LOCUS       NM_006406                956 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peroxiredoxin 4 (PRDX4), mRNA.
ACCESSION   NM_006406
VERSION     NM_006406.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 956)
  AUTHORS   Lu,Z., Tang,Y., Qin,R., Han,Z., Chen,H., Cao,L., Zhang,P., Yang,X.,
            Yu,W., Cheng,N. and Sun,Y.
  TITLE     Revealing Prdx4 as a potential diagnostic and therapeutic target
            for acute pancreatitis based on machine learning analysis
  JOURNAL   BMC Med Genomics 17 (1), 93 (2024)
   PUBMED   38641608
  REMARK    GeneRIF: Revealing Prdx4 as a potential diagnostic and therapeutic
            target for acute pancreatitis based on machine learning analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 956)
  AUTHORS   Han,J., Itoh,T., Shioya,A., Sakurai,M., Oyama,T., Kumagai,M.,
            Takamura,H., Okuro,M., Mukai,T., Kitakata,H., Inagaki,M.,
            Higashi,M., Guo,X. and Yamada,S.
  TITLE     The combination of the low immunohistochemical expression of
            peroxiredoxin 4 and perilipin 2 predicts longer survival in
            pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly
            playing a main role
  JOURNAL   Histol Histopathol 38 (12), 1415-1427 (2023)
   PUBMED   37787446
  REMARK    GeneRIF: The combination of the low immunohistochemical expression
            of peroxiredoxin 4 and perilipin 2 predicts longer survival in
            pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly
            playing a main role.
REFERENCE   3  (bases 1 to 956)
  AUTHORS   Aihaiti,Y., Tuerhong,X., Zheng,H., Cai,Y., Yang,M. and Xu,P.
  TITLE     Peroxiredoxin 4 regulates tumor-cell-like characteristics of
            fibroblast-like synoviocytes in rheumatoid arthritis through
            PI3k/Akt signaling pathway
  JOURNAL   Clin Immunol 237, 108964 (2022)
   PUBMED   35263665
  REMARK    GeneRIF: Peroxiredoxin 4 regulates tumor-cell-like characteristics
            of fibroblast-like synoviocytes in rheumatoid arthritis through
            PI3k/Akt signaling pathway.
REFERENCE   4  (bases 1 to 956)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 956)
  AUTHORS   Han,K., Du,S.S., Wang,H., Qiao,J.J., Zhang,X., Wang,P. and
            Shen,F.H.
  TITLE     [Differential expression of PRDX4 in alveolar macrophages of
            patients with silicosis]
  JOURNAL   Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 39 (1), 17-19 (2021)
   PUBMED   33535333
  REMARK    GeneRIF: [Differential expression of PRDX4 in alveolar macrophages
            of patients with silicosis].
REFERENCE   6  (bases 1 to 956)
  AUTHORS   Leonard,D., Ajuh,P., Lamond,A.I. and Legerski,R.J.
  TITLE     hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA
            splicing
  JOURNAL   Biochem Biophys Res Commun 308 (4), 793-801 (2003)
   PUBMED   12927788
REFERENCE   7  (bases 1 to 956)
  AUTHORS   Wagner,E., Luche,S., Penna,L., Chevallet,M., Van Dorsselaer,A.,
            Leize-Wagner,E. and Rabilloud,T.
  TITLE     A method for detection of overoxidation of cysteines:
            peroxiredoxins are oxidized in vivo at the active-site cysteine
            during oxidative stress
  JOURNAL   Biochem J 366 (Pt 3), 777-785 (2002)
   PUBMED   12059788
REFERENCE   8  (bases 1 to 956)
  AUTHORS   Shen,C. and Nathan,C.
  TITLE     Nonredundant antioxidant defense by multiple two-cysteine
            peroxiredoxins in human prostate cancer cells
  JOURNAL   Mol Med 8 (2), 95-102 (2002)
   PUBMED   12080185
  REMARK    GeneRIF: 2-Cys Prxs act in a mutually nonredundant and sometimes
            stress-specific fashion to protect human cells from oxidant injury.
            The substantial resistance of human cells to hydroperoxides may
            result in part from the additive action of multiple Prxs
REFERENCE   9  (bases 1 to 956)
  AUTHORS   Sasagawa,I., Matsuki,S., Suzuki,Y., Iuchi,Y., Tohya,K., Kimura,M.,
            Nakada,T. and Fujii,J.
  TITLE     Possible involvement of the membrane-bound form of peroxiredoxin 4
            in acrosome formation during spermiogenesis of rats
  JOURNAL   Eur J Biochem 268 (10), 3053-3061 (2001)
   PUBMED   11358524
REFERENCE   10 (bases 1 to 956)
  AUTHORS   Jin,D.Y., Chae,H.Z., Rhee,S.G. and Jeang,K.T.
  TITLE     Regulatory role for a novel human thioredoxin peroxidase in
            NF-kappaB activation
  JOURNAL   J Biol Chem 272 (49), 30952-30961 (1997)
   PUBMED   9388242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093011.3 and U25182.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006406.1.
            
            Summary:  The protein encoded by this gene is an antioxidant enzyme
            and belongs to the peroxiredoxin family. The protein is localized
            to the cytoplasm. Peroxidases of the peroxiredoxin family reduce
            hydrogen peroxide and alkyl hydroperoxides to water and alcohol
            with the use of reducing equivalents derived from thiol-containing
            donor molecules. This protein has been found to play a regulatory
            role in the activation of the transcription factor NF-kappaB.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.149159.1,
                                           SRR5189655.6776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379341.9/ ENSP00000368646.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC093011.3         42284-42318         c
            36-956              U25182.1           1-921
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..956
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /note="peroxiredoxin 4"
                     /db_xref="GeneID:10549"
                     /db_xref="HGNC:HGNC:17169"
                     /db_xref="MIM:300927"
     exon            1..319
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..894
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin peroxidase (antioxidant enzyme);
                     prx-IV; peroxiredoxin IV; antioxidant enzyme AOE372;
                     thioredoxin peroxidase AO372; thioredoxin-dependent
                     peroxide reductase A0372; epididymis secretory sperm
                     binding protein Li 97n; thioredoxin-dependent
                     peroxiredoxin 4"
                     /codon_start=1
                     /product="peroxiredoxin-4 precursor"
                     /protein_id="NP_006397.1"
                     /db_xref="CCDS:CCDS14206.1"
                     /db_xref="GeneID:10549"
                     /db_xref="HGNC:HGNC:17169"
                     /db_xref="MIM:300927"
                     /translation="MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERP
                     RTREEECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELK
                     LTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWI
                     NTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLND
                     LPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN"
     exon            320..437
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..554
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     exon            555..677
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     exon            678..808
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..843
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     exon            844..956
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /note="hexamer: AATAAA"
     polyA_site      956
                     /gene="PRDX4"
                     /gene_synonym="AOE37-2; AOE372; HEL-S-97n; PRX-4"
                     /note="major polyA site"
ORIGIN      
        1 gtgcacgcgg ttgtagctgc ccggcggcgg cagaagcggc gctcgcgcca agggacgtgt
       61 ttctgcgctc gcgtggtcat ggaggcgctg ccgctgctag ccgcgacaac tccggaccac
      121 ggccgccacc gaaggctgct tctgctgccg ctactgctgt tcctgctgcc ggctggagct
      181 gtgcagggct gggagacaga ggagaggccc cggactcgcg aagaggagtg ccacttctac
      241 gcgggtggac aagtgtaccc gggagaggca tcccgggtat cggtcgccga ccactccctg
      301 cacctaagca aagcgaagat ttccaagcca gcgccctact gggaaggaac agctgtgatc
      361 gatggagaat ttaaggagct gaagttaact gattatcgtg ggaaatactt ggttttcttc
      421 ttctacccac ttgatttcac atttgtgtgt ccaactgaaa ttatcgcttt tggcgacaga
      481 cttgaagaat tcagatctat aaatactgaa gtggtagcat gctctgttga ttcacagttt
      541 acccatttgg cctggattaa tacccctcga agacaaggag gacttgggcc aataaggatt
      601 ccacttcttt cagatttgac ccatcagatc tcaaaggact atggtgtata cctagaggac
      661 tcaggccaca ctcttagagg tctcttcatt attgatgaca aaggaatcct aagacaaatt
      721 actctgaatg atcttcctgt gggtagatca gtggatgaga cactacgttt ggttcaagca
      781 ttccagtaca ctgacaaaca cggagaagtc tgccctgctg gctggaaacc tggtagtgaa
      841 acaataatcc cagatccagc tggaaagctg aagtatttcg ataaactgaa ttgagaaata
      901 cttcttcaag ttatgatgct tgaaagttct caataaagtt cacggtttca ttacca
//
