LOCUS       NM_004905               1690 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens peroxiredoxin 6 (PRDX6), mRNA.
ACCESSION   NM_004905
VERSION     NM_004905.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Chen,Z., Lin,J., Wang,H., Wang,J. and Zhang,Z.
  TITLE     Expression and clinical role of PRDX6 in lung adenocarcinoma
  JOURNAL   J Int Med Res 52 (3), 3000605241236276 (2024)
   PUBMED   38506348
  REMARK    GeneRIF: Expression and clinical role of PRDX6 in lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Chhunchha,B., Kumar,R., Kubo,E., Thakur,P. and Singh,D.P.
  TITLE     Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory
            Response in Lens Epithelial Cells
  JOURNAL   Int J Mol Sci 24 (22), 16276 (2023)
   PUBMED   38003466
  REMARK    GeneRIF: Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven
            Inflammatory Response in Lens Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Morey,K., Pearson,O., Sivak,L., Brown,K., Mejia,G., Colmer,K.,
            Melchers,A., Keech,W. and Brown,A.
  TITLE     An Aboriginal-led consortium approach to chronic disease action for
            health equity and holistic wellbeing
  JOURNAL   Health Promot J Austr 34 (3), 634-643 (2023)
   PUBMED   37386720
  REMARK    GeneRIF: An Aboriginal-led consortium approach to chronic disease
            action for health equity and holistic wellbeing.
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Xiong,M., Guo,M., Huang,D., Li,J. and Zhou,Y.
  TITLE     Effect of PRDX6 gene polymorphism on susceptibility to chronic
            obstructive pulmonary disease in the Chinese Han population
  JOURNAL   Clin Respir J 17 (7), 638-646 (2023)
   PUBMED   37329238
  REMARK    GeneRIF: Effect of PRDX6 gene polymorphism on susceptibility to
            chronic obstructive pulmonary disease in the Chinese Han
            population.
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Di Sanzo,M., Cozzolino,F., Battaglia,A.M., Aversa,I., Monaco,V.,
            Sacco,A., Biamonte,F., Palmieri,C., Procopio,F., Santamaria,G.,
            Ortuso,F., Pucci,P., Monti,M. and Faniello,M.C.
  TITLE     Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell
            Proliferation and Migration
  JOURNAL   Int J Mol Sci 23 (21), 12987 (2022)
   PUBMED   36361777
  REMARK    GeneRIF: Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits
            Cell Proliferation and Migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Golaz,O., Hughes,G.J., Frutiger,S., Paquet,N., Bairoch,A.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Appel,R.D., Walzer,C. et
            al.
  TITLE     Plasma and red blood cell protein maps: update 1993
  JOURNAL   Electrophoresis 14 (11), 1223-1231 (1993)
   PUBMED   8313871
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Yeats,D.A. and Bakhle,Y.S.
  TITLE     Phospholipases A2 and C of human lung; subcellular distribution and
            substrate selectivity
  JOURNAL   Biochim Biophys Acta 1003 (2), 189-195 (1989)
   PUBMED   2730891
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Akesson,B.
  TITLE     Work in progress. Occurence of phospholipase A1 and A2 in human
            decidua
  JOURNAL   Prostaglandins 9 (5), 667-673 (1975)
   PUBMED   240188
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139142.10.
            
            On Nov 25, 2018 this sequence version replaced NM_004905.2.
            
            Summary: The protein encoded by this gene is a member of the
            thiol-specific antioxidant protein family. This protein is a
            bifunctional enzyme with two distinct active sites. It is involved
            in redox regulation of the cell; it can reduce H(2)O(2) and short
            chain organic, fatty acid, and phospholipid hydroperoxides. It may
            play a role in the regulation of phospholipid turnover as well as
            in protection against oxidative injury. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.76094.1,
                                           SRR5189664.89295.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340385.6/ ENSP00000342026.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL139142.10        3202-3359
            159-315             AL139142.10        7193-7349
            316-462             AL139142.10        11228-11374
            463-609             AL139142.10        12122-12268
            610-1690            AL139142.10        13602-14682
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..1690
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /note="peroxiredoxin 6"
                     /db_xref="GeneID:9588"
                     /db_xref="HGNC:HGNC:16753"
                     /db_xref="MIM:602316"
     exon            1..158
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..738
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /EC_number="3.1.1.4"
                     /EC_number="2.3.1.23"
                     /EC_number="1.11.1.27"
                     /note="antioxidant protein 2; non-selenium glutathione
                     peroxidase; acidic calcium-independent phospholipase A2;
                     1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; liver 2D
                     page spot 40; red blood cells page spot 12;
                     glutathione-dependent peroxiredoxin; epididymis secretory
                     sperm binding protein Li 128m; LPC acyltransferase 5;
                     lyso-PC acyltransferase 5; lysophosphatidylcholine
                     acyltransferase 5"
                     /codon_start=1
                     /product="peroxiredoxin-6"
                     /protein_id="NP_004896.1"
                     /db_xref="CCDS:CCDS1307.1"
                     /db_xref="GeneID:9588"
                     /db_xref="HGNC:HGNC:16753"
                     /db_xref="MIM:602316"
                     /translation="MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFT
                     PVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPI
                     IDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEI
                     LRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYL
                     RYTPQP"
     exon            159..315
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /inference="alignment:Splign:2.1.0"
     exon            316..462
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /inference="alignment:Splign:2.1.0"
     exon            463..609
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1690
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /note="hexamer: AATGAA"
     polyA_site      890
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /note="major polyA site"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="PRDX6"
                     /gene_synonym="1-Cys; aiPLA2; AOP2; HEL-S-128m; LPCAT-5;
                     NSGPx; p29; PRX"
ORIGIN      
        1 gcttcttcgc cagaaccaac cggttgcttg ctgtcccagc ggcgccccct catcaccgtc
       61 gccatgcccg gaggtctgct tctcggggac gtggctccca actttgaggc caataccacc
      121 gtcggccgca tccgtttcca cgactttctg ggagactcat ggggcattct cttctcccac
      181 cctcgggact ttaccccagt gtgcaccaca gagcttggca gagctgcaaa gctggcacca
      241 gaatttgcca agaggaatgt taagttgatt gccctttcaa tagacagtgt tgaggaccat
      301 cttgcctgga gcaaggatat caatgcttac aattgtgaag agcccacaga aaagttacct
      361 tttcccatca tcgatgatag gaatcgggag cttgccatcc tgttgggcat gctggatcca
      421 gcagagaagg atgaaaaggg catgcctgtg acagctcgtg tggtgtttgt ttttggtcct
      481 gataagaagc tgaagctgtc tatcctctac ccagctacca ctggcaggaa ctttgatgag
      541 attctcaggg tagtcatctc tctccagctg acagcagaaa aaagggttgc caccccagtt
      601 gattggaagg atggggatag tgtgatggtc cttccaacca tccctgaaga agaagccaaa
      661 aaacttttcc cgaaaggagt cttcaccaaa gagctcccat ctggcaagaa atacctccgc
      721 tacacacccc agccttaagt ctcttggaga agctggtgct gtgagccaga ggatgtcagc
      781 tgccaattgt gttttcctgc agcaattcca taaacacatc ctggtgtcat cacagccaag
      841 gtttttaggt tgctatacca atggcttatt aaatgaaaat ggcactaaaa gtttcttgag
      901 attctttata ctctctgcct tcagcaatca attccattca tacatcagca ctctgctggt
      961 tctgtttgaa atatgttctg tatttaaaac tcaaatcttg ttggatctct gcagggcttg
     1021 tgaccaatga agtcatattt gttgatggtt gacaaagctt gcttcactcc atcagagaat
     1081 gactatcaat ttttttttaa ctgtcctatc acgtcctctc ctgtcaccca ttttgaagag
     1141 tggcagaact tgaagttcaa cttcctctgt aaatatccaa gtataaagcc caggaacttc
     1201 tagaataacc cagatgcgct ttaatttttt ttaatatgtt ttgatcacag aacttctaga
     1261 ataacccaga tgctctttca tattctttta atacatcttg atcacagctg ggggaaaaaa
     1321 agctttttaa ttctatacct tcctagtaga taagtgaaga gcagggaaag agacctttaa
     1381 atattttgct ataaaaaaat ttgtgataag tttctatcaa aatggggaga ttgcagaaaa
     1441 ggcttccctt ggctcccaag gaggtgtagc aggtgtgagc aatattagtg ccatgtgcct
     1501 ttcacacagg gtttgcattt atcagtctgt tttccgatga tgtgtacatg aaagagtaca
     1561 ccatgtgaag agaagagaga atgattgaaa atgttttagt atagaactct tcttgcagtg
     1621 ggttgctatt ttctagattt tactttttag ggaacaaaat aaaatccttt gttaaaactg
     1681 ggtcagagaa
//
