LOCUS       NM_005809                925 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens peroxiredoxin 2 (PRDX2), mRNA.
ACCESSION   NM_005809
VERSION     NM_005809.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 925)
  AUTHORS   Xue,R., Fan,Z. and An,Y.
  TITLE     Knockdown of PRDX2 Inhibits the Proliferation, Growth, Migration,
            Invasion, and MMP9 Activity of Ewing's Sarcoma Cells Cultured In
            Vitro
  JOURNAL   Cancer Rep (Hoboken) 7 (9), e2122 (2024)
   PUBMED   39234629
  REMARK    GeneRIF: Knockdown of PRDX2 Inhibits the Proliferation, Growth,
            Migration, Invasion, and MMP9 Activity of Ewing's Sarcoma Cells
            Cultured In Vitro.
REFERENCE   2  (bases 1 to 925)
  AUTHORS   Li,P., Wang,W., Zhu,B., Wang,Y., Li,J., Wang,C., Wang,C. and Li,Q.
  TITLE     PRDX2 regulates stemness contributing to cisplatin resistance and
            metastasis in bladder cancer
  JOURNAL   Environ Toxicol 39 (5), 2869-2880 (2024)
   PUBMED   38294069
  REMARK    GeneRIF: PRDX2 regulates stemness contributing to cisplatin
            resistance and metastasis in bladder cancer.
REFERENCE   3  (bases 1 to 925)
  AUTHORS   Balasubramanian,P., Vijayarangam,V., Deviparasakthi,M.K.G.,
            Palaniyandi,T., Ravi,M., Natarajan,S., Viswanathan,S., Baskar,G.,
            Wahab,M.R.A. and Surendran,H.
  TITLE     Implications and progression of peroxiredoxin 2 (PRDX2) in various
            human diseases
  JOURNAL   Pathol Res Pract 254, 155080 (2024)
   PUBMED   38219498
  REMARK    GeneRIF: Implications and progression of peroxiredoxin 2 (PRDX2) in
            various human diseases.
            Review article
REFERENCE   4  (bases 1 to 925)
  AUTHORS   Han,Y.H., Kim,S.U., Kwon,T.H., Lee,D.S., Ha,H.L., Park,D.S.,
            Woo,E.J., Lee,S.H., Kim,J.M., Chae,H.B., Lee,S.Y., Kim,B.Y.,
            Yoon,D.Y., Rhee,S.G., Fibach,E. and Yu,D.Y.
  TITLE     Peroxiredoxin II is essential for preventing hemolytic anemia from
            oxidative stress through maintaining hemoglobin stability
  JOURNAL   Biochem Biophys Res Commun 426 (3), 427-432 (2012)
   PUBMED   22960070
  REMARK    GeneRIF: These findings suggest that Prx II plays an important role
            in preventing hemolytic anemia from oxidative stress by binding to
            Hb as a decameric structure to stabilize it.
REFERENCE   5  (bases 1 to 925)
  AUTHORS   Low,F.M., Hampton,M.B. and Winterbourn,C.C.
  TITLE     Peroxiredoxin 2 and peroxide metabolism in the erythrocyte
  JOURNAL   Antioxid Redox Signal 10 (9), 1621-1630 (2008)
   PUBMED   18479207
  REMARK    Review article
REFERENCE   6  (bases 1 to 925)
  AUTHORS   Pahl,P., Berger,R., Hart,I., Chae,H.Z., Rhee,S.G. and Patterson,D.
  TITLE     Localization of TDPX1, a human homologue of the yeast
            thioredoxin-dependent peroxide reductase gene (TPX), to chromosome
            13q12
  JOURNAL   Genomics 26 (3), 602-606 (1995)
   PUBMED   7607688
REFERENCE   7  (bases 1 to 925)
  AUTHORS   Chae,H.Z., Robison,K., Poole,L.B., Church,G., Storz,G. and
            Rhee,S.G.
  TITLE     Cloning and sequencing of thiol-specific antioxidant from mammalian
            brain: alkyl hydroperoxide reductase and thiol-specific antioxidant
            define a large family of antioxidant enzymes
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7017-7021 (1994)
   PUBMED   8041738
REFERENCE   8  (bases 1 to 925)
  AUTHORS   Lim,Y.S., Cha,M.K., Kim,H.K. and Kim,I.H.
  TITLE     The thiol-specific antioxidant protein from human brain: gene
            cloning and analysis of conserved cysteine regions
  JOURNAL   Gene 140 (2), 279-284 (1994)
   PUBMED   8144038
REFERENCE   9  (bases 1 to 925)
  AUTHORS   Lim,Y.S., Cha,M.K., Yun,C.H., Kim,H.K., Kim,K. and Kim,I.H.
  TITLE     Purification and characterization of thiol-specific antioxidant
            protein from human red blood cell: a new type of antioxidant
            protein
  JOURNAL   Biochem Biophys Res Commun 199 (1), 199-206 (1994)
   PUBMED   8123012
REFERENCE   10 (bases 1 to 925)
  AUTHORS   Shau,H., Butterfield,L.H., Chiu,R. and Kim,A.
  TITLE     Cloning and sequence analysis of candidate human natural
            killer-enhancing factor genes
  JOURNAL   Immunogenetics 40 (2), 129-134 (1994)
   PUBMED   8026862
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP248561.1 and BC000452.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005809.5.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            antioxidant enzymes, which reduce hydrogen peroxide and alkyl
            hydroperoxides. The encoded protein plays an antioxidant protective
            role in cells, and it may contribute to the antiviral activity of
            CD8(+) T-cells. The crystal structure of this protein has been
            resolved to 2.7 angstroms. This protein prevents hemolytic anemia
            from oxidative stress by stabilizing hemoglobin, thus making this
            gene a therapeutic target for patients with hemolytic anemia. This
            protein may have a proliferative effect and play a role in cancer
            development or progression. Related pseudogenes have been
            identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.565439.1,
                                           SRR1163655.50229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000301522.3/
                                                  ENSP00000301522.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BP248561.1         111-121
            12-925              BC000452.2         1-914
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..925
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /note="peroxiredoxin 2"
                     /db_xref="GeneID:7001"
                     /db_xref="HGNC:HGNC:9353"
                     /db_xref="MIM:600538"
     exon            1..61
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            62..173
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..667
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /EC_number="1.11.1.24"
                     /note="thiol-specific antioxidant 1; thioredoxin
                     peroxidase 1; torin; thioredoxin-dependent peroxide
                     reductase 1; natural killer cell-enhancing factor B;
                     epididymis secretory sperm binding protein Li 2a;
                     thioredoxin-dependent peroxiredoxin 2"
                     /codon_start=1
                     /product="peroxiredoxin-2"
                     /protein_id="NP_005800.3"
                     /db_xref="CCDS:CCDS12281.1"
                     /db_xref="GeneID:7001"
                     /db_xref="HGNC:HGNC:9353"
                     /db_xref="MIM:600538"
                     /translation="MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYP
                     LDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIP
                     LLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQ
                     AFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN"
     exon            174..327
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            328..450
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            451..581
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     exon            582..925
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /note="hexamer: AATAAA"
     polyA_site      925
                     /gene="PRDX2"
                     /gene_synonym="HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII;
                     PTX1; TDPX1; TPX1; TSA"
                     /note="major polyA site"
ORIGIN      
        1 ggcgctgaga acgcgggtcc acgcgtgtga tcgtccgtgc gtctagcctt tgcccacgca
       61 gctttcagtc atggcctccg gtaacgcgcg catcggaaag ccagcccctg acttcaaggc
      121 cacagcggtg gttgatggcg ccttcaaaga ggtgaagctg tcggactaca aagggaagta
      181 cgtggtcctc tttttctacc ctctggactt cacttttgtg tgccccaccg agatcatcgc
      241 gttcagcaac cgtgcagagg acttccgcaa gctgggctgt gaagtgctgg gcgtctcggt
      301 ggactctcag ttcacccacc tggcttggat caacaccccc cggaaagagg gaggcttggg
      361 ccccctgaac atccccctgc ttgctgacgt gaccagacgc ttgtctgagg attacggcgt
      421 gctgaaaaca gatgagggca ttgcctacag gggcctcttt atcatcgatg gcaagggtgt
      481 ccttcgccag atcactgtta atgatttgcc tgtgggacgc tccgtggatg aggctctgcg
      541 gctggtccag gccttccagt acacagacga gcatggggaa gtttgtcccg ctggctggaa
      601 gcctggcagt gacacgatta agcccaacgt ggatgacagc aaggaatatt tctccaaaca
      661 caattaggct ggctaacgga tagtgagctt gtgcccctgc ctaggtgcct gtgctgggtg
      721 tccacctgtg cccccacctg ggtgccctat gctgacccag gaaaggccag acctgcccct
      781 ccaaactcca cagtatggga ccctggaggg ctaggccaag gccttctcat gcctccacct
      841 agaagctgaa tagtgacgcc ctcccccaag cccacccagc cgcacacagg cctagaggta
      901 accaataaag tattagggaa aggtg
//
