LOCUS       NM_013237               1226 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens PRELI domain containing 1 (PRELID1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_013237
VERSION     NM_013237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Xi,S., Cai,H., Lu,J., Zhang,Y., Yu,Y., Chen,F., Huang,Q., Wang,F.
            and Chen,Z.
  TITLE     The pseudogene PRELID1P6 promotes glioma progression via the
            hnHNPH1-Akt/mTOR axis
  JOURNAL   Oncogene 40 (26), 4453-4467 (2021)
   PUBMED   34108621
  REMARK    GeneRIF: The pseudogene PRELID1P6 promotes glioma progression via
            the hnHNPH1-Akt/mTOR axis.
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Miliara,X., Tatsuta,T., Berry,J.L., Rouse,S.L., Solak,K.,
            Chorev,D.S., Wu,D., Robinson,C.V., Matthews,S. and Langer,T.
  TITLE     Structural determinants of lipid specificity within Ups/PRELI lipid
            transfer proteins
  JOURNAL   Nat Commun 10 (1), 1130 (2019)
   PUBMED   30850607
  REMARK    GeneRIF: Structural determinants of lipid specificity within
            Ups/PRELI lipid transfer proteins has been reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Gillen,A.E., Brechbuhl,H.M., Yamamoto,T.M., Kline,E., Pillai,M.M.,
            Hesselberth,J.R. and Kabos,P.
  TITLE     Alternative Polyadenylation of PRELID1 Regulates Mitochondrial ROS
            Signaling and Cancer Outcomes
  JOURNAL   Mol Cancer Res 15 (12), 1741-1751 (2017)
   PUBMED   28912168
  REMARK    GeneRIF: This study suggests that the regulation of PRELID1
            expression, by alternative polyadenylation and other mechanisms,
            plays a role in mitochondrial ROS signaling and represents a novel
            prognostic factor and therapeutic target in cancer
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Kim,B.Y., Cho,M.H., Kim,K.J., Cho,K.J., Kim,S.W., Kim,H.S.,
            Jung,W.W., Lee,B.H., Lee,B.H. and Lee,S.G.
  TITLE     Effects of PRELI in Oxidative-Stressed HepG2 Cells
  JOURNAL   Ann Clin Lab Sci 45 (4), 419-425 (2015)
   PUBMED   26275693
  REMARK    GeneRIF: PRELI plays an important role in the suppression of
            apoptosis in HepG2 cells in response to oxidative stress.
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Ma,W., McKeller,M.R., Rangel,R., Ortiz-Quintero,B., Blackburn,M.R.
            and Martinez-Valdez,H.
  TITLE     Spare PRELI gene loci: failsafe chromosome insurance?
  JOURNAL   PLoS One 7 (5), e37949 (2012)
   PUBMED   22666421
  REMARK    GeneRIF: PRELI is a vital LEA B cell protein with failsafe genetics
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   McKeller,M.R., Herrera-Rodriguez,S., Ma,W., Ortiz-Quintero,B.,
            Rangel,R., Cande,C., Sims-Mourtada,J.C., Melnikova,V., Kashi,C.,
            Phan,L.M., Chen,Z., Huang,P., Dunner,K. Jr., Kroemer,G., Singh,K.K.
            and Martinez-Valdez,H.
  TITLE     Vital function of PRELI and essential requirement of its LEA motif
  JOURNAL   Cell Death Dis 1 (2), e21 (2010)
   PUBMED   21364629
  REMARK    GeneRIF: PRELI interacts with OPA1 to maintain mitochondria
            structures intact, sustain balanced ion(-)/proton(+) gradients,
            promote oxidative phosphorylation reactions, regulate pro- and
            antiapoptotic protein traffic and enable cell responses to induced
            death.
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Tahvanainen,J., Kallonen,T., Lahteenmaki,H., Heiskanen,K.M.,
            Westermarck,J., Rao,K.V. and Lahesmaa,R.
  TITLE     PRELI is a mitochondrial regulator of human primary T-helper cell
            apoptosis, STAT6, and Th2-cell differentiation
  JOURNAL   Blood 113 (6), 1268-1277 (2009)
   PUBMED   18945965
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Fox,E.J., Stubbs,S.A., Kyaw Tun,J., Leek,J.P., Markham,A.F. and
            Wright,S.C.
  TITLE     PRELI (protein of relevant evolutionary and lymphoid interest) is
            located within an evolutionarily conserved gene cluster on
            chromosome 5q34-q35 and encodes a novel mitochondrial protein
  JOURNAL   Biochem J 378 (Pt 3), 817-825 (2004)
   PUBMED   14640972
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Guzman-Rojas,L., Sims,J.C., Rangel,R., Guret,C., Sun,Y.,
            Alcocer,J.M. and Martinez-Valdez,H.
  TITLE     PRELI, the human homologue of the avian px19, is expressed by
            germinal center B lymphocytes
  JOURNAL   Int Immunol 12 (5), 607-612 (2000)
   PUBMED   10784606
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007268.1, BU956915.1 and
            AA844687.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013237.3.
            
            Summary: This gene encodes a member of the late embryogenesis
            abundant motif-containing protein family. The encoded protein is
            localized to mitochondria and may function as a cytoprotectant by
            regulating cell death and differentiation. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. Several related pseudogenes have been identified.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007268.1, SRR1803617.314925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18945965, 14640972;
                                                  reported by MitoCarta
            MANE Ensembl match                 :: ENST00000303204.9/
                                                  ENSP00000302114.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               BC007268.1         1-636
            637-892             BU956915.1         225-480
            893-1226            AA844687.1         26-359              c
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1226
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="PRELI domain containing 1"
                     /db_xref="GeneID:27166"
                     /db_xref="HGNC:HGNC:30255"
                     /db_xref="MIM:605733"
     exon            1..279
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..847
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; px19-like protein; PRELI domain-containing
                     protein 1, mitochondrial; 25 kDa protein of relevant
                     evolutionary and lymphoid interest"
                     /codon_start=1
                     /product="PRELI domain-containing protein 1, mitochondrial
                     isoform 1 precursor"
                     /protein_id="NP_037369.1"
                     /db_xref="CCDS:CCDS4415.1"
                     /db_xref="GeneID:27166"
                     /db_xref="HGNC:HGNC:30255"
                     /db_xref="MIM:605733"
                     /translation="MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREV
                     TPDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYVLEDSIVDPQNQTMTTFTWNINH
                     ARLMVVEERCVYCVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMK
                     GFEYILAKLQGEAPSKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQF
                     V"
     exon            280..505
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /inference="alignment:Splign:2.1.0"
     exon            506..619
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /inference="alignment:Splign:2.1.0"
     exon            620..698
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1226
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="hexamer: ATTAAA"
     polyA_site      938
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="major polyA site"
     regulatory      1206..1211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="hexamer: AATAAA"
     polyA_site      1226
                     /gene="PRELID1"
                     /gene_synonym="CGI-106; PRELI; PX19; SBBI12"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggccgg acaactcatg gcggcggcgg cggcggcggc agctgcttgg gcgcggtgcg
       61 gtggtgactg agctacgagc ctggcggcgg gtgtgcgccg agccccggcc cggcccggcc
      121 ctcgcgtgcc tcccaggctc cgcacccctg atgctgcgcg ggtgctgagc ccgcttcggc
      181 cgggacgatg gtgaagtatt tcctgggcca gagcgtgctc cggagttcct gggaccaagt
      241 gttcgccgcc ttctggcagc ggtacccgaa tccctatagc aaacatgtct tgacggaaga
      301 catagtacac cgggaggtga cccctgacca gaaactgctg tcccggcgac tcctgaccaa
      361 gaccaacagg atgccacgct gggccgagcg actatttcct gccaatgttg ctcactcggt
      421 gtacgtcctg gaggactcta ttgtggaccc acagaatcag accatgacta ccttcacctg
      481 gaacatcaac cacgcccggc tgatggtggt ggaggaacga tgtgtttact gtgtgaactc
      541 tgacaacagt ggctggactg aaatccgccg ggaagcctgg gtctcctcta gcttatttgg
      601 tgtctccaga gctgtccagg aatttggtct tgcccgattc aaaagcaacg tgaccaagac
      661 tatgaagggt tttgaatata tcttggctaa gctgcaaggc gaggcccctt ccaaaacact
      721 tgttgagaca gccaaggaag ccaaggagaa ggcaaaggag acggcactgg cagctacaga
      781 gaaggccaag gacctcgcca gcaaggcggc caccaagaag cagcagcagc agcaacagtt
      841 tgtgtagcca gtctaccacc accacagcac cccagacagc taggcttagc ctctctgccc
      901 tcccttcatt gtactttatc attaaaaatc aacttccagc cctgtctgct gtctacgtgg
      961 tgggttgtgg ggatgcagtt tggcatctgc agtacaccaa gcacatgatt catgtctgag
     1021 ccaggtctgc ttattctccc attgggcagc tgaggaccga ggcacagagg tgcggtgact
     1081 tgcccggggc tccaggtagc ctgcaggtta actggcggta agtgctagac tgtaagcccg
     1141 acaagggcag ggcttttggt tttgttctct gatgtgtctc agtatctagc acataataga
     1201 cactcaataa atacttgttg aattca
//
