LOCUS       NM_001098173            3393 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens PR/SET domain 7 (PRDM7), mRNA.
ACCESSION   NM_001098173 XM_005256274
VERSION     NM_001098173.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Blazer,L.L., Lima-Fernandes,E., Gibson,E., Eram,M.S., Loppnau,P.,
            Arrowsmith,C.H., Schapira,M. and Vedadi,M.
  TITLE     PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4
            Trimethyltransferase
  JOURNAL   J Biol Chem 291 (26), 13509-13519 (2016)
   PUBMED   27129774
  REMARK    GeneRIF: These studies indicate that after a single serine to
            tyrosine mutation at residue 357 (S357Y), PRDM7 regains the
            substrate specificities and catalytic activities similar to its
            evolutionary predecessor, including the ability to efficiently
            methylate H3K36.
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Sun,X.J., Xu,P.F., Zhou,T., Hu,M., Fu,C.T., Zhang,Y., Jin,Y.,
            Chen,Y., Chen,S.J., Huang,Q.H., Liu,T.X. and Chen,Z.
  TITLE     Genome-wide survey and developmental expression mapping of
            zebrafish SET domain-containing genes
  JOURNAL   PLoS One 3 (1), e1499 (2008)
   PUBMED   18231586
  REMARK    GeneRIF: Evolutionary analysis suggests that human PRDM7 and PRDM9
            genes, a pair of close paralogs corresponding to a single mouse
            gene Prdm9, were generated by a recent gene duplication event after
            the divergence of the ancestors of human and mouse.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Fumasoni,I., Meani,N., Rambaldi,D., Scafetta,G., Alcalay,M. and
            Ciccarelli,F.D.
  TITLE     Family expansion and gene rearrangements contributed to the
            functional specialization of PRDM genes in vertebrates
  JOURNAL   BMC Evol Biol 7, 187 (2007)
   PUBMED   17916234
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Jiang,G.L. and Huang,S.
  TITLE     The yin-yang of PR-domain family genes in tumorigenesis
  JOURNAL   Histol Histopathol 15 (1), 109-117 (2000)
   PUBMED   10668202
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133919.3, AM690991.1 and
            AF274348.1.
            
            On or before Jun 17, 2020 this sequence version replaced
            XM_005256274.3, NM_001098173.1.
            
            Summary: This gene encodes a member of a family of proteins that
            may have roles in transcription and other nuclear processes. The
            encoded protein contains a KRAB (Kruppel-associated box) domain -A
            box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and
            may function as a histone methyltransferase. [provided by RefSeq,
            Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AM690991.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000449207.8/ ENSP00000396732.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC133919.3         101659-101764       c
            107-171             AC133919.3         100364-100428       c
            172-460             AM690991.1         2-290
            461-461             AC133919.3         99380-99380         c
            462-2093            AM690991.1         292-1923
            2094-2094           AC133919.3         82298-82298         c
            2095-3393           AF274348.1         1144-2442
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..3393
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /note="PR/SET domain 7"
                     /db_xref="GeneID:11105"
                     /db_xref="HGNC:HGNC:9351"
                     /db_xref="MIM:609759"
     exon            1..106
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            107..260
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1670
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /EC_number="2.1.1.354"
                     /note="probable histone-lysine N-methyltransferase PRDM7;
                     PR-domain family protein 4; PR domain zinc finger protein
                     7; PR domain 7; PR domain containing 7; [histone
                     H3]-lysine4 N-methyltransferase PRDM7"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase PRDM7"
                     /protein_id="NP_001091643.1"
                     /db_xref="CCDS:CCDS45557.1"
                     /db_xref="GeneID:11105"
                     /db_xref="HGNC:HGNC:9351"
                     /db_xref="MIM:609759"
                     /translation="MSPERSQEESPEGDTERTERKPMVKDAFKDISIYFTKEEWAEMG
                     DWEKTRYRNVKMNYNALITVGLRATRPAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVK
                     PPWMAFRGEQSKHQKGMPKASFNNESSLRELSGTPNLLNTSDSEQAQKPVSPPGEAST
                     SGQHSRLKLELRRKETEGKMYSLRERKGHAYKEISEPQDDDYLYCEMCQNFFIDSCAA
                     HGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPY
                     EGRITEDEEAANSGYSWLITKGRNCYEYVDGKDKSSANWMRYVNCARDDEEQNLVAFQ
                     YHRQIFYRTCRVIRPGCELLVWSGDEYGQELGIRSSIEPAESLGQAVNCWSGMGMSMA
                     RNWASSGAASGRKSSWQGENQSQRSIHVPHAVWPFQVKNFSVNMWNAITPLRTSQDHL
                     QENFSNQRIPAQGIRIRSGNILIHAAVMTKPKVKRSKKGPNS"
     exon            261..384
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            385..492
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            493..542
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            543..699
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            700..801
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1073
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1141
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1424
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3393
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3372..3377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="PRDM7"
                     /gene_synonym="PFM4; ZNF910"
                     /note="major polyA site"
ORIGIN      
        1 ctgagcggct ccgagaagac gcccggccag ggtgaacacc gcggcaggag aaaacgggag
       61 actgtgaaga gcatggggag cctttgtcgt gcagcgtgaa acccttgagc ctttggccta
      121 ggagctggga gactcagggg cccttcccac actcagaatt ggagcagggc cttctagaca
      181 gtcccagcac catgagccct gaaaggtccc aagaggagag cccagaagga gacacagaga
      241 gaacagagcg gaagcccatg gtcaaagatg ccttcaaaga catttccata tacttcacca
      301 aggaagaatg ggcagaaatg ggagactggg agaaaactcg ctataggaat gtgaaaatga
      361 actataatgc actgattact gtaggtctca gagccactcg accagctttc atgtgtcacc
      421 gaaggcaggc catcaaactc caggtggatg acacagaaga ttccgatgaa gaatggacac
      481 ctaggcagca agtcaaacct ccttggatgg ccttcagagg agaacagagt aaacaccaga
      541 agggaatgcc caaggcgtca ttcaataatg aatctagttt gagagaattg tcaggaacgc
      601 caaatttact gaatacaagt gactcagagc aggctcagaa accagtgtcc cctcctggag
      661 aagcaagtac ctctggacag cactctagac taaaactgga actcaggagg aaggagactg
      721 aaggaaagat gtatagcctg cgagaaagaa agggtcatgc atacaaagag atcagcgagc
      781 cacaggatga tgactacctc tattgtgaga tgtgtcagaa cttcttcatt gacagctgtg
      841 ctgctcatgg gccccctaca tttgtaaagg acagtgcagt ggacaagggg catcccaacc
      901 gttcagccct cagtctgccc ccggggctga gaattgggcc atcaggcatc cctcaggctg
      961 ggcttggagt atggaacgag gcatctgatc tgccactggg tctgcacttt ggcccctatg
     1021 agggccgaat tacagaagac gaagaggcag ccaacagtgg atattcctgg ctaatcacca
     1081 aggggagaaa ctgctatgag tatgtggatg gaaaagataa atcctcggcc aactggatga
     1141 ggtatgtgaa ctgtgcccgg gatgatgaag agcagaacct ggtggccttc cagtaccaca
     1201 ggcagatctt ctatagaacc tgccgagtca ttaggccagg ctgtgaactg ctggtctggt
     1261 ctggggatga gtatggccag gaactgggca tcagatcttc tatagaacct gccgagtcat
     1321 taggccaggc tgtgaactgc tggtctggta tggggatgag tatggccagg aactgggcat
     1381 caagtggggc agcaagtgga agaaagagct catggcaggg agagaaccaa agccagagat
     1441 ccatccatgt ccctcatgct gtctggcctt ttcaagtcaa aaatttctca gtcaacatgt
     1501 ggaacgcaat cactcctctc agaacttccc aggaccatct gcaagaaaac ttctccaacc
     1561 agagaatccc tgcccagggg atcagaatca ggagcggcaa tattctgatc cacgctgctg
     1621 taatgacaaa accaaaggtc aagagatcaa agaaaggtcc aaactcttga ataaaaggac
     1681 atggcagagg gagatttcaa gggccttttc tagcccaccc aaaggacaaa tggggagctc
     1741 tagagtggga gaaagaatga tggaagaaga gtccagaaca ggccagaaag tgaatccagg
     1801 gaacacaggc aaattatttg tgggggtagg aatctcaaga attgcgaaag tcaaatatgg
     1861 agagtgtggg caaggtttca gtgataagtc agatgttatt acacaccaaa ggacacacac
     1921 aggggggaag ccctacgtct gcagagagtg tgggagggct ttagccggaa gtcagacctc
     1981 ctcagtcacc agaggacaca cacaggggag aagccttatg tctgcagaga gtgtgagcgg
     2041 ggctttagcc ggaagtcagt cctcctcatt caccagagga cacacagggg agacgcccca
     2101 gtctgcagga aggatgagta agtcattagt aataaaacct tatctcaata gccacaagaa
     2161 gacaaacgtg atcaccacac acttgcacac cccagctctg aggtggcttc agcgaaagtc
     2221 tgctaacccc ttacattccc cgagagtgta aagagatcgg aaataactaa ttaaacaaat
     2281 ccgccacttt catgactaga gttgaggaag aacaggggat agttctgtaa gtgttcgggg
     2341 gacgtcaaca tgtgtggttg tttcccgcac tgatcccctc cattttttgt gttttgcctc
     2401 ctgttctaat taattttgtc tccatacata tctgaacccc aagtgtgtac ctcattcttc
     2461 ccttatcact gaaggaagga agagtccaga agggccacag agaactcaaa cgttcagttc
     2521 aagtctccac aggaattcaa ccccagaaag acataaactt ggagtccatc tggtttaatt
     2581 attggagaat cgattcccaa gtccaggaag agaaatgtag ggttttacag agtcgcagca
     2641 ggaaagagag ctccctggtc tcctgggaag tgtgacctct tctaatggac ccctctcctc
     2701 tgctgccata ctcccccttg gctccccctg tctcctctcc tgatttcctc caatctctgt
     2761 agccccagaa gtgaacgcca gacaggaaca cgcatgtgtg tatatatgtg ttcacgtgtg
     2821 ctatgtgtgt taagcctgca tgcatgggtg tgggggtatg tgccctctgt gtacgtatct
     2881 gtgtgagtgt gggggtttca agggtgtatt aggaataacg ctcaaaatcc taaggaaatt
     2941 gaatactctg agagaagaga gacagaccct ctcatactgt tttatattgt tttatactca
     3001 gaaaaggaaa aagaagcaaa actaaaggca ggtagcctgg cgcctaggaa ccagacctga
     3061 aaccaaggaa ccagacccga aaccaggcct gggccggcct gacctaagcc tggtagttaa
     3121 aattcgaccc ctgacctagc aactgatgtt atctatagat tatagaaaga cattgtgaaa
     3181 cttcccggtc tgttctgttc cactctgacc atcggtgcat gcagcccctg tcacctaccc
     3241 cctgcttgct caatcgatca cgaccctctc acgtggaccc ccttagagtt gtgagccctt
     3301 aaaagggaca ggaattgctc actcggggag ctcggctctt gagacagcag tcttgctgat
     3361 gctcctggcc gaataaaccg cttccttctt taa
//
