LOCUS       NM_001393987            6663 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens PR/SET domain 2 (PRDM2), transcript variant 6, mRNA.
ACCESSION   NM_001393987
VERSION     NM_001393987.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6663)
  AUTHORS   Di Donato,M., Di Zazzo,E., Salvati,A., Sorrentino,C., Giurato,G.,
            Fiore,D., Proto,M.C., Rienzo,M., Casamassimi,A., Gazzerro,P.,
            Bifulco,M., Castoria,G., Weisz,A., Nassa,G. and Abbondanza,C.
  TITLE     RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal
            cancer
  JOURNAL   J Transl Med 21 (1), 736 (2023)
   PUBMED   37853459
  REMARK    GeneRIF: RIZ2 at the crossroad of the EGF/EGFR signaling in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6663)
  AUTHORS   Di Zazzo,E., Rienzo,M., Casamassimi,A., De Rosa,C., Medici,N.,
            Gazzerro,P., Bifulco,M. and Abbondanza,C.
  TITLE     Exploring the putative role of PRDM1 and PRDM2 transcripts as
            mediators of T lymphocyte activation
  JOURNAL   J Transl Med 21 (1), 217 (2023)
   PUBMED   36964555
  REMARK    GeneRIF: Exploring the putative role of PRDM1 and PRDM2 transcripts
            as mediators of T lymphocyte activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6663)
  AUTHORS   Wei,D., Yiyuan,C., Qian,L., Jianhua,L., Yazhuo,Z. and Hua,G.
  TITLE     The absence of PRDM2 involved the tumorigenesis of somatotroph
            adenomas through regulating c-Myc
  JOURNAL   Gene 737, 144456 (2020)
   PUBMED   32044406
  REMARK    GeneRIF: PRDM2 negatively regulated the expression of c-Myc in
            somatotroph adenomas, and testified the synergism between PRDM2
            gene therapy and c-Myc inhibitor in vitro experiment
REFERENCE   4  (bases 1 to 6663)
  AUTHORS   Liu,Q., Qu,X., Xie,X., He,P. and Huang,S.
  TITLE     Repression of Akt3 gene transcription by the tumor suppressor RIZ1
  JOURNAL   Sci Rep 8 (1), 1528 (2018)
   PUBMED   29367689
  REMARK    GeneRIF: The authors have found that overexpression of RIZ1 in
            HEK293 cells reduced the expression of Akt3 protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6663)
  AUTHORS   Xue,Y., Chen,R., Du,W., Yang,F. and Wei,X.
  TITLE     RIZ1 and histone methylation status in pituitary adenomas
  JOURNAL   Tumour Biol 39 (7), 1010428317711794 (2017)
   PUBMED   28718376
  REMARK    GeneRIF: Promoter region methylation of RIZ1 may play an important
            role in the epigenetic silencing of RIZ1 expression in pituitary
            adenomas, which may translate into important diagnostic and
            therapeutic applications
REFERENCE   6  (bases 1 to 6663)
  AUTHORS   Liu,L., Shao,G., Steele-Perkins,G. and Huang,S.
  TITLE     The retinoblastoma interacting zinc finger gene RIZ produces a PR
            domain-lacking product through an internal promoter
  JOURNAL   J Biol Chem 272 (5), 2984-2991 (1997)
   PUBMED   9006946
REFERENCE   7  (bases 1 to 6663)
  AUTHORS   Buyse,I.M., Takahashi,E.I. and Huang,S.
  TITLE     Physical mapping of the retinoblastoma interacting zinc finger gene
            RIZ to D1S228 on chromosome 1p36
  JOURNAL   Genomics 34 (1), 119-121 (1996)
   PUBMED   8661032
REFERENCE   8  (bases 1 to 6663)
  AUTHORS   Muraosa,Y., Takahashi,K., Yoshizawa,M. and Shibahara,S.
  TITLE     cDNA cloning of a novel protein containing two zinc-finger domains
            that may function as a transcription factor for the human
            heme-oxygenase-1 gene
  JOURNAL   Eur J Biochem 235 (3), 471-479 (1996)
   PUBMED   8654390
REFERENCE   9  (bases 1 to 6663)
  AUTHORS   Shapiro,V.S., Lee,P. and Winoto,A.
  TITLE     Identification and cloning of the G3B cDNA encoding a 3' segment of
            a protein binding to GATA-3
  JOURNAL   Gene 163 (2), 329-330 (1995)
   PUBMED   7590293
REFERENCE   10 (bases 1 to 6663)
  AUTHORS   Buyse,I.M., Shao,G. and Huang,S.
  TITLE     The retinoblastoma protein binds to RIZ, a zinc-finger protein that
            shares an epitope with the adenovirus E1A protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4467-4471 (1995)
   PUBMED   7538672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031277.1.
            
            Summary: This tumor suppressor gene is a member of a nuclear
            histone/protein methyltransferase superfamily. It encodes a zinc
            finger protein that can bind to retinoblastoma protein, estrogen
            receptor, and the TPA-responsive element (MTE) of the
            heme-oxygenase-1 gene. Although the functions of this protein have
            not been fully characterized, it may (1) play a role in
            transcriptional regulation during neuronal differentiation and
            pathogenesis of retinoblastoma, (2) act as a transcriptional
            activator of the heme-oxygenase-1 gene, and (3) be a specific
            effector of estrogen action. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB208877.1, SRR14038194.1761608.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL031277.1         120821-120893       c
            74-184              AL031277.1         97120-97230         c
            185-4598            AL031277.1         87477-91890         c
            4599-4742           AL031277.1         53738-53881         c
            4743-6663           AL031277.1         45229-47149         c
FEATURES             Location/Qualifiers
     source          1..6663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..6663
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="PR/SET domain 2"
                     /db_xref="GeneID:7799"
                     /db_xref="HGNC:HGNC:9347"
                     /db_xref="MIM:601196"
     exon            1..73
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..184
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..4719
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /EC_number="2.1.1.355"
                     /note="isoform e is encoded by transcript variant 6;
                     retinoblastoma protein-binding zinc finger protein;
                     retinoblastoma protein-interacting zinc finger protein;
                     MTE-binding protein; PR domain zinc finger protein 2;
                     zinc-finger DNA-binding protein; GATA-3 binding protein
                     G3B; zinc finger protein RIZ; lysine N-methyltransferase
                     8; PR domain-containing protein 2; PR domain containing 2,
                     with ZNF domain; PR domain 2"
                     /codon_start=1
                     /product="PR domain zinc finger protein 2 isoform e"
                     /protein_id="NP_001380916.1"
                     /db_xref="GeneID:7799"
                     /db_xref="HGNC:HGNC:9347"
                     /db_xref="MIM:601196"
                     /translation="MRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPA
                     WEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNEN
                     SVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFP
                     CQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRK
                     PSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENG
                     EVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQ
                     NVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASA
                     DLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIK
                     AETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISAT
                     EIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAG
                     LTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLD
                     LSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKP
                     TTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVEST
                     PDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPS
                     SSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSS
                     SSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREE
                     PQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKD
                     KTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRP
                     QNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRL
                     GLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPE
                     LHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNF
                     SVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNRE
                     FTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAE
                     IKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPI
                     RMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRF
                     NIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPY
                     ITRQYRKVKAPAAAQFQGPFFKE"
     exon            185..4598
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4742
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            4743..6663
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5082
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
     regulatory      6631..6636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="hexamer: AATAAA"
     polyA_site      6663
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="major polyA site"
ORIGIN      
        1 gagatagcag ctgcgattga ggaagagcga gccagcgccc ggagcaagcg gagctccccc
       61 aagagccgga aagggaagaa aaaatcccag gaaaataaaa acaaaggaaa caaaatccaa
      121 gacatacaac tgaagacaag tgagccagat ttcacctctg caaatatgag agattctgca
      181 gaaggtccta aagaagacga agagaagcct tcagcctcag cacttgagca gccggccacc
      241 ctccaggagg tggccagtca ggaggtgcct ccagaactag caacccctgc ccctgcctgg
      301 gagccacagc cagaaccaga cgagcgatta gaagcggcag cttgtgaggt gaatgatttg
      361 ggggaagagg aggaggagga agaggaggag gatgaagaag aagaagaaga tgatgatgat
      421 gatgagttgg aagacgaggg ggaagaagaa gccagcatgc caaatgaaaa ttctgtgaaa
      481 gagccagaaa tacggtgtga tgagaagcca gaagatttat tagaggaacc aaaaacaact
      541 tcagaagaaa ctcttgaaga ctgctcagag gtaacacctg ccatgcaaat ccccagaact
      601 aaagaagagg ccaatggtga tgtatttgaa acgtttatgt ttccgtgtca acattgtgaa
      661 aggaagttta caaccaaaca ggggcttgag cgtcacatgc atatccatat atccaccgtc
      721 aatcatgctt tcaaatgcaa gtactgtggg aaagcctttg gcacacagat taaccggcgg
      781 cgacatgagc ggcgccatga agcagggtta aagcggaaac ccagccaaac actacagccg
      841 tcagaggatc tggctgatgg caaagcatct ggagaaaacg ttgcttcaaa agatgattcg
      901 agtcctccca gtcttgggcc agactgtctg atcatgaatt cagagaaggc ttcccaagac
      961 acaataaatt cttctgtcgt agaagagaat ggggaagtta aagaacttca tccgtgcaaa
     1021 tattgtaaaa aggtttttgg aactcatact aatatgagac ggcatcagcg tagagttcac
     1081 gaacgtcatc tgattcccaa aggtgtacgg cgaaaaggag gccttgaaga gccccagcct
     1141 ccagcagaac aggcccaggc cacccagaac gtgtatgtac caagcacaga gccggaggag
     1201 gaaggggaag cagatgatgt gtacatcatg gacatttcta gcaatatctc tgaaaactta
     1261 aattactata ttgatggtaa aattcaaact aataacaaca ctagtaactg tgatgtgatt
     1321 gagatggagt ctgcttcggc agatttgtat ggtataaatt gtctgctcac tccagttaca
     1381 gtggaaatta ctcaaaatat aaagaccaca caggtccctg taacagaaga tcttcctaaa
     1441 gagcctttgg gcagcacaaa tagtgaggcc aagaagcgga gaactgcgag cccacctgca
     1501 ctgcccaaaa ttaaggccga aacagactct gaccccatgg tcccctcttg ctctttaagt
     1561 cttcctctta gcatatcaac aacagaggca gtgtctttcc acaaagagaa aagtgtttat
     1621 ttgtcatcaa agctcaaaca acttcttcaa acccaagata aactaactcc tgcagggatt
     1681 tcagcaactg aaatagctaa attaggtcct gtttgtgtgt ctgctcctgc atcaatgttg
     1741 cctgtgacct caagtaggtt taagaggcgg accagctctc ctcccagttc tccacagcac
     1801 agtcctgccc ttcgagactt tggaaagcca agtgatggga aagcagcatg gaccgatgcc
     1861 gggctgactt ccaaaaaatc caaattagaa agtcacagcg actcaccagc atggagtttg
     1921 tctgggagag atgagagaga aactgtgagc cctccatgct ttgatgaata taaaatgtct
     1981 aaagagtgga cagctagttc tgcttttagc agtgtgtgca accagcagcc actggattta
     2041 tccagcggtg tcaaacagaa ggctgagggt acaggcaaga ctccagtcca gtgggaatct
     2101 gtcttagatc tcagtgtgca taaaaagcat tgtagtgact ctgaaggcaa ggaattcaaa
     2161 gaaagtcatt cagtgcagcc tacgtgtagt gctgtaaaga aaaggaaacc aaccacctgc
     2221 atgctgcaga aggttcttct caatgaatat aatggcatcg atttacctgt agaaaaccct
     2281 gcagatggga ccaggagccc aagtccttgt aaatccctag aagctcagcc agatcctgac
     2341 ctcggtccgg gctctggttt ccctgcccct actgttgagt ccacacctga tgtttgtcct
     2401 tcatcacctg ccctgcagac accctccctt tcatccggtc agctgcctcc tctcttgatc
     2461 cccacagatc cctcttcccc tccaccctgt cccccggtat taactgttgc cactccgccc
     2521 cctcccctcc ttcctaccgt acctcttcca gccccctctt ccagtgcatc tccacaccca
     2581 tgcccctctc cactctcaaa tgccaccgca cagtccccac ttccaattct gtccccaaca
     2641 gtgtccccct ctccctctcc cattcctccc gtggagcccc tgatgtctgc cgcctcaccc
     2701 gggcctccaa cactttcttc ttcctcctct tcatcttcct cctcctcttc gttttcttct
     2761 tcatcttcct cctcttctcc ttctccacct cctctctccg caatatcatc tgttgtttcc
     2821 tctggtgata atctggaggc ttctctcccc atgatatctt tcaaacagga ggaattagag
     2881 aatgaaggtc tgaaacccag ggaagagccc cagtctgctg ctgaacagga tgttgttgtt
     2941 caggaaacat tcaacaaaaa ctttgtttgc aacgtctgtg aatcaccttt tctttccatt
     3001 aaagatctaa ccaaacattt atctattcat gctgaagaat ggcccttcaa atgtgaattt
     3061 tgtgtgcagc tttttaagga taaaacggac ttgtcagaac atcgcttttt gcttcatgga
     3121 gttgggaata tctttgtgtg ttctgtttgt aaaaaagaat ttgctttttt gtgcaatttg
     3181 cagcagcacc agcgagatct ccacccagat aaggtgtgca cacatcacga gtttgaaagc
     3241 gggactctga ggccccagaa ctttacagat cccagcaagg cccatgtaga gcatatgcag
     3301 agcttgccag aagatccttt agaaacttct aaagaagaag aggagttaaa tgattcctct
     3361 gaagagcttt acacgactat aaaaataatg gcttctggaa taaagacaaa agatccagat
     3421 gttcgattgg gcctcaatca gcattaccca agctttaaac cacctccatt tcagtaccat
     3481 caccgtaacc ccatggggat tggtgtgaca gccacaaatt tcactacaca caatattcca
     3541 cagactttca ctaccgccat tcgctgcaca aagtgtggaa aaggtgtcga caatatgccg
     3601 gagttgcaca aacatatcct ggcttgtgct tctgcaagtg acaagaagag gtacacgcct
     3661 aagaaaaacc cagtaccatt aaaacaaact gtgcaaccca aaaatggcgt ggtggtttta
     3721 gataactctg ggaaaaatgc cttccgacga atgggacagc ccaaaaggct taactttagt
     3781 gttgagctca gcaaaatgtc gtcgaataag ctcaaattaa atgcattgaa gaaaaaaaat
     3841 cagctagtac agaaagcaat tcttcagaaa aacaaatctg caaagcagaa ggccgacttg
     3901 aaaaatgctt gtgagtcatc ctctcacatc tgcccttact gtaatcgaga gttcacttac
     3961 attggaagcc tgaataaaca cgccgccttc agctgtccca aaaaacccct ttctcctccc
     4021 aaaaaaaaag tttctcattc atctaagaaa ggtggacact catcacctgc aagtagtgac
     4081 aaaaacagta acagcaacca ccgcagacgg acagcggatg cggagattaa aatgcaaagc
     4141 atgcagactc cgttgggcaa gaccagagcc cgcagctcag gccccaccca agtcccactt
     4201 ccctcctcat ccttcaggtc caagcagaac gtcaagtttg cagcttcggt gaaatccaaa
     4261 aaaccaagct cctcctcttt aaggaactcc agcccgataa gaatggccaa aataactcat
     4321 gttgagggga aaaaacctaa agctgtggcc aagaatcatt ctgctcagct ttccagcaaa
     4381 acatcacgga gcctgcacgt gagggtacag aaaagcaaag ctgttttaca aagcaaatcc
     4441 accttggcga gtaagaaaag aacagaccgg ttcaatataa aatctagaga gcggagtggg
     4501 gggccagtca cccggagcct tcagctggca gctgctgctg acttgagtga gaacaagaga
     4561 gaggacggca gcgccaagca ggagctgaag gacttcagct acagcctccg cttggcgtcc
     4621 cgatgctctc caccagcggc cccgtacatc accaggcagt ataggaaggt caaagctcca
     4681 gctgcagccc agttccaggg accattcttc aaagagtaga cactctggct gctccctgac
     4741 agcacctgaa gtgacctgga atcagtgaag ccaaagggac tggcagtctg ccctgcaggg
     4801 agtaccgacc tatcccagtt gtgtgaggct gcgagagaaa gggagtgcat gtgcgcgcgt
     4861 gcatgtgtgc gtgcgtgtgt gttcacgtgt tctcgtgcgg gcgcgtgagt ggtcttcaaa
     4921 cgagggtccc gatccccggg gcggcaggaa gggggccgac tccacgctgt cctttgggat
     4981 gatacttgga tgcagctctt gggaccgtgt tctgcagccc agccttcctg ttggggtggg
     5041 gcctctccta ctatgcaatt tttcaagagc tccttgaccc tgctttttgc ttcttgagtt
     5101 gtcttttgcc attatgggga ctttggtttg acccaggggt cagccttagg aaggccttca
     5161 ggaggaggcc gagttcccct tcagtaccac ccctctctcc ccaccttccc tctcccggca
     5221 acatctctgg gaatcaacag catattgaca cgttggagcc gagcctgaac atgcccctcg
     5281 gccccagcac atggaaaacc cccttccttg cctaaggtgt ctgagtttct ggctcttgag
     5341 gcatttccag acttgaaatt ctcatcagtc cattgctctt gagtctttgc agagaacctc
     5401 agatcaggtg cacctgggag aaagactttg tccccactta cagatctatc tcctcccttg
     5461 ggaagggcag ggaatgggga cggtgtatgg aggggaggga tctcctgcgc ccttcattgc
     5521 cacacttggt gggaccatga acatctttag tgtctgagct tctcaaatta gctgcaatag
     5581 gaaaaaaaca aattgggaaa tgaaaaaaaa atgggaagat taaaaagcac agggggaaga
     5641 agaagagatt tcggaggcca tcctgccagg ggcggacggg gctgactcct gctctctgga
     5701 ggacggtcag tccatgtctc ggagaaacgg gtgagctgag cttggcgttt ggacccagtt
     5761 cagtgaggtt cttgggtttt gtgcctttgg ggcagacccc aggcaaggat gtctgagacc
     5821 acttgggcgc tgttttctca gctccaattt caagagtgag ctatcaaacc cagagcggaa
     5881 ggagggagct ctgatgagca cggtttgtca cacgataaag ggattttttt tttcagggct
     5941 actacggttg atcttgcaac tctgtaaata tgtatgtaga cacttttaaa agcacgtatt
     6001 tatgtccctg actgtaaatg ctccattttt aaagttttat aacttgtgtt atttaatgag
     6061 tcagtcaatc ggctgcagta tgggatctga taaggatcta ggagaagggt ctcatgcgga
     6121 ccctcacatg ggcagaaaaa tggtggtcat tggccgacat cacagttttc ctgtttccca
     6181 cccagctaaa aaccgttgtt tgctttaaat tttcataaac tggaatcctt tcacccgctc
     6241 ctacagctaa ccctcacaag catgaagtgc tgtggctgtt ccttatccta atgatgcgct
     6301 tttgtcccgt aaatgttaac actcatgaag cataccccgg cctctcagtt cttgagggcc
     6361 tccccaccgc agcagcaagg aaagctcacg aaccccaaac ctggcaagtc acctgcagcc
     6421 catggtgagc tctgggaagt gtggttgagg ccttggggtc actccttttt tgcatgtgca
     6481 aatgtgctgg tcacccttca acgctcccag acggtcagga aaactgttcc aatcatgaaa
     6541 aggggggatg attttgtaaa agtggcattt cctggtcagt ggtggtcttc aagacgacag
     6601 ctctgtatct gccatgtgaa gagaattaac aataaaagtg tgaagagcga ttgtgaggaa
     6661 caa
//
