LOCUS       NM_018699               5207 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens PR/SET domain 5 (PRDM5), transcript variant 1, mRNA.
ACCESSION   NM_018699
VERSION     NM_018699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5207)
  AUTHORS   Ren,Y., Wang,Y., Fang,L., Ma,M., Ge,L., Su,C., Xin,L., He,J.,
            Yang,J. and Liu,X.
  TITLE     Deregulation of PRDM5 promotes cell proliferation by regulating
            JAK/STAT signaling pathway through SOCS1 in human lung
            adenocarcinoma
  JOURNAL   Cancer Med 12 (4), 4568-4578 (2023)
   PUBMED   36127737
  REMARK    GeneRIF: Deregulation of PRDM5 promotes cell proliferation by
            regulating JAK/STAT signaling pathway through SOCS1 in human lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 5207)
  AUTHORS   Guo,J., Yang,Q., Wei,S., Shao,J., Zhao,T., Guo,L., Liu,J., Chen,J.
            and Wang,G.
  TITLE     Low expression of PRDM5 predicts poor prognosis of esophageal
            squamous cell carcinoma
  JOURNAL   BMC Cancer 22 (1), 745 (2022)
   PUBMED   35799142
  REMARK    GeneRIF: Low expression of PRDM5 predicts poor prognosis of
            esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5207)
  AUTHORS   Zhang,C., Liu,Z., Sheng,Y., Wu,B., Song,Y., Ye,G., Qi,Y. and
            Zhao,S.
  TITLE     PRDM5 suppresses oesophageal squamous carcinoma cells and modulates
            14-3-3zeta/Akt signalling pathway
  JOURNAL   Clin Exp Pharmacol Physiol 49 (3), 370-379 (2022)
   PUBMED   34757658
  REMARK    GeneRIF: PRDM5 suppresses oesophageal squamous carcinoma cells and
            modulates 14-3-3zeta/Akt signalling pathway.
REFERENCE   4  (bases 1 to 5207)
  AUTHORS   Dhooge,T., Van Damme,T., Syx,D., Mosquera,L.M., Nampoothiri,S.,
            Radhakrishnan,A., Simsek-Kiper,P.O., Utine,G.E., Bonduelle,M.,
            Migeotte,I., Essawi,O., Ceylaner,S., Al Kindy,A., Tinkle,B.,
            Symoens,S. and Malfait,F.
  TITLE     More than meets the eye: Expanding and reviewing the clinical and
            mutational spectrum of brittle cornea syndrome
  JOURNAL   Hum Mutat 42 (6), 711-730 (2021)
   PUBMED   33739556
  REMARK    GeneRIF: More than meets the eye: Expanding and reviewing the
            clinical and mutational spectrum of brittle cornea syndrome.
            Review article
REFERENCE   5  (bases 1 to 5207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5207)
  AUTHORS   Duan,Z., Person,R.E., Lee,H.H., Huang,S., Donadieu,J., Badolato,R.,
            Grimes,H.L., Papayannopoulou,T. and Horwitz,M.S.
  TITLE     Epigenetic regulation of protein-coding and microRNA genes by the
            Gfi1-interacting tumor suppressor PRDM5
  JOURNAL   Mol Cell Biol 27 (19), 6889-6902 (2007)
   PUBMED   17636019
  REMARK    GeneRIF: Results identify PRDM5, which acts as a sequence-specific,
            DNA binding transcription factor that targets
            hematopoiesis-associated protein-coding and microRNA genes, some of
            which are targets of Gfi1.
REFERENCE   7  (bases 1 to 5207)
  AUTHORS   Watanabe,Y., Toyota,M., Kondo,Y., Suzuki,H., Imai,T.,
            Ohe-Toyota,M., Maruyama,R., Nojima,M., Sasaki,Y., Sekido,Y.,
            Hiratsuka,H., Shinomura,Y., Imai,K., Itoh,F. and Tokino,T.
  TITLE     PRDM5 identified as a target of epigenetic silencing in colorectal
            and gastric cancer
  JOURNAL   Clin Cancer Res 13 (16), 4786-4794 (2007)
   PUBMED   17699856
  REMARK    GeneRIF: Data suggest that epigenetic alteration of PRDM5 (e.g.,
            methylation of its 5'-CpG island or trimethylation of Lys(27) of
            histone H3) likely plays a key role in the progression of
            gastrointestinal cancers and may be a useful molecular marker.
REFERENCE   8  (bases 1 to 5207)
  AUTHORS   Deng,Q. and Huang,S.
  TITLE     PRDM5 is silenced in human cancers and has growth suppressive
            activities
  JOURNAL   Oncogene 23 (28), 4903-4910 (2004)
   PUBMED   15077163
  REMARK    GeneRIF: PRDM5 caused G2/M arrest and apoptosis upon infection of
            tumor cells. These results suggest that inactivation of PRDM5 may
            play a role in carcinogenesis.
REFERENCE   9  (bases 1 to 5207)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   10 (bases 1 to 5207)
  AUTHORS   Jiang,G.L. and Huang,S.
  TITLE     The yin-yang of PR-domain family genes in tumorigenesis
  JOURNAL   Histol Histopathol 15 (1), 109-117 (2000)
   PUBMED   10668202
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104795.1, AC104068.3 and
            AC025741.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 23, 2020 this sequence version replaced NM_018699.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            of the PR-domain protein family. It contains a PR-domain and
            multiple zinc finger motifs. Transcription factors of the PR-domain
            family are known to be involved in cell differentiation and
            tumorigenesis. [provided by RefSeq, Jul 2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1923321.1,
                                           SRR14038195.1396930.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264808.8/ ENSP00000264808.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC104795.1         106931-107141       c
            212-295             AC104795.1         91889-91972         c
            296-418             AC104068.3         89989-90111         c
            419-593             AC104068.3         57742-57916         c
            594-768             AC104068.3         54924-55098         c
            769-861             AC104068.3         53403-53495         c
            862-983             AC104068.3         53024-53145         c
            984-1063            AC104068.3         47941-48020         c
            1064-1148           AC104068.3         36232-36316         c
            1149-1306           AC104068.3         34838-34995         c
            1307-1400           AC104068.3         21569-21662         c
            1401-1561           AC104068.3         17714-17874         c
            1562-1655           AC104068.3         13759-13852         c
            1656-1741           AC025741.5         179345-179430       c
            1742-1846           AC025741.5         135101-135205       c
            1847-5207           AC025741.5         116707-120067       c
FEATURES             Location/Qualifiers
     source          1..5207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..5207
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /note="PR/SET domain 5"
                     /db_xref="GeneID:11107"
                     /db_xref="HGNC:HGNC:9349"
                     /db_xref="MIM:614161"
     exon            1..211
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2011
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /EC_number="2.1.1.-"
                     /note="isoform 1 is encoded by transcript variant 1; PR
                     domain zinc finger protein 5; PR domain containing 5; PR
                     domain 5"
                     /codon_start=1
                     /product="PR domain zinc finger protein 5 isoform 1"
                     /protein_id="NP_061169.2"
                     /db_xref="CCDS:CCDS3716.1"
                     /db_xref="GeneID:11107"
                     /db_xref="HGNC:HGNC:9349"
                     /db_xref="MIM:614161"
                     /translation="MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRM
                     PEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEG
                     ENIFYLAVEDIETDTELLIGYLDSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGRKDR
                     LGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQALQRHV
                     LQCTAKSSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDARFVCKADSCGKRLKSK
                     DALKRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQ
                     LKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYK
                     NHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVH
                     VQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHI
                     RSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRGLDEHKRT
                     HTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNI
                     HGVADS"
     exon            212..295
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..418
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..593
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..768
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..861
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..983
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1063
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1148
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1306
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1400
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1561
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1655
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1741
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1846
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..5207
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5183..5188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /note="hexamer: AATAAA"
     polyA_site      5207
                     /gene="PRDM5"
                     /gene_synonym="BCS2; PFM2"
                     /note="major polyA site"
ORIGIN      
        1 atttcctcct tccctgccgg tttctcccct ctaccctggc accccaaatt tcgatgtgcc
       61 gcctgccggg cgctaagcgc cggtgttgag agaggcggcg gccgccgcgc ccgggaaaat
      121 gctgggcatg tacgtgccgg acaggttctc cctgaagtcc tcccgggttc aggacggcat
      181 ggggctctac acggcccgca gagtgcgaaa gggtgaaaag ttcggaccct ttgctggaga
      241 gaagagaatg cctgaagact tggatgaaaa tatggattac aggttgatgt gggaggttcg
      301 tgggagtaag ggagaagttt tgtacatttt ggatgctacc aacccacggc actccaactg
      361 gcttcgcttc gttcatgagg caccatctca ggagcagaag aacttggctg ccattcaaga
      421 aggagaaaac attttctatt tggcagttga agatatagaa acagacacgg agcttctgat
      481 tggctacctg gatagtgaca tggaggctga ggaggaagaa cagcaaatta tgacagtcat
      541 caaagaaggg gaagttgaaa attctagaag acaatcaaca gcgggcagaa aagatcgcct
      601 tggctgtaaa gaggactatg cttgtcctca atgtgaatcg agttttacca gtgaggatat
      661 tcttgctgag catctccaga cattgcacca gaaacccaca gaggagaaag aatttaagtg
      721 caagaactgt gggaagaaat tcccagttaa gcaggctttg caaagacatg ttcttcagtg
      781 cacagcgaaa agcagtctaa aggagtcttc gcgaagtttt cagtgctctg tttgcaattc
      841 ttccttcagt tcagcatcga gttttgagca gcaccaggag acttgccggg gggatgccag
      901 gtttgtgtgc aaggctgaca gctgtggaaa gaggctgaag agcaaggatg ccctgaaaag
      961 acaccaggaa aatgtccaca ctggagatcc taagaaaaag cttatatgtt cagtgtgcaa
     1021 taaaaagtgt tcttcagcat caagcctaca ggaacataga aagattcatg agatatttga
     1081 ttgtcaagaa tgtatgaaga aatttatttc agctaatcag ctaaaacgtc atatgatcac
     1141 ccactcagaa aaacgaccct ataattgcga gatttgtaat aagtctttca agaggcttga
     1201 tcaagtgggt gctcacaaag taatacacag cgaagacaaa ccttacaaat gcaaactttg
     1261 tggaaaggga tttgcccaca gaaatgttta caagaatcat aagaagaccc actctgagga
     1321 gagaccgttc caatgtgaag aatgtaaagc tttgttccgg accccatttt ctttacagag
     1381 acacctgcta atacataaca gtgagaggac tttcaagtgc catcactgcg atgctacctt
     1441 taagaggaag gatacattaa atgttcatgt ccaggtggtt catgaaagac acaagaagta
     1501 taggtgtgag ctatgtaata aggcctttgt tacaccttca gtgcttagaa gtcataagaa
     1561 aacacataca ggagaaaagg agaaaatctg tccatattgt ggccagaaat ttgccagcag
     1621 tggtacactc agagttcata tccggagcca cacaggtgag cgtccctatc aatgtcctta
     1681 ctgtgaaaaa ggattcagta aaaatgatgg actgaagatg cacattcgta ctcacaccag
     1741 ggagaagccg tacaagtgct cagagtgcag caaggccttc agccagaagc gaggcctgga
     1801 tgagcacaag aggacgcaca ctggagaaaa gccttttcag tgtgatgttt gtgatttggc
     1861 ttttagcctg aagaaaatgc tgattcgaca caagatgact cataatccca atcgtcccct
     1921 ggcagaatgc cagttttgcc ataagaagtt tacaaggaat gactacctca aagtgcacat
     1981 ggacaatatc catggtgtag ctgacagcta ataggggctg taaaggaatt aaactattca
     2041 gaagggctcc taatatgaat cccagatttt tatcacctga tcagcataac agaagtagcc
     2101 aaaagtgact tactggtctc atagttctta tttgcctaca tttagagtct gtagatgcat
     2161 atgcaaccaa aaaaaagtct tacttttaac aagaaatggt ataaatggaa aaaaaataca
     2221 actccatagc cttgcaaaat gcaacttgtg ctctgtctta taaaaatgga gaaaggagtc
     2281 atggctctct ttcttggcca tccctctgta atgaagttta taatatactt ccctaatagg
     2341 cctttttatt ttattgttat tctttgtgtg tctgtgtgtc tgtgtgtctg tatgtgtctg
     2401 tgtgtgtgca ctcacttgca aatgccagtt gttgcagctg gttttaccaa tttaaataga
     2461 aataaatcaa gatatccaac tatttctttg cagatgagga taagaataag ttatcaaagt
     2521 ctcaagtttg ataggaaaat aaatagttgc tattttataa gacaaaccaa gagctgagct
     2581 tatctaatag ctctgtgcaa caaatgagtt taaaatagat atttgataac taaaacatct
     2641 attaaaatat tgctcatttt agaggattct taggaaacat tatttattct catcattcag
     2701 atgcagacat tcatggtctg gaatactttt ataagttcta cacaaaaatg accatcacat
     2761 ttaaatattc agcaggctac ccctcttgaa tttagaccat ttagctttag aaattaacag
     2821 tataccaata tatataatta aaaatagaaa ccaaatagat tctctgtatt tggcaacaga
     2881 gtggcagaac aatagtggca tctccacatt tgttaggatg aacatagccc tttcccctct
     2941 ccttccataa aagtgcacag aacatgttag tgcagataca gtcctcagaa cattaacatt
     3001 ccattttgca aaagacattt tccagaatct tggcagtagg taattctgaa acacttttga
     3061 attaccttca atcatcccat ataattagga atccagaata caaagtacaa acttggcaat
     3121 tgttatgatt gaaactgtca ctgatgctta agggaaattg aagcaagaag cataatttct
     3181 tcctttaggt tatatttcag caaaatactt gacagcaaca tacaatgaac agcttgtttg
     3241 gagagatgat atgatacaat gtaatagtga tgtcaaaata acctggagga atatccaaaa
     3301 accagaaaaa cgttaaaatg aagcccaact catgaacctc tctaactgaa gcccagtcaa
     3361 aagaaaggaa gtatagtttt aaggaagtta tttggttcta atgagttaag gagaaaggtt
     3421 atctgagaca cagttctttg acttcaggaa tctcatttta gaattatatt catgcccagt
     3481 tccagtttta aaaagaaaca taaagattca atgtagacat ttgaatgttg taaaatacta
     3541 aatttgaaac tcagaagaga taacttttaa aaacataaat cctaaaatta tagtttagaa
     3601 gatatttaag tatagttata tgtagtattt tgaatctgaa attatagact gtattttata
     3661 aaaataaatt ttggtcttgt ttctcactat atcatttgtt tcaacaatat atttttagat
     3721 ctaaagtgtt ttcattttaa tatgatagtg tgtttaatat catttgaata taaaaagaca
     3781 gctgtaaaat ttgatagtgt gtattattta agcacatcct gtatatttct ttgaatgctg
     3841 ctttctctat atgggatgct ttatatcccg attatgtgat gaatgtaaaa cttgaaagga
     3901 gtccaaattc caattttgtg taatctcagt gagtcacagt tcacatggct gctggggaaa
     3961 ttaccctgaa aactgtggtg tcgctatgct gtggagtaaa cagacaggca agaggtgctg
     4021 ggctttatcc tgctgaaggt ttatagacat ggaaatcttt agaaaatggt gtagaaggac
     4081 ctacaccaga gagtggtaca ccactctctc ctttcagagg actgaaacca aaacaagtcc
     4141 ttagtagact atttgtatgc tgtaaatttt tatccaaaag acaagtattc atgggtagtt
     4201 tcagatatat tagcatttgc ttgctaaaac ttttaaatta cttagtaata accaaaaaaa
     4261 gacactattt taggcatgat tgatcaattg aaagcataga taatcataag gaaaagtctt
     4321 acagacaagc tgaagtacag gtacctactt tgaaatgtct tctgtttcct gctgtgaaag
     4381 attttggctg gggtattttc ttgagaaaag accagaccct taggtgccta taaagtctaa
     4441 gtaattgaga cttagaaatt ggctaagtaa atttaagaga cgttcaataa tgtaggtggg
     4501 ttcagatacc cttttataat aactgtcttc ttagtatatt aacactcaag atgtttgtgt
     4561 atctttaatt tgcctttgtt tcacaataac tggcttttgt tttccttttc atggtgtgtt
     4621 gttggctata tagaggcatt tattggtaaa ttataatcag cagttgcacc atggaagtat
     4681 tcttggtgat aaattcttgg ggttacatag tatagttaac atgttatttt caagaaacat
     4741 gagtgtgtgt gtctgtgtgt gtgtgtctga agagtatcac ttatatgcag tgcatataca
     4801 tgtaagtgca ttactttgct caaatatctt ctgacctatt acagtcaact catgcatgag
     4861 tgtgaacatg tattacagaa ggtcttacag ccttagtttc tgttttagat tttatgtgct
     4921 gcttcctttc tcaaacaaaa gcatgaaagg aaagaggata agtactagaa atattcattt
     4981 ttttccttca caaatctaaa tgttgcttat gaaaactcat cttagagtaa tgaatatgtg
     5041 gaagtgggta ggtaggagga aatgtgcctc tttaaaatcc taaaatttta ccattgatat
     5101 tgacatttgt ttgcgtgtat ataaatggag catgtgtaaa tatagaattc caatagcatt
     5161 ttttatttta ttataaatct ataataaata tatataaatc actacca
//
