LOCUS       NM_181697                945 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens peroxiredoxin 1 (PRDX1), transcript variant 3, mRNA.
ACCESSION   NM_181697
VERSION     NM_181697.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Shen,Y., You,Z., Li,L., Tang,X. and Shan,X.
  TITLE     The interaction of PRDX1 with Cofilin promotes oral squamous cell
            carcinoma metastasis
  JOURNAL   Int J Cancer 155 (7), 1290-1302 (2024)
   PUBMED   38738971
  REMARK    GeneRIF: The interaction of PRDX1 with Cofilin promotes oral
            squamous cell carcinoma metastasis.
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Fan,X., Liu,F., Wang,X., Wang,Y., Chen,Y., Shi,C., Su,X., Tan,M.,
            Yan,Q., Peng,J., Shao,J., Xiong,Y. and Lin,A.
  TITLE     LncFASA promotes cancer ferroptosis via modulating PRDX1 phase
            separation
  JOURNAL   Sci China Life Sci 67 (3), 488-503 (2024)
   PUBMED   37955780
  REMARK    GeneRIF: LncFASA promotes cancer ferroptosis via modulating PRDX1
            phase separation.
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Hao,J., Song,Z., Su,J., Li,L., Zou,L. and Zou,K.
  TITLE     The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy
            resistance in non-small cell lung cancer by targeting the
            NF-kappaB/p65 pathway
  JOURNAL   Cell Signal 110, 110806 (2023)
   PUBMED   37468052
  REMARK    GeneRIF: The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy
            resistance in non-small cell lung cancer by targeting the
            NF-kappaB/p65 pathway.
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Li,S., Zhang,Y., Lu,R., Lv,X., Lei,Q., Tang,D., Dai,Q., Deng,Z.,
            Liao,X., Tu,S., Yang,H., Xie,Y., Meng,J., Yuan,Q., Qin,J., Pu,J.,
            Peng,Z. and Tao,L.
  TITLE     Peroxiredoxin 1 aggravates acute kidney injury by promoting
            inflammation through Mincle/Syk/NF-kappaB signaling
  JOURNAL   Kidney Int 104 (2), 305-323 (2023)
   PUBMED   37164261
  REMARK    GeneRIF: Peroxiredoxin 1 aggravates acute kidney injury by
            promoting inflammation through Mincle/Syk/NF-kappaB signaling.
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Moretton,A., Kourtis,S., Ganez Zapater,A., Calabro,C., Espinar
            Calvo,M.L., Fontaine,F., Darai,E., Abad Cortel,E., Block,S.,
            Pascual-Reguant,L., Pardo-Lorente,N., Ghose,R., Vander Heiden,M.G.,
            Janic,A., Muller,A.C., Loizou,J.I. and Sdelci,S.
  TITLE     A metabolic map of the DNA damage response identifies PRDX1 in the
            control of nuclear ROS scavenging and aspartate availability
  JOURNAL   Mol Syst Biol 19 (7), e11267 (2023)
   PUBMED   37259925
  REMARK    GeneRIF: A metabolic map of the DNA damage response identifies
            PRDX1 in the control of nuclear ROS scavenging and aspartate
            availability.
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Sauri,H., Butterfield,L., Kim,A. and Shau,H.
  TITLE     Antioxidant function of recombinant human natural killer enhancing
            factor
  JOURNAL   Biochem Biophys Res Commun 208 (3), 964-969 (1995)
   PUBMED   7702627
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Shau,H. and Kim,A.
  TITLE     Identification of natural killer enhancing factor as a major
            antioxidant in human red blood cells
  JOURNAL   Biochem Biophys Res Commun 199 (1), 83-88 (1994)
   PUBMED   8123050
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Prosperi,M.T., Apiou,F., Dutrillaux,B. and Goubin,G.
  TITLE     Organization and chromosomal assignment of two human PAG gene loci:
            PAGA encoding a functional gene and PAGB a processed pseudogene
  JOURNAL   Genomics 19 (2), 236-241 (1994)
   PUBMED   8188254
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Shau,H., Butterfield,L.H., Chiu,R. and Kim,A.
  TITLE     Cloning and sequence analysis of candidate human natural
            killer-enhancing factor genes
  JOURNAL   Immunogenetics 40 (2), 129-134 (1994)
   PUBMED   8026862
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Shau,H., Gupta,R.K. and Golub,S.H.
  TITLE     Identification of a natural killer enhancing factor (NKEF) from
            human erythroid cells
  JOURNAL   Cell Immunol 147 (1), 1-11 (1993)
   PUBMED   8462106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021683.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181697.2.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            antioxidant enzymes, which reduce hydrogen peroxide and alkyl
            hydroperoxides. The encoded protein may play an antioxidant
            protective role in cells, and may contribute to the antiviral
            activity of CD8(+) T-cells. This protein may have a proliferative
            effect and play a role in cancer development or progression. Four
            transcript variants encoding the same protein have been identified
            for this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR, compared to variant 1. All four variants encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.166821.1, BC021683.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319248.13/ ENSP00000361152.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               BC021683.1         7-951
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..945
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /note="peroxiredoxin 1"
                     /db_xref="GeneID:5052"
                     /db_xref="HGNC:HGNC:9352"
                     /db_xref="MIM:176763"
     exon            1..56
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..173
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..667
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin-dependent peroxide reductase 2;
                     proliferation-associated gene A; natural killer-enhancing
                     factor A; thioredoxin peroxidase 2;
                     proliferation-associated gene protein; natural killer
                     cell-enhancing factor A; epididymis secretory sperm
                     binding protein; thioredoxin-dependent peroxiredoxin 1"
                     /codon_start=1
                     /product="peroxiredoxin-1"
                     /protein_id="NP_859048.1"
                     /db_xref="CCDS:CCDS522.1"
                     /db_xref="GeneID:5052"
                     /db_xref="HGNC:HGNC:9352"
                     /db_xref="MIM:176763"
                     /translation="MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFY
                     PLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNI
                     PLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLV
                     QAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK"
     exon            174..327
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            328..450
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..581
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..945
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      745..750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /note="hexamer: AGTAAA"
     polyA_site      769
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
     regulatory      928..933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /note="hexamer: ATTAAA"
     polyA_site      945
                     /gene="PRDX1"
                     /gene_synonym="MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB;
                     PRX1; PRXI; TDPX2"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcttgtt cttgcctggt gtcggtggtt agtttctgcg acttgtgttg ggactgctga
       61 taggaagatg tcttcaggaa atgctaaaat tgggcaccct gcccccaact tcaaagccac
      121 agctgttatg ccagatggtc agtttaaaga tatcagcctg tctgactaca aaggaaaata
      181 tgttgtgttc ttcttttacc ctcttgactt cacctttgtg tgccccacgg agatcattgc
      241 tttcagtgat agggcagaag aatttaagaa actcaactgc caagtgattg gtgcttctgt
      301 ggattctcac ttctgtcatc tagcatgggt caatacacct aagaaacaag gaggactggg
      361 acccatgaac attcctttgg tatcagaccc gaagcgcacc attgctcagg attatggggt
      421 cttaaaggct gatgaaggca tctcgttcag gggccttttt atcattgatg ataagggtat
      481 tcttcggcag atcactgtaa atgacctccc tgttggccgc tctgtggatg agactttgag
      541 actagttcag gccttccagt tcactgacaa acatggggaa gtgtgcccag ctggctggaa
      601 acctggcagt gataccatca agcctgatgt ccaaaagagc aaagaatatt tctccaagca
      661 gaagtgagcg ctgggctgtt ttagtgccag gctgcggtgg gcagccatga gaacaaaacc
      721 tcttctgtat tttttttttc cattagtaaa acacaagact tcagattcag ccgaattgtg
      781 gtgtcttaca aggcaggcct ttcctacagg gggtggagag accagccttt cttcctttgg
      841 taggaatggc ctgagttggc gttgtgggca ggctactggt ttgtatgatg tattagtaga
      901 gcaacccatt aatcttttgt agtttgtatt aaacttgaac tgaga
//
