LOCUS       NM_001393986            7279 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens PR/SET domain 2 (PRDM2), transcript variant 5, mRNA.
ACCESSION   NM_001393986 XM_017002256
VERSION     NM_001393986.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7279)
  AUTHORS   Di Donato,M., Di Zazzo,E., Salvati,A., Sorrentino,C., Giurato,G.,
            Fiore,D., Proto,M.C., Rienzo,M., Casamassimi,A., Gazzerro,P.,
            Bifulco,M., Castoria,G., Weisz,A., Nassa,G. and Abbondanza,C.
  TITLE     RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal
            cancer
  JOURNAL   J Transl Med 21 (1), 736 (2023)
   PUBMED   37853459
  REMARK    GeneRIF: RIZ2 at the crossroad of the EGF/EGFR signaling in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7279)
  AUTHORS   Di Zazzo,E., Rienzo,M., Casamassimi,A., De Rosa,C., Medici,N.,
            Gazzerro,P., Bifulco,M. and Abbondanza,C.
  TITLE     Exploring the putative role of PRDM1 and PRDM2 transcripts as
            mediators of T lymphocyte activation
  JOURNAL   J Transl Med 21 (1), 217 (2023)
   PUBMED   36964555
  REMARK    GeneRIF: Exploring the putative role of PRDM1 and PRDM2 transcripts
            as mediators of T lymphocyte activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7279)
  AUTHORS   Wei,D., Yiyuan,C., Qian,L., Jianhua,L., Yazhuo,Z. and Hua,G.
  TITLE     The absence of PRDM2 involved the tumorigenesis of somatotroph
            adenomas through regulating c-Myc
  JOURNAL   Gene 737, 144456 (2020)
   PUBMED   32044406
  REMARK    GeneRIF: PRDM2 negatively regulated the expression of c-Myc in
            somatotroph adenomas, and testified the synergism between PRDM2
            gene therapy and c-Myc inhibitor in vitro experiment
REFERENCE   4  (bases 1 to 7279)
  AUTHORS   Liu,Q., Qu,X., Xie,X., He,P. and Huang,S.
  TITLE     Repression of Akt3 gene transcription by the tumor suppressor RIZ1
  JOURNAL   Sci Rep 8 (1), 1528 (2018)
   PUBMED   29367689
  REMARK    GeneRIF: The authors have found that overexpression of RIZ1 in
            HEK293 cells reduced the expression of Akt3 protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7279)
  AUTHORS   Xue,Y., Chen,R., Du,W., Yang,F. and Wei,X.
  TITLE     RIZ1 and histone methylation status in pituitary adenomas
  JOURNAL   Tumour Biol 39 (7), 1010428317711794 (2017)
   PUBMED   28718376
  REMARK    GeneRIF: Promoter region methylation of RIZ1 may play an important
            role in the epigenetic silencing of RIZ1 expression in pituitary
            adenomas, which may translate into important diagnostic and
            therapeutic applications
REFERENCE   6  (bases 1 to 7279)
  AUTHORS   Liu,L., Shao,G., Steele-Perkins,G. and Huang,S.
  TITLE     The retinoblastoma interacting zinc finger gene RIZ produces a PR
            domain-lacking product through an internal promoter
  JOURNAL   J Biol Chem 272 (5), 2984-2991 (1997)
   PUBMED   9006946
REFERENCE   7  (bases 1 to 7279)
  AUTHORS   Buyse,I.M., Takahashi,E.I. and Huang,S.
  TITLE     Physical mapping of the retinoblastoma interacting zinc finger gene
            RIZ to D1S228 on chromosome 1p36
  JOURNAL   Genomics 34 (1), 119-121 (1996)
   PUBMED   8661032
REFERENCE   8  (bases 1 to 7279)
  AUTHORS   Muraosa,Y., Takahashi,K., Yoshizawa,M. and Shibahara,S.
  TITLE     cDNA cloning of a novel protein containing two zinc-finger domains
            that may function as a transcription factor for the human
            heme-oxygenase-1 gene
  JOURNAL   Eur J Biochem 235 (3), 471-479 (1996)
   PUBMED   8654390
REFERENCE   9  (bases 1 to 7279)
  AUTHORS   Shapiro,V.S., Lee,P. and Winoto,A.
  TITLE     Identification and cloning of the G3B cDNA encoding a 3' segment of
            a protein binding to GATA-3
  JOURNAL   Gene 163 (2), 329-330 (1995)
   PUBMED   7590293
REFERENCE   10 (bases 1 to 7279)
  AUTHORS   Buyse,I.M., Shao,G. and Huang,S.
  TITLE     The retinoblastoma protein binds to RIZ, a zinc-finger protein that
            shares an epitope with the adenovirus E1A protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4467-4471 (1995)
   PUBMED   7538672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359771.27, AL583942.12 and
            AL031277.1.
            
            On Mar 25, 2021 this sequence version replaced XM_017002256.1.
            
            Summary: This tumor suppressor gene is a member of a nuclear
            histone/protein methyltransferase superfamily. It encodes a zinc
            finger protein that can bind to retinoblastoma protein, estrogen
            receptor, and the TPA-responsive element (MTE) of the
            heme-oxygenase-1 gene. Although the functions of this protein have
            not been fully characterized, it may (1) play a role in
            transcriptional regulation during neuronal differentiation and
            pathogenesis of retinoblastoma, (2) act as a transcriptional
            activator of the heme-oxygenase-1 gene, and (3) be a specific
            effector of estrogen action. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311066.10/ ENSP00000312352.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL359771.27        95441-95553
            114-187             AL583942.12        1608-1681
            188-305             AL031277.1         139191-139308       c
            306-409             AL031277.1         137426-137529       c
            410-562             AL031277.1         128151-128303       c
            563-689             AL031277.1         120821-120947       c
            690-800             AL031277.1         97120-97230         c
            801-5214            AL031277.1         87477-91890         c
            5215-5358           AL031277.1         53738-53881         c
            5359-7279           AL031277.1         45229-47149         c
FEATURES             Location/Qualifiers
     source          1..7279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..7279
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="PR/SET domain 2"
                     /db_xref="GeneID:7799"
                     /db_xref="HGNC:HGNC:9347"
                     /db_xref="MIM:601196"
     exon            1..113
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            114..187
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..5335
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /EC_number="2.1.1.355"
                     /note="isoform a is encoded by transcript variant 5;
                     retinoblastoma protein-binding zinc finger protein;
                     retinoblastoma protein-interacting zinc finger protein;
                     MTE-binding protein; PR domain zinc finger protein 2;
                     zinc-finger DNA-binding protein; GATA-3 binding protein
                     G3B; zinc finger protein RIZ; lysine N-methyltransferase
                     8; PR domain-containing protein 2; PR domain containing 2,
                     with ZNF domain; PR domain 2"
                     /codon_start=1
                     /product="PR domain zinc finger protein 2 isoform a"
                     /protein_id="NP_001380915.1"
                     /db_xref="CCDS:CCDS150.1"
                     /db_xref="GeneID:7799"
                     /db_xref="HGNC:HGNC:9347"
                     /db_xref="MIM:601196"
                     /translation="MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGV
                     WATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV
                     NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASAR
                     SKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSA
                     SALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEE
                     DEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDC
                     SEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKC
                     KYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPS
                     LGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHER
                     HLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENL
                     NYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDL
                     PKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKE
                     KSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSP
                     PSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPP
                     CFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKH
                     CSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPS
                     PCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSS
                     PPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPS
                     PSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSG
                     DNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSI
                     KDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLC
                     NLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEEL
                     NDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNF
                     TTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQ
                     PKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQK
                     NKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSS
                     KKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFR
                     SKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRS
                     LHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKRED
                     GSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE"
     exon            188..305
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..409
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..562
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..689
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..800
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..5214
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5358
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            5359..7279
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5698
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
     regulatory      7247..7252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="hexamer: AATAAA"
     polyA_site      7279
                     /gene="PRDM2"
                     /gene_synonym="HUMHOXY1; KMT8; KMT8A; MTB-ZF; RIZ; RIZ1;
                     RIZ2"
                     /note="major polyA site"
ORIGIN      
        1 acttccgact ggagtcaaga tggcggcggc gcggccgcgg gcgccggggc cggcgaaaca
       61 gcggcggcgg cggcggccct cggtgctctg aggcgctggc gcggcgggcg cggggttcat
      121 gtaatcaaag aagtttcttt gttgtgtgta tctttacaga acacaacagg aattgaaaat
      181 gaatcagaac actactgagc ctgtggcggc caccgagacc ctggctgagg tacccgaaca
      241 tgtgctgcga ggacttccgg aggaagtgag gcttttccct tctgctgttg acaagacccg
      301 gattggtgtc tgggccacta aaccaatttt aaaaggcaaa aaatttgggc catttgttgg
      361 tgataagaaa aaaagatctc aggttaagaa taatgtatac atgtgggagg tgtattaccc
      421 aaatttggga tggatgtgca ttgatgccac tgatccagag aagggaaact ggctgcgata
      481 tgtgaattgg gcttgctcag gagaagagca aaatttattc ccactggaaa tcaacagagc
      541 catttactat aaaactttaa agccaatcgc gccgggcgag gagctcctgg tctggtacaa
      601 tggggaagac aaccctgaga tagcagctgc gattgaggaa gagcgagcca gcgcccggag
      661 caagcggagc tcccccaaga gccggaaagg gaagaaaaaa tcccaggaaa ataaaaacaa
      721 aggaaacaaa atccaagaca tacaactgaa gacaagtgag ccagatttca cctctgcaaa
      781 tatgagagat tctgcagaag gtcctaaaga agacgaagag aagccttcag cctcagcact
      841 tgagcagccg gccaccctcc aggaggtggc cagtcaggag gtgcctccag aactagcaac
      901 ccctgcccct gcctgggagc cacagccaga accagacgag cgattagaag cggcagcttg
      961 tgaggtgaat gatttggggg aagaggagga ggaggaagag gaggaggatg aagaagaaga
     1021 agaagatgat gatgatgatg agttggaaga cgagggggaa gaagaagcca gcatgccaaa
     1081 tgaaaattct gtgaaagagc cagaaatacg gtgtgatgag aagccagaag atttattaga
     1141 ggaaccaaaa acaacttcag aagaaactct tgaagactgc tcagaggtaa cacctgccat
     1201 gcaaatcccc agaactaaag aagaggccaa tggtgatgta tttgaaacgt ttatgtttcc
     1261 gtgtcaacat tgtgaaagga agtttacaac caaacagggg cttgagcgtc acatgcatat
     1321 ccatatatcc accgtcaatc atgctttcaa atgcaagtac tgtgggaaag cctttggcac
     1381 acagattaac cggcggcgac atgagcggcg ccatgaagca gggttaaagc ggaaacccag
     1441 ccaaacacta cagccgtcag aggatctggc tgatggcaaa gcatctggag aaaacgttgc
     1501 ttcaaaagat gattcgagtc ctcccagtct tgggccagac tgtctgatca tgaattcaga
     1561 gaaggcttcc caagacacaa taaattcttc tgtcgtagaa gagaatgggg aagttaaaga
     1621 acttcatccg tgcaaatatt gtaaaaaggt ttttggaact catactaata tgagacggca
     1681 tcagcgtaga gttcacgaac gtcatctgat tcccaaaggt gtacggcgaa aaggaggcct
     1741 tgaagagccc cagcctccag cagaacaggc ccaggccacc cagaacgtgt atgtaccaag
     1801 cacagagccg gaggaggaag gggaagcaga tgatgtgtac atcatggaca tttctagcaa
     1861 tatctctgaa aacttaaatt actatattga tggtaaaatt caaactaata acaacactag
     1921 taactgtgat gtgattgaga tggagtctgc ttcggcagat ttgtatggta taaattgtct
     1981 gctcactcca gttacagtgg aaattactca aaatataaag accacacagg tccctgtaac
     2041 agaagatctt cctaaagagc ctttgggcag cacaaatagt gaggccaaga agcggagaac
     2101 tgcgagccca cctgcactgc ccaaaattaa ggccgaaaca gactctgacc ccatggtccc
     2161 ctcttgctct ttaagtcttc ctcttagcat atcaacaaca gaggcagtgt ctttccacaa
     2221 agagaaaagt gtttatttgt catcaaagct caaacaactt cttcaaaccc aagataaact
     2281 aactcctgca gggatttcag caactgaaat agctaaatta ggtcctgttt gtgtgtctgc
     2341 tcctgcatca atgttgcctg tgacctcaag taggtttaag aggcggacca gctctcctcc
     2401 cagttctcca cagcacagtc ctgcccttcg agactttgga aagccaagtg atgggaaagc
     2461 agcatggacc gatgccgggc tgacttccaa aaaatccaaa ttagaaagtc acagcgactc
     2521 accagcatgg agtttgtctg ggagagatga gagagaaact gtgagccctc catgctttga
     2581 tgaatataaa atgtctaaag agtggacagc tagttctgct tttagcagtg tgtgcaacca
     2641 gcagccactg gatttatcca gcggtgtcaa acagaaggct gagggtacag gcaagactcc
     2701 agtccagtgg gaatctgtct tagatctcag tgtgcataaa aagcattgta gtgactctga
     2761 aggcaaggaa ttcaaagaaa gtcattcagt gcagcctacg tgtagtgctg taaagaaaag
     2821 gaaaccaacc acctgcatgc tgcagaaggt tcttctcaat gaatataatg gcatcgattt
     2881 acctgtagaa aaccctgcag atgggaccag gagcccaagt ccttgtaaat ccctagaagc
     2941 tcagccagat cctgacctcg gtccgggctc tggtttccct gcccctactg ttgagtccac
     3001 acctgatgtt tgtccttcat cacctgccct gcagacaccc tccctttcat ccggtcagct
     3061 gcctcctctc ttgatcccca cagatccctc ttcccctcca ccctgtcccc cggtattaac
     3121 tgttgccact ccgccccctc ccctccttcc taccgtacct cttccagccc cctcttccag
     3181 tgcatctcca cacccatgcc cctctccact ctcaaatgcc accgcacagt ccccacttcc
     3241 aattctgtcc ccaacagtgt ccccctctcc ctctcccatt cctcccgtgg agcccctgat
     3301 gtctgccgcc tcacccgggc ctccaacact ttcttcttcc tcctcttcat cttcctcctc
     3361 ctcttcgttt tcttcttcat cttcctcctc ttctccttct ccacctcctc tctccgcaat
     3421 atcatctgtt gtttcctctg gtgataatct ggaggcttct ctccccatga tatctttcaa
     3481 acaggaggaa ttagagaatg aaggtctgaa acccagggaa gagccccagt ctgctgctga
     3541 acaggatgtt gttgttcagg aaacattcaa caaaaacttt gtttgcaacg tctgtgaatc
     3601 accttttctt tccattaaag atctaaccaa acatttatct attcatgctg aagaatggcc
     3661 cttcaaatgt gaattttgtg tgcagctttt taaggataaa acggacttgt cagaacatcg
     3721 ctttttgctt catggagttg ggaatatctt tgtgtgttct gtttgtaaaa aagaatttgc
     3781 ttttttgtgc aatttgcagc agcaccagcg agatctccac ccagataagg tgtgcacaca
     3841 tcacgagttt gaaagcggga ctctgaggcc ccagaacttt acagatccca gcaaggccca
     3901 tgtagagcat atgcagagct tgccagaaga tcctttagaa acttctaaag aagaagagga
     3961 gttaaatgat tcctctgaag agctttacac gactataaaa ataatggctt ctggaataaa
     4021 gacaaaagat ccagatgttc gattgggcct caatcagcat tacccaagct ttaaaccacc
     4081 tccatttcag taccatcacc gtaaccccat ggggattggt gtgacagcca caaatttcac
     4141 tacacacaat attccacaga ctttcactac cgccattcgc tgcacaaagt gtggaaaagg
     4201 tgtcgacaat atgccggagt tgcacaaaca tatcctggct tgtgcttctg caagtgacaa
     4261 gaagaggtac acgcctaaga aaaacccagt accattaaaa caaactgtgc aacccaaaaa
     4321 tggcgtggtg gttttagata actctgggaa aaatgccttc cgacgaatgg gacagcccaa
     4381 aaggcttaac tttagtgttg agctcagcaa aatgtcgtcg aataagctca aattaaatgc
     4441 attgaagaaa aaaaatcagc tagtacagaa agcaattctt cagaaaaaca aatctgcaaa
     4501 gcagaaggcc gacttgaaaa atgcttgtga gtcatcctct cacatctgcc cttactgtaa
     4561 tcgagagttc acttacattg gaagcctgaa taaacacgcc gccttcagct gtcccaaaaa
     4621 acccctttct cctcccaaaa aaaaagtttc tcattcatct aagaaaggtg gacactcatc
     4681 acctgcaagt agtgacaaaa acagtaacag caaccaccgc agacggacag cggatgcgga
     4741 gattaaaatg caaagcatgc agactccgtt gggcaagacc agagcccgca gctcaggccc
     4801 cacccaagtc ccacttccct cctcatcctt caggtccaag cagaacgtca agtttgcagc
     4861 ttcggtgaaa tccaaaaaac caagctcctc ctctttaagg aactccagcc cgataagaat
     4921 ggccaaaata actcatgttg aggggaaaaa acctaaagct gtggccaaga atcattctgc
     4981 tcagctttcc agcaaaacat cacggagcct gcacgtgagg gtacagaaaa gcaaagctgt
     5041 tttacaaagc aaatccacct tggcgagtaa gaaaagaaca gaccggttca atataaaatc
     5101 tagagagcgg agtggggggc cagtcacccg gagccttcag ctggcagctg ctgctgactt
     5161 gagtgagaac aagagagagg acggcagcgc caagcaggag ctgaaggact tcagctacag
     5221 cctccgcttg gcgtcccgat gctctccacc agcggccccg tacatcacca ggcagtatag
     5281 gaaggtcaaa gctccagctg cagcccagtt ccagggacca ttcttcaaag agtagacact
     5341 ctggctgctc cctgacagca cctgaagtga cctggaatca gtgaagccaa agggactggc
     5401 agtctgccct gcagggagta ccgacctatc ccagttgtgt gaggctgcga gagaaaggga
     5461 gtgcatgtgc gcgcgtgcat gtgtgcgtgc gtgtgtgttc acgtgttctc gtgcgggcgc
     5521 gtgagtggtc ttcaaacgag ggtcccgatc cccggggcgg caggaagggg gccgactcca
     5581 cgctgtcctt tgggatgata cttggatgca gctcttggga ccgtgttctg cagcccagcc
     5641 ttcctgttgg ggtggggcct ctcctactat gcaatttttc aagagctcct tgaccctgct
     5701 ttttgcttct tgagttgtct tttgccatta tggggacttt ggtttgaccc aggggtcagc
     5761 cttaggaagg ccttcaggag gaggccgagt tccccttcag taccacccct ctctccccac
     5821 cttccctctc ccggcaacat ctctgggaat caacagcata ttgacacgtt ggagccgagc
     5881 ctgaacatgc ccctcggccc cagcacatgg aaaaccccct tccttgccta aggtgtctga
     5941 gtttctggct cttgaggcat ttccagactt gaaattctca tcagtccatt gctcttgagt
     6001 ctttgcagag aacctcagat caggtgcacc tgggagaaag actttgtccc cacttacaga
     6061 tctatctcct cccttgggaa gggcagggaa tggggacggt gtatggaggg gagggatctc
     6121 ctgcgccctt cattgccaca cttggtggga ccatgaacat ctttagtgtc tgagcttctc
     6181 aaattagctg caataggaaa aaaacaaatt gggaaatgaa aaaaaaatgg gaagattaaa
     6241 aagcacaggg ggaagaagaa gagatttcgg aggccatcct gccaggggcg gacggggctg
     6301 actcctgctc tctggaggac ggtcagtcca tgtctcggag aaacgggtga gctgagcttg
     6361 gcgtttggac ccagttcagt gaggttcttg ggttttgtgc ctttggggca gaccccaggc
     6421 aaggatgtct gagaccactt gggcgctgtt ttctcagctc caatttcaag agtgagctat
     6481 caaacccaga gcggaaggag ggagctctga tgagcacggt ttgtcacacg ataaagggat
     6541 tttttttttc agggctacta cggttgatct tgcaactctg taaatatgta tgtagacact
     6601 tttaaaagca cgtatttatg tccctgactg taaatgctcc atttttaaag ttttataact
     6661 tgtgttattt aatgagtcag tcaatcggct gcagtatggg atctgataag gatctaggag
     6721 aagggtctca tgcggaccct cacatgggca gaaaaatggt ggtcattggc cgacatcaca
     6781 gttttcctgt ttcccaccca gctaaaaacc gttgtttgct ttaaattttc ataaactgga
     6841 atcctttcac ccgctcctac agctaaccct cacaagcatg aagtgctgtg gctgttcctt
     6901 atcctaatga tgcgcttttg tcccgtaaat gttaacactc atgaagcata ccccggcctc
     6961 tcagttcttg agggcctccc caccgcagca gcaaggaaag ctcacgaacc ccaaacctgg
     7021 caagtcacct gcagcccatg gtgagctctg ggaagtgtgg ttgaggcctt ggggtcactc
     7081 cttttttgca tgtgcaaatg tgctggtcac ccttcaacgc tcccagacgg tcaggaaaac
     7141 tgttccaatc atgaaaaggg gggatgattt tgtaaaagtg gcatttcctg gtcagtggtg
     7201 gtcttcaaga cgacagctct gtatctgcca tgtgaagaga attaacaata aaagtgtgaa
     7261 gagcgattgt gaggaacaa
//
