gttctgctgg ttgtctgatg
      961 atggtgtcag ggcagctaag gacaggataa aggcctggag agggtgcttg tgcccttatg
     1021 ttatcagcac cgttgttcct aggattcgtg aggggattct ggaaccaata agggagttga
     1081 actggtacct gattcacggg tggactggaa caaacaggaa tgtaccagac ctatgttgaa
     1141 gctaagccgt atttataaca atgtttaaga ttctcagaaa tcaggagatt tttatcctat
     1201 ccataagtaa tatgtaactg ccataagtat agcttttaga atgtaatatg taaactgtga
     1261 tttggtcctc tggaaaaaaa aaaatgaaat gaagagtggg aaggcagttt cttttctgct
     1321 aattcgttct gtgatggtga gcaagcaaat cattaacctc tctgtttttt attgggcaaa
     1381 tggggataat caggcacagg tctttccgcc aatgcgttat gatgattaaa gaaggtaatt
     1441 ttgtgcaggg ttttaagtca acagacagac ctgggtttga atccaagtgc tggcacctac
     1501 ttgctcagtg atcatgaaca caattttaaa tctttctgaa tctcatttaa aaaaatttgt
     1561 gaaacaagat gatagaatta attttgtgag attgttggac tgatttgaga tcatgcctat
     1621 gaagtaccta gcacactgcc tagtacatag tagaagtcca ggaaatggaa gccattatta
     1681 tgtaaaacat tttgcaaagg tactttttaa ctgtaacgta aagtggtact actgtttgaa
     1741 acttagatgg cagtagtttg catttctcgt gatcagaagc caaaatataa atacatacta
     1801 cctaaaaaat cttgaagaga ggtaataatt tgaaattcat cttcttaaga taaaaatcag
     1861 ggcagggtgt ggtggcttat gcctgtaatc ccagtacttt gggaggccga ggcgggtgga
     1921 tcacaaggtc aggagttcga gaccagcctg gccaatatgg tgaaaccccg tctctactaa
     1981 aaatacaaaa aaattagctg ggcgtggtgg cgcatgcctg taatcctagc tacttgggag
     2041 tctgaggcag gagaattgct tgaactcagg aggtgaaggt tgcagtaagc tgagattgtg
     2101 ccactgcacc ccagcctggg tgacagagca agactccatc acaaaaaaaa aaaaaaaaaa
     2161 aaaaaattca ggccgttact ggagagtctt ggggaaattt ttttttaaaa tgtctgaaaa
     2221 tttttccact taatccattg atgaatttca aagcaattgt attttttcat acaagcctgc
     2281 cactgtgagc ctgttcttat tgtatctgag ctctttgtgc tgcctgaatt ttgtctctta
     2341 atttcttttc agcttcatag tgtttcattc ttcaattgtg ttggagggaa aaataatggt
     2401 agaaactaaa acacactttg accttttttt tccaatttgt agatggcatt tggtaggctt
     2461 ttggagtaat agcctatttc aaaaaataaa aggtgatgca aattattgtg gaagtgagag
     2521 gcaagaaatt tgtatttgga ggttgacatt agagtaagtt taacccttca cactcaaaaa
     2581 ctcccatcct ctgaaggcag gagttctcaa ccttggctgt ctgttaggat tgcttgggga
     2641 gctttctgca attctgatgc ctgggttgct tctcagacca aaaatcagaa tctcaggtag
     2701 tggaaccaag gcatcagctt taaaaaaaac tcctttggta gttccagtgg gcagctaaga
     2761 acactacagt gacttttagg tatttgcaga caatatttaa tttttttctt aatatctctg
     2821 tggttggaaa ggatctttgt agcaggaatt tttttattag aaatagacca aggcacagag
     2881 aggttgaatt tctgccttgt gtgcccggtt ccagcacagt gcggttgtgt cgttggtctt
     2941 ttttagtatt tcctatttcc aattttctaa gaaaagacag aattaaaaaa aaaatctcct
     3001 agttttttat tggcaaccaa ttcagaattg tttaaaacat tgtgctggcc aaaacaaaaa
     3061 acatgtttgc cagccagtag tttttagcct ctgcttccag agtgttaagg acaggcctaa
     3121 acatcctggc caagctttaa tggatttgca tttttgtact ctggatgtaa gttttattct
     3181 gcctctcctc taagactact tttagatgta tcttcctcct cattcctaaa taatcctcag
     3241 ggattacttt tcctcactca gtaattttcc ccctgcaggc agctattgct tccagcttca
     3301 catatatggc ttagaaattt tatggtcttt tttttttttt ttttcattta cttttttttg
     3361 agatagggtc tcactatgtt tatcaggctg gtcttgaact tctggcctca aatgatcctc
     3421 ctgcctctgc ctctgcctcc caaagtgctg ggattacagg cttgagccac tgtgtctgtc
     3481 ctctttttgg aattaattag ggcttgttaa tttttttaaa ttatatgttt tgtgataaaa
     3541 catttagaag tccatgtttt ttattctgta ctgtgtagct taagaaatgt caaaaccagg
     3601 agtacaggct tattgggcac actagaaaca agagtgggaa agggttaatt cacagacctg
     3661 gccagtctcc tcctgtcttc aaggcgatga tttaccctgt gattctcaga cttcacatgt
     3721 accagaaatc tttggggcaa cgtgctaacg tgcaggttct cagtcccttt ccccagcgat
     3781 tctgattcgt ggaatttcag ttgatcattc aggacacagt ataaagttct tatgcagaga
     3841 gaagctgact tgaactatcc ctatatgact gaggtgcttt taccaggaag gggcttttat
     3901 agtttcagtc atatatggat gaaaaaggtg ctgtattctt tttctatgaa ctactttgtg
     3961 tattttataa gcagtatata tgtactgata cttgtttatc agacattgtg cggtgcatgg
     4021 tgtagaaaac tcaaggttat tcttttaact tgcacatctt ttttacttta tttcaatcat
     4081 ttacatcaaa ctatttctta atttagtata catttctctg cttttgcaaa cacagtctac
     4141 tggggataat taaatctttt cagagtcgtc atatatgttt ttaattcttt caggccctac
     4201 ttagttttgt taaagtccct acactgaagg ctccagatac atttgctctt tgagttctac
     4261 catggttttt agagtttttc ttttccctca cttttatctg tcatttatct ctcccattac
     4321 tgtgcctacc tctaggaagc tttctctaat ttgccctggg gttgggaaat tgtgtaactg
     4381 catactatat gttgaataag agtagagagg atttgaatga ggttttgaga ggctgttcta
     4441 gcaataaaaa tgaatgtact ttgctacatt gacttggtga cattatttca gtggctcaac
     4501 tctcttcccc taacttactt ctttatcctc atctgcagtt gtcatatttg tgaactcgcg
     4561 gcaagtgaga tattgctaga aataatttct cttgatcaat aaaccattgt ctcccccagc
     4621 tgtgttagtg tttttgtgta ttcagttcta taatgtgaaa cttaagagga ttaaaactca
     4681 aaaaatgatc aggccaaatt tttatgtggg atgaagtgtt tctgattcag tgttattgtg
     4741 atatagagct ataaattagt tgtttaccta tgaaattcct tcctgcagtc attctgaaat
     4801 aaagttgtta cagctga
//
