LOCUS       NM_012094                860 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens peroxiredoxin 5 (PRDX5), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_012094
VERSION     NM_012094.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Wang,R., Mi,Y., Ni,J., Wang,Y., Ding,L., Ran,X., Sun,Q., Tan,S.Y.,
            Koeffler,H.P., Feng,N. and Chen,Y.Q.
  TITLE     Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer
  JOURNAL   Adv Sci (Weinh) 11 (9), e2304939 (2024)
   PUBMED   38115765
  REMARK    GeneRIF: Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer.
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Czerwinska,K., Januszewska,L., Markiewicz-Gorka,I., Jaremkow,A.,
            Martynowicz,H., Pawlas,K., Mazur,G., Poreba,R. and Gac,P.
  TITLE     Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant
            status in patients with suspected obstructive sleep apnea
  JOURNAL   Sleep Breath 28 (1), 211-219 (2024)
   PUBMED   37495908
  REMARK    GeneRIF: Selenoprotein P, peroxiredoxin-5, renalase, and total
            antioxidant status in patients with suspected obstructive sleep
            apnea.
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Tasakova,O.S., Golubtzova,N.N. and Gunin,A.G.
  TITLE     [Thioredoxin-reductase in fibroblasts of human dermis in the
            process of aging.]
  JOURNAL   Adv Gerontol 36 (4), 584-591 (2023)
   PUBMED   38010188
  REMARK    GeneRIF: [Thioredoxin-reductase in fibroblasts of human dermis in
            the process of aging.].
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Knoops,B., Goemaere,J., Van der Eecken,V. and Declercq,J.P.
  TITLE     Peroxiredoxin 5: structure, mechanism, and function of the
            mammalian atypical 2-Cys peroxiredoxin
  JOURNAL   Antioxid Redox Signal 15 (3), 817-829 (2011)
   PUBMED   20977338
  REMARK    Review article
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Nguyen-Nhu,N.T., Berck,J., Clippe,A., Duconseille,E., Cherif,H.,
            Boone,C., Van der Eecken,V., Bernard,A., Banmeyer,I. and Knoops,B.
  TITLE     Human peroxiredoxin 5 gene organization, initial characterization
            of its promoter and identification of alternative forms of mRNA
  JOURNAL   Biochim Biophys Acta 1769 (7-8), 472-483 (2007)
   PUBMED   17628720
  REMARK    GeneRIF: we present new alternative splicing variants encoded
            specifically by human PRDX5 gene. The characterization of human
            PRDX5 gene revealed complexity of its regulation & high variability
            of sequences that might be associated with pathological situations.
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Seo,M.S., Kang,S.W., Kim,K., Baines,I.C., Lee,T.H. and Rhee,S.G.
  TITLE     Identification of a new type of mammalian peroxiredoxin that forms
            an intramolecular disulfide as a reaction intermediate
  JOURNAL   J Biol Chem 275 (27), 20346-20354 (2000)
   PUBMED   10751410
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Wattiez,R., Hermans,C., Bernard,A., Lesur,O. and Falmagne,P.
  TITLE     Human bronchoalveolar lavage fluid: two-dimensional gel
            electrophoresis, amino acid microsequencing and identification of
            major proteins
  JOURNAL   Electrophoresis 20 (7), 1634-1645 (1999)
   PUBMED   10424490
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Kropotov,A., Sedova,V., Ivanov,V., Sazeeva,N., Tomilin,A.,
            Krutilina,R., Oei,S.L., Griesenbeck,J., Buchlow,G. and Tomilin,N.
  TITLE     A novel human DNA-binding protein with sequence similarity to a
            subfamily of redox proteins which is able to repress
            RNA-polymerase-III-driven transcription of the Alu-family
            retroposons in vitro
  JOURNAL   Eur J Biochem 260 (2), 336-346 (1999)
   PUBMED   10095767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001453.6 and AP003774.4.
            
            On Nov 23, 2018 this sequence version replaced NM_012094.4.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            antioxidant enzymes, which reduce hydrogen peroxide and alkyl
            hydroperoxides. The encoded protein interacts with peroxisome
            receptor 1 and plays an antioxidant protective role in different
            tissues under normal conditions and during inflammatory processes.
            The use of alternate transcription start sites is thought to result
            in transcript variants that use different in-frame translational
            start codons to generate isoforms that are targeted to the
            mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S).
            Multiple related pseudogenes have been defined for this gene.
            [provided by RefSeq, Nov 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (L).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110983.1, SRR1163657.16695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000265462.9/
                                                  ENSP00000265462.4
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AP001453.6         90303-90568
            267-401             AP003774.4         735-869
            402-533             AP003774.4         1662-1793
            534-572             AP003774.4         1866-1904
            573-634             AP003774.4         2008-2069
            635-860             AP003774.4         2587-2812
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..860
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /note="peroxiredoxin 5"
                     /db_xref="GeneID:25824"
                     /db_xref="HGNC:HGNC:9355"
                     /db_xref="MIM:606583"
     exon            1..266
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..740
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /EC_number="1.11.1.24"
                     /note="isoform L precursor is encoded by transcript
                     variant 1; antioxidant enzyme B166; thioredoxin peroxidase
                     PMP20; peroxisomal antioxidant enzyme; TPx type VI; liver
                     tissue 2D-page spot 71B; Alu co-repressor 1; epididymis
                     secretory protein Li 55; peroxiredoxin-5, mitochondrial;
                     peroxiredoxin V; thioredoxin reductase;
                     thioredoxin-dependent peroxiredoxin 5"
                     /codon_start=1
                     /product="peroxiredoxin-5, mitochondrial isoform L
                     precursor"
                     /protein_id="NP_036226.2"
                     /db_xref="CCDS:CCDS8069.1"
                     /db_xref="GeneID:25824"
                     /db_xref="HGNC:HGNC:9355"
                     /db_xref="MIM:606583"
                     /translation="MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVR
                     SFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSK
                     THLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKE
                     TDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL"
     exon            267..401
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     exon            402..533
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     exon            534..572
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     exon            573..634
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     exon            635..860
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      836..841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /note="hexamer: AATAAA"
     polyA_site      860
                     /gene="PRDX5"
                     /gene_synonym="ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20;
                     PRDX6; prx-V; PRXV; SBBI10"
                     /note="major polyA site"
ORIGIN      
        1 cttccgcagg gtgtcgccgc tgtgccgcta gcggtgcccc gcctgctgcg gtggcaccag
       61 ccaggaggcg gagtggaagt ggccgtgggg cgggtatggg actagctggc gtgtgcgccc
      121 tgagacgctc agcgggctat atactcgtcg gtggggccgg cggtcagtct gcggcagcgg
      181 cagcaagacg gtacagtgaa ggagagtggg cgtctggcgg ggtccgcagt ttcagcagag
      241 ccgctgcagc catggcccca atcaaggtgg gagatgccat cccagcagtg gaggtgtttg
      301 aaggggagcc agggaacaag gtgaacctgg cagagctgtt caagggcaag aagggtgtgc
      361 tgtttggagt tcctggggcc ttcacccctg gatgttccaa gacacacctg ccagggtttg
      421 tggagcaggc tgaggctctg aaggccaagg gagtccaggt ggtggcctgt ctgagtgtta
      481 atgatgcctt tgtgactggc gagtggggcc gagcccacaa ggcggaaggc aaggttcggc
      541 tcctggctga tcccactggg gcctttggga aggagacaga cttattacta gatgattcgc
      601 tggtgtccat ctttgggaat cgacgtctca agaggttctc catggtggta caggatggca
      661 tagtgaaggc cctgaatgtg gaaccagatg gcacaggcct cacctgcagc ctggcaccca
      721 atatcatctc acagctctga ggccctgggc cagattactt cctccacccc tccctatctc
      781 acctgcccag ccctgtgctg gggccctgca attggaatgt tggccagatt tctgcaataa
      841 acacttgtgg tttgcggcca
//
