LOCUS       NM_006793               1553 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens peroxiredoxin 3 (PRDX3), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_006793
VERSION     NM_006793.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Su,W., Guo,Y., Wang,Q., Ma,L., Zhang,Q., Zhang,Y., Geng,Y., Jin,T.,
            Guo,J., Yang,R., Niu,Z., Ren,L., Wang,Y., Ning,Z., Li,W., He,W.,
            Sun,J., Li,T., Li,Z., Shan,H. and Liang,H.
  TITLE     YAP1 inhibits the senescence of alveolar epithelial cells by
            targeting Prdx3 to alleviate pulmonary fibrosis
  JOURNAL   Exp Mol Med 56 (7), 1643-1654 (2024)
   PUBMED   38945958
  REMARK    GeneRIF: YAP1 inhibits the senescence of alveolar epithelial cells
            by targeting Prdx3 to alleviate pulmonary fibrosis.
REFERENCE   2  (bases 1 to 1553)
  AUTHORS   Meng,Y., Lin,W., Wang,N., Wei,X., Mei,P., Wang,X., Zhang,C.,
            Huang,Q. and Liao,Y.
  TITLE     USP7-mediated ERbeta stabilization mitigates ROS accumulation and
            promotes osimertinib resistance by suppressing PRDX3 SUMOylation in
            non-small cell lung carcinoma
  JOURNAL   Cancer Lett 582, 216587 (2024)
   PUBMED   38097136
  REMARK    GeneRIF: USP7-mediated ERbeta stabilization mitigates ROS
            accumulation and promotes osimertinib resistance by suppressing
            PRDX3 SUMOylation in non-small cell lung carcinoma.
REFERENCE   3  (bases 1 to 1553)
  AUTHORS   Li,H., Cao,Y., Chang,C., Huang,W., Su,S., Peng,Z. and Zhang,J.
  TITLE     Knockdown of circSOD2 ameliorates osteoarthritis progression via
            the miR-224-5p/PRDX3 axis
  JOURNAL   J Orthop Surg Res 18 (1), 432 (2023)
   PUBMED   37312219
  REMARK    GeneRIF: Knockdown of circSOD2 ameliorates osteoarthritis
            progression via the miR-224-5p/PRDX3 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1553)
  AUTHORS   Yan,H., Cai,X., Fu,S., Zhang,X. and Zhang,J.
  TITLE     PRDX3 promotes resistance to cisplatin in gastric cancer cells
  JOURNAL   J Cancer Res Ther 18 (7), 1994-2000 (2022)
   PUBMED   36647961
  REMARK    GeneRIF: PRDX3 promotes resistance to cisplatin in gastric cancer
            cells.
REFERENCE   5  (bases 1 to 1553)
  AUTHORS   Wonsey,D.R., Zeller,K.I. and Dang,C.V.
  TITLE     The c-Myc target gene PRDX3 is required for mitochondrial
            homeostasis and neoplastic transformation
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6649-6654 (2002)
   PUBMED   12011429
  REMARK    GeneRIF: PRDX3 is a c-Myc target gene that is requried to maintain
            normal mitochondrial function. c-Myc directly activates expression
            of a mitochondrial peroxiredoxin that is required for Myc-mediated
            transformation.
REFERENCE   6  (bases 1 to 1553)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   7  (bases 1 to 1553)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   8  (bases 1 to 1553)
  AUTHORS   Watabe,S., Hiroi,T., Yamamoto,Y., Fujioka,Y., Hasegawa,H., Yago,N.
            and Takahashi,S.Y.
  TITLE     SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria
  JOURNAL   Eur J Biochem 249 (1), 52-60 (1997)
   PUBMED   9363753
REFERENCE   9  (bases 1 to 1553)
  AUTHORS   Tsuji,K., Copeland,N.G., Jenkins,N.A. and Obinata,M.
  TITLE     Mammalian antioxidant protein complements alkylhydroperoxide
            reductase (ahpC) mutation in Escherichia coli
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 377-381 (1995)
   PUBMED   7733872
REFERENCE   10 (bases 1 to 1553)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007062.1, CD687044.1 and
            BC008435.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006793.4.
            
            Summary: This gene encodes a mitochondrial protein with antioxidant
            function. The protein is similar to the C22 subunit of Salmonella
            typhimurium alkylhydroperoxide reductase, and it can rescue
            bacterial resistance to alkylhydroperoxide in E. coli that lack the
            C22 subunit. The human and mouse genes are highly conserved, and
            they map to the regions syntenic between mouse and human
            chromosomes. Sequence comparisons with recently cloned mammalian
            homologs suggest that these genes consist of a family that is
            responsible for the regulation of cellular proliferation,
            differentiation and antioxidant functions. This family member can
            protect cells from oxidative stress, and it can promote cell
            survival in prostate cancer. Alternative splicing of this gene
            results in multiple transcript variants. Related pseudogenes have
            been identified on chromosomes 1, 3, 13 and 22. [provided by
            RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008435.1, AK130897.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000298510.4/
                                                  ENSP00000298510.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               BC007062.1         9-401
            394-570             CD687044.1         418-594
            571-1553            BC008435.1         563-1545
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..1553
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /note="peroxiredoxin 3"
                     /db_xref="GeneID:10935"
                     /db_xref="HGNC:HGNC:9354"
                     /db_xref="MIM:604769"
     exon            1..58
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..793
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /EC_number="1.11.1.24"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; antioxidant protein 1; thioredoxin-dependent
                     peroxide reductase, mitochondrial; peroxiredoxin III;
                     protein MER5 homolog; epididymis secretory sperm binding
                     protein; thioredoxin-dependent peroxiredoxin 3"
                     /codon_start=1
                     /product="thioredoxin-dependent peroxide reductase,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_006784.1"
                     /db_xref="CCDS:CCDS7611.1"
                     /db_xref="GeneID:10935"
                     /db_xref="HGNC:HGNC:9354"
                     /db_xref="MIM:604769"
                     /translation="MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLL
                     CSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPL
                     DFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIAL
                     LSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKA
                     FQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ"
     exon            59..191
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     exon            192..333
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     exon            334..469
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     exon            470..573
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     exon            574..739
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1553
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="PRDX3"
                     /gene_synonym="AOP-1; AOP1; HBC189; MER5; PPPCD; PRO1748;
                     prx-III; SCAR32; SP-22"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgcccg agtgcactga agatggcggc tgctgtagga cggttgctcc gagcgtcggt
       61 tgcccgacat gtgagtgcca ttccttgggg catttctgcc actgcagccc tcaggcctgc
      121 tgcatgtgga agaacgagct tgacaaattt attgtgttct ggttccagtc aagcaaaatt
      181 attcagcacc agttcctcat gccatgcacc tgctgtcacc cagcatgcac cctattttaa
      241 gggtacagcc gttgtcaatg gagagttcaa agacctaagc cttgatgact ttaaggggaa
      301 atatttggtg cttttcttct atcctttgga tttcaccttt gtgtgtccta cagaaattgt
      361 tgcttttagt gacaaagcta acgaatttca cgacgtgaac tgtgaagttg tcgcagtctc
      421 agtggattcc cactttagcc atcttgcctg gataaataca ccaagaaaga atggtggttt
      481 gggccacatg aacatcgcac tcttgtcaga cttaactaag cagatttccc gagactacgg
      541 tgtgctgtta gaaggttctg gtcttgcact aagaggtctc ttcataattg accccaatgg
      601 agtcatcaag catttgagcg tcaacgatct cccagtgggc cgaagcgtgg aagaaaccct
      661 ccgcttggtg aaggcgttcc agtatgtaga aacacatgga gaagtctgcc cagcgaactg
      721 gacaccggat tctcctacga tcaagccaag tccagctgct tccaaagagt actttcagaa
      781 ggtaaatcag tagatcaccc atgtgtatct gcaccttctc aactgagaga agaaccacag
      841 ttgaaacctg cttttatcat tttcaagatg gttatttgta gaaggcaagg aaccaattat
      901 gcttgtattc ataagtatta ctctaaatgt tttgtttttg taattctggc taagaccttt
      961 taaacatggt tagttgctag tacaaggaat cctttattgg taacatcttg gtggctggct
     1021 agctagtttc tacagaacat aatttgcctc tatagaaggc tattcttaga tcatgtctca
     1081 atggaaacac tcttctttct tagccttact tgaatcttgc ctataataaa gtagagcaac
     1141 acacattgaa agcttctgat caacggtcct gaaattttca tcttgaatgt ctttgtatta
     1201 aactgaattt tcttttaagc taacaaagat cataattttc aatgattagc cgtgtaactc
     1261 ctgcaatgaa tgtttatgtg attgaagcaa atgtgaatcg tattatttta aaaagtggca
     1321 gagtgactta actgatcatg catgatccct catccctgaa attgagttta tgtagtcatt
     1381 ttacttattt tattcattag ctaactttgt ctatgtatat ttctagatat tgattagtgt
     1441 aatcgattat aaaggatatt tatcaaatcc agggattgca ttttgaaatt ataattattt
     1501 tctttgctga agtattcatt gtaaaacata caaaataaac atattttaaa aca
//
